{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:02:57Z","timestamp":1769608977205,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32001704"],"award-info":[{"award-number":["32001704"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002888","name":"Beijing Municipal Education Commission","doi-asserted-by":"publisher","award":["KM202110011004"],"award-info":[{"award-number":["KM202110011004"]}],"id":[{"id":"10.13039\/501100002888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jnutbio.2022.108956","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T12:45:17Z","timestamp":1644237917000},"page":"108956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Protective effects of 5-heptadecylresorcinol against adipocyte mitochondrial dysfunction through upregulation of Sirt3-mediated autophagy"],"prefix":"10.1016","volume":"103","author":[{"given":"Yiming","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0843-0358","authenticated-orcid":false,"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Speakman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoqun","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoguo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2022.108956_bib0001","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.2105\/AJPH.2016.303326","article-title":"Determinants and consequences of obesity","volume":"106","author":"Hruby","year":"2016","journal-title":"Am J Public Health"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0002","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.arr.2016.09.008","article-title":"Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis","volume":"35","author":"Kalinkovich","year":"2017","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0003","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1111\/bph.15215","article-title":"Small molecule-driven SIRT3-autophagy-mediated NLRP3 inflammasome inhibition ameliorates inflammatory crosstalk between macrophages and adipocytes","volume":"177","author":"Zhang","year":"2020","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110672","article-title":"Phenolic compounds from coffee by-products modulate adipogenesis-related inflammation, mitochondrial dysfunction, and insulin resistance in adipocytes, via insulin\/PI3K\/AKT signaling pathways","volume":"132","author":"Rebollo-Hernanz","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0005","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.3390\/antiox9121193","article-title":"Identification of dietary phytochemicals capable of enhancing the autophagy flux in HeLa and Caco-2 human cell lines","volume":"9","author":"Ohnishi","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0006","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s13105-019-00708-1","article-title":"The role of autophagy in brown and beige adipose tissue plasticity","volume":"76","author":"Cair\u00f3","year":"2020","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101005","article-title":"Adipocyte-specific Beclin1 deletion impairs lipolysis and mitochondrial integrity in adipose tissue","volume":"39","author":"Son","year":"2020","journal-title":"Mol Metab"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0008","first-page":"1","article-title":"Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice","volume":"4","author":"Ko","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0009","article-title":"5-Heptadecylresorcinol, a biomarker for whole grain rye consumption, ameliorates cognitive impairments and neuroinflammation in APP\/PS1 transgenic mice","volume":"64","author":"Liu","year":"2020","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0010","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3390\/nu11020465","article-title":"Long-Term whole grain wheat and rye intake reflected by adipose tissue Alkylresorcinols and breast cancer: A case-cohort study","volume":"11","author":"Wu","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0011","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3945\/jn.114.202754","article-title":"Wheat alkylresorcinols suppress high-fat, high-sucrose diet-induced obesity and glucose intolerance by increasing insulin sensitivity and cholesterol excretion in male mice","volume":"145","author":"Oishi","year":"2015","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0012","doi-asserted-by":"crossref","first-page":"9241","DOI":"10.1021\/acs.jafc.8b02911","article-title":"Identification, quantification, and anti-inflammatory activity of 5- n-Alkylresorcinols from 21 different wheat varieties","volume":"66","author":"Liu","year":"2018","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0013","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1021\/acs.jafc.7b01567","article-title":"Inhibitory effect of piceatannol on TNF-\u03b1-mediated inflammation and insulin resistance in 3T3-L1 Adipocytes","volume":"65","author":"Li","year":"2017","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0014","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jff.2015.06.014","article-title":"A novel Gynostemma pentaphyllum saponin and its adipogenesis inhibitory effect through modulating Wnt\/beta-catenin pathway and cell cycle in mitotic clonal expansion","volume":"17","author":"Liu","year":"2015","journal-title":"J Funct Foods"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0015","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1039\/C9FO03028J","article-title":"5-Heptadecylresorcinol attenuates oxidative damage and mitochondria-mediated apoptosis through activation of the SIRT3\/FOXO3a signaling pathway in neurocytes","volume":"11","author":"Liu","year":"2020","journal-title":"Food Funct"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0016","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"Faseb J"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0017","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.2337\/db14-1933","article-title":"DAPK2 downregulation associates with attenuated adipocyte autophagic clearance in human obesity","volume":"64","author":"Soussi","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0018","doi-asserted-by":"crossref","first-page":"9237","DOI":"10.1021\/acs.jafc.7b03382","article-title":"Gypenosides reduced the risk of overweight and insulin resistance in C57BL\/6J mice through modulating adipose thermogenesis and gut microbiota","volume":"65","author":"Liu","year":"2017","journal-title":"Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0019","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1002\/mnfr.201500324","article-title":"Milk-derived peptide Val-Pro-Pro (VPP) inhibits obesity-induced adipose inflammation via an angiotensin-converting enzyme (ACE) dependent cascade","volume":"59","author":"Sawada","year":"2015","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0020","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1042\/BCJ20190468","article-title":"Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics","volume":"477","author":"Yang","year":"2020","journal-title":"Biochem J"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0021","article-title":"Cocoa shell aqueous phenolic extract preserves mitochondrial function and insulin sensitivity by attenuating inflammation between macrophages and adipocytes in vitro","volume":"63","author":"Rebollo-Hernanz","year":"2019","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0022","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jnutbio.2013.12.004","article-title":"Dietary cocoa reduces metabolic endotoxemia and adipose tissue inflammation in high-fat fed mice","volume":"25","author":"Gua","year":"2014","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0023","first-page":"53","article-title":"Macrophage and adipocyte mitochondrial dysfunction in obesity-induced metabolic diseases","volume":"38","author":"Wang","year":"2020","journal-title":"World J Mens Health"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0024","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1056\/NEJMra1215233","article-title":"M.D. Mitochondrial dynamics\u2013mitochondrial fission and fusion in human diseases","volume":"369","author":"Archer","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0025","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.2337\/db15-1624","article-title":"Nitric oxide produced by macrophages inhibits adipocyte differentiation and promotes profibrogenic responses in preadipocytes to induce adipose tissue fibrosis","volume":"65","author":"Jang","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0026","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3389\/fendo.2019.00570","article-title":"Dysregulated mitochondrial dynamics and metabolism in obesity, diabetes, and cancer","volume":"10","author":"Dai","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0027","doi-asserted-by":"crossref","first-page":"26185","DOI":"10.1074\/jbc.M503062200","article-title":"Disruption of fusion results in mitochondrial heterogeneity and dysfunction","volume":"28","author":"Chen","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0028","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.15252\/embj.201694914","article-title":"Mfn2 is critical for brown adipose tissue thermogenic function","volume":"36","author":"Boutant","year":"2017","journal-title":"EMBO J"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0029","first-page":"71","article-title":"Mitochondrial dysfunction is induced by the overexpression of UCP4 in 3T3-L1 adipocytes","volume":"25","author":"Gao","year":"2010","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0030","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.bbrc.2018.02.199","article-title":"PINK1-Parkin alleviates metabolic stress induced by obesity in adipose tissue and in 3T3-L1 preadipocytes","volume":"498","author":"Cui","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0031","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.3390\/nu12103072","article-title":"Epigallocatechin-3-gallate reduces visceral adiposity partly through the regulation of beclin1-dependent autophagy in white adipose tissues","volume":"12","author":"Choi","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0032","doi-asserted-by":"crossref","first-page":"924","DOI":"10.3390\/antiox9100924","article-title":"Involvement of HO-1 and autophagy in the protective effect of magnolol in hepatic steatosis-induced NLRP3 inflammasome activation in vivo and in vitro","volume":"9","author":"Kuo","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0033","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1152\/ajpendo.00057.2018","article-title":"NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism","volume":"315","author":"Porter","year":"2018","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0034","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3390\/ijms21020372","article-title":"SIRT3 acts as a positive autophagy regulator to promote lipid mobilization in adipocytes via activating AMPK","volume":"21","author":"Zhang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0035","first-page":"3517","article-title":"SIRT3 deficiency exacerbates p53\/Parkin-mediated mitophagy inhibition and promotes mitochondrial dysfunction: Implication for aged hearts","volume":"4","author":"Li","year":"2018","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jnutbio.2022.108956_bib0036","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.3390\/nu10121962","article-title":"Myricetin exerts anti-obesity effects through upregulation of SIRT3 in adipose tissue","volume":"10","author":"Akindehin","year":"2018","journal-title":"Nutrients"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286322000274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286322000274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:33:56Z","timestamp":1760628836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286322000274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":36,"alternative-id":["S0955286322000274"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2022.108956","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of 5-heptadecylresorcinol against adipocyte mitochondrial dysfunction through upregulation of Sirt3-mediated autophagy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2022.108956","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108956"}}