{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:01:09Z","timestamp":1791021669878,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jnutbio.2021.108863","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T20:50:07Z","timestamp":1631307007000},"page":"108863","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"special_numbering":"C","title":["Probiotics alleviate autoimmune hepatitis in mice through modulation of gut microbiota and intestinal permeability"],"prefix":"10.1016","volume":"98","author":[{"given":"Qingqing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3590-227X","authenticated-orcid":false,"given":"Weiping","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jnutbio.2021.108863_bib0001","doi-asserted-by":"crossref","first-page":"18017","DOI":"10.1038\/nrdp.2018.17","article-title":"Autoimmune hepatitis","volume":"4","author":"Mieli-Vergani","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jnutbio.2021.108863_bib0002","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-pathol-020117-043534","article-title":"Cellular and Molecular Mechanisms of Autoimmune Hepatitis","volume":"13","author":"Webb","year":"2018","journal-title":"Annu Rev Pathol"},{"issue":"1","key":"10.1016\/j.jnutbio.2021.108863_bib0003","first-page":"1","article-title":"Hellenic Association for the Study of the Liver Clinical Practice Guidelines: Autoimmune hepatitis","volume":"32","author":"Dalekos","year":"2019","journal-title":"Ann Gastroenterol"},{"issue":"6","key":"10.1016\/j.jnutbio.2021.108863_bib0004","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/MCG.0000000000000805","article-title":"Contractor Q. Natural History and Treatment Outcomes of Severe Autoimmune Hepatitis","volume":"51","author":"Sonthalia","year":"2017","journal-title":"J Clin Gastroenterol"},{"issue":"1","key":"10.1016\/j.jnutbio.2021.108863_bib0005","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/hep.1840110106","article-title":"Experimental autoimmune hepatitis: disease induction, time course and T-cell reactivity","volume":"11","author":"Lohse","year":"1990","journal-title":"Hepatology"},{"issue":"42","key":"10.1016\/j.jnutbio.2021.108863_bib0006","doi-asserted-by":"crossref","first-page":"9257","DOI":"10.3748\/wjg.v22.i42.9257","article-title":"Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis","volume":"22","author":"Czaja","year":"2016","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.jnutbio.2021.108863_bib0007","doi-asserted-by":"crossref","first-page":"36365","DOI":"10.1038\/srep36365","article-title":"Enterogenous bacterial glycolipids are required for the generation of natural killer T cells mediated liver injury","volume":"6","author":"Wei","year":"2016","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.jnutbio.2021.108863_bib0008","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/apt.15754","article-title":"A disease-specific decline of the relative abundance of Bifidobacterium in patients with autoimmune hepatitis","volume":"51","author":"Liwinski","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.jnutbio.2021.108863_bib0009","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/gutjnl-2018-317836","article-title":"Alterations of gut microbiome in autoimmune hepatitis","volume":"69","author":"Wei","year":"2020","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.jnutbio.2021.108863_bib0010","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1128\/CMR.16.4.658-672.2003","article-title":"Potential uses of probiotics in clinical practice","volume":"16","author":"Reid","year":"2003","journal-title":"Clin Microbiol Rev"},{"issue":"10","key":"10.1016\/j.jnutbio.2021.108863_bib0011","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.4049\/jimmunol.1402598","article-title":"Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88","volume":"15","author":"Guo","year":"2015","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.jnutbio.2021.108863_bib0012","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.3390\/nu12061874","article-title":"Changes in the intestinal microbiome during a multispecies probiotic intervention in Compensated Cirrhosis","volume":"12","author":"Horvath","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2021.108863_bib0013","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1749-6632.2009.04059.x","article-title":"Effect of probiotics on intestinal barrier function","volume":"1165","author":"Mennigen","year":"2009","journal-title":"Ann N Y Acad Sci"},{"issue":"19","key":"10.1016\/j.jnutbio.2021.108863_bib0014","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201800298","article-title":"The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade","volume":"62","author":"Robles-Vera","year":"2018","journal-title":"Mol Nutr Food Res"},{"issue":"6","key":"10.1016\/j.jnutbio.2021.108863_bib0015","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1021\/acs.jafc.5b06177","article-title":"Lactobacillus plantarum NCU116 Attenuates Cyclophosphamide-Induced Immunosuppression and Regulates Th17\/Treg Cell Immune Responses in Mice","volume":"64","author":"Xie","year":"2016","journal-title":"J Agric Food Chem"},{"issue":"1","key":"10.1016\/j.jnutbio.2021.108863_bib0016","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1038\/s41467-019-10703-1","article-title":"BIS Investigator Group, Vuillermin P, Nanan R. Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia","volume":"10","author":"Hu","year":"2019","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.jnutbio.2021.108863_bib0017","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/hep.28001","article-title":"B cells expressing CD11b effectively inhibit CD4+ T-cell responses and ameliorate experimental autoimmune hepatitis in mice","volume":"62","author":"Liu","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jnutbio.2021.108863_bib0018","unstructured":"Ministry of Health of the People\u2032s Republic of China, <2010>NO.65:the species list can be used for food[EB\/OL]. 2010. (in Chinese) https:\/\/doi.org\/"},{"issue":"3","key":"10.1016\/j.jnutbio.2021.108863_bib0019","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2021.108863_bib0020","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.clim.2018.11.003","article-title":"Treg\/Th17 imbalance is associated with poor autoimmune hepatitis prognosis","volume":"198","author":"Liu","year":"2019","journal-title":"Clin Immunol"},{"issue":"25","key":"10.1016\/j.jnutbio.2021.108863_bib0021","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.3748\/wjg.v19.i25.4083","article-title":"Azathioprine-induced fever in autoimmune hepatitis","volume":"19","author":"Khoury","year":"2013","journal-title":"World J Gastroenterol"},{"issue":"8","key":"10.1016\/j.jnutbio.2021.108863_bib0022","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1097\/MEG.0000000000000648","article-title":"Autoimmune hepatitis and long-term disease course in children in Turkey, a single-center experience","volume":"28","author":"Karakoyun","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.jnutbio.2021.108863_bib0023","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jaut.2009.08.010","article-title":"Aetiopathogenesis of autoimmune hepatitis","volume":"34","author":"Longhi","year":"2010","journal-title":"J Autoimmun"},{"issue":"2","key":"10.1016\/j.jnutbio.2021.108863_bib0024","doi-asserted-by":"crossref","first-page":"98","DOI":"10.15171\/mejdd.2018.134","article-title":"Enhanced Th17 Responses in Patients with Autoimmune Hepatitis","volume":"11","author":"Behfarjam","year":"2019","journal-title":"Middle East J Dig Dis"},{"issue":"4","key":"10.1016\/j.jnutbio.2021.108863_bib0025","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2174\/1386207322666190402160455","article-title":"Expression and Significance of Th17 Cells and Related Factors in Patients with Autoimmune Hepatitis","volume":"22","author":"An","year":"2019","journal-title":"Comb Chem High Throughput Screen"},{"issue":"8","key":"10.1016\/j.jnutbio.2021.108863_bib0026","doi-asserted-by":"crossref","first-page":"534","DOI":"10.21037\/atm.2020.03.203","article-title":"Decreased Foxp3 and function of Tregs caused immune imbalance and liver injury in patients with autoimmune liver diseases post-liver transplantation","volume":"8","author":"Liu","year":"2020","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.jnutbio.2021.108863_bib0027","doi-asserted-by":"crossref","first-page":"6204","DOI":"10.12659\/MSM.915408","article-title":"Foxp3+ Treg Cells Are Associated with Pathological Process of Autoimmune Hepatitis by Activating Methylation Modification in Autoimmune Hepatitis Patients","volume":"25","author":"Chen","year":"2019","journal-title":"Med Sci Monit"},{"issue":"8","key":"10.1016\/j.jnutbio.2021.108863_bib0028","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/gene.2014.45","article-title":"Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-\u03b2","volume":"15","author":"Palomares","year":"2014","journal-title":"Genes Immun"},{"issue":"8","key":"10.1016\/j.jnutbio.2021.108863_bib0029","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.3390\/ijms19082212","article-title":"Hepatoprotective Effects of Lactobacillus on Carbon Tetrachloride-Induced Acute Liver Injury in Mice","volume":"19","author":"Chen","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2021.108863_bib0030","doi-asserted-by":"crossref","unstructured":"Kuzmich NN, Sivak KV, Chubarev VN, Porozov YB, Savateeva-Lyubimova TN, Peri F. TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis. Vaccines (Basel). 2017;5(4):34-59. https:\/\/doi.org\/10.3390\/vaccines5040034","DOI":"10.3390\/vaccines5040034"},{"issue":"1","key":"10.1016\/j.jnutbio.2021.108863_bib0031","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrgastro.2016.169","article-title":"The intestinal epithelial barrier: a therapeutic target?","volume":"14","author":"Odenwald","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.jnutbio.2021.108863_bib0032","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jhep.2012.06.011","article-title":"Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats","volume":"57","author":"Zhang","year":"2012","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.jnutbio.2021.108863_bib0033","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1055\/s-0035-1571276","article-title":"Targeting Dysbiosis for the Treatment of Liver Disease","volume":"36","author":"Anand","year":"2016","journal-title":"Semin Liver Dis"},{"issue":"4","key":"10.1016\/j.jnutbio.2021.108863_bib0034","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3390\/nu12041107","article-title":"The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome","volume":"12","author":"Markowiak-Kope\u0107","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2021.108863_bib0035","doi-asserted-by":"crossref","first-page":"106062","DOI":"10.1016\/j.intimp.2019.106062","article-title":"Inulin alleviates inflammation of alcoholic liver disease via SCFAs-inducing suppression of M1 and facilitation of M2 macrophages in mice","volume":"78","author":"Wang","year":"2020","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10.1016\/j.jnutbio.2021.108863_bib0036","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/ni0111-5","article-title":"Diet, gut microbiota and immune responses","volume":"12","author":"Maslowski","year":"2011","journal-title":"Nat Immunol"},{"issue":"3","key":"10.1016\/j.jnutbio.2021.108863_bib0037","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1530\/JOE-20-0018","article-title":"SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD","volume":"245","author":"Deng","year":"2020","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jnutbio.2021.108863_bib0038","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.nutres.2019.07.001","article-title":"Gnotobiotic mice inoculated with Firmicutes, but not Bacteroidetes, deteriorate nonalcoholic fatty liver disease severity by modulating hepatic lipid metabolism","volume":"69","author":"Chen","year":"2019","journal-title":"Nutr Res"},{"issue":"10","key":"10.1016\/j.jnutbio.2021.108863_bib0039","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/intimm\/dxaa041","article-title":"The impact of metabolites derived from the gut microbiota on immune regulation and diseases","volume":"32","author":"Ohno","year":"2020","journal-title":"Int Immunol"},{"issue":"6","key":"10.1016\/j.jnutbio.2021.108863_bib0040","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/liv.12380","article-title":"Protective effect of Bifidobacterium pseudocatenulatum CECT7765 against induced bacterial antigen translocation in experimental cirrhosis","volume":"34","author":"Moratalla","year":"2014","journal-title":"Liver Int"},{"key":"10.1016\/j.jnutbio.2021.108863_bib0041","doi-asserted-by":"crossref","first-page":"173267","DOI":"10.1016\/j.ejphar.2020.173267","article-title":"Palmatine ameliorates Helicobacter pylori-induced chronic atrophic gastritis by inhibiting MMP-10 through ADAM17\/EGFR","volume":"882","author":"Chen","year":"2020","journal-title":"Eur J Pharmacol"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286321002837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286321002837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:35:31Z","timestamp":1760628931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286321002837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":41,"alternative-id":["S0955286321002837"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2021.108863","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Probiotics alleviate autoimmune hepatitis in mice through modulation of gut microbiota and intestinal permeability","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2021.108863","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108863"}}