{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:56:48Z","timestamp":1790488608884,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.jnutbio.2018.10.009","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T21:45:21Z","timestamp":1540849521000},"page":"80-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Secretion of a gastrointestinal hormone, cholecystokinin, by hop-derived bitter components activates sympathetic nerves in brown adipose tissue"],"prefix":"10.1016","volume":"64","author":[{"given":"Takahiro","family":"Yamazaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumie","family":"Morimoto-Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiori","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayoko","family":"Kitao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2018.10.009_bb0005","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0092-8674(03)00844-4","article-title":"The receptors for mammalian sweet and umami taste","volume":"115","author":"Zhao","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0010","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.conb.2004.06.003","article-title":"The sweet and the bitter of mammalian taste","volume":"14","author":"Scott","year":"2004","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jnutbio.2016.08.015","article-title":"Effects of chlorogenic acid, caffeine and coffee on components of the purinergic system of streptozotocin-induced diabetic rats","author":"Stefanello","year":"2016","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0020","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0955-2863(00)00119-4","article-title":"Increases in VO2max and metabolic markers of fat oxidation by caffeine, carnitine, and choline supplementation in rats","volume":"11","author":"Sachan","year":"2000","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0025","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1007\/s00125-014-3326-5","article-title":"Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways","volume":"57","author":"Kim","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0030","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1039\/C4FO00970C","article-title":"The anti-obesity effect of green tea polysaccharide, polyphenols and caffeine in rats fed with high-fat diet","volume":"6","author":"Xu","year":"2015","journal-title":"Food Funct"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0035","doi-asserted-by":"crossref","first-page":"C726","DOI":"10.1152\/ajpcell.00003.2006","article-title":"Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2+ channels","volume":"291","author":"Chen","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0040","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nm1168","article-title":"Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120","volume":"11","author":"Hirasawa","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0045","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4062\/biomolther.2012.077","article-title":"Hesperetin stimulates cholecystokinin secretion in enteroendocrine STC-1 cells","volume":"21","author":"Kim","year":"2013","journal-title":"Biomol Ther"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0050","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4162\/nrp.2014.8.2.146","article-title":"Naringenin stimulates cholecystokinin secretion in STC-1 cells","volume":"8","author":"Park","year":"2014","journal-title":"Nutr Res Pract"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0055","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.regpep.2009.11.007","article-title":"Soybean beta 51-63 peptide stimulates cholecystokinin secretion via a calcium-sensing receptor in enteroendocrine STC-1 cells","volume":"159","author":"Nakajima","year":"2010","journal-title":"Regul Pept"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0060","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tem.2012.11.006","article-title":"Nutrient sensing in the gut: new roads to therapeutics?","volume":"24","author":"Janssen","year":"2013","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0065","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.coph.2007.09.006","article-title":"Mechanisms of CCK signaling from gut to brain","volume":"7","author":"Raybould","year":"2007","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0070","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1098\/rstb.2006.1856","article-title":"Gastrointestinal hormones regulating appetite","volume":"361","author":"Chaudhri","year":"2006","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0075","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1210\/en.2004-1266","article-title":"The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats","volume":"146","author":"Koda","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0080","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2005.03.011","article-title":"The inhibitory effects of peripheral administration of peptide YY 3\u201336 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal\u2013brainstem\u2013hypothalamic pathway","volume":"1044","author":"Abbott","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0085","doi-asserted-by":"crossref","first-page":"G156","DOI":"10.1152\/ajpgi.00569.2005","article-title":"Targeted disruption of the murine CCK1 receptor gene reduces intestinal lipid-induced feedback inhibition of gastric function","volume":"291","author":"Whited","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0090","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1042\/BJ20110009","article-title":"Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK","volume":"438","author":"Jeon","year":"2011","journal-title":"Biochem J"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0095","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jnutbio.2017.04.011","article-title":"Xanthohumol, a hop-derived prenylated flavonoid, promotes macrophage reverse cholesterol transport","volume":"47","author":"Hirata","year":"2017","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0100","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jnutbio.2017.07.011","article-title":"Protective effect of xanthohumol against age-related brain damage","volume":"49","author":"Rancan","year":"2017","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0105","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/mnfr.200500027","article-title":"Dietary supplement of isohumulones inhibits the formation of aberrant crypt foci with a concomitant decrease in prostaglandin E2 level in rat colon","volume":"49","author":"Nozawa","year":"2005","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0110","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1079\/BJN20041384","article-title":"Dietary isohumulones, the bitter components of beer, raise plasma HDL-cholesterol levels and reduce liver cholesterol and triacylglycerol contents similar to PPARalpha activations in C57BL\/6 mice","volume":"93","author":"Miura","year":"2005","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0115","doi-asserted-by":"crossref","first-page":"33456","DOI":"10.1074\/jbc.M403456200","article-title":"Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance","volume":"279","author":"Yajima","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0120","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1074\/jbc.M116.763813","article-title":"Iso-\u03b1-acids, bitter components of beer, prevent inflammation and cognitive decline induced in a mouse model of Alzheimer's disease","volume":"292","author":"Ano","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0125","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/sj.ijo.0802965","article-title":"Prevention of diet-induced obesity by dietary isomerized hop extract containing isohumulones, in rodents","volume":"29","author":"Yajima","year":"2005","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0130","first-page":"61","article-title":"Simultaneous analysis of hop bittering components by high-performance liquid chromatography. II. Evaluation of hop deterioration","volume":"45","author":"Ono","year":"1987","journal-title":"J Am Soc Brew Chem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0135","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1021\/jf3047187","article-title":"Identification and quantification of the oxidation products derived from alpha-acids and beta-acids during storage of hops ( Humulus lupulus L.)","volume":"61","author":"Taniguchi","year":"2013","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0140","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1021\/np4008427","article-title":"Structural elucidation of humulone autoxidation products and analysis of their occurrence in stored hops","volume":"77","author":"Taniguchi","year":"2014","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0145","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1080\/09168451.2015.1042832","article-title":"Development of preparative and analytical methods of the hop bitter acid oxide fraction and chemical properties of its components","volume":"79","author":"Taniguchi","year":"2015","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0150","doi-asserted-by":"crossref","first-page":"11602","DOI":"10.1021\/jf504394h","article-title":"Analysis of the components of hard resin in hops (Humulus lupulus L.) and structural elucidation of their transformation products formed during the brewing process","volume":"62","author":"Taniguchi","year":"2014","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0155","first-page":"118","article-title":"Contributions of hop hard resins to beer quality","volume":"65","author":"Almaguer","year":"2012","journal-title":"Brew Sci"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0160","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12937-016-0144-2","article-title":"Matured hop extract reduces body fat in healthy overweight humans: a randomized, double-blind, placebo-controlled parallel group study","volume":"15","author":"Morimoto-Kobayashi","year":"2016","journal-title":"Nutr J"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0165","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jnutbio.2016.08.012","article-title":"Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat-fed mice and in clonal brown adipocytes","volume":"39","author":"Pahlavani","year":"2017","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0170","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jnutbio.2016.11.009","article-title":"Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-fat-diet-induced obese rats by activating beta-adrenergic signaling","volume":"40","author":"Oi-Kano","year":"2017","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0175","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jnutbio.2003.08.005","article-title":"Green tea reduces body fat accretion caused by high-fat diet in rats through beta-adrenoceptor activation of thermogenesis in brown adipose tissue","volume":"14","author":"Choo","year":"2003","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0180","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000214834","article-title":"Green tea (\u2212)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice","volume":"54","author":"Lee","year":"2009","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131042","article-title":"Matured hop bittering components induce thermogenesis in brown adipose tissue via sympathetic nerve activity","volume":"10","author":"Morimoto-Kobayashi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0190","first-page":"1349","article-title":"Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expression","volume":"136","author":"Rindi","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0195","doi-asserted-by":"crossref","first-page":"G1368","DOI":"10.1152\/ajpgi.00135.2010","article-title":"The steroid glycoside hg-12 from Hoodia gordonii activates the human bitter receptor TAS2R14 and induces CCK release from HuTu-80 cells","volume":"299","author":"Le Nev\u00e9","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0200","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neulet.2005.04.010","article-title":"Olfactory stimulation with scent of lavender oil affects autonomic nerves, lipolysis and appetite in rats","volume":"383","author":"Shen","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0205","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2009.05.067","article-title":"Effect of 4G-alpha-glucopyranosyl hesperidin on brown fat adipose tissue- and cutaneous-sympathetic nerve activity and peripheral body temperature","volume":"461","author":"Shen","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0210","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bbrc.2005.01.139","article-title":"Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1","volume":"329","author":"Katsuma","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0215","doi-asserted-by":"crossref","first-page":"H79","DOI":"10.1111\/j.1750-3841.2009.01074.x","article-title":"Peptide-YY is released by the intestinal cell line STC-1","volume":"74","author":"Geraedts","year":"2009","journal-title":"J Food Sci"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0220","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0091-3057(92)90429-J","article-title":"The CCK-A receptor antagonist, devazepide, blocks the anorectic action of CCK but not peripheral serotonin in rats","volume":"43","author":"Eberle-Wang","year":"1992","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0225","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1172\/JCI36461","article-title":"SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice","volume":"118","author":"Jeon","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0230","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.foodchem.2011.05.013","article-title":"Different tastants and low-caloric sweeteners induce differential effects on the release of satiety hormones","volume":"129","author":"Geraedts","year":"2011","journal-title":"Food Chem"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0235","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1172\/JCI30227","article-title":"Gastrointestinal regulation of food intake","volume":"117","author":"Cummings","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051898","article-title":"Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats","volume":"7","author":"Blouet","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0245","doi-asserted-by":"crossref","first-page":"15069","DOI":"10.1073\/pnas.0706890104","article-title":"Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1","volume":"104","author":"Jang","year":"2007","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0250","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1073\/pnas.042617699","article-title":"Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells","volume":"99","author":"Wu","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0255","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/chemse\/bji022","article-title":"Characterization of bitter taste responses of intestinal STC-1 cells","volume":"30","author":"Masuho","year":"2005","journal-title":"Chem Senses"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0260","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s12078-009-9049-1","article-title":"Three TAS2R bitter taste receptors mediate the psychophysical responses to bitter compounds of hops (Humulus lupulus L.) and beer","volume":"2","author":"Intelmann","year":"2009","journal-title":"Chemosens Percept"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0265","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.2337\/db09-0530","article-title":"High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity","volume":"58","author":"Saito","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0270","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1152\/japplphysiol.00128.2010","article-title":"Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses","volume":"110","author":"Ono","year":"2011","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0275","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1152\/japplphysiol.00828.2002","article-title":"Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog","volume":"95","author":"Masuda","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jnutbio.2018.10.009_bb0280","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1172\/JCI67803","article-title":"Recruited brown adipose tissue as an antiobesity agent in humans","volume":"123","author":"Yoneshiro","year":"2013","journal-title":"J Clin Invest"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286318302778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286318302778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:26:17Z","timestamp":1760628377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286318302778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":56,"alternative-id":["S0955286318302778"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.10.009","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Secretion of a gastrointestinal hormone, cholecystokinin, by hop-derived bitter components activates sympathetic nerves in brown adipose tissue","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}