{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T02:43:01Z","timestamp":1776393781907,"version":"3.51.2"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004576","name":"Ministry of Agriculture and Rural Development","doi-asserted-by":"publisher","award":["19-16-0001"],"award-info":[{"award-number":["19-16-0001"]}],"id":[{"id":"10.13039\/501100004576","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jnutbio.2021.108867","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T15:16:44Z","timestamp":1632496604000},"page":"108867","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Grape pomace reduces the severity of non-alcoholic hepatic steatosis and the development of steatohepatitis by improving insulin sensitivity and reducing ectopic fat deposition in mice"],"prefix":"10.1016","volume":"98","author":[{"given":"Tehila","family":"Daniel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaella","family":"Ben-Shachar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elyashiv","family":"Drori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharleen","family":"Hamad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Permyakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elad","family":"Ben-Cnaan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0948-0093","authenticated-orcid":false,"given":"Joseph","family":"Tam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohar","family":"Kerem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1706-0136","authenticated-orcid":false,"given":"Tovit","family":"Rosenzweig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2021.108867_bib0001","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","article-title":"The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: a systematic review and meta-analysis","volume":"71","author":"Younossi","year":"2019","journal-title":"J Hepatol"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0002","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0003","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3803\/EnM.2019.34.3.226","article-title":"Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective","volume":"34","author":"Rhee","year":"2019","journal-title":"Endocrinol Metab (Seoul)"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0004","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/hep.29466","article-title":"Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease","volume":"67","author":"Estes","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0005","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/hep.28785","article-title":"The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0006","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12944-017-0572-9","article-title":"A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease","volume":"16","author":"Chen","year":"2017","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0007","doi-asserted-by":"crossref","first-page":"873","DOI":"10.2337\/dc11-1849","article-title":"Prevalence of prediabetes and diabetes and metabolic profile of patients with nonalcoholic fatty liver disease (NAFLD)","volume":"35","author":"Ortiz-Lopez","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0008","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1440-1746.2004.03312.x","article-title":"Non-alcoholic steatohepatitis in type 2 diabetes mellitus","volume":"19","author":"Gupte","year":"2004","journal-title":"J Gastroenterol Hepatol"},{"issue":"Suppl 1","key":"10.1016\/j.jnutbio.2021.108867_bib0009","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1016\/j.jhep.2008.01.009","article-title":"Non-alcoholic fatty liver disease: the mist gradually clears","volume":"48","author":"de Alwis","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0010","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nrendo.2011.72","article-title":"Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment","volume":"7","author":"Smith","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0011","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.3748\/wjg.v19.i8.1158","article-title":"From fatty liver to fibrosis: a tale of \"second hit\"","volume":"19","author":"Basaranoglu","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0012","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1053\/j.gastro.2006.05.054","article-title":"Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance","volume":"131","author":"Tilg","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0013","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1073\/pnas.0603509103","article-title":"Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance","volume":"103","author":"Tuncman","year":"2006","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.jnutbio.2021.108867_bib0014","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1053\/j.gastro.2019.11.311","article-title":"Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis","volume":"158","author":"Schwabe","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0015","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.3389\/fimmu.2019.02893","article-title":"Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack","volume":"10","author":"Oates","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0016","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20020351","article-title":"Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis","volume":"20","author":"Poti","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0017","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6723931","article-title":"Dietary Polyphenols, Mediterranean Diet, Prediabetes, and Type 2 Diabetes: A Narrative Review of the Evidence","volume":"2017","author":"Guasch-Ferre","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0018","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23092114","article-title":"Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice","volume":"23","author":"de Souza Mesquita","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0019","doi-asserted-by":"crossref","DOI":"10.3390\/nu10111604","article-title":"Bergamot Polyphenols Boost Therapeutic Effects of the Diet on Non-Alcoholic Steatohepatitis (NASH) Induced by \"Junk Food\": Evidence for Anti-Inflammatory Activity","volume":"10","author":"Parafati","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0020","first-page":"1523","article-title":"Green tea polyphenols attenuate hepatic steatosis, and reduce insulin resistance and inflammation in high-fat diet-induced rats","volume":"44","author":"Xia","year":"2019","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0021","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1039\/C5FO01065A","article-title":"Grape pomace and grape pomace extract improve insulin signaling in high-fat-fructose fed rat-induced metabolic syndrome","volume":"7","author":"Rodriguez Lanzi","year":"2016","journal-title":"Food Funct"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0022","doi-asserted-by":"crossref","first-page":"17778","DOI":"10.3390\/ijms151017778","article-title":"The beneficial effects of combined grape pomace and omija fruit extracts on hyperglycemia, adiposity and hepatic steatosis in db\/db mice: a comparison with major index compounds","volume":"15","author":"Cho","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0023","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3746\/pnf.2015.20.2.94","article-title":"Effects of the Combined Extracts of Grape Pomace and Omija Fruit on Hyperglycemia and Adiposity in Type 2 Diabetic Mice","volume":"20","author":"Cho","year":"2015","journal-title":"Prev Nutr Food Sci"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0024","doi-asserted-by":"crossref","first-page":"E334","DOI":"10.1152\/ajpendo.00107.2017","article-title":"Reduced obesity, diabetes, and steatosis upon cinnamon and grape pomace are associated with changes in gut microbiota and markers of gut barrier","volume":"314","author":"Van Hul","year":"2018","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0025","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jff.2017.04.043","article-title":"Red wine and wine pomace reduced the development of insulin resistance and liver steatosis in HFD-fed mice","volume":"34","author":"Rosenzweig","year":"2017","journal-title":"J Funct Foods"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0026","unstructured":"Iland P. Techniques for Chemical Analysis and Quality Monitoring During Winemaking: Patrick Iland Wine Promotions; 2000."},{"key":"10.1016\/j.jnutbio.2021.108867_bib0027","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/bph.14849","article-title":"Dual inhibition of cannabinoid CB1 receptor and inducible NOS attenuates obesity-induced chronic kidney disease","volume":"177","author":"Udi","year":"2020","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0028","doi-asserted-by":"crossref","first-page":"14052","DOI":"10.1038\/s41598-020-70765-w","article-title":"C57BL\/6J substrain differences in response to high-fat diet intervention","volume":"10","author":"Siersb\u00e6k","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0029","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115922","article-title":"Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology","volume":"9","author":"Liang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0030","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/17460441.2018.1410135","article-title":"Dash A. Non-alcoholic fatty liver disease (NAFLD) models in drug discovery","volume":"13","author":"Cole","year":"2018","journal-title":"Expert Opin Drug Discov"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0031","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1172\/JCI119034","article-title":"Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria","volume":"98","author":"Sidossis","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0032","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.2337\/diabetes.48.8.1607","article-title":"Metabolic factors contributing to increased resting metabolic rate and decreased insulin-induced thermogenesis during the development of type 2 diabetes","volume":"48","author":"Weyer","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0033","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3389\/fendo.2019.00548","article-title":"Resting Energy Expenditure, Insulin Resistance and UCP1 Expression in Human Subcutaneous and Visceral Adipose Tissue of Patients With Obesity","volume":"10","author":"Bettini","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0034","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1038\/s41598-017-01907-w","article-title":"Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger","volume":"7","author":"Kullmann","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0035","doi-asserted-by":"crossref","first-page":"9048","DOI":"10.1523\/JNEUROSCI.22-20-09048.2002","article-title":"The catabolic action of insulin in the brain is mediated by melanocortins","volume":"22","author":"Benoit","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0036","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.2337\/db12-0025","article-title":"Intranasal insulin suppresses food intake via enhancement of brain energy levels in humans","volume":"61","author":"Jauch-Chara","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0037","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1038\/s41467-020-15686-y","article-title":"Brain insulin sensitivity is linked to adiposity and body fat distribution","volume":"11","author":"Kullmann","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0038","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jpeds.2007.12.036","article-title":"Insulin resistance, hyperinsulinemia, and energy intake in overweight children","volume":"152","author":"Han","year":"2008","journal-title":"J Pediatr"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0039","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1210\/endo.130.6.1597158","article-title":"Inhibition of hypothalamic neuropeptide Y gene expression by insulin","volume":"130","author":"Schwartz","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0040","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.molmet.2017.03.013","article-title":"Insulin controls food intake and energy balance via NPY neurons","volume":"6","author":"Loh","year":"2017","journal-title":"Mol Metab"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0041","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1172\/JCI119621","article-title":"Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects","volume":"100","author":"Boden","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0042","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1126\/science.289.5487.2122","article-title":"Role of brain insulin receptor in control of body weight and reproduction","volume":"289","author":"Bruning","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0043","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2337\/diabetes.55.03.06.db05-0917","article-title":"Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance","volume":"55","author":"Kim","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0044","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00394-017-1576-y","article-title":"Blood\u2013brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study","volume":"58","author":"Figueira","year":"2019","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0045","doi-asserted-by":"crossref","first-page":"11456","DOI":"10.1038\/s41598-017-11512-6","article-title":"Polyphenols journey through blood-brain barrier towards neuronal protection","volume":"7","author":"Figueira","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0046","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0047","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-981-10-8684-7_3","article-title":"Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease","volume":"1061","author":"Farrell","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0048","doi-asserted-by":"crossref","first-page":"E506","DOI":"10.1152\/ajpendo.00586.2009","article-title":"Insulin-sensitive obesity","volume":"299","author":"Kloting","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0049","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1172\/JCI96139","article-title":"Insulin resistance causes inflammation in adipose tissue","volume":"128","author":"Shimobayashi","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030759","article-title":"Insulin and Insulin Receptors in Adipose Tissue Development","volume":"20","author":"Cignarelli","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0051","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1210\/en.2004-0321","article-title":"Peroxisome proliferator-activated receptor gamma agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob\/ob mice","volume":"145","author":"Sell","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0052","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1194\/jlr.M011320","article-title":"Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes","volume":"52","author":"Goto","year":"2011","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0053","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1194\/jlr.M050005","article-title":"Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic beta3-adrenergic receptor activation","volume":"55","author":"Mottillo","year":"2014","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0054","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cell.2014.12.022","article-title":"Leptin and insulin act on POMC neurons to promote the browning of white fat","volume":"160","author":"Dodd","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0055","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrendo.2013.204","article-title":"Adipose tissue browning and metabolic health","volume":"10","author":"Bartelt","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0056","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cmet.2007.12.009","article-title":"Selective versus total insulin resistance: a pathogenic paradox","volume":"7","author":"Brown","year":"2008","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0057","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1002\/hep.26988","article-title":"Relationship between disease severity, hyperinsulinemia, and impaired insulin clearance in patients with nonalcoholic steatohepatitis","volume":"59","author":"Bril","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0058","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.2337\/diabetes.49.12.2094","article-title":"A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia","volume":"49","author":"Weyer","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0059","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1210\/jc.2007-0334","article-title":"Insulin resistance, insulin response, and obesity as indicators of metabolic risk","volume":"92","author":"Ferrannini","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0060","doi-asserted-by":"crossref","first-page":"843","DOI":"10.2337\/diacare.24.5.843","article-title":"Hyperinsulinemia predicts fatal liver cancer but is inversely associated with fatal cancer at some other sites: the Paris Prospective Study","volume":"24","author":"Balkau","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0061","doi-asserted-by":"crossref","first-page":"E1195","DOI":"10.1152\/ajpendo.00513.2004","article-title":"PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes","volume":"288","author":"Schadinger","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0062","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jnutbio.2010.04.009","article-title":"An increase in liver PPARgamma2 is an initial event to induce fatty liver in response to a diet high in butter: PPARgamma2 knockdown improves fatty liver induced by high-saturated fat","volume":"22","author":"Yamazaki","year":"2011","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0063","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.livres.2018.12.001","article-title":"Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2","volume":"2","author":"Lee","year":"2018","journal-title":"Liver Res"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0064","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.exger.2007.10.011","article-title":"Downregulation of plasma insulin levels and hepatic PPARgamma expression during the first week of caloric restriction in mice","volume":"43","author":"Mulligan","year":"2008","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0065","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40659-015-0040-9","article-title":"Wine grape pomace flour improves blood pressure, fasting glucose and protein damage in humans: a randomized controlled trial","volume":"48","author":"Urquiaga","year":"2015","journal-title":"Biol Res"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0066","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.1039\/C8FO01323C","article-title":"A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome markers","volume":"9","author":"Martinez-Maqueda","year":"2018","journal-title":"Food Funct"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0067","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jnutbio.2009.02.003","article-title":"Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the insulin signaling pathway differently from insulin","volume":"21","author":"Montagut","year":"2010","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0068","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1210\/en.2004-0764","article-title":"Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines","volume":"145","author":"Pinent","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0069","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102435","article-title":"Grape seeds proanthocyanidins: an overview of in vivo bioactivity in animal models","volume":"11","author":"Rodr\u00edguez-P\u00e9rez","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0070","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fchem.2018.00040","article-title":"Isolation and Characterization of Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Polyphenolic Compounds From Dodonaea viscosa and Their Kinetic Analysis","volume":"6","author":"Uddin","year":"2018","journal-title":"Front Chem"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114109","article-title":"Analysis of polyphenolic metabolites from in vitro gastrointestinal digested soft fruit extracts identify malvidin-3-glucoside as an inhibitor of PTP1B","volume":"178","author":"Barik","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0072","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jnutbio.2018.03.009","article-title":"Short-chain fatty acids suppress food intake by activating vagal afferent neurons","volume":"57","author":"Goswami","year":"2018","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0073","doi-asserted-by":"crossref","first-page":"16574","DOI":"10.1038\/s41598-019-53242-x","article-title":"Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3","volume":"9","author":"Shimizu","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2021.108867_bib0074","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jare.2020.02.015","article-title":"From winery waste to bioactive compounds and new polymeric biocomposites: A contribution to the circular economy concept","volume":"24","author":"Ferri","year":"2020","journal-title":"J Adv Res"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286321002874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286321002874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:35:42Z","timestamp":1760628942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286321002874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":74,"alternative-id":["S0955286321002874"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2021.108867","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Grape pomace reduces the severity of non-alcoholic hepatic steatosis and the development of steatohepatitis by improving insulin sensitivity and reducing ectopic fat deposition in mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2021.108867","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108867"}}