{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:31:08Z","timestamp":1783999868093,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01430-2014"],"award-info":[{"award-number":["APQ-01430-2014"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.jnutbio.2019.06.006","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T17:06:50Z","timestamp":1561136810000},"page":"108208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Role of adipose tissue inflammation in fat pad loss induced by fasting in lean and mildly obese mice"],"prefix":"10.1016","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1917-8944","authenticated-orcid":false,"given":"D\u00e9bora Romualdo","family":"Lacerda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia Anuncia\u00e7\u00e3o","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Let\u00edcia Malheiros","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Fernandes","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albena Nunes","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiana Lopes","family":"Sabino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Pinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Batista","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danusa Dias","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Martins","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adaliene Versiani Matos","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2019.06.006_bb0005","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1172\/JCI57132","article-title":"Inflammatory links between obesity and metabolic disease","volume":"121","author":"Lumeng","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/imr.12216","article-title":"A decade of progress in adipose tissue macrophage biology","volume":"262","author":"Hill","year":"2014","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0015","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.2337\/db05-1304","article-title":"Mature-onset obesity in interleukin-1 receptor I knockout mice","volume":"55","author":"Garc\u00eda","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0020","doi-asserted-by":"crossref","first-page":"E466","DOI":"10.1152\/ajpendo.00266.2012","article-title":"Inflammation during obesity is not all bad: evidence from animal and human studies","volume":"304","author":"Ye","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0025","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cmet.2014.05.005","article-title":"Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling","volume":"20","author":"Asterholm","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0030","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/oby.20142","article-title":"Lack of platelet-activating factor receptor protects mice against diet-induced adipose inflammation and insulin-resistance despite fat pad expansion","volume":"22","author":"Menezes-Garcia","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0035","doi-asserted-by":"crossref","unstructured":"Martins LB, Oliveira MC, Menezes-Garcia Z, Rodrigues DF, Lana JP, Vieira QV, Teixeira MM, Ferreira AVM. Paradoxical role of tumor necrosis factor on metabolic dysfunction and adipose tissue expansion in mice. Nutrition 2017.","DOI":"10.1016\/j.nut.2017.07.006"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0040","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1210\/en.2011-1346","article-title":"Constitutive activation of IKK\u03b2 in adipose tissue prevents diet-induced obesity in mice","volume":"153","author":"Jiao","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0045","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.nut.2006.04.008","article-title":"Proteolytic and lipolytic responses to starvation","volume":"22","author":"Finn","year":"2006","journal-title":"Nutrition"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0050","doi-asserted-by":"crossref","first-page":"E205","DOI":"10.1152\/ajpendo.00053.2015","article-title":"Fat in flames: influence of cytokines and pattern recognition receptors on adipocyte lipolysis","volume":"309","author":"Grant","year":"2015","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0055","doi-asserted-by":"crossref","first-page":"24665","DOI":"10.1074\/jbc.273.38.24665","article-title":"Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes","volume":"273","author":"Souza","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0060","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.tem.2006.08.003","article-title":"Importance of TNF alpha and neutral lipases in human adipose tissue lipolysis","volume":"17","author":"Langin","year":"2006","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0065","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.2337\/db06-S007","article-title":"Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome","volume":"55","author":"Ruderman","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0070","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nri3041","article-title":"The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease","volume":"11","author":"Gleeson","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0075","doi-asserted-by":"crossref","unstructured":"Kosteli A, Sugaru E, Haemmerle G, Martin JF, Lei J, Zechner R, Ferrante AW Jr. Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest, 2010;120:3466\u20133479.","DOI":"10.1172\/JCI42845"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0080","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2337\/diabetes.49.5.677","article-title":"Fuel selection in human skeletal muscle in insulin resistance: a reexamination","volume":"49","author":"Kelley","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0085","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1467-789X.2008.00544.x","article-title":"Metabolic flexibility in the development of insulin resistance and type 2 diabetes: effects of lifestyle","volume":"10","author":"Corpeleijn","year":"2009","journal-title":"Obes Rev"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0090","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1111\/j.1467-789X.2010.00812.x","article-title":"Metabolic flexibility and obesity in children and youth","volume":"12","author":"Aucouturier","year":"2011","journal-title":"Obes Rev"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0095","doi-asserted-by":"crossref","first-page":"E395","DOI":"10.1002\/oby.20230","article-title":"Acute and sustained inflammation and metabolic dysfunction induced by high refined carbohydrate-containing diet in mice","volume":"21","author":"Oliveira","year":"2013","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0100","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1113\/expphysiol.2014.082511","article-title":"Osteopetrosis in obese female rats is site-specifically inhibited by physical training","volume":"100","author":"Lacerda","year":"2015","journal-title":"Exp Physiol"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0105","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1139\/apnm-2018-0523","article-title":"Aerobic training reduces immune cell recruitment and cytokine levels in adipose tissue in obese mice","volume":"44","author":"Lacerda","year":"2019","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0110","article-title":"Tumor necrosis factor, but not neutrophils, alters the metabolic profile in acute experimental arthritis","volume":"11","author":"Oliveira","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0115","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nm.2627","article-title":"The cellular and signaling networks linking the immune system and metabolism in disease","volume":"18","author":"Osborn","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0120","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nm0102-75","article-title":"Interleukin-6-deficient mice develop mature-onset obesity","volume":"8","author":"Wallenius","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0125","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.cellimm.2011.05.008","article-title":"Experimental food allergy leads to adipose tissue inflammation, systemic metabolic alterations and weight loss in mice","volume":"270","author":"Dourado","year":"2011","journal-title":"Cell Immunol"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0130","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00421-009-1070-1","article-title":"Exhaustive exercise causes an anti-inflammatory effect in skeletal muscle and a pro-inflammatory effect in adipose tissue in rats","volume":"106","author":"Rosa Neto","year":"2009","journal-title":"Eu J Appl Physiol"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0135","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.bbalip.2010.04.012","article-title":"\u03b23-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK","volume":"1801","author":"Mottillo","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0140","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1016-8478(23)12877-9","article-title":"The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors","volume":"30","author":"Lee","year":"2006","journal-title":"Mol Cells"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0145","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.ATV.0000251608.09329.9a","article-title":"Role of the toll-like receptor 4\/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages","volume":"27","author":"Suganami","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0150","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-2567.2008.02892.x","article-title":"Fatty acid-induced induction of toll-like receptor-4\/nuclear factor-kappaB pathway in adipocytes links nutritional signaling with innate immunity","volume":"126","author":"Schaeffler","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0155","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.bbalip.2013.04.004","article-title":"Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner","volume":"1831","author":"Long","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/8601359","article-title":"Lack of platelet-activating factor receptor attenuates experimental food allergy but not its metabolic alterations regarding adipokine levels","author":"Batista","year":"2016","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0165","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.psc.2011.08.004","article-title":"Dietary approaches to the treatment of obesity","volume":"34","author":"Makris","year":"2011","journal-title":"Psychiatr Clin North Am"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0170","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/ijo.2014.214","article-title":"Fasting for weight loss: an effective strategy or latest dieting trend?","volume":"39","author":"Johnstone","year":"2015","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0175","doi-asserted-by":"crossref","first-page":"E1076","DOI":"10.1152\/ajpendo.00177.2004","article-title":"Impaired plasma fatty acid oxidation in extremely obese women","volume":"287","author":"Thyfault","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0180","doi-asserted-by":"crossref","first-page":"E354","DOI":"10.1152\/ajpendo.00301.2003","article-title":"Excess body fat in men decreases plasma fatty acid availability and oxidation during endurance exercise","volume":"286","author":"Mittendorfer","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0185","doi-asserted-by":"crossref","first-page":"R499","DOI":"10.1152\/ajpregu.2000.279.2.R499","article-title":"Activation of alpha(2)-adrenergic receptors impairs exercise-induced lipolysis in SCAT of obese subjects","volume":"279","author":"Stich","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"4","key":"10.1016\/j.jnutbio.2019.06.006_bb0190","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/JES.0b013e31825d53fc","article-title":"Severe obesity: evidence for a deranged metabolic program in skeletal muscle?","volume":"40","author":"Houmard","year":"2012","journal-title":"Exerc Sport Sci Rev"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0195","article-title":"Differential immunometabolic phenotype in Th1 and Th2 dominant mouse strains in response to high-fat feeding","volume":"28","author":"Jovicic","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0200","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00125-013-2846-8","article-title":"Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding","volume":"56","author":"Montgomery","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.jnutbio.2019.06.006_bb0205","first-page":"1","article-title":"Immunological and metabolic effects of high refined carbohydrate-containing diet in food allergic mice","volume":"1","author":"Yamada","year":"2015","journal-title":"Nutrition"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286318304303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286318304303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:28:03Z","timestamp":1760628483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286318304303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":41,"alternative-id":["S0955286318304303"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2019.06.006","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of adipose tissue inflammation in fat pad loss induced by fasting in lean and mildly obese mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2019.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108208"}}