{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:58:06Z","timestamp":1786993086631,"version":"build-2736575974"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"am","delay-in-days":310,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"National Center for Complementary and Integrated Health of the National Institutes of Health","award":["1R01AT007077"],"award-info":[{"award-number":["1R01AT007077"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.jnutbio.2018.04.014","type":"journal-article","created":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T20:43:18Z","timestamp":1525207398000},"page":"90-101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":115,"special_numbering":"C","title":["Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice"],"prefix":"10.1016","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-6349","authenticated-orcid":false,"given":"Hana","family":"Alkhalidy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"McMillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Hulver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-8198","authenticated-orcid":false,"given":"Dongmin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2018.04.014_bb0005","series-title":"National Vital Statistics Reports: From the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System","first-page":"1","article-title":"Deaths: leading causes for 2011","volume":"64","author":"Heron","year":"2015"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0010","series-title":"National Diabetes Statistics Report | Data & Statistics | Diabetes | CDC","year":"2017"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1478-7954-8-29","article-title":"Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence","volume":"8","author":"Boyle","year":"2010","journal-title":"Popul Health Metrics"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0020","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2337\/dc12-2625","article-title":"Economic costs of diabetes in the U.S. in 2012","volume":"36","author":"American Diabetes A","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0025","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1210\/edrv.23.2.0461","article-title":"Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes","volume":"23","author":"Lewis","year":"2002","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0030","doi-asserted-by":"crossref","first-page":"600","DOI":"10.2337\/diabetes.55.03.06.db05-1054","article-title":"Pancreatic beta-cells secrete insulin in fast- and slow-release forms","volume":"55","author":"Michael","year":"2006","journal-title":"Diabetes"},{"issue":"Suppl. 1","key":"10.1016\/j.jnutbio.2018.04.014_bb0035","doi-asserted-by":"crossref","first-page":"S212","DOI":"10.2337\/diabetes.51.2007.S212","article-title":"Accurate assessment of beta-cell function: the hyperbolic correction","volume":"51","author":"Bergman","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0040","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0002-9343(85)90579-0","article-title":"Glucose regulation in non-insulin-dependent diabetes mellitus. Interaction between pancreatic islets and the liver","volume":"79","author":"Halter","year":"1985","journal-title":"Am J Med"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0045","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jhep.2007.04.002","article-title":"Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences","volume":"47","author":"Leclercq","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0050","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0140-6736(10)62037-5","article-title":"National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9\u00b71 million participants","volume":"377","author":"Finucane","year":"2011","journal-title":"Lancet (Lond Engl)"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0055","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jdiacomp.2006.07.005","article-title":"Prevalence and trends of insulin resistance, impaired fasting glucose, and diabetes","volume":"21","author":"Ioannou","year":"2007","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0060","doi-asserted-by":"crossref","first-page":"E745","DOI":"10.1152\/ajpendo.00030.2002","article-title":"The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice","volume":"283","author":"Rolin","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0065","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.bone.2013.12.013","article-title":"Oleanolic acid acetate inhibits osteoclast differentiation by downregulating PLC\u03b32\u2013Ca(2+)\u2013NFATc1 signaling, and suppresses bone loss in mice","volume":"60","author":"Kim","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0070","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.jnutbio.2012.03.008","article-title":"Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic \u03b2-cell survival and function via CREB","volume":"24","author":"Zhang","year":"2013","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0075","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/ejcn.2013.89","article-title":"Impact of thearubigins on the estimation of total dietary flavonoids in the European prospective investigation into Cancer and nutrition (EPIC) study","volume":"67","author":"Zamora-Ros","year":"2013","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0080","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/jn\/138.3.562","article-title":"Dietary intake and major food sources of polyphenols in Finnish adults","volume":"138","author":"Ovaskainen","year":"2008","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0085","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2174\/138955711795305335","article-title":"A review on the dietary flavonoid kaempferol","volume":"11","author":"Calder\u00f3n-Monta\u00f1o","year":"2011","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0090","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/532984","article-title":"Small molecule kaempferol promotes insulin sensitivity and preserved pancreatic \u03b2-cell mass in middle-aged obese diabetic mice","volume":"2015","author":"Alkhalidy","year":"2015","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0095","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1172\/JCI17305","article-title":"Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones","volume":"112","author":"Norris","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0100","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/oby.2006.137","article-title":"Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training*","volume":"14","author":"Cortright","year":"2006","journal-title":"Obesity"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0105","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cmet.2005.09.002","article-title":"Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans","volume":"2","author":"Hulver","year":"2005","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0110","unstructured":"Enzymatic Activity of Glucose-6-Phosphatase [EC 3.1.3.9]. Sigma-Aldrich. https:\/\/www.sigmaaldrich.com\/technical-documents\/protocols\/biology\/enzymatic-assay-of-glucose-6-phosphatase.html"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0115","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0021-9258(18)66180-0","article-title":"A microcolorimetric method for the determination of inorganic phosphorus","volume":"202","author":"Taussky","year":"1953","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0120","unstructured":"Enzymatic Activity Assay of Pyruvate Carboxylase, 1999, [EC 6.4.1.1]."},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0125","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/978-1-61779-430-8_27","article-title":"Mouse model of diet-induced obesity and insulin resistance","volume":"821","author":"Wang","year":"2012","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0130","doi-asserted-by":"crossref","first-page":"975","DOI":"10.2337\/diabetes.49.6.975","article-title":"Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia study","volume":"49","author":"Tripathy","year":"2000","journal-title":"Diabetes"},{"issue":"Suppl. 6a","key":"10.1016\/j.jnutbio.2018.04.014_bb0135","doi-asserted-by":"crossref","first-page":"2S","DOI":"10.1016\/S0002-9343(00)00336-3","article-title":"The importance of the beta-cell in the pathogenesis of type 2 diabetes mellitus","volume":"108","author":"Kahn","year":"2000","journal-title":"Am J Med"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0140","doi-asserted-by":"crossref","first-page":"E149","DOI":"10.1152\/ajpendo.00040.2013","article-title":"Adaptive \u03b2-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression","volume":"305","author":"Stamateris","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0145","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1002\/jcp.25039","article-title":"GLP-2 as beneficial factor in the glucose homeostasis in mice fed a high fat diet","volume":"230","author":"Baldassano","year":"2015","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0150","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.cell.2012.02.017","article-title":"Mechanisms for insulin resistance: common threads and missing links","volume":"148","author":"Samuel","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.55.01.06.db05-0926","article-title":"The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy","volume":"55","author":"Matschinsky","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20080595","article-title":"Glucokinase and molecular aspects of liver glycogen metabolism","volume":"414","author":"Agius","year":"2008","journal-title":"Biochem J"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0165","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1146\/annurev.ph.54.030192.004215","article-title":"Regulation of net hepatic glucose uptake in vivo","volume":"54","author":"Pagliassotti","year":"1992","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0170","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cmet.2011.06.003","article-title":"Hormonal regulation of hepatic glucose production in health and disease","volume":"14","author":"Lin","year":"2011","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0175","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.2337\/db10-1032","article-title":"Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy","volume":"59","author":"Rizza","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0180","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0735-1097(02)02051-X","article-title":"Relationship between obesity, insulin resistance, and coronary heart disease risk","volume":"40","author":"Abbasi","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0185","first-page":"S4","article-title":"Examining the mechanisms of glucose regulation","volume":"18","author":"Triplitt","year":"2012","journal-title":"Am J Manag Care"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0190","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0065-2571(97)00001-0","article-title":"The physiological role of glucokinase binding and translocation in hepatocytes","volume":"38","author":"Agius","year":"1998","journal-title":"Adv Enzyme Regul"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/iub.411","article-title":"Liver glucokinase: an overview on the regulatory mechanisms of its activity","volume":"63","author":"Massa","year":"2011","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0200","doi-asserted-by":"crossref","first-page":"272","DOI":"10.2337\/diabetes.49.2.272","article-title":"Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity","volume":"49","author":"Basu","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0205","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1126\/science.1084073","article-title":"Allosteric activators of glucokinase: potential role in diabetes therapy","volume":"301","author":"Grimsby","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0210","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejphar.2011.05.009","article-title":"Chronic glucokinase activation reduces glycaemia and improves glucose tolerance in high-fat diet fed mice","volume":"663","author":"Winzell","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0215","doi-asserted-by":"crossref","first-page":"30479","DOI":"10.1074\/jbc.271.48.30479","article-title":"Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis","volume":"271","author":"Agius","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0220","doi-asserted-by":"crossref","first-page":"10597","DOI":"10.1074\/jbc.275.14.10597","article-title":"The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte","volume":"275","author":"de la Iglesia","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0225","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nm.2686","article-title":"Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1","volume":"18","author":"Lu","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0230","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/nature05861","article-title":"Akt\/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator","volume":"447","author":"Li","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0235","doi-asserted-by":"crossref","first-page":"12121","DOI":"10.1073\/pnas.0812547106","article-title":"Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with type 2 diabetes","volume":"106","author":"Samuel","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0240","doi-asserted-by":"crossref","first-page":"35245","DOI":"10.1074\/jbc.C110.175851","article-title":"FoxOs function synergistically to promote glucose production","volume":"285","author":"Haeusler","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0245","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cmet.2007.08.006","article-title":"Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver","volume":"6","author":"Matsumoto","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0250","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1172\/JCI200112876","article-title":"The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression","volume":"108","author":"Nakae","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0255","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nature01667","article-title":"Insulin-regulated hepatic gluconeogenesis through FOXO1\u2013PGC-1alpha interaction","volume":"423","author":"Puigserver","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0260","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/378785a0","article-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0265","doi-asserted-by":"crossref","first-page":"13150","DOI":"10.1074\/jbc.273.21.13150","article-title":"Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation characterization of dominant-negative mutant of PKB","volume":"273","author":"Weeren","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0270","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1097-2765(05)00015-8","article-title":"Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction","volume":"6","author":"Michael","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0275","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/305549a0","article-title":"Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin","volume":"305","author":"Granner","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0280","doi-asserted-by":"crossref","first-page":"20144","DOI":"10.1074\/jbc.273.32.20144","article-title":"Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin","volume":"273","author":"Dickens","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0285","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s00125-014-3455-x","article-title":"Increased gluconeogenesis in youth with newly diagnosed type 2 diabetes","volume":"58","author":"Chung","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0290","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.2337\/db06-1776","article-title":"Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose: role of increased rates of gluconeogenesis","volume":"56","author":"Bock","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0295","doi-asserted-by":"crossref","first-page":"E409","DOI":"10.1210\/jc.2012-3056","article-title":"Pathogenesis of prediabetes: role of the liver in isolated fasting hyperglycemia and combined fasting and postprandial hyperglycemia","volume":"98","author":"Basu","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0300","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.3390\/md11114193","article-title":"Anti-diabetic effect of balanced deep-sea water and its mode of action in high-fat diet induced diabetic mice","volume":"11","author":"Ha","year":"2013","journal-title":"Mar Drugs"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0305","doi-asserted-by":"crossref","first-page":"969","DOI":"10.2337\/diabetes.49.6.969","article-title":"Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes","volume":"49","author":"Clore","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0310","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.2337\/db09-1625","article-title":"Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo","volume":"59","author":"Ramnanan","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0315","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.2337\/db12-1311","article-title":"Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance","volume":"62","author":"Kumashiro","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0320","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0006-2952(96)00660-0","article-title":"In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase","volume":"53","author":"Bahl","year":"1997","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0325","first-page":"E1130","article-title":"Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss","volume":"277","author":"Kelley","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0330","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1172\/JCI117600","article-title":"Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus","volume":"94","author":"Kelley","year":"1994","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0335","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.2337\/diabetes.49.12.2063","article-title":"Mechanism by which metformin reduces glucose production in type 2 diabetes","volume":"49","author":"Hundal","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0340","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1172\/JCI30862","article-title":"Dominant role for glucose in beta cell compensation of insulin resistance","volume":"117","author":"Weir","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0345","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1053\/meta.2000.8606","article-title":"Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging","volume":"49","author":"Utsugi","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0350","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2337\/diab.40.3.401","article-title":"Coordinate reduction of rat pancreatic islet glucokinase and proinsulin mRNA by exercise training","volume":"40","author":"Koranyi","year":"1991","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2018.04.014_bb0355","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1152\/jappl.1996.80.1.240","article-title":"Changes in insulin action and GLUT-4 with 6 days of inactivity in endurance runners","volume":"80","author":"Vukovich","year":"1996","journal-title":"J Appl Physiol"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286317310112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286317310112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:24:27Z","timestamp":1760628267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286317310112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":71,"alternative-id":["S0955286317310112"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.04.014","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}