{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:01:51Z","timestamp":1792101711324,"version":"4.4.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T00:00:00Z","timestamp":1562371200000},"content-version":"am","delay-in-days":308,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.jnutbio.2018.06.003","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T11:50:09Z","timestamp":1528717809000},"page":"136-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Down-regulation of placental folate transporters in intrauterine growth restriction"],"prefix":"10.1016","volume":"59","author":[{"given":"Yi-Yung","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-0341","authenticated-orcid":false,"given":"Madhulika B.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Grattton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa L.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2018.06.003_bb0005","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJM199212243272602","article-title":"Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation","volume":"327","author":"Czeizel","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1475-2891-11-75","article-title":"Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation","volume":"11","author":"Fekete","year":"2012","journal-title":"Nutr J"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0015","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/ajcn\/83.5.993","article-title":"Folate and human reproduction","volume":"83","author":"Tamura","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0020","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/mnfr.201200084","article-title":"Influence of maternal folate status on human fetal growth parameters","volume":"57","author":"van Uitert","year":"2013","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0025","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1753-4887.2009.00265.x","article-title":"Fetal programming: link between early nutrition, DNA methylation, and complex diseases","volume":"68","author":"Chmurzynska","year":"2010","journal-title":"Nutr Rev"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra0708473","article-title":"Effect of in utero and early-life conditions on adult health and disease","volume":"359","author":"Gluckman","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0035","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev-nutr-072610-145133","article-title":"Mechanisms of membrane transport of folates into cells and across epithelia","volume":"31","author":"Zhao","year":"2011","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0040","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.1167\/iovs.07-0288","article-title":"Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types","volume":"48","author":"Umapathy","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0045","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.cell.2006.09.041","article-title":"Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption","volume":"127","author":"Qiu","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0050","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1271\/bbb.80112","article-title":"Placental folate transport during pregnancy","volume":"72","author":"Yasuda","year":"2008","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0055","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.placenta.2009.11.017","article-title":"Expression of folate transporters in human placenta and implications for homocysteine metabolism","volume":"31","author":"Solanky","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0060","doi-asserted-by":"crossref","first-page":"83.e17","DOI":"10.1016\/j.ajog.2011.02.053","article-title":"Fetal serum folate concentrations and placental folate transport in obese women","volume":"205","author":"Carter","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0065","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1203\/00006450-199710000-00016","article-title":"Association between the activity of the system a amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine growth restriction","volume":"42","author":"Glazier","year":"1997","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0070","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1203\/00006450-199311000-00019","article-title":"Amino acid (system a) transporter activity in microvillous membrane vesicles from the placentas of appropriate and small for gestational age babies","volume":"34","author":"Mahendran","year":"1993","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0075","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1042\/CS20150511","article-title":"Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR","volume":"129","author":"Chen","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0080","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1203\/00006450-199808000-00016","article-title":"Intrauterine growth restriction is associated with a reduced activity of placental taurine transporters","volume":"44","author":"Norberg","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0085","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1203\/00006450-199810000-00011","article-title":"Placental transport of leucine and lysine is reduced in intrauterine growth restriction","volume":"44","author":"Jansson","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0090","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1210\/jc.2002-021926","article-title":"Activity and protein expression of Na+K+ ATPase are reduced in microvillous syncytiotrophoblast plasma membranes isolated from pregnancies complicated by intrauterine growth restriction","volume":"88","author":"Johansson","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0095","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1210\/jc.2002-020214","article-title":"Activity and expression of the Na+\/H+ exchanger is reduced in syncytiotrophoblast microvillous plasma membranes isolated from preterm intrauterine growth restriction pregnancies","volume":"87","author":"Johansson","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0100","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jsgi.2006.04.006","article-title":"Placental lactate transporter activity and expression in intrauterine growth restriction","volume":"13","author":"Settle","year":"2006","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0105","first-page":"1554","article-title":"Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation","volume":"77","author":"Jansson","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0110","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1053\/plac.2002.0941","article-title":"ATP-dependent Ca2+ transport across basal membrane of human syncytiotrophoblast in pregnancies complicated by intrauterine growth restriction or diabetes","volume":"24","author":"Strid","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0115","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1203\/PDR.0b013e3181b9b4a3","article-title":"Comparison of the transport characteristics of bioactive substances in IUGR and normal placentas","volume":"66","author":"Keating","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0120","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.placenta.2003.11.010","article-title":"Placental folate transport and binding are not impaired in pregnancies complicated by fetal growth restriction","volume":"25","author":"Bisseling","year":"2004","journal-title":"Placenta"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0125","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.placenta.2015.12.007","article-title":"Relationship between folate transporters expression in human placentas at term and birth weights","volume":"38","author":"Caviedes","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0130","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7124186","article-title":"Increased umbilical cord PAI-1 levels in placental insufficiency are associated with fetal hypoxia and angiogenesis","volume":"2016","author":"Seferovic","year":"2016","journal-title":"Dis Markers"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0135","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0005-2736(90)90157-J","article-title":"Simultaneous preparation of paired, syncytial, microvillous and basal membranes from human placenta","volume":"1029","author":"Illsley","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0140","first-page":"R287","article-title":"Na+\/K+-ATPase is distributed to microvillous and basal membrane of the syncytiotrophoblast in the human placenta","volume":"279","author":"Johansson","year":"2000","journal-title":"Am J Phys"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0150","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1038\/s41598-017-03888-2","article-title":"Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice","volume":"7","author":"Rosario","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0155","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1113\/jphysiol.2012.238014","article-title":"Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells","volume":"591","author":"Rosario","year":"2013","journal-title":"J Physiol"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0160","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1113\/jphysiol.2007.129676","article-title":"Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth","volume":"582","author":"Roos","year":"2007","journal-title":"J Physiol"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0165","first-page":"1055","article-title":"Folate, vitamin B12, and homocysteine levels in south Asian women with growth-retarded fetuses","volume":"84","author":"Lindblad","year":"2005","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0170","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11154-012-9214-8","article-title":"Fetal programming: maternal nutrition and role of one-carbon metabolism","volume":"13","author":"Yajnik","year":"2012","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0175","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1079\/BJN20041395","article-title":"The influence of erythrocyte folate and serum vitamin B12 status on birth weight","volume":"93","author":"Relton","year":"2005","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0180","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.3945\/jn.109.106666","article-title":"Antenatal micronutrient supplementation reduces metabolic syndrome in 6- to 8-year-old children in rural Nepal","volume":"139","author":"Stewart","year":"2009","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0185","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2016.0845","article-title":"Association between maternal prepregnancy body mass index and plasma folate concentrations with child metabolic health","volume":"170","author":"Wang","year":"2016","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0190","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1017\/S0007114507815819","article-title":"The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption","volume":"99","author":"Burdge","year":"2008","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0195","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1210\/jc.2003-032234","article-title":"Triglyceride hydrolase activities and expression of fatty acid binding proteins in human placenta in pregnancies complicated by IUGR and diabetes","volume":"89","author":"Magnusson","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2018.06.003_bb0200","doi-asserted-by":"crossref","DOI":"10.4155\/fsoa-2015-0015","article-title":"Folic acid supplementation: what is new? Fetal, obstetric, long-term benefits and risks","volume":"2","author":"Moussa","year":"2016","journal-title":"Future Sci OA"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286318301153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286318301153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:25:12Z","timestamp":1760628312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286318301153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":39,"alternative-id":["S0955286318301153"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.06.003","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Down-regulation of placental folate transporters in intrauterine growth restriction","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}