{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:20:11Z","timestamp":1790630411779,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201612051"],"award-info":[{"award-number":["SZSM201612051"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017127","name":"Shenzhen Municipal People&apos;s Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017127","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672891"],"award-info":[{"award-number":["81672891"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970467"],"award-info":[{"award-number":["81970467"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jnutbio.2022.109106","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T17:16:47Z","timestamp":1658078207000},"page":"109106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["High-fat diet alleviates colitis by inhibiting ferroptosis via solute carrier family seven member 11"],"prefix":"10.1016","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6738-1122","authenticated-orcid":false,"given":"Xiaoli","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafu","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2022.109106_bib0001","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3516128","article-title":"High-fat diet promotes DSS-induced ulcerative colitis by downregulated FXR expression through the TGFB pathway","volume":"2020","author":"Zhao","year":"2020","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0002","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00535-013-0777-2","article-title":"Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases","volume":"48","author":"Leone","year":"2013","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0003","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.bbrc.2019.11.158","article-title":"High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage","volume":"522","author":"Tanaka","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0004","doi-asserted-by":"crossref","first-page":"G453","DOI":"10.1152\/ajpgi.00103.2019","article-title":"High-fat diet promotes experimental colitis by inducing oxidative stress in the colon","volume":"317","author":"Li","year":"2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0005","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.3389\/fimmu.2018.02608","article-title":"Maternal high fat diet alters gut microbiota of offspring and exacerbates DSS-induced colitis in adulthood","volume":"9","author":"Xie","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0006","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1038\/s41467-018-03773-0","article-title":"Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20\/CCR-6-mediated lymphocyte recruitment","volume":"9","author":"Wunderlich","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0007","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.lfs.2018.08.017","article-title":"Gut inflammation exacerbates hepatic injury in the high-fat diet induced NAFLD mouse: Attention to the gut-vascular barrier dysfunction","volume":"209","author":"Cheng","year":"2018","journal-title":"Life Sci"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0008","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jnutbio.2017.01.012","article-title":"A food-based approach that targets interleukin-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis","volume":"43","author":"Sido","year":"2017","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0009","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3945\/jn.113.174615","article-title":"High-fat diet-induced obesity exacerbates inflammatory bowel disease in genetically susceptible Mdr1a\u2212\/\u2212 male mice","volume":"143","author":"Paik","year":"2013","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0010","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1084\/jem.20042397","article-title":"Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve","volume":"202","author":"Luyer","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0011","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.cell.2017.03.023","article-title":"Physiologic medium rewires cellular metabolism and reveals uric acid as an endogenous inhibitor of UMP synthase","volume":"169","author":"Cantor","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0012","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.aba3683","article-title":"High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide","volume":"373","author":"Yoo","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0013","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuroscience.2017.05.050","article-title":"Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency","volume":"357","author":"Schriever","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0014","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of non-apoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0015","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0016","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis","volume":"172","author":"Ingold","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0017","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.canlet.2015.07.031","article-title":"Xc\u00a0\u2212\u00a0inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism","volume":"368","author":"Ma","year":"2015","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0018","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: The role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0019","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41419-020-2299-1","article-title":"Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis","volume":"11","author":"Xu","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2020.06.005","article-title":"Ferroptosis mediated DSS-induced ulcerative colitis associated with Nrf2\/HO-1 signaling pathway","volume":"225","author":"Chen","year":"2020","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118356","article-title":"Curculigoside inhibits ferroptosis in ulcerative colitis through the induction of GPX4","volume":"259","author":"Wang","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0022","doi-asserted-by":"crossref","first-page":"9367","DOI":"10.1080\/21655979.2021.2001913","article-title":"Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction","volume":"12","author":"Xiao","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0023","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/ibd\/izaa124","article-title":"IL-37d negatively regulates NLRP3 transcription via receptor-mediated pathway and alleviates DSS-induced colitis","volume":"27","author":"Li","year":"2021","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0024","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.stem.2017.12.017","article-title":"Phospholipid remodeling and cholesterol availability regulate intestinal stemness and tumorigenesis","volume":"22","author":"Wang","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0025","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1038\/nprot.2013.153","article-title":"In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture","volume":"8","author":"Miyoshi","year":"2013","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0026","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1093\/ibd\/izz007","article-title":"Silibinin retards colitis-associated carcinogenesis by repression of Cdc25C in mouse model","volume":"25","author":"Li","year":"2019","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0027","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1093\/gerona\/glz263","article-title":"Aging increases the severity of colitis and the related changes to the gut barrier and gut microbiota in humans and mice","volume":"75","author":"Liu","year":"2020","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0028","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1158\/2159-8290.CD-19-0338","article-title":"Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11","volume":"9","author":"Lang","year":"2019","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0029","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature17173","article-title":"High-fat diet enhances stemness and tumorigenicity of intestinal progenitors","volume":"531","author":"Beyaz","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0030","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.nutres.2016.10.004","article-title":"A high-fat diet differentially regulates glutathione phenotypes in the obesity-prone mouse strains DBA\/2J, C57BL\/6J, and AKR","volume":"36","author":"Norris","year":"2016","journal-title":"J. Nutr Res."},{"key":"10.1016\/j.jnutbio.2022.109106_bib0031","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrgastro.2016.181","article-title":"Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes","volume":"14","author":"Singh","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0032","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.1073\/pnas.1721711115","article-title":"Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation","volume":"115","author":"Wang","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0033","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.7314\/APJCP.2015.16.10.4161","article-title":"Obesity and obese-related chronic low-grade inflammation in promotion of colorectal cancer development","volume":"16","author":"Pietrzyk","year":"2015","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0034","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0036","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0037","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1158\/0008-5472.CAN-19-0369","article-title":"Stearoyl-CoA desaturase 1 protects ovarian cancer cells from ferroptotic cell death","volume":"79","author":"Tesfay","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0038","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2018.11.016","article-title":"Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state","volume":"26","author":"Magtanong","year":"2019","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0039","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.freeradbiomed.2021.10.022","article-title":"High-fat diet aggravates colitis-associated carcinogenesis by evading ferroptosis in the ER stress-mediated pathway","volume":"177","author":"Zhang","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0040","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900873","article-title":"Plant- and fish-derived n-3 PUFAs suppress citrobacter rodentium-induced colonic inflammation","volume":"64","author":"Maattanen","year":"2020","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0041","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1136\/gutjnl-2013-305304","article-title":"Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease","volume":"63","author":"Ananthakrishnan","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0042","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2982.2012.01921.x","article-title":"Intestinal barrier function in health and gastrointestinal disease","volume":"24","author":"Camilleri","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0043","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1136\/gutjnl-2011-301364","article-title":"Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium","volume":"62","author":"G\u00fcnther","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0044","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0045","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2022.109106_bib0046","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","author":"Koppula","year":"2020","journal-title":"Protein Cell"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286322001747?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286322001747?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:36:09Z","timestamp":1760628969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286322001747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":46,"alternative-id":["S0955286322001747"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2022.109106","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-fat diet alleviates colitis by inhibiting ferroptosis via solute carrier family seven member 11","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2022.109106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109106"}}