{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:37:13Z","timestamp":1790836633347,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.jnutbio.2018.03.024","type":"journal-article","created":{"date-parts":[[2018,4,7]],"date-time":"2018-04-07T19:31:06Z","timestamp":1523129466000},"page":"170-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"special_numbering":"C","title":["Polyphenol-rich green tea extract improves adipose tissue metabolism by down-regulating miR-335 expression and mitigating insulin resistance and inflammation"],"prefix":"10.1016","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5503-3967","authenticated-orcid":false,"given":"Rosemari","family":"Otton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anaysa Paola","family":"Bolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia Torres","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Paradiso","family":"Marinovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Livia Silva","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Alves","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2018.03.024_bb0005","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.mce.2017.04.009","article-title":"Small non coding RNAs in adipocyte biology and obesity","volume":"456","author":"Amri","year":"2017","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jnutbio.2018.03.024_bb0010","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.redox.2017.01.020","article-title":"Shortcuts to a functional adipose tissue: the role of small non-coding RNAs","volume":"12","author":"Brandao","year":"2017","journal-title":"Redox Biol"},{"issue":"3","key":"10.1016\/j.jnutbio.2018.03.024_bb0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nrendo.2016.142","article-title":"Anti-obesogenic and antidiabetic effects of plants and mushrooms","volume":"13","author":"Martel","year":"2017","journal-title":"Nat Rev Endocrinol"},{"issue":"5091","key":"10.1016\/j.jnutbio.2018.03.024_bb0020","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"issue":"7394","key":"10.1016\/j.jnutbio.2018.03.024_bb0025","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature10986","article-title":"A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism","volume":"484","author":"Herman","year":"2012","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.03.024_bb0030","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/ijo.2015.170","article-title":"MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics","volume":"40","author":"Deiuliis","year":"2016","journal-title":"Int J Obes"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.03.024_bb0035","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.apsb.2015.01.002","article-title":"Emerging role of microRNAs in lipid metabolism","volume":"5","author":"Yang","year":"2015","journal-title":"Acta Pharm Sin B"},{"issue":"12","key":"10.1016\/j.jnutbio.2018.03.024_bb0040","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/obr.12452","article-title":"Therapeutic potential of green tea on risk factors for type 2 diabetes in obese adults \u2014 a review","volume":"17","author":"Ferreira","year":"2016","journal-title":"Obes Rev"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.03.024_bb0045","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1006\/abbi.2000.1742","article-title":"Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells","volume":"376","author":"Ahmad","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2018.03.024_bb0050","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1177\/0192623310382437","article-title":"Fourteen-week toxicity study of green tea extract in rats and mice","volume":"38","author":"Chan","year":"2010","journal-title":"Toxicol Pathol"},{"issue":"12","key":"10.1016\/j.jnutbio.2018.03.024_bb0055","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1093\/jn\/133.12.4172","article-title":"Epigallocatechin-3-gallate is absorbed but extensively glucuronidated following oral administration to mice","volume":"133","author":"Lambert","year":"2003","journal-title":"J Nutr"},{"issue":"7","key":"10.1016\/j.jnutbio.2018.03.024_bb0060","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1007\/s00394-015-1033-8","article-title":"Green tea extract activates AMPK and ameliorates white adipose tissue metabolic dysfunction induced by obesity","volume":"55","author":"Rocha","year":"2016","journal-title":"Eur J Nutr"},{"issue":"3","key":"10.1016\/j.jnutbio.2018.03.024_bb0065","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1007\/s00394-015-0940-z","article-title":"Green tea polyphenol extract in vivo attenuates inflammatory features of neutrophils from obese rats","volume":"55","author":"Albuquerque","year":"2016","journal-title":"Eur J Nutr"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.03.024_bb0070","doi-asserted-by":"crossref","first-page":"C961","DOI":"10.1152\/ajpcell.00547.2009","article-title":"Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK","volume":"298","author":"Gaidhu","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.03.024_bb0075","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.febslet.2007.11.051","article-title":"TNF-alpha and adipocyte biology","volume":"582","author":"Cawthorn","year":"2008","journal-title":"FEBS Lett"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.03.024_bb0080","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.molmet.2017.01.010","article-title":"Astrocyte IKKbeta\/NF-kappaB signaling is required for diet-induced obesity and hypothalamic inflammation","volume":"6","author":"Douglass","year":"2017","journal-title":"Mol Metab"},{"key":"10.1016\/j.jnutbio.2018.03.024_bb0085","doi-asserted-by":"crossref","DOI":"10.1038\/srep22862","article-title":"miR-155 deletion in female mice prevents diet-induced obesity","volume":"6","author":"Gaudet","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.03.024_bb0090","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12013-013-9708-3","article-title":"MiR-335, an adipogenesis-related microRNA, is involved in adipose tissue inflammation","volume":"68","author":"Zhu","year":"2014","journal-title":"Cell Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2018.03.024_bb0095","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2174\/1871523015666160915154443","article-title":"Anti-inflammatory action of green tea","volume":"15","author":"Ohishi","year":"2016","journal-title":"Antiinflamm Antiallergy Agents Med Chem"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.03.024_bb0100","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.bbrc.2009.05.058","article-title":"The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice","volume":"385","author":"Nakanishi","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.jnutbio.2018.03.024_bb0105","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1079\/BJN20051502","article-title":"Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men","volume":"94","author":"Berube-Parent","year":"2005","journal-title":"Br J Nutr"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.03.024_bb0110","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1080\/10408398.2014.986672","article-title":"A minireview of effects of green tea on energy expenditure","volume":"57","author":"Turkozu","year":"2017","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"6","key":"10.1016\/j.jnutbio.2018.03.024_bb0115","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/ajcn\/70.6.1040","article-title":"Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans","volume":"70","author":"Dulloo","year":"1999","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.03.024_bb0120","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cmet.2013.01.001","article-title":"Adiponectin receptor as a key player in healthy longevity and obesity-related diseases","volume":"17","author":"Yamauchi","year":"2013","journal-title":"Cell Metab"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.03.024_bb0125","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2337\/diabetes.50.5.1126","article-title":"Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys","volume":"50","author":"Hotta","year":"2001","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.03.024_bb0130","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cmet.2016.04.011","article-title":"Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk","volume":"23","author":"Stern","year":"2016","journal-title":"Cell Metab"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.03.024_bb0135","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1189\/jlb.68.4.437","article-title":"Leptin in the regulation of immunity, inflammation, and hematopoiesis","volume":"68","author":"Fantuzzi","year":"2000","journal-title":"J Leukoc Biol"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.03.024_bb0140","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cmet.2015.06.004","article-title":"Adiponectin enhances cold-induced browning of subcutaneous adipose tissue via promoting M2 macrophage proliferation","volume":"22","author":"Hui","year":"2015","journal-title":"Cell Metab"},{"issue":"12","key":"10.1016\/j.jnutbio.2018.03.024_bb0145","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1038\/oby.2007.360","article-title":"Improved insulin sensitivity and adiponectin level after exercise training in obese Korean youth","volume":"15","author":"Kim","year":"2007","journal-title":"Obesity"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.03.024_bb0150","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10.1016\/j.jnutbio.2018.03.024_bb0155","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1046\/j.1365-2796.1999.00490.x","article-title":"The role of TNFalpha and TNF receptors in obesity and insulin resistance","volume":"245","author":"Hotamisligil","year":"1999","journal-title":"J Intern Med"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.03.024_bb0160","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jnutbio.2008.12.003","article-title":"Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells","volume":"21","author":"Tsang","year":"2010","journal-title":"J Nutr Biochem"},{"issue":"10","key":"10.1016\/j.jnutbio.2018.03.024_bb0165","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/mc.22175","article-title":"Regulation of p53-targeting microRNAs by polycyclic aromatic hydrocarbons: implications in the etiology of multiple myeloma","volume":"54","author":"Gordon","year":"2015","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.jnutbio.2018.03.024_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-13-421","article-title":"Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization","volume":"13","author":"Jang","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jnutbio.2018.03.024_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms2742","article-title":"miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit","volume":"4","author":"Chen","year":"2013","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.03.024_bb0180","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/jmcb\/mjs044","article-title":"Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155","volume":"4","author":"Cai","year":"2012","journal-title":"J Mol Cell Biol"},{"issue":"6","key":"10.1016\/j.jnutbio.2018.03.024_bb0185","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bbadis.2009.02.013","article-title":"miR-155 gene: a typical multifunctional microRNA","volume":"1792","author":"Faraoni","year":"2009","journal-title":"Biochim Biophys Acta"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286317308902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286317308902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:25:19Z","timestamp":1760628319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286317308902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":37,"alternative-id":["S0955286317308902"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.03.024","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polyphenol-rich green tea extract improves adipose tissue metabolism by down-regulating miR-335 expression and mitigating insulin resistance and inflammation","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.03.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}