{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:52:48Z","timestamp":1780051968111,"version":"3.53.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002781","name":"University of Calcutta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jnutbio.2023.109283","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T02:38:04Z","timestamp":1676342284000},"page":"109283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Targeted tumor killing by pomegranate polyphenols: Pro-oxidant role of a classical antioxidant"],"prefix":"10.1016","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-4882","authenticated-orcid":false,"given":"Sudeshna","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7767-6047","authenticated-orcid":false,"given":"Payal","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayan","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreetama","family":"Choudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2444-3597","authenticated-orcid":false,"given":"Ankur","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Ahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arghya","family":"Adhikary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1898-4437","authenticated-orcid":false,"given":"Sreya","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2023.109283_bib0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41392-017-0004-3","article-title":"Controlled drug delivery vehicles for cancer treatment and their performance","volume":"3","author":"Senapati","year":"2018","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"10.1016\/j.jnutbio.2023.109283_bib0002","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ccr.2006.08.009","article-title":"Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate","volume":"10","author":"Trachootham","year":"2006","journal-title":"Cancer Cell"},{"issue":"11","key":"10.1016\/j.jnutbio.2023.109283_bib0003","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3390\/biom9110735","article-title":"Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements","volume":"9","author":"Aggarwal","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0004","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9051542","article-title":"ROS-mediated cancer cell killing through dietary phytochemicals","volume":"2019","author":"NavaneethaKrishnan","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108812","article-title":"Pomegranate polyphenols attenuate inflammation and hepatic damage in tumor-bearing mice: crucial role of NF-\u03baB and the Nrf2\/GSH axis","volume":"97","author":"Mukherjee","year":"2021","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0006","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.710304","article-title":"Polyphenols as antitumor agents targeting key players in cancer-driving signaling pathways","volume":"12","author":"Ch\u00e1irez-Ram\u00edrez","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0007","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.3389\/fphar.2019.01614","article-title":"Phytochemicals in cancer treatment: from preclinical studies to clinical practice","volume":"10","author":"Choudhari","year":"2020","journal-title":"Front Pharmacol"},{"issue":"11","key":"10.1016\/j.jnutbio.2023.109283_bib0008","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.jnutbio.2015.06.003","article-title":"Gold-conjugated green tea nanoparticles for enhanced anti-tumor activities and hepatoprotection\u2013synthesis, characterization and in vitro evaluation","volume":"26","author":"Mukherjee","year":"2015","journal-title":"J Nutr Biochem"},{"issue":"12","key":"10.1016\/j.jnutbio.2023.109283_bib0009","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.jnutbio.2013.07.005","article-title":"Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-\u03baB pathways","volume":"24","author":"Mukherjee","year":"2013","journal-title":"J Nutr Biochem"},{"issue":"4","key":"10.1016\/j.jnutbio.2023.109283_bib0010","first-page":"568","article-title":"Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). Free Radic","volume":"43","author":"Sandur","year":"2007","journal-title":"Biol Med"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109283_bib0011","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/pcan.2012.20","article-title":"A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer","volume":"16","author":"Paller","year":"2013","journal-title":"Prostate Cancer Prostatic Dis"},{"issue":"8","key":"10.1016\/j.jnutbio.2023.109283_bib0012","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.3390\/nu13082733","article-title":"Punicalagin in cancer prevention-via signaling pathways targeting","volume":"13","author":"Berdowska","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0013","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5297162","article-title":"Therapeutic effects of Punica granatum (Pomegranate): an updated review of clinical trials","volume":"2021","author":"Eghbali","year":"2021","journal-title":"J Nutr Metab"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0014","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jnutbio.2016.09.001","article-title":"Pomegranate protects against arsenic-induced p53-dependent ROS-mediated inflammation and apoptosis in liver cells","volume":"38","author":"Choudhury","year":"2016","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jnutbio.2018.12.009","article-title":"Dietary pomegranate supplement alleviates murine pancreatitis by modulating Nrf2-p21 interaction and controlling apoptosis to survival switch","volume":"66","author":"Gupta","year":"2019","journal-title":"J Nutr Biochem"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109283_bib0016","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13058-020-01296-5","article-title":"Triple-negative breast cancer molecular subtyping and treatment progress","volume":"22","author":"Yin","year":"2020","journal-title":"Breast Cancer Res"},{"issue":"9","key":"10.1016\/j.jnutbio.2023.109283_bib0017","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1158\/1535-7163.MCT-08-0136","article-title":"Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism","volume":"7","author":"Rettig","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0018","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biomaterials.2015.01.007","article-title":"PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a","volume":"51","author":"Bhattacharya","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0019","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.biomaterials.2015.10.044","article-title":"Tailored-CuO-nanowire decorated with folic acid mediated coupling of the mitochondrial-ROS generation and miR425-PTEN axis in furnishing potent anti-cancer activity in human triple negative breast carcinoma cells","volume":"76","author":"Ahir","year":"2016","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109283_bib0020","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12903-018-0694-0","article-title":"Molecular damage and responses of oral keratinocyte to hydrogen peroxide","volume":"19","author":"Lin","year":"2019","journal-title":"BMC Oral Health"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109283_bib0021","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0022","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0003-9861(81)90095-3","article-title":"Cytosolic factors which affect microsomal lipid peroxidation in lung and liver","volume":"206","author":"Wright","year":"1981","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0023","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3, 4-bromobenzeneoxide as the hepatotoxic intermediate","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0024","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","article-title":"Enzymic methods for quantitative determination of nanogram amounts of total and oxidised glutathione: applications to mammalian blood and other tissues","volume":"3","author":"Tietze","year":"1969","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0025","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/0006-2952(84)90353-8","article-title":"Differential distribution of glutathione and glutathione related enzymes in rabbit kidney: possible implications in analgesic neuropathy","volume":"33","author":"Mohandas","year":"1984","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0026","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferase: first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0027","series-title":"CRC handbook of methods for oxygen radical research","first-page":"283","author":"Catalase activity Claiborne","year":"1985"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0028","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0027-5107(85)90216-7","article-title":"Superoxide dismutase isoenzyme in tissues and plasma from New Zealand black mice, nude mice and normal BALB\/C mice","volume":"148","author":"Marklund","year":"1985","journal-title":"Mutat Res"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0029","doi-asserted-by":"crossref","first-page":"L806","DOI":"10.1152\/ajplung.2000.278.4.L806","article-title":"Expression of heme oxygenase 1 in lungs in chronic hypoxia","volume":"278","author":"Carraway","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0030","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0006-2952(02)01383-7","article-title":"A physiological threshold for protection against menadione toxicity by human NAD(P)H:quinone oxidoreductase (NQO1) in Chinese hamster ovary (CHO) cells","volume":"64","author":"De Haan","year":"2002","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"10.1016\/j.jnutbio.2023.109283_bib0031","first-page":"366","article-title":"A continuous spectrophotometric assay for NADPH-cytochrome P450 reductase activity using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide","volume":"38","author":"Yim","year":"2005","journal-title":"J Biochem Mol Biol"},{"issue":"13","key":"10.1016\/j.jnutbio.2023.109283_bib0032","doi-asserted-by":"crossref","first-page":"8826","DOI":"10.1074\/jbc.M112.429316","article-title":"Selective induction of tumor cell apoptosis by a novel P450-mediated reactive oxygen species (ROS) inducer methyl 3-(4-nitrophenyl) propiolate","volume":"288","author":"Sun","year":"2013","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.jnutbio.2023.109283_bib0033","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.cellsig.2015.03.013","article-title":"Reactive oxygen species in the tumor niche triggers altered activation of macrophages and immunosuppression: Role of fluoxetine","volume":"27","author":"Ghosh","year":"2015","journal-title":"Cell Signal"},{"issue":"10","key":"10.1016\/j.jnutbio.2023.109283_bib0034","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrc1189","article-title":"Cancer chemoprevention with dietary phytochemicals","volume":"3","author":"Surh","year":"2003","journal-title":"Nature Rev Cancer"},{"issue":"2","key":"10.1016\/j.jnutbio.2023.109283_bib0035","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.3390\/cancers2021288","article-title":"Interfering with ROS metabolism in cancer cells: the potential role of quercetin","volume":"2","author":"Gibellini","year":"2010","journal-title":"Cancers (Basel)"},{"issue":"8","key":"10.1016\/j.jnutbio.2023.109283_bib0036","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1080\/10715760802317663","article-title":"Glutathione and apoptosis","volume":"42","author":"Circu","year":"2008","journal-title":"Free Radic Res"},{"issue":"10","key":"10.1016\/j.jnutbio.2023.109283_bib0037","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/cdd.2009.107","article-title":"Apoptosis and glutathione, beyond an anti-oxidant","volume":"16","author":"Franco","year":"2009","journal-title":"Cell Death Differ"},{"issue":"5","key":"10.1016\/j.jnutbio.2023.109283_bib0038","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/cas.12630","article-title":"Epithelial-mesenchymal transition is regulated at post-transcriptional levels by transforming growth factor-\u03b2 signaling during tumor progression","volume":"106","author":"Saitoh","year":"2015","journal-title":"Cancer Sci"},{"issue":"5","key":"10.1016\/j.jnutbio.2023.109283_bib0039","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/10715761003667554","article-title":"Reactive oxygen species in cancer","volume":"44","author":"Liou","year":"2010","journal-title":"Free Radic Res"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109283_bib0040","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/molecules25010063","article-title":"Epigallocatechin gallate, curcumin, and resveratrol: from dietary sources to human MicroRNA modulation","volume":"25","author":"Cione","year":"2019","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.jnutbio.2023.109283_bib0041","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1021\/jf073035s","article-title":"Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States","volume":"56","author":"Seeram","year":"2008","journal-title":"J Agric Food Chem"},{"issue":"8","key":"10.1016\/j.jnutbio.2023.109283_bib0042","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2174\/187152010794474000","article-title":"Pomegranate extract, a pro-oxidant with antiproliferative and proapoptotic activities preferentially towards carcinoma cells","volume":"10","author":"Weisburg","year":"2010","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0043","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/761264","article-title":"Oxidative stress, prooxidants, and antioxidants: the interplay","volume":"2014","author":"Rahal","year":"2014","journal-title":"Biomed Res Int"},{"issue":"4","key":"10.1016\/j.jnutbio.2023.109283_bib0044","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bbagen.2007.11.016","article-title":"Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells","volume":"1780","author":"Kunwar","year":"2008","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"10.1016\/j.jnutbio.2023.109283_bib0045","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/abbi.2000.1832","article-title":"Peroxidase-catalyzed formation of quercetin quinone methide-glutathione adducts","volume":"378","author":"Awad","year":"2000","journal-title":"Arch Biochem Biophys"},{"issue":"4","key":"10.1016\/j.jnutbio.2023.109283_bib0046","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0891-5849(00)00481-0","article-title":"Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation","volume":"30","author":"Galati","year":"2001","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"10.1016\/j.jnutbio.2023.109283_bib0047","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0006-291X(03)01438-4","article-title":"Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementation","volume":"308","author":"Boots","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"issue":"1-2","key":"10.1016\/j.jnutbio.2023.109283_bib0048","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0891-5849(98)00167-1","article-title":"Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product","volume":"26","author":"Metodiewa","year":"1999","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"10.1016\/j.jnutbio.2023.109283_bib0049","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00726-005-0271-8","article-title":"Non-irradiation-derived reactive oxygen species (ROS) and cancer: therapeutic implications","volume":"31","author":"Agostinelli","year":"2006","journal-title":"Amino Acids"},{"issue":"6802","key":"10.1016\/j.jnutbio.2023.109283_bib0050","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/35030140","article-title":"Superoxide dismutase as a target for the selective killing of cancer cells","volume":"407","author":"Huang","year":"2000","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jnutbio.2023.109283_bib0051","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00411-013-0463-z","article-title":"Studies on black tea (Camellia sinensis) extract as a potential antioxidant and a probable radioprotector","volume":"52","author":"Pal","year":"2013","journal-title":"Radiat Environ Biophys"},{"issue":"5","key":"10.1016\/j.jnutbio.2023.109283_bib0052","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1002\/cam4.2101","article-title":"Nrf2 in cancers: a double-edged sword","volume":"8","author":"Wu","year":"2019","journal-title":"Cancer Med"},{"issue":"11","key":"10.1016\/j.jnutbio.2023.109283_bib0053","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.freeradbiomed.2011.03.008","article-title":"Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2\/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs","volume":"50","author":"Tang","year":"2011","journal-title":"Free Radic Biol Med"},{"issue":"44","key":"10.1016\/j.jnutbio.2023.109283_bib0054","doi-asserted-by":"crossref","first-page":"33761","DOI":"10.1074\/jbc.M604748200","article-title":"Constitutive overexpression of Nrf2-dependent Heme Oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by Epigallocatechin 3-Gallate","volume":"281","author":"Kweon","year":"2006","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.jnutbio.2023.109283_bib0055","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.3390\/nu11081926","article-title":"Targeting glutathione metabolism: partner in crime in anticancer therapy","volume":"11","author":"Desideri","year":"2019","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.jnutbio.2023.109283_bib0056","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1089\/ars.2012.4553","article-title":"Glutathione efflux and cell death","volume":"17","author":"Franco","year":"2012","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109283_bib0057","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.freeradbiomed.2008.03.013","article-title":"Hispolon induces apoptosis in human gastric cancer cells through a ROS-mediated mitochondrial pathway","volume":"45","author":"Chen","year":"2008","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109283_bib0058","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1124\/jpet.110.171983","article-title":"Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line","volume":"336","author":"Guha","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"10.1016\/j.jnutbio.2023.109283_bib0059","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3390\/cancers2020483","article-title":"Nrf2 and NF-\u03baB and their concerted modulation in cancer pathogenesis and progression","volume":"2","author":"Bellezza","year":"2010","journal-title":"Cancers"},{"issue":"51","key":"10.1016\/j.jnutbio.2023.109283_bib0060","doi-asserted-by":"crossref","first-page":"6817","DOI":"10.1038\/sj.onc.1209942","article-title":"Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression","volume":"25","author":"Basseres","year":"2006","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109283_bib0061","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"10.1016\/j.jnutbio.2023.109283_bib0062","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3390\/cancers13030401","article-title":"TGF-\u03b2 in cancer: metabolic driver of the tolerogenic crosstalk in the tumor microenvironment","volume":"13","author":"Angioni","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.jnutbio.2023.109283_bib0063","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"10.1016\/j.jnutbio.2023.109283_bib0064","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/onc.2013.597","article-title":"Selective killing of lung cancer cells by miRNA-506 molecule through inhibiting NF-\u03baB p65 to evoke reactive oxygen species generation and p53 activation","volume":"34","author":"Yin","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.jnutbio.2023.109283_bib0065","first-page":"106","article-title":"Antioxidant-pro-oxidant","volume":"1","author":"Singh","year":"2016","journal-title":"In J Tech Res Sci."},{"key":"10.1016\/j.jnutbio.2023.109283_bib0066","series-title":"Reactive oxygen species (ROS) in living cells","article-title":"Role of antioxidant phytochemicals in prevention, formation and treatment of cancer","author":"Kocyigit","year":"2017"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286323000177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286323000177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:38:11Z","timestamp":1760629091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286323000177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":66,"alternative-id":["S0955286323000177"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109283","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted tumor killing by pomegranate polyphenols: Pro-oxidant role of a classical antioxidant","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109283","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109283"}}