{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:55:13Z","timestamp":1788306913527,"version":"build-2803163510"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jnutbio.2022.108977","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T02:25:42Z","timestamp":1646274342000},"page":"108977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Obesity phenotype induced by high-fat diet leads to maternal-fetal constraint, placental inefficiency, and fetal growth restriction in mice"],"prefix":"10.1016","volume":"104","author":[{"given":"Ana Paula Varela","family":"Sanches","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josilene Lopes","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9384-2076","authenticated-orcid":false,"given":"Ma\u00edra Schuchter","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-117X","authenticated-orcid":false,"given":"Bruna de Souza","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane \u00c9rica","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00eds Ang\u00e9lica de Paula","family":"Simino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio Alberto","family":"Torsoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Souza","family":"Torsoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marciane","family":"Milanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia","family":"Ign\u00e1cio-Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2022.108977_bib0001","unstructured":"WHO. World health statistics. 2012."},{"key":"10.1016\/j.jnutbio.2022.108977_bib0002","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.2337\/dc09-1489","article-title":"Birth Weight: Genetic and intrauterine environment in normal pregnancy","volume":"32","author":"Fallucca","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0003","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/bmb\/60.1.5","article-title":"The thrifty phenotype hypothesis","volume":"60","author":"Hales","year":"2001","journal-title":"Br Med Bull"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0004","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-2796.2007.01809.x","article-title":"The origins of the developmental origins theory","volume":"261","author":"Barker","year":"2007","journal-title":"J Intern Med"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0005","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000091506","article-title":"Imprinted genes, placental development and fetal growth","volume":"65","author":"Fowden","year":"2006","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0006","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1467-789X.2011.00867.x","article-title":"Birth weight and subsequent risk of obesity: a systematic review and meta-analysis","volume":"12","author":"Yu","year":"2011","journal-title":"Obes Rev"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0007","first-page":"42","article-title":"Association between maternal body mass index and the birth weight of neonates","volume":"13","author":"Upadhyay","year":"2011","journal-title":"Nepal Med Coll J"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0008","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s00125-006-0264-x","article-title":"Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism","volume":"49","author":"Catalano","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0009","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1001\/archpedi.161.8.745","article-title":"prepregnancy obesity as a risk factor for structural birth defects","volume":"161","author":"Waller","year":"2007","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0010","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ogc.2009.03.003","article-title":"Pregnancy and obesity","volume":"36","author":"Yogev","year":"2009","journal-title":"Obstet Gynecol Clin North Am"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0011","first-page":"E439","article-title":"Metabolic programming: fetal origins of obesity and metabolic syndrome in the adult","volume":"291","author":"Ismail-Beigi","year":"2006","journal-title":"Am J Physiol Metab"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0012","series-title":"Growth and Development: Physiological Aspects. Encycl. Hum. Nutr","first-page":"399","author":"Hay","year":"2013"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0013","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1113\/JP273684","article-title":"A Western-style obesogenic diet alters maternal metabolic physiology with consequences for fetal nutrient acquisition in mice","volume":"595","author":"Musial","year":"2017","journal-title":"J Physiol"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0014","doi-asserted-by":"crossref","first-page":"44650","DOI":"10.1038\/srep44650","article-title":"Exercise rescues obese mothers\u2019 insulin sensitivity, placental hypoxia and male offspring insulin sensitivity","volume":"7","author":"Fernandez-Twinn","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0015","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1017\/S000711451200089X","article-title":"Protein restriction in early life is associated with changes in insulin sensitivity and pancreatic \u03b2-cell function during pregnancy","volume":"109","author":"Ign\u00e1cio-Souza","year":"2013","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0016","doi-asserted-by":"crossref","first-page":"8980","DOI":"10.1038\/s41598-021-88518-8","article-title":"MicroRNA Let-7 targets AMPK and impairs hepatic lipid metabolism in offspring of maternal obese pregnancies","volume":"11","author":"Simino","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0017","doi-asserted-by":"crossref","DOI":"10.1172\/JCI32661","article-title":"Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates","author":"McCurdy","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0018","doi-asserted-by":"crossref","first-page":"R1464","DOI":"10.1152\/ajpregu.91015.2008","article-title":"Maternal obesity is necessary for programming effect of high-fat diet on offspring","volume":"296","author":"White","year":"2009","journal-title":"Am J Physiol Integr Comp Physiol"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0019","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ijo.2016.70","article-title":"The metabolic response to a high-fat diet reveals obesity-prone and -resistant phenotypes in mice with distinct mRNA-seq transcriptome profiles","volume":"40","author":"Choi","year":"2016","journal-title":"Int J Obes"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0020","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1136\/bmj.323.7325.1331","article-title":"Fetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort: longitudinal study","volume":"323","author":"Parsons","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0021","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1161\/01.CIR.94.6.1310","article-title":"Birth weight and adult hypertension and obesity in women","volume":"94","author":"Curhan","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0022","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1161\/CIRCULATIONAHA.106.617811","article-title":"Promotion of faster weight gain in infants born small for gestational age","volume":"115","author":"Singhal","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0023","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.siny.2004.03.001","article-title":"Maternal constraint of fetal growth and its consequences","volume":"9","author":"Gluckman","year":"2004","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0024","first-page":"1","article-title":"Maternal resistance to diet-induced obesity partially protects newborn and post-weaning male mice offspring from metabolic disturbances","author":"Simino LA de","year":"2020","journal-title":"J Dev Orig Health Dis"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0025","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1055\/s-0034-1395691","article-title":"The role of non-placental signals in the adaptation of islets to pregnancy","volume":"47","author":"Drynda","year":"2014","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0026","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1210\/endo.143.4.8722","article-title":"Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance","volume":"143","author":"Freemark","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0027","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2337\/db15-1531","article-title":"Proximity to delivery alters insulin sensitivity and glucose metabolism in pregnant mice","volume":"65","author":"Musial","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0028","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/s41366-020-0561-3","article-title":"Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice","volume":"44","author":"de Barros Mucci","year":"2020","journal-title":"Int J Obes"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0029","article-title":"Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance","author":"Hufnagel","year":"2021","journal-title":"J Physiol"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0030","first-page":"223","article-title":"Comparative aspects of placental efficiency","volume":"58","author":"Wilson","year":"2001","journal-title":"Reprod Suppl"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0031","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1113\/jphysiol.2009.173013","article-title":"Placental efficiency and adaptation: endocrine regulation","volume":"587","author":"Fowden","year":"2009","journal-title":"J Physiol"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0032","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10654-015-9993-9","article-title":"Is the fetoplacental ratio a differential marker of fetal growth restriction in small for gestational age infants?","volume":"30","author":"Luque-Fernandez","year":"2015","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0033","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1113\/expphysiol.1997.sp004034","article-title":"Placental transporter activity and expression in relation to fetal growth","volume":"82","author":"Sibley","year":"1997","journal-title":"Exp Physiol"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0034","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.placenta.2017.11.008","article-title":"Birth weight to placenta weight ratio and its relationship to ultrasonic measurements, maternal and neonatal morbidity: A prospective cohort study of nulliparous women","volume":"63","author":"Salavati","year":"2018","journal-title":"Placenta"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1210\/jc.2012-2667","article-title":"Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies","volume":"98","author":"Jansson","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0036","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/ajcn\/72.2.378","article-title":"Early risk factors for increased adiposity: a cohort study of African American subjects followed from birth to young adulthood","volume":"72","author":"Stettler","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0037","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.lfs.2018.10.008","article-title":"Differential effects of high-fat diets before pregnancy and\/or during pregnancy on fetal growth development","volume":"212","author":"Song","year":"2018","journal-title":"Life Sci"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0038","doi-asserted-by":"crossref","first-page":"l2381","DOI":"10.1136\/bmj.l2381","article-title":"Pre-eclampsia: pathophysiology and clinical implications","author":"Burton","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/neuro.08.019.2009","article-title":"Prenatal stress, glucocorticoids and the programming of adult disease","volume":"3","author":"Cottrell","year":"2009","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0040","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/mp.2016.41","article-title":"Transgenerational transmission and modification of pathological traits induced by prenatal immune activation","volume":"22","author":"Weber-Stadlbauer","year":"2017","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0041","doi-asserted-by":"crossref","first-page":"212","DOI":"10.2174\/1573396314666180712114531","article-title":"Neonatal and long-term consequences of fetal growth restriction","volume":"14","author":"Colella","year":"2018","journal-title":"Curr Pediatr Rev"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0042","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1210\/endo.137.5.8612496","article-title":"Glucokinase, hexokinase, glucose transporter 2, and glucose metabolism in islets during pregnancy and prolactin-treated islets in vitro: mechanisms for long term up-regulation of islets","volume":"137","author":"Weinhaus","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0043","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s004390050658","article-title":"Absence of human placental lactogen and placental growth hormone (HGH-V) during pregnancy: PCR analysis of the deletion","volume":"102","author":"Rygaard","year":"1998","journal-title":"Hum Genet"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0044","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1089\/gtmb.2013.0009","article-title":"Prolactin receptor gene polymorphisms are associated with gestational diabetes","volume":"17","author":"Le","year":"2013","journal-title":"Genet Test Mol Biomarkers"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0045","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1385\/ENDO:19:1:43","article-title":"Lipid Metabolism in Pregnancy and its Consequences in the Fetus and Newborn","volume":"19","author":"Herrera","year":"2002","journal-title":"Endocrine"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0046","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1210\/jcem.86.5.7463","article-title":"Hypoadiponectinemia in obesity and Type 2 Diabetes: close association with insulin resistance and hyperinsulinemia","volume":"86","author":"Weyer","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0047","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1055\/s-2004-825726","article-title":"Adiponectin mRNA levels in parametrial adipose tissue and serum adiponectin levels are reduced in mice during late pregnancy","volume":"36","author":"Kondo","year":"2004","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2012.05.004","article-title":"Interleukin-6 in pregnancy and gestational disorders","volume":"95","author":"Prins","year":"2012","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0049","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224754","article-title":"Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy","volume":"14","author":"Kappen","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0050","doi-asserted-by":"crossref","first-page":"R1569","DOI":"10.1152\/ajpregu.00385.2015","article-title":"Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy","volume":"309","author":"D\u00edaz","year":"2015","journal-title":"Am J Physiol Integr Comp Physiol"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0051","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.111.098095","article-title":"Modulation of fatty acid transport and metabolism by maternal obesity in the human full-term placenta1","volume":"87","author":"Dub\u00e9","year":"2012","journal-title":"Biol Reprod"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0052","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/ajcn\/84.4.853","article-title":"Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins","volume":"84","author":"Larqu\u00e9","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0053","doi-asserted-by":"crossref","first-page":"e25865","DOI":"10.1371\/journal.pone.0025865","article-title":"The expression and function of fatty acid transport protein-2 and -4 in the murine placenta","volume":"6","author":"Mishima","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0054","doi-asserted-by":"crossref","first-page":"49512","DOI":"10.1074\/jbc.M309759200","article-title":"Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality","volume":"278","author":"Gimeno","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0055","doi-asserted-by":"crossref","first-page":"30360","DOI":"10.1074\/jbc.271.48.30360","article-title":"Molecular cloning of cDNA encoding Rat Very Long-chain Acyl-CoA Synthetase","volume":"271","author":"Uchiyama","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0056","doi-asserted-by":"crossref","first-page":"e50208","DOI":"10.1371\/journal.pone.0050208","article-title":"Placental growth factor for the prediction of adverse outcomes in patients with suspected preeclampsia or intrauterine growth restriction","volume":"7","author":"Sibiude","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0057","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1530\/REP-17-0253","article-title":"Decreased PGF may contribute to trophoblast dysfunction in fetal growth restriction","volume":"154","author":"Wu","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0058","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3109\/14767058.2013.766694","article-title":"Placental growth factor (PlGF): a key to optimizing fetal growth","volume":"26","author":"Vrachnis","year":"2013","journal-title":"J Matern Neonatal Med"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0059","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/35052073","article-title":"Untangling the ErbB signalling network","volume":"2","author":"Yarden","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0060","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jash.2012.12.006","article-title":"Serum placental growth factor as a predictor of early onset preeclampsia in overweight\/obese pregnant women","volume":"7","author":"Ghosh","year":"2013","journal-title":"J Am Soc Hypertens"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0061","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/emboj\/17.3.719","article-title":"A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor","volume":"17","author":"Sibilia","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0062","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1126\/science.7618084","article-title":"Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype","volume":"269","author":"Threadgill","year":"1995","journal-title":"Science (80-)"},{"key":"10.1016\/j.jnutbio.2022.108977_bib0063","doi-asserted-by":"crossref","first-page":"16992","DOI":"10.1038\/s41598-019-53490-x","article-title":"Integration of TGF-\u03b2-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells","volume":"9","author":"Budi","year":"2019","journal-title":"Sci Rep"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286322000481?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286322000481?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:36:34Z","timestamp":1760628994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286322000481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":63,"alternative-id":["S0955286322000481"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2022.108977","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Obesity phenotype induced by high-fat diet leads to maternal-fetal constraint, placental inefficiency, and fetal growth restriction in mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2022.108977","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108977"}}