{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:42:23Z","timestamp":1778575343014,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Funds for the Development of Human Resources in Science and Technology"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.jnutbio.2018.11.004","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T21:35:02Z","timestamp":1543872902000},"page":"26-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Novel metabolic disturbances in marginal vitamin B6-deficient rat heart"],"prefix":"10.1016","volume":"65","author":[{"given":"Thanutchaporn","family":"Kumrungsee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5721-1445","authenticated-orcid":false,"given":"Dwi Eva","family":"Nirmagustina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Arima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Onishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihisa","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Yanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2018.11.004_bb0005","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/STROKEAHA.110.578906","article-title":"Dietary folate and vitamin B6 and B12 intake in relation to mortality from cardiovascular diseases: Japan collaborative cohort study","volume":"41","author":"Cui","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0010","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/978-94-007-2199-9_14","article-title":"Vitamin B6 and cardiovascular disease","volume":"56","author":"Friso","year":"2012","journal-title":"Subcell Biochem"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0015","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1515\/cclm-2012-0553","article-title":"Mechanisms of the beneficial effects of vitamin B6 and pyridoxal 5-phosphate on cardiac performance in ischemic heart disease","volume":"51","author":"Dhalla","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0020","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.acvd.2009.07.002","article-title":"The controversial role of B-vitamins in cardiovascular risk: an update","volume":"102","author":"Ntaios","year":"2009","journal-title":"Arch Cardiovasc Dis"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0025","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3945\/ajcn.2009.28571","article-title":"Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study","volume":"91","author":"Shen","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0030","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1161\/01.CIR.103.23.2788","article-title":"Low circulating vitamin B6 is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels","volume":"103","author":"Friso","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0035","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.jnutbio.2013.08.005","article-title":"Dietary vitamin B6 intake modulates colonic inflammation in the IL10\u2212\/\u2212 model of inflammatory bowel disease","volume":"24","author":"Selhub","year":"2013","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0040","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mam.2016.08.001","article-title":"Inflammation, vitamin B6 and related pathways","volume":"53","author":"Ueland","year":"2016","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0045","first-page":"481","article-title":"Arteriosclerotic lesions in pyridoxine-deficient monkeys","volume":"25","author":"Rinehart","year":"1949","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0050","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1152\/physrev.00039.2012","article-title":"Physiology and pathophysiology of carnosine","volume":"93","author":"Boldyrev","year":"2013","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0055","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1043-4526(09)57003-9","article-title":"Carnosine and its possible roles in nutrition and health","volume":"57","author":"Hipkiss","year":"2009","journal-title":"Adv Food Nutr Res"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0060","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s40064-015-1074-8","article-title":"Dietary supplemental vitamin B6 increases carnosine and anserine concentrations in the heart of rats","volume":"4","author":"Suidasari","year":"2015","journal-title":"SpringerPlus"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0063544","article-title":"Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects","volume":"8","author":"Gregory","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0070","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s00394-015-0934-x","article-title":"Investigation of vitamin B6 inadequacy, induced by exposure to the anti-B6 factor 1-amino D-proline, on plasma lipophilic metabolites of rats: a metabolomics approach","volume":"55","author":"Mayengbam","year":"2016","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0075","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0080","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0083-6729(08)60500-2","article-title":"A critical review of minimal vitamin B6 requirements for growth in various species with a proposed method of calculation","volume":"48","author":"Coburn","year":"1994","journal-title":"Vitam Horm"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0085","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1093\/jn\/131.8.2204","article-title":"Vitamin B-6\u2013supplemented diets compared with a low vitamin B-6 diet suppress azoxymethane-induced colon tumorigenesis in mice by reducing cell proliferation","volume":"131","author":"Komatsu","year":"2001","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0090","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1021\/ac990976y","article-title":"Amino acid analysis by capillary electrophoresis electrospray ionization mass spectrometry","volume":"72","author":"Soga","year":"2000","journal-title":"Anal Chem"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0095","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1021\/pr034020m","article-title":"Quantitative metabolome analysis using capillary electrophoresis mass spectrometry","volume":"2","author":"Soga","year":"2003","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0100","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3177\/jnsv.58.446","article-title":"Comparative study on the responses of concentrations of B6-vitamers in several tissues of mice to the dietary level of pyridoxine","volume":"58","author":"Masisi","year":"2012","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0076-6879(97)80095-X","article-title":"Determination of vitamin B6 vitamers and metabolites in a biological sample","volume":"280","author":"Tsuge","year":"1997","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0110","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0378-4347(00)83848-7","article-title":"Determination of gamma-aminobutyric acid in human cerebrospinal fluid by isocratic high-performance liquid chromatography","volume":"529","author":"Kamisaki","year":"1990","journal-title":"J Chromatogr"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0115","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1007\/s11033-009-9902-y","article-title":"An examination of aspartate decarboxylase and glutamate decarboxylase activity in mosquitoes","volume":"37","author":"Richardson","year":"2010","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0120","doi-asserted-by":"crossref","first-page":"40898","DOI":"10.1074\/jbc.M112.393728","article-title":"Role of glutamate decarboxylase-like protein 1 (GADL1) in taurine biosynthesis","volume":"287","author":"Liu","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0125","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1128\/jb.141.3.1291-1297.1980","article-title":"\u03b2-Alanine synthesis in Escherichia coli","volume":"141","author":"Cronan","year":"1980","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0130","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0361-9230(01)00565-2","article-title":"Influence of pyridoxal 5\u2032-phosphate alone and in combination with vigabatrin on brain GABA measured by 1H-NMR-spectroscopy","volume":"55","author":"Mueller","year":"2001","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0135","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0304-4165(84)90159-4","article-title":"Catabolism of polyamines in the rat. Polyamines and their non-\u03b1-amino acid metabolites","volume":"802","author":"Van den Berg","year":"1984","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0140","first-page":"345","article-title":"Biosynthesis of riboflavin, folic acid, thiamine, and pantothenic acid","volume":"53","author":"Brown","year":"1982","journal-title":"Adv Enzymol Relat Areas Mol Biol"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0145","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.nut.2014.04.021","article-title":"Effects of oral administration of orodispersible levo-carnosine on quality of life and exercise performance in patients with chronic heart failure","volume":"31","author":"Lombardi","year":"2015","journal-title":"Nutrition"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0150","first-page":"849","article-title":"Anti-ischemic activity of carnosine","volume":"65","author":"Stvolinsky","year":"2000","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0155","first-page":"1389","article-title":"The protective effect of carnosine in hypoxia and reoxygenation of the isolated rat heart","volume":"57","author":"Prokop'eva","year":"1992","journal-title":"Biokhimilia"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0160","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s10517-008-0081-y","article-title":"Cardioprotective effect of histidine-containing dipeptides in pharmacological cold cardioplegia","volume":"145","author":"Bokeriya","year":"2008","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0165","doi-asserted-by":"crossref","first-page":"868","DOI":"10.2174\/138920110793262105","article-title":"Protective effect of natural antioxidants on heart against ischemia-reperfusion damage","volume":"11","author":"Zhao","year":"2010","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0170","first-page":"115","article-title":"Lactate and lactate clearance in acute cardiac care patients","volume":"1","author":"Attan\u00e0","year":"2012","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0175","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pharep.2013.08.008","article-title":"Effects of carnosine on prooxidant-antioxidant status in heart tissue, plasma and erythrocytes of rats with isoproterenol-induced myocardial infarction","volume":"66","author":"Evran","year":"2014","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0180","doi-asserted-by":"crossref","DOI":"10.1038\/srep13131","article-title":"Histamine deficiency exacerbates myocardial injury in acute myocardial infarction through impaired macrophage infiltration and increased cardiomyocyte apoptosis","volume":"5","author":"Deng","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0185","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.brainres.2013.07.004","article-title":"Role of histidine\/histamine in carnosine-induced neuroprotection during ischemic brain damage","volume":"1527","author":"Bae","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0190","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF01997607","article-title":"The presence and significance of carnosine in histamine-containing tissues of several mammalian species","volume":"31","author":"Flancbaum","year":"1990","journal-title":"Agents Actions"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0195","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.thromres.2013.12.022","article-title":"Pro- and anti-inflammatory effects of histamine on tissue factor and TNF expression in monocytes of human blood","volume":"133","author":"\u00d8sterud","year":"2014","journal-title":"Thromb Res"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0200","doi-asserted-by":"crossref","first-page":"H286","DOI":"10.1152\/ajpheart.00733.2013","article-title":"Protective effects of histamine on Gq-mediated relaxation in regenerated endothelium","volume":"306","author":"Chan","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0205","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.jacc.2015.02.018","article-title":"Metabolic disturbances identified in plasma are associated with outcomes in patients with heart failure: diagnostic and prognostic value of metabolomics","volume":"65","author":"Cheng","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0117325","article-title":"Plasma amino acid profiling identifies specific amino acid associations with cardiovascular function in patients with systolic heart failure","volume":"10","author":"Hakuno","year":"2015","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jnutbio.2018.11.004_bb0215","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0955-2863(99)00058-3","article-title":"Effects of dietary polyamines and clofibrate on metabolism of polyamines in the rat","volume":"10","author":"Brodal","year":"1999","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0220","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0024-3205(74)90087-3","article-title":"Regulation of ornithine decarboxylase synthesis effect of a nutritional deficiency of vitamin B6","volume":"4","author":"Sturman","year":"1974","journal-title":"Life Sci"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0225","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/nm.4222","article-title":"Cardioprotection and lifespan extension by the natural polyamine spermidine","volume":"22","author":"Eisenberg","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0230","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.mehy.2010.03.008","article-title":"Polyamine intake, dietary pattern, and cardiovascular disease","volume":"75","author":"Soda","year":"2010","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0235","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/jn\/75.2.175","article-title":"Effect of various vitamin deficiencies on citric acid metabolism in the rat","volume":"75","author":"de Luca","year":"1961","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0240","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1161\/CIRCULATIONAHA.105.569137","article-title":"Metabolomic identification of novel biomarkers of myocardial ischemia","volume":"112","author":"Sabatine","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0245","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/CIRCRESAHA.113.300376","article-title":"Cardiac metabolism in heart failure: implications beyond ATP production","volume":"113","author":"Doenst","year":"2013","journal-title":"Circ Res"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0250","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-201X.1998.0400e.x","article-title":"Cardiac accumulation of citrate during brief myocardial ischaemia and reperfusion in the pig in vivo","volume":"164","author":"Hassel","year":"1998","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0255","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrcardio.2016.203","article-title":"Expert consensus document: mitochondrial function as a therapeutic target in heart failure","volume":"14","author":"Brown","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0260","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0005-2744(76)90044-9","article-title":"Specificity and distribution of mammalian carnosinase","volume":"429","author":"Lenney","year":"1976","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0265","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1113\/jphysiol.1991.sp018673","article-title":"Intestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactulose","volume":"439","author":"Gardner","year":"1991","journal-title":"J Physiol"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0270","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0006-291X(74)91010-9","article-title":"Regulation of pyridoxal 5\u2032-phosphate metabolism in liver","volume":"61","author":"Li","year":"1974","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0275","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1093\/jn\/119.10.1392","article-title":"Evaluation of vitamin B-6 status and function of rats fed excess pyridoxine","volume":"119","author":"Schaeffer","year":"1989","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2018.11.004_bb0280","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/jn\/131.6.1777","article-title":"Assessment of vitamin B-6 status in young women consuming a controlled diet containing four levels of vitamin B-6 provides an estimated average requirement and recommended dietary allowance","volume":"131","author":"Hansen","year":"2001","journal-title":"J Nutr"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286318303978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286318303978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:25:38Z","timestamp":1760628338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286318303978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":56,"alternative-id":["S0955286318303978"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.11.004","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel metabolic disturbances in marginal vitamin B6-deficient rat heart","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}