{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:54:15Z","timestamp":1779224055250,"version":"3.51.4"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"am","delay-in-days":297,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000063","name":"Office of Dietary Supplements","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA174926"],"award-info":[{"award-number":["R01CA174926"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R34AT007837"],"award-info":[{"award-number":["R34AT007837"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AT006896"],"award-info":[{"award-number":["R01AT006896"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31AT009938"],"award-info":[{"award-number":["F31AT009938"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"United States Department of Agriculture","doi-asserted-by":"publisher","award":["2014-38420-21799"],"award-info":[{"award-number":["2014-38420-21799"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16POST27250138"],"award-info":[{"award-number":["16POST27250138"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30DK058404"],"award-info":[{"award-number":["P30DK058404"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jnutbio.2018.09.021","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T13:51:56Z","timestamp":1539265916000},"page":"150-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Curcumin, but not curcumin-glucuronide, inhibits Smad signaling in TGF\u03b2-dependent bone metastatic breast cancer cells and is enriched in bone compared to other tissues"],"prefix":"10.1016","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7940-4889","authenticated-orcid":false,"given":"Andrew G","family":"Kunihiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia A","family":"Brickey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer B","family":"Frye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula B","family":"Luis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4215-967X","authenticated-orcid":false,"given":"Claus","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet L","family":"Funk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2018.09.021_bb0005","author":"Howlader"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0010","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/cncr.11132","article-title":"Mechanisms of osteolytic bone metastases in breast carcinoma","volume":"97","author":"K\u00e4k\u00f6nen","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0015","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bone.2010.07.005","article-title":"Dysregulation of developmental pathways in bone metastasis","volume":"48","author":"Sethi","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0020","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.cell.2012.10.005","article-title":"SnapShot: Bone metastasis","volume":"151","author":"Ell","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0025","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s00109-015-1329-4","article-title":"Bone metastasis and the metastatic niche","volume":"93","author":"Ren","year":"2015","journal-title":"J Mol Med"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0030","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1535-6108(03)00132-6","article-title":"A multigenic program mediating breast cancer metastasis to bone","volume":"3","author":"Kang","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0035","doi-asserted-by":"crossref","first-page":"13909","DOI":"10.1073\/pnas.0506517102","article-title":"Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway","volume":"102","author":"Kang","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0040","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12307-011-0075-6","article-title":"TGF\u03b2 in the bone microenvironment: role in breast cancer metastases","volume":"4","author":"Buijs","year":"2011","journal-title":"Cancer Microenviron"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0045","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1172\/JCI118947","article-title":"Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis","volume":"98","author":"Guise","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0050","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1172\/JCI3523","article-title":"TGF-\u03b2 signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development","volume":"103","author":"Yin","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0055","doi-asserted-by":"crossref","first-page":"24571","DOI":"10.1074\/jbc.M202561200","article-title":"Transforming growth factor-\u03b2 stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways","volume":"277","author":"K\u00e4k\u00f6nen","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0060","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/nm.1943","article-title":"Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis","volume":"15","author":"Korpal","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0065","doi-asserted-by":"crossref","first-page":"16618","DOI":"10.1073\/pnas.1117610109","article-title":"TGF-\u03b2 blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma","volume":"109","author":"Liu","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0070","doi-asserted-by":"crossref","first-page":"6218","DOI":"10.2174\/1381612811319340013","article-title":"Bioactivity of turmeric-derived curcuminoids and related metabolites in breast Cancer","volume":"19","author":"Wright","year":"2013","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0075","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1021\/np300663v","article-title":"Curcuminoids block TGF-\u03b2 signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis","volume":"76","author":"Wright","year":"2013","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0080","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.bmc.2013.11.006","article-title":"Curcumin glucuronides: assessing the proliferative activity against human cell lines","volume":"22","author":"Pal","year":"2014","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0085","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.foodchem.2013.11.021","article-title":"Comparison of the effects of curcumin and curcumin glucuronide in human hepatocellular carcinoma HepG2 cells","volume":"151","author":"Shoji","year":"2014","journal-title":"Food Chem"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0090","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2006-957450","article-title":"Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers","volume":"64","author":"Shoba","year":"1998","journal-title":"Planta Med"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0095","first-page":"1058","article-title":"Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production","volume":"61","author":"Ireson","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0100","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/sj.bjc.6601623","article-title":"Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration","volume":"90","author":"Garcea","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0105","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/cgt.2012.41","article-title":"Intravenous administration of adenoviruses targeting transforming growth factor beta signaling inhibits established bone metastases in 4T1 mouse mammary tumor model in an immunocompetent syngeneic host","volume":"19","author":"Zhang","year":"2012","journal-title":"Cancer Gene Ther"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1349-7006.2008.01012.x","article-title":"Transforming growth factor-\u03b2 signaling at the tumor\u2013bone interface promotes mammary tumor growth and osteoclast activation","volume":"100","author":"Futakuchi","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0115","doi-asserted-by":"crossref","first-page":"8012","DOI":"10.1073\/pnas.121616198","article-title":"Short tandem repeat profiling provides an international reference standard for human cell lines","volume":"98","author":"Masters","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0120","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/1097-0215(20010101)91:1<76::AID-IJC1012>3.0.CO;2-8","article-title":"Invasion and metastasis of a mammary tumor involves TGF-\u03b2 signaling","volume":"91","author":"McEarchern","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0125","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1158\/1078-0432.CCR-03-0325","article-title":"Zoledronic acid inhibits visceral metastases in the 4T1\/luc mouse breast cancer model","volume":"10","author":"Hiraga","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0130","series-title":"A novel orthotopic model of breast cancer metastasis to bone","first-page":"163","author":"Lelekakis","year":"1999"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0135","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1021\/np050327j","article-title":"Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis","volume":"69","author":"Funk","year":"2006","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0140","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bcp.2017.03.002","article-title":"Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes","volume":"132","author":"Luis","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0145","first-page":"969","article-title":"\u03b2-Glucuronidase deficiency mucopolysaccharidosis: methods for enzymatic diagnosis","volume":"82","author":"Glaser","year":"1973","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J Basic Clin Pharm"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0155","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0090-9556(24)15211-7","article-title":"Biotransformation of curcumin through reduction and glucuronidation in mice","volume":"27","author":"Pan","year":"1999","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0160","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00280-011-1749-y","article-title":"Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice","volume":"69","author":"Zhongfa","year":"2012","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0165","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11095-014-1469-1","article-title":"Enhanced oral delivery of curcumin from N-trimethyl chitosan surface-modified solid lipid nanoparticles: pharmacokinetic and brain distribution evaluations","volume":"32","author":"Ramalingam","year":"2015","journal-title":"Pharm Res"},{"issue":"110","key":"10.1016\/j.jnutbio.2018.09.021_bb0170","doi-asserted-by":"crossref","DOI":"10.3791\/53936","article-title":"Murine hind limb long bone dissection and bone marrow isolation","author":"Amend","year":"2016","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0175","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1007\/s10439-008-9577-x","article-title":"The mechanical environment of bone marrow: a review","volume":"36","author":"Gurkan","year":"2008","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0180","first-page":"3059","article-title":"Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites","volume":"51","author":"Powell","year":"1991","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0185","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF02967374","article-title":"Parathyroid hormone-related protein in breast cancer tissues: relationship between primary and metastatic sites","volume":"1","author":"Kohno","year":"1994","journal-title":"Breast Cancer"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0190","first-page":"3172","article-title":"Coexpression of parathyroid hormone related protein and its receptor in early breast cancer predicts poor patient survival","volume":"8","author":"Linforth","year":"2002","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-015-1873-x","article-title":"Co-expression of parathyroid hormone related protein and TGF-beta in breast cancer predicts poor survival outcome","volume":"15","author":"Xu","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0200","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1177\/15.11.680","article-title":"Cytochemical demonstration of \u03b2-glucuronidase activity in blood and bone marrow cells","volume":"5","author":"Lorbacher","year":"1967","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0205","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bone.2010.08.004","article-title":"TGF-\u03b2 in cancer and bone: implications for treatment of bone metastases","volume":"48","author":"Ju\u00e1rez","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0210","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cytogfr.2005.09.006","article-title":"TGF-\u03b2 and cancer","volume":"17","author":"Bierie","year":"2006","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0215","first-page":"21","article-title":"Actions of TGF-\u03b2 as tumor suppressor and pro-metastatic factor in human cancer","volume":"1775","author":"Pardali","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0220","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGF\u03b2 in cancer","volume":"134","author":"Massagu\u00e9","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0225","doi-asserted-by":"crossref","first-page":"964","DOI":"10.7150\/ijbs.4564","article-title":"Complexities of TGF-\u03b2 targeted cancer therapy","volume":"8","author":"Connolly","year":"2012","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0230","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3810","article-title":"Targeting the TGF\u03b2 signalling pathway in disease","volume":"11","author":"Akhurst","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0235","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature13145","article-title":"Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone","volume":"507","author":"Kusumbe","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bonekey.2015.29","article-title":"Assessment of bone vascularization and its role in bone remodeling","volume":"4","author":"Lafage-Proust","year":"2015","journal-title":"Bonekey Rep"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0245","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-4419-9129-4_3","article-title":"Animal model of bone metastasis","volume":"118","author":"Rosol","year":"2004","journal-title":"Cancer Treat Res"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0250","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1158\/1055-9965.EPI-07-2693","article-title":"Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects","volume":"17","author":"Vareed","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11130-016-0590-1","article-title":"Curcumin, a compound from natural sources, a true scientific challenge \u2014 a review","volume":"72","author":"Stani\u0107","year":"2017","journal-title":"Plant Foods Hum Nutr"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0260","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1002\/art.22180","article-title":"Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis","volume":"54","author":"Funk","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0265","doi-asserted-by":"crossref","first-page":"9498","DOI":"10.1021\/jf101873f","article-title":"Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) is dependent on extract composition","volume":"58","author":"Wright","year":"2010","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bonekey.2016.20","article-title":"Therapeutic actions of curcumin in bone disorders","volume":"5","author":"Rohanizadeh","year":"2016","journal-title":"Bonekey Rep"},{"key":"10.1016\/j.jnutbio.2018.09.021_bb0275","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.phymed.2008.06.007","article-title":"The ovariectomized, mature rat model of postmenopausal osteoporosis: an assessment of the bone sparing effects of curcumin","volume":"15","author":"French","year":"2008","journal-title":"Phytomedicine"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286318304704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286318304704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:27:25Z","timestamp":1760628445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286318304704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":55,"alternative-id":["S0955286318304704"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.09.021","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin, but not curcumin-glucuronide, inhibits Smad signaling in TGF\u03b2-dependent bone metastatic breast cancer cells and is enriched in bone compared to other tissues","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.09.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}