{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:19:43Z","timestamp":1791519583583,"version":"4.3.4"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"SERB-DST\/MOFPI","award":["SERB\/MOFPI\/0028\/2013"],"award-info":[{"award-number":["SERB\/MOFPI\/0028\/2013"]}]},{"DOI":"10.13039\/501100010892","name":"Department of Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010892","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.jnutbio.2018.09.002","type":"journal-article","created":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T04:31:42Z","timestamp":1536813102000},"page":"167-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Bio-accessible milk casein derived tripeptide (LLY) mediates overlapping anti- inflammatory and anti-oxidative effects under cellular (Caco-2) and in vivo milieu"],"prefix":"10.1016","volume":"62","author":[{"given":"Kandukuri","family":"Sowmya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dev","family":"Mala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Iqbal","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh Kumar","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-773X","authenticated-orcid":false,"given":"Suman","family":"Kapila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Kapila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2018.09.002_bb0005","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3390\/md10050963","article-title":"Bioactive peptides and Depsipeptides with anticancer potential: Sources from marine animals","volume":"10","author":"Suarez-Jimenez","year":"2012","journal-title":"Mar Drugs"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0010","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.idairyj.2005.10.012","article-title":"Bioactive peptides: production and functionality","volume":"16","author":"Korhonen","year":"2006","journal-title":"Int Dairy J"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0015","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.idairyj.2009.06.001","article-title":"Casein-derived bioactive peptides: biological effects, industrial uses, safety aspects and regulatory status","volume":"19","author":"Phelan","year":"2009","journal-title":"Int Dairy J"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0020","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.2174\/1381612033454892","article-title":"Food-derived bioactive peptides-opportunities for designing future foods","volume":"9","author":"Korhonen","year":"2003","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0025","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jff.2009.01.007","article-title":"Milk-derived bioactive peptides: From science to applications","volume":"1","author":"Korhonen","year":"2009","journal-title":"J Funct Foods"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3168\/jds.2016-11846","article-title":"Assessment of multifunctional activity of bioactive peptides derived from fermented milk by specific Lactobacillus plantarum strains","volume":"100","author":"Aguilar-Toal\u00e1","year":"2017","journal-title":"J Dairy Sci"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0035","series-title":"Biotechnology of Bioactive Compounds","first-page":"483","article-title":"Food-derived multifunctional bioactive proteins and peptides: Sources and production","author":"Agyei","year":"2015"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0040","doi-asserted-by":"crossref","first-page":"11527","DOI":"10.1073\/pnas.91.24.11527","article-title":"Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway","volume":"91","author":"Anderson","year":"1994","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0045","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1038\/ki.2008.516","article-title":"Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease","volume":"7","author":"Cachofeiro","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0050","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1080\/10715760601059672","article-title":"Which comes first: renal inflammation or oxidative stress in spontaneously hypertensive rats?","volume":"41","author":"Biswas","year":"2007","journal-title":"Free Radic Res"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0055","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0002-9440(10)65396-5","article-title":"Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons","volume":"154","author":"Zhang","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0060","first-page":"1330","article-title":"Role of oxidative stress in human health: An overview","volume":"3","author":"Chaitanya","year":"2010","journal-title":"J Pharm Res"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1155\/2014\/327452","article-title":"Antioxidant and anti-inflammatory effects of selected natural compounds contained in a dietary supplement on two human immortalized keratinocyte lines","volume":"2014","author":"Fasano","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0070","first-page":"813","article-title":"Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis","volume":"51","author":"Huang","year":"1991","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0075","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.4049\/jimmunol.163.6.3474","article-title":"Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity","volume":"163","author":"Jobin","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0080","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2174\/187152906779010737","article-title":"Anti-inflammatory effects of different drugs\/agents with antioxidant property on endothelial expression of adhesion molecules","volume":"6","author":"Chen","year":"2006","journal-title":"Curr Drug Targets Cardiovasc Haematol Disord"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0085","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neulet.2004.03.036","article-title":"Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia","volume":"363","author":"Luo","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0090","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1160\/TH03-03-0136","article-title":"Anti inflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression","volume":"90","author":"Zhang","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0095","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/ijc.24967","article-title":"The dark side of curcumin","volume":"126","author":"Moron","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0100","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/ki.2013.276","article-title":"Therapeutic use of traditional Chinese herbal medications for chronic kidney diseases","volume":"84","author":"Zhong","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0105","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.biotechadv.2011.01.001","article-title":"Industrial-scale manufacturing of pharmaceutical grade bioactive peptides","volume":"29","author":"Agyei","year":"2011","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0110","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jnutbio.2007.11.010","article-title":"The possible role of food-derived bioactive peptides in reducing the risk of cardiovascular disease","volume":"19","author":"Erdman","year":"2008","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0115","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.2174\/0929867321666140205135739","article-title":"Potential clinical applications of multi-functional milk proteins and peptides in cancer management","volume":"2","author":"Chen","year":"2014","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0120","first-page":"527","article-title":"Complete nucleotide sequence of the bovine \u00df-casein gene","volume":"41","author":"Bonsing","year":"1988","journal-title":"Aust J Agric Res"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0125","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0378-1119(92)90129-D","article-title":"Cloning of the goat \u03b2-casein-encoding gene and expression in transgenic mice","volume":"121","author":"Roberts","year":"1992","journal-title":"Gene"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0130","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.3168\/jds.S0022-0302(04)73386-X","article-title":"Single nucleotide polymorphisms in the ovine casein genes detected by polymerase chain reaction-single strand conformation polymorphism","volume":"87","author":"Ceriotti","year":"2004","journal-title":"J Dairy Sci"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0135","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00217-011-1642-2","article-title":"Detection of \u03b2-casein variants in yak (Bos grunniens) by PCR-SSCP","volume":"234","author":"Cui","year":"2012","journal-title":"Eur Food Res Technol"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0140","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0014-5793(87)81017-7","article-title":"Immunostimulating properties and three-dimensional structure of two tripeptides from human and cow caseins","volume":"218","author":"Berthou","year":"1987","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0145","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s12602-012-9107-x","article-title":"Comparative evaluation of oral administration of probiotic Lactobacilli-fermented milks on macrophage function","volume":"4","author":"Kapila","year":"2012","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0150","first-page":"102","article-title":"Dahi containing probiotic Lactobacillus acidophilus and Lactobacillus casei has a protective effect against Salmonella enteritidis infection in mice","volume":"21","author":"Jain","year":"2009","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0160","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","article-title":"Antioxidant activity applying an improved ABTS radical cation decolorization assay","volume":"26","author":"Re","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0165","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1021\/jf010586o","article-title":"Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe","volume":"49","author":"Ou","year":"2001","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0170","first-page":"111","article-title":"Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay","volume":"134","author":"Cathcart","year":"1983","journal-title":"Anal Chem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0175","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissues by thiobarbituric acid test","volume":"86","author":"Uchiyama","year":"1978","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0180","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0185","first-page":"121","article-title":"Catalase in vitro","author":"Aebi","year":"1984","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0190","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of superoxide dismutase anion radical in autooxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"42","author":"Marklund","year":"1974","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0195","first-page":"158","article-title":"Studies of qualitative and quantitative characterization of erythrocyte glutathione peroxidise","volume":"70","author":"Paglia","year":"1967","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0200","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidiniumthiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0205","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2- \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0210","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.3346\/jkms.2011.26.11.1474","article-title":"Sulforaphane induces antioxidative and anti proliferative responses by generating reactive oxygen species in human bronchial epithelial BEAS-2B cells","volume":"26","author":"Lee","year":"2011","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0215","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1155\/2013\/801418","article-title":"Curcumin pretreatment induces Nrf2 and an antioxidant response and prevents hemin-induced toxicity in primary cultures of cerebellar granule neurons of rats","volume":"2013","author":"Gonz\u00e1lez-Reyes","year":"2013","journal-title":"Oxidative Med Cell Longev"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0220","doi-asserted-by":"crossref","first-page":"C1196","DOI":"10.1152\/ajpcell.1991.261.6.C1196","article-title":"A spectroscopic method for assessing confluence of epithelial cell cultures","volume":"261","author":"Jovov","year":"1991","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0225","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.foodchem.2015.05.121","article-title":"Transepithelial transport of milk derived bioactive peptide VLPVPQK","volume":"190","author":"Vij","year":"2016","journal-title":"Food Chem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0230","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver","volume":"582","author":"Moron","year":"1989","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0235","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1432-1033.1984.tb08609.x","article-title":"Immunostimulating hexapeptide from human casein: amino acid sequence, synthesis and biological properties","volume":"145","author":"Parker","year":"1984","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0240","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0014-5793(96)00207-4","article-title":"Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins","volume":"383","author":"Kayser","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0245","first-page":"512","article-title":"Bovine kepa-casein as inhibitor of the proliferation of mouse splenocytes induced by lipopolysaccharide stimulation","volume":"47","author":"Otani","year":"1992","journal-title":"Milchwissenschaft"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0250","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2527\/jas.53953","article-title":"Effect of milk hydrolysates on inflammation markers and drug-induced transcriptional alterations in cell-based models","volume":"90","author":"Nielsen","year":"2012","journal-title":"J Anim Sci"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0255","doi-asserted-by":"crossref","first-page":"17549","DOI":"10.3402\/fnr.v56i0.17549","article-title":"High hydrostatic pressure pre- treatment of whey proteins enhances whey protein hydrolysate inhibition of oxidative stress and IL-8 secretion in intestinal epithelial cells","volume":"56","author":"Piccolomini","year":"2012","journal-title":"Food Nutr Res"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0260","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1017\/S0007114512004655","article-title":"Whey protein hydrolysates decrease IL-8 secretion in lipopolysaccharide (LPS)-stimulated respiratory epithelial cells by affecting LPS binding to Toll-like receptor 4","volume":"110","author":"Iskandar","year":"2013","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0265","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/jsfa.7159","article-title":"Generation and identification of anti-inflammatory peptides from bovine \u03b2-casein using enzyme preparations fromcod and hog","volume":"96","author":"Altmann","year":"2016","journal-title":"J Sci Food Agric"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0270","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s00394-013-0606-7","article-title":"Comparative evaluation of cow \u03b2-casein variants (A1\/A2) consumption on Th2-mediated inflammatory response in mouse gut","volume":"53","author":"Haq","year":"2014","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0275","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1590\/S0101-20612013005000074","article-title":"Biotechnological richness of the north-eastern semi-arid region: antioxidant activity of casein hydrolysates from Moxot\u00f3 goat milk (Capra hircus Linnaeus, 1758) obtained by papain action","volume":"33","author":"Bezerra","year":"2013","journal-title":"Food Sci Technol"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0280","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/jsfa.2063","article-title":"Identification of antioxidant and ACE-inhibitory peptides in fermented milk","volume":"85","author":"Hern\u00e1ndez-Ledesma","year":"2005","journal-title":"J Sci Food Agric"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0285","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1021\/jf021191n","article-title":"Antioxidative properties of tripeptide libraries prepared by the combinatorial chemistry","volume":"51","author":"Saito","year":"2003","journal-title":"J Agric Food Chem"},{"issue":"72","key":"10.1016\/j.jnutbio.2018.09.002_bb0290","first-page":"1","article-title":"The structure-activity relationship of the antioxidant peptides from natural proteins","volume":"21","author":"Zou","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0295","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jfca.2006.01.003","article-title":"Comparison of ABTS, DPPH, FRAP, and ORAC assays for estimating antioxidant activity from guava fruits extracts","volume":"19","author":"Thaipong","year":"2006","journal-title":"J Food Compos Anal"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0300","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.foodchem.2011.05.129","article-title":"Caseinophosphopeptides exert partial and site-specific cytoprotection against H 2O2- induced oxidative stress in Caco-2 cells","volume":"129","author":"Garcia-Nebot","year":"2011","journal-title":"Food Chem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0305","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0300-483X(00)00277-8","article-title":"Reactive oxygen species mediated membrane damage induced by fullerene derivatives and its possible biological implications","volume":"155","author":"Kamat","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0310","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1080\/19476337.2013.792296","article-title":"In vitro cytoprotection of modified casein hydrolysates by plastein reaction on rat hepatocyte cells","volume":"12","author":"Zhao","year":"2014","journal-title":"CyTA J Food"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0315","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.foodchem.2012.04.122","article-title":"Protection of lung fibroblast MRC-5 cells against hydrogen peroxide-induced oxidative damage by 0.1\u20132.8 kDa antioxidative peptides isolated from whey protein hydrolysate","volume":"135","author":"Kong","year":"2012","journal-title":"Food Chem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0320","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1023\/A:1012256521840","article-title":"In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosine","volume":"225","author":"Nagasawa","year":"2001","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0325","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.redox.2015.07.008","article-title":"Antioxidant responses and cellular adjustments to oxidative stress","volume":"6","author":"Espinosa-Diez","year":"2015","journal-title":"Redox Biol"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0330","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.idairyj.2008.12.004","article-title":"Potential bioactive effects of casein hydrolysates on human cultured cells","volume":"19","author":"Phelan","year":"2009","journal-title":"Int Dairy J"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0335","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jfda.2016.10.014","article-title":"Cytotoxic and antioxidant capacity of camel milk peptides: Effects of isolated peptide on superoxide dismutase and catalase gene expression","volume":"25","author":"Homayouni-Tabrizi","year":"2016","journal-title":"J Food Drug Anal"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0340","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1158\/1535-7163.885.3.7","article-title":"A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway","volume":"3","author":"Zhang","year":"2004","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0345","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.freeradbiomed.2004.02.074","article-title":"Nrf2 signaling in coordinated activation of antioxidant gene expression","volume":"36","author":"Jaiswal","year":"2004","journal-title":"Free Radic Biol Med"},{"issue":"11","key":"10.1016\/j.jnutbio.2018.09.002_bb0350","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.bcp.2008.07.017","article-title":"Activation of Nrf2-antioxidant signalling attenuates NF\u03baB-inflammatory response and elicits apoptosis","volume":"76","author":"Li","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0355","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrd4002","article-title":"Modulation of oxidative stress as an anticancer strategy","volume":"12","author":"Gorrini","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0360","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/mnfr.200900443","article-title":"The (193\u2013209) 17-residues peptide of bovine \u03b2-casein is transported through Caco-2 monolayer","volume":"54","author":"Regazzo","year":"2010","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0365","doi-asserted-by":"crossref","first-page":"8143","DOI":"10.1021\/acs.jafc.5b01824","article-title":"Transport of Antihypertensive Peptide RVPSL, Ovotransferrin 328\u2013332, in Human Intestinal Caco-2 Cell Monolayers","volume":"63","author":"Ding","year":"2015","journal-title":"J Agric Food Chem"},{"issue":"11","key":"10.1016\/j.jnutbio.2018.09.002_bb0370","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1023\/A:1016472119387","article-title":"Esterase-Sensitive cyclic prodrugs of peptides: Evaluation of an acyloxyalkoxy promoiety in a model hexapeptide","volume":"13","author":"Pauletti","year":"1996","journal-title":"Pharm Res"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.09.002_bb0375","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1023\/A:1012040425146","article-title":"Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway","volume":"14","author":"Pauletti","year":"1997","journal-title":"Pharm Res"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0380","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1271\/bbb.66.378","article-title":"Transepithelial transport of the bioactive tripeptide, Val-Pro-Pro, in human intestinal Caco-2 cell monolayers","volume":"66","author":"Satake","year":"2002","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0385","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2174\/1389450033491028","article-title":"Di\/tripeptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions","volume":"4","author":"Nielsen","year":"2003","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0390","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1023\/A:1011916613875","article-title":"Adsorptive-mediated transcytosis of a synthetic basic peptide, 001-C8 in Caco-2 cells","volume":"15","author":"Sai","year":"1998","journal-title":"Pharm Res"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0395","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1093\/jn\/134.8.1935","article-title":"Various non digestible saccharides open a paracellular calcium transport pathway with the induction of intracellular calcium signaling in human intestinal Caco-2 cells","volume":"134","author":"Suzuki","year":"2004","journal-title":"J Nutr"},{"issue":"11","key":"10.1016\/j.jnutbio.2018.09.002_bb0400","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0278-6915(84)90165-0","article-title":"Influence of surface-active food additives on the integrity and permeability of rat intestinal mucosa","volume":"22","author":"Tagesson","year":"1984","journal-title":"Food Chem Toxicol"},{"issue":"06","key":"10.1016\/j.jnutbio.2018.09.002_bb0405","first-page":"576","article-title":"Effect of polyoxyl 35 castor oil and Polysorbate 80 on the intestinal absorption of digoxin in vitro","volume":"50","author":"Cornaire","year":"2000","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0410","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0958-6946(97)00040-X","article-title":"Colloidal aspects of ice cream-A review","volume":"7","author":"Goff","year":"1997","journal-title":"Int Dairy J"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0415","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.toxrep.2016.01.003","article-title":"Hepato and neuro-protective effects of watermelon juice on acute ethanol-induced oxidative stress in rats","volume":"3","author":"Oyenihi","year":"2016","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0420","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.mam.2004.02.019","article-title":"Oxidative stress and antioxidant defenses in ethanol-induced cell injury","volume":"25","author":"Koch","year":"2004","journal-title":"Mol Asp Med"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0425","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0741-8329(01)00176-8","article-title":"Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system","volume":"25","author":"Husain","year":"2001","journal-title":"Alcohol"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0430","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4103\/0253-7613.81504","article-title":"Effect of alcohol on blood glucose and antioxidant enzymes in the liver and kidney of diabetic rats","volume":"43","author":"Shanmugam","year":"2011","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0435","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jep.2006.12.024","article-title":"Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice","volume":"111","author":"Li","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0440","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/hep.1840040402","article-title":"Hepatic glutathione homeostasis in the rat: efflux accounts for glutathione turnover","volume":"4","author":"Lauterburg","year":"1984","journal-title":"Hepatology"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0445","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.78","article-title":"Regulation of cytochrome P450 2E1expression by ethanol: role of oxidative stress-mediated pkc\/jnk\/sp1 pathway","volume":"4","author":"Jin","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0450","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1016\/S0021-9258(20)82163-2","article-title":"Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450","volume":"259","author":"Ingelman-Sundberg","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0455","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/hep.22222","article-title":"Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice","volume":"47","author":"Lu","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0460","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/BF02976925","article-title":"Protein drug oral delivery: The recent progress","volume":"25","author":"Lee","year":"2002","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0465","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148868","article-title":"Carvedilol improves inflammatory response, oxidative stress and fibrosis in the alcohol-induced liver injury in rats by regulating kuppfer cells and hepatic stellate cells","volume":"11","author":"De Araujo Junior","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0470","doi-asserted-by":"crossref","first-page":"33157","DOI":"10.1074\/jbc.271.52.33157","article-title":"Witt, Prostaglandin-endoperoxide H synthases (cyclooxygenases)-1 and \u22122","volume":"271","author":"Smith","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0475","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1460-9568.2006.05298.x","article-title":"Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats","volume":"25","author":"Pascual","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0480","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1128\/IAI.05727-11","article-title":"Gene expression profiles of immune mediators and histopathological findings in animal models of leptospirosis: comparison between susceptible hamsters and resistant mice","volume":"79","author":"Matsui","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.jnutbio.2018.09.002_bb0485","first-page":"594","article-title":"Effect of Resveratrol on COX-2 gene and hepatic oxidative stress induced by alcohol in rats","volume":"4","author":"Munusamy","year":"2011","journal-title":"J Pharm Res"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286317303248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286317303248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:26:22Z","timestamp":1760628382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286317303248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":97,"alternative-id":["S0955286317303248"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.09.002","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bio-accessible milk casein derived tripeptide (LLY) mediates overlapping anti- inflammatory and anti-oxidative effects under cellular (Caco-2) and in vivo milieu","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}