{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:44:45Z","timestamp":1790365485255,"version":"4.1.0"},"reference-count":159,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Major National Scientific Research Projects","award":["2015CB943102"],"award-info":[{"award-number":["2015CB943102"]}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["31572365"],"award-info":[{"award-number":["31572365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Sci-tech innovation team of Shaanxi province","award":["2017KCT-24"],"award-info":[{"award-number":["2017KCT-24"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.jnutbio.2018.10.020","type":"journal-article","created":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T02:22:29Z","timestamp":1541816549000},"page":"206-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Gut microbiota: a potential manipulator for host adipose tissue and energy metabolism"],"prefix":"10.1016","volume":"64","author":[{"given":"Rong","family":"Bohan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Tianyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Tiantian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ruonan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Hongtao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Qiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0005","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1242\/dmm.009662","article-title":"The adipose organ at a glance","volume":"5","author":"Cinti","year":"2012","journal-title":"Dis Model Mech"},{"issue":"1\u20132","key":"10.1016\/j.jnutbio.2018.10.020_bb0010","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2013.12.012","article-title":"What we talk about when we talk about fat","volume":"156","author":"Rosen","year":"2014","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.jnutbio.2018.10.020_bb0015","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/obr.12197","article-title":"A new model of the role of psychological and emotional distress in promoting obesity: conceptual review with implications for treatment and prevention","volume":"15","author":"Hemmingsson","year":"2014","journal-title":"Obes Rev"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0020","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev-pathol-012615-044359","article-title":"Obesity, inflammation, and cancer","volume":"11","author":"Deng","year":"2016","journal-title":"Annu Rev Pathol"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.10.020_bb0025","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12383","article-title":"Melatonin promotes circadian rhythm- induced proliferation through Clock\/histone deacetylase 3\/c-Myc interaction in mouse adipose tissue","volume":"62","author":"Liu","year":"2017","journal-title":"J Pineal Res"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.10.020_bb0030","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.bpg.2014.07.002","article-title":"Adipose tissues as endocrine target organs","volume":"28","author":"Lanthier","year":"2014","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"15","key":"10.1016\/j.jnutbio.2018.10.020_bb0035","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJMoa0808718","article-title":"Cold activated brown adipose tissue in healthy men","volume":"360","author":"van Marken Lichtenbelt","year":"2009","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.jnutbio.2018.10.020_bb0040","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","article-title":"Identification and importance of brown adipose tissue in adult humans","volume":"360","author":"Cypess","year":"2009","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.jnutbio.2018.10.020_bb0045","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1056\/NEJMoa0808949","article-title":"Functional brown adipose tissue in healthy adults","author":"Virtanen","year":"2009","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0050","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00125-016-3904-9","article-title":"Adipose tissue macrophages: going off track during obesity","volume":"59","author":"Boutens","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2014.00190","article-title":"Impact of the gut microbiota on the development of obesity and type 2 diabetes mellitus","volume":"5","author":"Moreno-Indias","year":"2014","journal-title":"Front Microbiol"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.10.020_bb0060","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.4049\/jimmunol.1203100","article-title":"Role of the gut microbiota in the development and function of lymphoid cells","volume":"190","author":"Kamada","year":"2013","journal-title":"J Immunol"},{"issue":"7122","key":"10.1016\/j.jnutbio.2018.10.020_bb0065","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"issue":"7418","key":"10.1016\/j.jnutbio.2018.10.020_bb0070","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"issue":"34","key":"10.1016\/j.jnutbio.2018.10.020_bb0075","doi-asserted-by":"crossref","first-page":"13780","DOI":"10.1073\/pnas.0706625104","article-title":"Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases","volume":"104","author":"Frank","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.10.020_bb0080","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1017\/S0954422416000159","article-title":"Effects of flavonoids on intestinal inflammation, barrier integrity and changes in gut microbiota during diet-induced obesity","volume":"29","author":"Gil-Cardoso","year":"2016","journal-title":"Nutr Res Rev"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.10.020_bb0085","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.diabet.2014.02.004","article-title":"Glucose metabolism: focus on gut microbiota, the endocannabinoid system and beyond","volume":"40","author":"Cani","year":"2014","journal-title":"Diabetes Metab"},{"issue":"6","key":"10.1016\/j.jnutbio.2018.10.020_bb0090","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.chom.2007.10.010","article-title":"Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota","volume":"2","author":"Bates","year":"2007","journal-title":"Cell Host Microbe"},{"issue":"6","key":"10.1016\/j.jnutbio.2018.10.020_bb0095","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0100","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev-physiol-021909-135817","article-title":"Role of colonic short-chain fatty acid transport in diarrhea","volume":"72","author":"Binder","year":"2011","journal-title":"Annu Rev Physiol"},{"issue":"6052","key":"10.1016\/j.jnutbio.2018.10.020_bb0105","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking long-term dietary patterns with gut microbial enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.jnutbio.2018.10.020_bb0110","doi-asserted-by":"crossref","first-page":"6ra14","DOI":"10.1126\/scitranslmed.3000322","article-title":"The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice","volume":"1","author":"Turnbaugh","year":"2009","journal-title":"Sci Transl Med"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.10.020_bb0115","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cmet.2016.07.008","article-title":"Effects of gut microbiota manipulation by antibiotics on host metabolism in obese humans: a randomized double-blind placebo-controlled trial","volume":"24","author":"Reijnders","year":"2016","journal-title":"Cell Metab"},{"issue":"7464","key":"10.1016\/j.jnutbio.2018.10.020_bb0120","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature12506","article-title":"Richness of human gut microbiome correlates with metabolic markers","volume":"500","author":"Le Chatelier","year":"2013","journal-title":"Nature"},{"issue":"6380","key":"10.1016\/j.jnutbio.2018.10.020_bb0125","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1126\/science.aao5774","article-title":"Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes","volume":"359","author":"Zhao","year":"2018","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.jnutbio.2018.10.020_bb0130","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1017\/S0007114508094658","article-title":"Comparative effects of very low-carbohydrate, high-fat and high-carbohydrate, low-fat weight-loss diets on bowel habit and faecal short-chain fatty acids and bacterial populations","volume":"101","author":"Brinkworth","year":"2009","journal-title":"Br J Nutr"},{"issue":"9","key":"10.1016\/j.jnutbio.2018.10.020_bb0135","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.bbalip.2014.06.002","article-title":"Role of free fatty acid receptors in the regulation of energy metabolism","volume":"1841","author":"Hara","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0140","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.coph.2016.08.009","article-title":"Development of novel ligands for peptide GPCRs","volume":"31","author":"Moran","year":"2016","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2016.00028","article-title":"GPR41 and GPR43 in obesity and inflammation \u2014 protective or causative?","volume":"7","author":"Ang","year":"2016","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0150","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2362.2010.02278.x","article-title":"Regulation of adipokine production in human adipose tissue by propionic acid","volume":"40","author":"Al-Lahham","year":"2010","journal-title":"Eur J Clin Investig"},{"issue":"19","key":"10.1016\/j.jnutbio.2018.10.020_bb0155","doi-asserted-by":"crossref","first-page":"8030","DOI":"10.1073\/pnas.1016088108","article-title":"Short- chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)","volume":"108","author":"Kimura","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7268","key":"10.1016\/j.jnutbio.2018.10.020_bb0160","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/nature08530","article-title":"Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43","volume":"461","author":"Maslowski","year":"2009","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.jnutbio.2018.10.020_bb0165","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.tips.2009.09.001","article-title":"GPR109A, GPR109B and GPR81, a family of hydroxyl-carboxylic acid receptors","volume":"30","author":"Ahmed","year":"2009","journal-title":"Trends Pharmacol Sci"},{"issue":"11","key":"10.1016\/j.jnutbio.2018.10.020_bb0170","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1073\/pnas.1215927110","article-title":"Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation","volume":"110","author":"Pluznick","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.jnutbio.2018.10.020_bb0175","doi-asserted-by":"crossref","first-page":"5092","DOI":"10.1210\/en.2005-0545","article-title":"Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43","volume":"146","author":"Hong","year":"2005","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.10.020_bb0180","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/db11-1019","article-title":"Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2","volume":"61","author":"Tolhurst","year":"2012","journal-title":"Diabetes"},{"issue":"13","key":"10.1016\/j.jnutbio.2018.10.020_bb0185","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1074\/jbc.M211609200","article-title":"The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids","volume":"278","author":"Brown","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0190","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms2852","article-title":"The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43","volume":"4","author":"Kimura","year":"2013","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.10.020_bb0195","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1073\/pnas.2637002100","article-title":"Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41","volume":"101","author":"Xiong","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"10.1016\/j.jnutbio.2018.10.020_bb0200","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1016\/j.febslet.2010.04.027","article-title":"Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids","volume":"584","author":"Zaibi","year":"2010","journal-title":"FEBS Lett"},{"issue":"16","key":"10.1016\/j.jnutbio.2018.10.020_bb0205","doi-asserted-by":"crossref","first-page":"8816","DOI":"10.1074\/jbc.M116.718460","article-title":"Activation of short and long chain fatty acid sensing machinery in the ileum lowers glucose production in vivo","volume":"291","author":"Zadeh-Tahmasebi","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2014.00236","article-title":"Free fatty acid receptors as therapeutic targets for the treatment of diabetes","volume":"5","author":"Ichimura","year":"2014","journal-title":"Front Pharmacol"},{"issue":"28","key":"10.1016\/j.jnutbio.2018.10.020_bb0215","doi-asserted-by":"crossref","first-page":"25481","DOI":"10.1074\/jbc.M301403200","article-title":"Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation","volume":"278","author":"Le Poul","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0220","doi-asserted-by":"crossref","DOI":"10.1038\/srep37589","article-title":"Short chain fatty acids prevent high-fat-diet-induced obesity in mice by regulating G protein-coupled receptors and gut microbiota","volume":"6","author":"Lu","year":"2016","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.10.020_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095268","article-title":"The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41","volume":"9","author":"Han","year":"2014","journal-title":"PLoS One"},{"issue":"43","key":"10.1016\/j.jnutbio.2018.10.020_bb0230","doi-asserted-by":"crossref","first-page":"16767","DOI":"10.1073\/pnas.0808567105","article-title":"Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41","volume":"105","author":"Samuel","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.jnutbio.2018.10.020_bb0235","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.febslet.2012.04.021","article-title":"Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation","volume":"586","author":"Inoue","year":"2012","journal-title":"FEBS Lett"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0240","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.jnutbio.2018.10.020_bb0245","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11605-009-1045-x","article-title":"Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8","volume":"14","author":"Cresci","year":"2010","journal-title":"J Gastrointest Surg"},{"issue":"12","key":"10.1016\/j.jnutbio.2018.10.020_bb0250","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1194\/jlr.M050955","article-title":"Inflammation stimulates niacin receptor (GPR109A\/HCA2) expression in adipose tissue and macrophages","volume":"55","author":"Feingold","year":"2014","journal-title":"J Lipid Res"},{"issue":"11","key":"10.1016\/j.jnutbio.2018.10.020_bb0255","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1017\/S0007114515003621","article-title":"Supplementation of sodium butyrate protects mice from the development of non-alcoholic steatohepatitis (NASH)","volume":"114","author":"Jin","year":"2015","journal-title":"Br J Nutr"},{"issue":"7","key":"10.1016\/j.jnutbio.2018.10.020_bb0260","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.2337\/db08-1637","article-title":"Butyrate improves insulin sensitivity and increases energy expenditure in mice","volume":"58","author":"Gao","year":"2009","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.10.020_bb0265","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/dom.12811","article-title":"The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro","volume":"19","author":"Pingitore","year":"2017","journal-title":"Diabetes Obes Metab"},{"issue":"7415","key":"10.1016\/j.jnutbio.2018.10.020_bb0270","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature11552","article-title":"Functional interactions between the gut microbiota and host metabolism","volume":"489","author":"Tremaroli","year":"2012","journal-title":"Nature"},{"issue":"31","key":"10.1016\/j.jnutbio.2018.10.020_bb0275","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0280","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4611","article-title":"The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism","volume":"5","author":"Frost","year":"2014","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.jnutbio.2018.10.020_bb0285","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3164\/jcbn.16-23","article-title":"Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-ay mice","volume":"59","author":"Hanatani","year":"2016","journal-title":"J Clin Biochem Nutr"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0290","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1210\/en.2015-1944","article-title":"Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes","volume":"157","author":"Hu","year":"2016","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0295","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/sj.bjp.0705682","article-title":"Regulation of microglial inflammatory response by sodium butyrate and short-chain fatty acids","volume":"141","author":"Huuskonen","year":"2004","journal-title":"Br J Pharmacol"},{"issue":"9","key":"10.1016\/j.jnutbio.2018.10.020_bb0300","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jnutbio.2007.08.002","article-title":"Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon","volume":"19","author":"Waldecker","year":"2008","journal-title":"J Nutr Biochem"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0305","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J Clin Invest"},{"issue":"12","key":"10.1016\/j.jnutbio.2018.10.020_bb0310","doi-asserted-by":"crossref","first-page":"1785-1758","DOI":"10.1172\/JCI20514","article-title":"Obesity-induced inflammatory changes in adipose tissue","volume":"112","author":"Wellen","year":"2003","journal-title":"J Clin Invest"},{"issue":"10","key":"10.1016\/j.jnutbio.2018.10.020_bb0315","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1161\/01.ATV.0000183883.72263.13","article-title":"A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha","volume":"25","author":"Suganami","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0320","first-page":"425","article-title":"Butyrate attenuates inflammation and lipolysis generated by the interaction of adipocytes and macrophages","volume":"20","author":"Ohira","year":"2003","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0325","article-title":"Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep"},{"issue":"30","key":"10.1016\/j.jnutbio.2018.10.020_bb0330","doi-asserted-by":"crossref","first-page":"18779","DOI":"10.1074\/jbc.272.30.18779","article-title":"The organization, promoter analysis, and expression of the human PPARgamma gene","volume":"272","author":"Fajas","year":"1997","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0335","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0092-8674(92)90031-7","article-title":"Control of the peroxisomal \u03b2-oxidation pathway by a novel family of nuclear hormone receptors","volume":"68","author":"Dreyer","year":"1992","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.jnutbio.2018.10.020_bb0340","doi-asserted-by":"crossref","first-page":"1341-1319","DOI":"10.1136\/gut.2006.093484","article-title":"PPARgamma as a new therapeutic target in inflammatory bowel diseases","volume":"55","author":"Dubuquoy","year":"2006","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.jnutbio.2018.10.020_bb0345","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S1097-2765(01)80012-5","article-title":"Loss-of-function mutations in PPAR gamma associated with human colon cancer","volume":"3","author":"Sarraf","year":"1999","journal-title":"Mol Cell"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0350","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/ni1018","article-title":"Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA","volume":"5","author":"Kelly","year":"2004","journal-title":"Nat Immunol"},{"issue":"3","key":"10.1016\/j.jnutbio.2018.10.020_bb0355","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1073\/pnas.0605374104","article-title":"Mechanisms underlying the resistance to diet-induced obesity in germ-free mice","volume":"104","author":"B\u00e4ckhed","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.jnutbio.2018.10.020_bb0360","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.cmet.2018.02.007","article-title":"Visceral adipose tissue immune homeostasis is regulated by the crosstalk between adipocytes and dendritic cell subsets","volume":"27","author":"Macdougall","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0365","doi-asserted-by":"crossref","DOI":"10.1038\/srep43199","article-title":"Commensal gut bacteria modulate phosphorylation-dependent PPAR\u03b3 transcriptional activity in human intestinal epithelial cells","volume":"7","author":"Nepelska","year":"2017","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.10.020_bb0370","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00018-015-2083-z","article-title":"Regulation of energy balance by a gut-brain axis and involvement of the gut microbiota","volume":"73","author":"Bauer","year":"2016","journal-title":"Cell Mol Life Sci"},{"issue":"7606","key":"10.1016\/j.jnutbio.2018.10.020_bb0375","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature18309","article-title":"Acetate mediates a microbiome-brain-\u03b2 cell axis promoting metabolic syndrome","volume":"534","author":"Perry","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0380","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.cell.2016.05.011","article-title":"Sensory neurons that detect stretch and nutrients in the digestive system","volume":"166","author":"Williams","year":"2016","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.jnutbio.2018.10.020_bb0385","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1136\/gutjnl-2014-307913","article-title":"Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults","volume":"64","author":"Chambers","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0390","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2012.00314","article-title":"Dynamic evolution of the LPS-detoxifying enzyme intestinal alkaline phosphatase in zebrash and other vertebrates","volume":"3","author":"Yang","year":"2012","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0395","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.me.27.020176.001015","article-title":"Biology of endotoxin","volume":"27","author":"Elin","year":"1976","journal-title":"Annu Rev Med"},{"issue":"6","key":"10.1016\/j.jnutbio.2018.10.020_bb0400","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18061163","article-title":"The complete structure of the core oligosaccharide from Edwardsiellatarda EIB 202 lipopolysaccharide","volume":"18","author":"Kaszowska","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0405","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4049\/jimmunol.1203103","article-title":"MyD88: a critical adaptor protein in innate immunity signal transduction","volume":"190","author":"Warner","year":"2013","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0410","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s12035-013-8425-7","article-title":"Role of the toll like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway","volume":"48","author":"Lucas","year":"2013","journal-title":"Mol Neurobiol"},{"issue":"6","key":"10.1016\/j.jnutbio.2018.10.020_bb0415","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.cell.2016.05.056","article-title":"Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans","volume":"165","author":"Vatanen","year":"2016","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.jnutbio.2018.10.020_bb0420","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.3945\/jn.109.104638","article-title":"Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers","volume":"139","author":"Peng","year":"2009","journal-title":"J Nutr"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.10.020_bb0425","doi-asserted-by":"crossref","first-page":"G518","DOI":"10.1152\/ajpgi.00024.2006","article-title":"Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis","volume":"292","author":"Brun","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"6","key":"10.1016\/j.jnutbio.2018.10.020_bb0430","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice","volume":"57","author":"Cani","year":"2008","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.jnutbio.2018.10.020_bb0435","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.4049\/jimmunol.168.9.4531","article-title":"Quantitative expression of toll-like receptor 1\u201310 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides","volume":"168","author":"Hornung","year":"2002","journal-title":"J Immunol"},{"issue":"11","key":"10.1016\/j.jnutbio.2018.10.020_bb0440","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.4049\/jimmunol.164.11.5998","article-title":"Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells","volume":"164","author":"Muzio","year":"2000","journal-title":"J Immunol"},{"issue":"8","key":"10.1016\/j.jnutbio.2018.10.020_bb0445","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat Immunol"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.10.020_bb0450","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"Medzhitov","year":"2001","journal-title":"Nat Rev Immunol"},{"issue":"32","key":"10.1016\/j.jnutbio.2018.10.020_bb0455","doi-asserted-by":"crossref","first-page":"24255","DOI":"10.1074\/jbc.M002137200","article-title":"The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes","volume":"275","author":"Lin","year":"2000","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.10.020_bb0460","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1523\/JNEUROSCI.2760-08.2009","article-title":"Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity","volume":"29","author":"Milanski","year":"2009","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.10.020_bb0465","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1128\/CMR.16.4.637-646.2003","article-title":"Role of toll-like receptors in pathogen recognition","volume":"16","author":"Janssens","year":"2003","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"10.1016\/j.jnutbio.2018.10.020_bb0470","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nri3446","article-title":"The history of toll-like receptors \u2014 redefining innate immunity","volume":"13","author":"O'Neill","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0475","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4878","article-title":"Hepatocyte toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance","volume":"5","author":"Jia","year":"2014","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.10.020_bb0480","doi-asserted-by":"crossref","first-page":"E386","DOI":"10.1152\/ajpendo.00087.2001","article-title":"Inducible nitric oxide synthase plays a role in LPS- induced hyperglycemia and insulin resistance","volume":"282","author":"Sugita","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.10.020_bb0485","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0891-5520(05)70085-4","article-title":"Nitric oxide in the pathogenesis of sepsis","volume":"13","author":"Symeonides","year":"1999","journal-title":"Infect Dis Clin N Am"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0490","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1073\/pnas.89.1.444","article-title":"S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds","volume":"89","author":"Stamler","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0495","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0896-6273(00)80310-4","article-title":"(S)NO signals: translocation, regulation, and a consensus motif","volume":"18","author":"Stamler","year":"1997","journal-title":"Neuron"},{"issue":"292","key":"10.1016\/j.jnutbio.2018.10.020_bb0500","doi-asserted-by":"crossref","first-page":"292ra98","DOI":"10.1126\/scitranslmed.aaa9134","article-title":"Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity","volume":"7","author":"Fu","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0505","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev-med-012510-175505","article-title":"Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes","volume":"62","author":"Musso","year":"2011","journal-title":"Annu Rev Med"},{"issue":"6","key":"10.1016\/j.jnutbio.2018.10.020_bb0510","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1210\/er.2009-0030","article-title":"Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk","volume":"31","author":"Manco","year":"2010","journal-title":"Endocr Rev"},{"issue":"7121","key":"10.1016\/j.jnutbio.2018.10.020_bb0515","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jnutbio.2018.10.020_bb0520","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.4049\/jimmunol.1402598","article-title":"Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88","volume":"195","author":"Guo","year":"2015","journal-title":"J Immunol"},{"issue":"7","key":"10.1016\/j.jnutbio.2018.10.020_bb0525","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.jnutbio.2018.10.020_bb0530","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.2337\/db08-0872","article-title":"Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes","volume":"57","author":"Lumeng","year":"2008","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.jnutbio.2018.10.020_bb0535","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.molmet.2013.06.005","article-title":"Metabolic endotoxemia directly increases the proliferation of adipocyte precursors at the onset of metabolic diseases through a CD14-dependent mechanism","volume":"2","author":"Luche","year":"2013","journal-title":"Mol Metab"},{"issue":"44","key":"10.1016\/j.jnutbio.2018.10.020_bb0540","doi-asserted-by":"crossref","first-page":"26476","DOI":"10.1074\/jbc.M115.677724","article-title":"Activation of toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress","volume":"290","author":"Okla","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0545","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00647","article-title":"Homeobox a5 promotes white adipose tissue browning through inhibition of the tenascin C\/toll-like receptor 4\/nuclear factor kappa B inflammatory signaling in mice","volume":"9","author":"Cao","year":"2018","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0550","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1182\/blood.V96.5.1723","article-title":"Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages","volume":"96","author":"Yokota","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0555","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.1428","article-title":"Lipopolysaccharide induces a downregulation of adiponectin receptors in-vitro and in-vivo","volume":"3","author":"Hall","year":"2015","journal-title":"PeerJ"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0560","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9039302","article-title":"Acinetobacter baumannii lipopolysaccharide influences adipokine expression in 3T3-L1 adipocytes","volume":"2017","author":"Unno","year":"2017","journal-title":"Mediat Inflamm"},{"issue":"9","key":"10.1016\/j.jnutbio.2018.10.020_bb0565","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1507\/endocrj.EJ14-0042","article-title":"The effects of LPS-induced endotoxemia on the expression of adiponectin and its receptors in female rats","volume":"61","author":"Iwasa","year":"2014","journal-title":"Endocr J"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.10.020_bb0570","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088127","article-title":"Prenatal exposure to lipopolysaccharide combined with pre- and postnatal high-fat diet result in lowered blood pressure and insulin resistance in offspring rats","volume":"9","author":"Hao","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.jnutbio.2018.10.020_bb0575","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111376","article-title":"Prenatal exposure to lipopolysaccharide results in local RAS activation in the adipose tissue of rat offspring","volume":"9","author":"Gao","year":"2014","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.jnutbio.2018.10.020_bb0580","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/bph.12445","article-title":"The concise guide to PHARMACOLOGY 2013\/14: G protein-coupled receptors","volume":"170","author":"Alexander","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0585","doi-asserted-by":"crossref","DOI":"10.1038\/msb.2010.46","article-title":"The endocannabinoid system links gut microbiota to adipogenesis","volume":"6","author":"Muccioli","year":"2010","journal-title":"Mol Syst Biol"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0590","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2011.00149","article-title":"Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue","volume":"2","author":"Geurts","year":"2011","journal-title":"Front Microbiol"},{"issue":"6","key":"10.1016\/j.jnutbio.2018.10.020_bb0595","doi-asserted-by":"crossref","first-page":"E1161","DOI":"10.1152\/ajpendo.00598.2009","article-title":"Apelin and APJ regulationin adipose tissue and skeletal muscle of type 2 diabetic mice and humans","volume":"298","author":"Dray","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0600","doi-asserted-by":"crossref","first-page":"18","DOI":"10.21307\/ane-2017-033","article-title":"Energy-dense diet triggers changes in gut microbiota, reorganization of gut-brain vagal communication and increases body fat accumulation","volume":"77","author":"Vaughn","year":"2017","journal-title":"Acta Neurobiol Exp (Wars)"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0605","first-page":"686","article-title":"High-fat-diet exposure induces IgG accumulation in hypothalamic microglia","volume":"5","author":"Yi","year":"2012","journal-title":"Dis Model Mech"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.10.020_bb0610","doi-asserted-by":"crossref","first-page":"1006-16.e4","DOI":"10.1053\/j.gastro.2012.06.034","article-title":"Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling","volume":"143","author":"Anitha","year":"2012","journal-title":"Gastroenterology"},{"issue":"6354","key":"10.1016\/j.jnutbio.2018.10.020_bb0615","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1126\/science.aan0677","article-title":"The intestinal micrbiota regulates body composition through NFIL3 and the circadian clock","volume":"357","author":"Wang","year":"2017","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0620","doi-asserted-by":"crossref","DOI":"10.4172\/2329-8901.1000159","article-title":"Probiotic Lactobacillus species strengthen intestinal barrier function and tight junction integrity in experimental necrotizing enterocolitis","volume":"5","author":"Blackwood","year":"2017","journal-title":"J Probiotics Health"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0625","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.01981","article-title":"Outer membrane vesicles and soluble factors released by probiotic Escherichia coli Nissle 1917 and commensal ECOR63 enhance barrier function by regulating expression of tight junction proteins in intestinal epithelial cells","volume":"7","author":"Alvarez","year":"2016","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0630","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/mnfr.201400548","article-title":"The perspective on cholesterol-lowering mechanisms of probiotics","volume":"59","author":"Ishimwe","year":"2015","journal-title":"Mol Nutr Food Res"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.10.020_bb0635","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.00080-13","article-title":"Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents","volume":"27","author":"Li\u00e9vin-Le Moal","year":"2014","journal-title":"Clin Microbiol Rev"},{"issue":"7","key":"10.1016\/j.jnutbio.2018.10.020_bb0640","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1084\/jem.20170495","article-title":"Commensal microbes provide first line defense against Listeria monocytogenes infection","volume":"214","author":"Becattini","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0645","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jnutbio.2015.11.018","article-title":"Fermented milk with probiotic Lactobacillus rhamnosus S1K3 (MTCC5957) protects mice from salmonella by enhancing immune and nonimmune protection mechanisms at intestinal mucosal level","volume":"30","author":"Kemgang","year":"2016","journal-title":"J Nutr Biochem"},{"issue":"11","key":"10.1016\/j.jnutbio.2018.10.020_bb0650","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.2337\/db11-0227","article-title":"Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin- resistant mice","volume":"60","author":"Everard","year":"2011","journal-title":"Diabetes"},{"issue":"7228","key":"10.1016\/j.jnutbio.2018.10.020_bb0655","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature07540","article-title":"A core gut microbiome in obese and lean twins","volume":"457","author":"Turnbaugh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0660","article-title":"Probiotics may delay the progression of nonalcoholic fatty liver disease by restoring the gut microbiota structure and improving intestinal endotoxemia","volume":"7","author":"Xue","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0665","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ismej.2014.99","article-title":"Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice","volume":"9","author":"Wang","year":"2015","journal-title":"ISME J"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.10.020_bb0670","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s11357-011-9294-5","article-title":"Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol","volume":"34","author":"Bj\u00f6rklund","year":"2012","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0675","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2015.00392","article-title":"Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders","volume":"9","author":"Kelly","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0680","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jnutbio.2016.11.011","article-title":"Salmosan, a \u03b2-galactomannan-rich product, in combination with Lactobacillus plantarum contributes to restore intestinal epithelial barrier function by modulation of cytokine production","volume":"41","author":"Brufau","year":"2017","journal-title":"J Nutr Biochem"},{"issue":"44","key":"10.1016\/j.jnutbio.2018.10.020_bb0685","doi-asserted-by":"crossref","first-page":"77489","DOI":"10.18632\/oncotarget.20536","article-title":"Lactobacillus reuteri ZJ617 maintains intestinal integrity via regulating tight junction, autophagy and apoptosis in mice challenged with lipopolysaccharide","volume":"8","author":"Cui","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.jnutbio.2018.10.020_bb0690","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/MPG.0000000000001310","article-title":"Secretions of Bifidobacterium infantis and Lactobacillus acidophilus protect intestinal epithelial barrier function","volume":"64","author":"Guo","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"3","key":"10.1016\/j.jnutbio.2018.10.020_bb0695","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jcmgh.2015.12.008","article-title":"Intestinal dysbiosis contributes to the delayed gastrointestinal transit in high-fat diet fed mice","volume":"2","author":"Anitha","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0700","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jbiosc.2011.12.016","article-title":"Effects of administration of Bifidobacterium animal is subsp. lactis GCL2505 on defecation frequency and bifidobacterial microbiota composition in humans","volume":"113","author":"Ishizuka","year":"2012","journal-title":"J Biosci Bioeng"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0705","doi-asserted-by":"crossref","DOI":"10.3390\/nu9050470","article-title":"Deleterious metabolic effects of high fructose intake: the preventive effect of lactobacillus kefiri administration","volume":"9","author":"Zubir\u00eda","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0710","article-title":"Live probiotic lactobacillus johnsonii BS15 promotes growth performance and lowers fat deposition by improving lipid metabolism, intestinal development, and gut microflora in broilers","volume":"8","author":"Wang","year":"2017","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0715","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054617","article-title":"Anti-obesity effect of lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice","volume":"8","author":"Kang","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jnutbio.2018.10.020_bb0720","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1365-2672.2010.04922.x","article-title":"Beneficial effect of oral administration of Lactobacillus casei strain Shirota on insulin resistance in diet-induced obesity mice","volume":"110","author":"Naito","year":"2011","journal-title":"J Appl Microbiol"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0725","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1017\/S0007114508043808","article-title":"Milk fermented by lactobacillus gasseri SBT2055 influences adipocyte size via inhibition of dietary fat absorption in Zucker rats","volume":"101","author":"Hamad","year":"2009","journal-title":"Br J Nutr"},{"issue":"Pt 5","key":"10.1016\/j.jnutbio.2018.10.020_bb0730","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1099\/ijs.0.02873-0","article-title":"Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium","volume":"54","author":"Derrien","year":"2004","journal-title":"Int J Syst Evol Microbiol"},{"issue":"8","key":"10.1016\/j.jnutbio.2018.10.020_bb0735","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/ismej.2012.6","article-title":"Microbes inside \u2014 from diversity to function: the case of Akkermansia","volume":"6","author":"Belzer","year":"2012","journal-title":"ISME J"},{"issue":"22","key":"10.1016\/j.jnutbio.2018.10.020_bb0740","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.jnutbio.2018.10.020_bb0745","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/gutjnl-2017-315732","article-title":"Does Akkermansia muciniphila play a role in type 1 diabetes?","volume":"67","author":"Mithieux","year":"2018","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jnutbio.2018.10.020_bb0750","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nm.4236","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice","volume":"23","author":"Plovier","year":"2017","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0755","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/gutjnl-2016-313432","article-title":"Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease","volume":"67","author":"Grander","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0760","doi-asserted-by":"crossref","DOI":"10.1038\/srep16643","article-title":"Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice","volume":"5","author":"Schneeberger","year":"2015","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.jnutbio.2018.10.020_bb0765","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1161\/ATVBAHA.116.307597","article-title":"Low-density lipoprotein receptor signaling mediates the triglyceride-lowering action of Akkermansia muciniphila in genetic-induced hyperlipidemia","volume":"36","author":"Shen","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"10.1016\/j.jnutbio.2018.10.020_bb0770","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.2337\/db14-1916","article-title":"Dietary polyphenols promote growth of the gut bacterium Akkermansia muciniphila and attenuate high-fat diet-induced metabolic syndrome","volume":"64","author":"Roopchand","year":"2015","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.jnutbio.2018.10.020_bb0775","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.282","article-title":"Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp Mol Med"},{"issue":"5","key":"10.1016\/j.jnutbio.2018.10.020_bb0780","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/gutjnl-2012-303839","article-title":"An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice","volume":"63","author":"Shin","year":"2014","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.jnutbio.2018.10.020_bb0785","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12399","article-title":"Melatonin prevents obesity through modulation of gut microbiota in mice","volume":"62","author":"Xu","year":"2017","journal-title":"J Pineal Res"},{"issue":"11","key":"10.1016\/j.jnutbio.2018.10.020_bb0790","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/AEM.04050-14","article-title":"Akkermansia muciniphila adheres to enterocytes and strengthens the integrity of the epithelial cell layer","volume":"81","author":"Reunanen","year":"2015","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jnutbio.2018.10.020_bb0795","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.01157","article-title":"Characterization of outer membrane proteome of Akkermansia muciniphila reveals sets of novel proteins exposed to the human intestine","volume":"7","author":"Ottman","year":"2016","journal-title":"Front Microbiol"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286318300561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286318300561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:27:44Z","timestamp":1760628464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286318300561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":159,"alternative-id":["S0955286318300561"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.10.020","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut microbiota: a potential manipulator for host adipose tissue and energy metabolism","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.10.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}