{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T22:08:35Z","timestamp":1779919715531,"version":"3.53.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971400"],"award-info":[{"award-number":["81971400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.jnutbio.2023.109432","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T11:37:39Z","timestamp":1693395459000},"page":"109432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Maternal protein deficiency impairs peroxisome biogenesis and leads to oxidative stress and ferroptosis in liver of fetal growth restriction offspring"],"prefix":"10.1016","volume":"121","author":[{"given":"Yanyan","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3940-8049","authenticated-orcid":false,"given":"Xiaomei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2023.109432_bib0001","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1017\/S002966511300387X","article-title":"The impact of early nutrition on the ageing trajectory","volume":"73","author":"Tarry-Adkins","year":"2014","journal-title":"Proc Nutr Soc"},{"issue":"Suppl 1","key":"10.1016\/j.jnutbio.2023.109432_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jhn.12212","article-title":"Nutrition in early life and the programming of adult disease: a review","volume":"28","author":"Langley-Evans","year":"2015","journal-title":"J Hum Nutr Diet"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0003","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3164\/jcbn.13-100","article-title":"Maternal protein restriction induces alterations in hepatic tumor necrosis factor-\u03b1\/CYP7A1 signaling and disorders regulation of cholesterol metabolism in the adult rat offspring","volume":"55","author":"Liu","year":"2014","journal-title":"J Clin Biochem Nutr"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0004","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.3390\/ijms19092605","article-title":"Role of nitric oxide in the cardiovascular and renal systems","volume":"19","author":"Ahmad","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0005","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8151836","article-title":"Lipopolysaccharide (LPS) aggravates high glucose- and hypoxia\/reoxygenation-induced injury through activating ROS-dependent NLRP3 inflammasome-mediated pyroptosis in H9C2 cardiomyocytes","volume":"2019","author":"Qiu","year":"2019","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0006","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1186\/cc1547","article-title":"Association of lipid peroxidation with hepatocellular injury in preterm infants","volume":"6","author":"Weinberger","year":"2002","journal-title":"Crit Care"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0007","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/13510002.2019.1596429","article-title":"Early onset of renal oxidative stress in small for gestational age newborn pigs","volume":"24","author":"Soni","year":"2019","journal-title":"Redox Rep"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0008","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1021\/acs.jafc.8b00726","article-title":"Effects of dietary l-arginine and N-carbamylglutamate supplementation on intestinal integrity, immune function, and oxidative status in intrauterine-growth-retarded suckling lambs","volume":"66","author":"Zhang","year":"2018","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0009","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3390\/nu10080977","article-title":"Beneficial and paradoxical roles of anti-oxidative nutritional support for non-alcoholic fatty liver disease","volume":"10","author":"Uchida","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0010","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1111\/j.1440-1746.2006.04640.x","article-title":"Role of mitochondria in non-alcoholic fatty liver disease","volume":"22","author":"Pessayre","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0011","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00418-018-1722-5","article-title":"The peroxisome: an update on mysteries 2.0","volume":"150","author":"Islinger","year":"2018","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0012","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.236943","article-title":"Recent insights into peroxisome biogenesis and associated diseases","volume":"133","author":"Fujiki","year":"2020","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0013","article-title":"Label-free proteomics of the fetal pancreas identifies deficits in the peroxisome in rats with intrauterine growth restriction","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxid Med Cell Long"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0014","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/s41598-023-28051-y","article-title":"Impaired placental hemodynamics and function in a non-human primate model of gestational protein restriction","volume":"13","author":"Lo","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0015","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/biolre\/ioab087","article-title":"No evidence of the unfolded protein response in the placenta of two rodent models of preeclampsia and intrauterine growth restriction","volume":"105","author":"Denkl","year":"2021","journal-title":"Biol Reprod"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0016","doi-asserted-by":"crossref","first-page":"eabh1541","DOI":"10.1126\/sciadv.abh1541","article-title":"Lipid-induced DRAM recruits STOM to lysosomes and induces LMP to promote exosome release from hepatocytes in NAFLD","volume":"7","author":"Zhang","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0017","article-title":"Peroxisome deficiency dysregulates fatty acid oxidization and exacerbates lipotoxicity in \u03b2 cells","volume":"2021","author":"Guan","year":"2021","journal-title":"Oxid Med Cell Long"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0018","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3389\/fendo.2018.00676","article-title":"Maternal protein restriction induces alterations in hepatic unfolded protein response-related molecules in adult rat offspring","volume":"9","author":"Liu","year":"2018","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0019","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1096\/fj.201801498R","article-title":"Peroxisomes can oxidize medium- and long-chain fatty acids through a pathway involving ABCD3 and HSD17B4","volume":"33","author":"Violante","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0020","doi-asserted-by":"crossref","first-page":"33216","DOI":"10.1073\/pnas.2009502117","article-title":"Towards the molecular architecture of the peroxisomal receptor docking complex","volume":"117","author":"Lill","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0021","doi-asserted-by":"crossref","first-page":"e45595","DOI":"10.15252\/embr.201745595","article-title":"Dual role of USP30 in controlling basal pexophagy and mitophagy","volume":"19","author":"Marcassa","year":"2018","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0022","series-title":"Biochemical and cell biological aspects of X-linked adrenoleukodystrophy","author":"Schackmann","year":"2017"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0023","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1038\/s41467-019-10991-7","article-title":"Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis","volume":"10","author":"Yoshida","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0024","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2017.06.027","article-title":"Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1\/TXNIP complex in cerebral ischemia reperfusion injury","volume":"336","author":"Hou","year":"2018","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0025","first-page":"1","article-title":"Low birth weight: effect on insulin sensitivity and lipid metabolism","volume":"59","author":"Jaquet","year":"2003","journal-title":"Horm Res"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2019.01.001","article-title":"IUGR: genetic influences, metabolic problems, environmental associations\/triggers, current and future management","volume":"33","author":"Darendeliler","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0027","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.tem.2016.12.003","article-title":"Peroxisomal dysfunction in age-related diseases","volume":"28","author":"Cipolla","year":"2017","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0028","doi-asserted-by":"crossref","first-page":"R397","DOI":"10.1016\/j.cub.2004.05.017","article-title":"Peroxisome membrane biogenesis: the stage is set","volume":"14","author":"Schliebs","year":"2004","journal-title":"Curr Biol"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0029","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.bbamcr.2006.09.030","article-title":"Import of peroxisomal membrane proteins: the interplay of Pex3p- and Pex19p-mediated interactions","volume":"1763","author":"Fujiki","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0030","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cmet.2014.01.002","article-title":"Peroxisomes: a nexus for lipid metabolism and cellular signaling","volume":"19","author":"Lodhi","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0031","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1086\/303086","article-title":"PEX3 is the causal gene responsible for peroxisome membrane assembly-defective Zellweger syndrome of complementation group G","volume":"67","author":"Ghaedi","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0032","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183150","article-title":"New insights into the distribution, protein abundance and subcellular localisation of the endogenous peroxisomal biogenesis proteins PEX3 and PEX19 in different organs and cell types of the adult mouse","volume":"12","author":"Colasante","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0033","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1016\/j.yexcr.2008.09.015","article-title":"The peroxin Pex14p is involved in LC3-dependent degradation of mammalian peroxisomes","volume":"314","author":"Hara-Kuge","year":"2008","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0034","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/j.febslet.2011.05.032","article-title":"A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity","volume":"585","author":"Kassmann","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0035","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/jmedgenet-2012-100778","article-title":"A novel defect of peroxisome division due to a homozygous non-sense mutation in the PEX11\u03b2 gene","volume":"49","author":"Ebberink","year":"2012","journal-title":"J Med Genet"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0036","doi-asserted-by":"crossref","DOI":"10.1002\/mgg3.1042","article-title":"Variant analysis of PEX11B gene from a family with peroxisome biogenesis disorder 14B by whole exome sequencing","volume":"8","author":"Tian","year":"2020","journal-title":"Mol Genet Genomic Med"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0037","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3390\/cells8070725","article-title":"Interplay between Zika virus and peroxisomes during Infection","volume":"8","author":"Wong","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0038","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/ncb2027","article-title":"The peroxisomal importomer constitutes a large and highly dynamic pore","volume":"12","author":"Meinecke","year":"2010","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0039","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1074\/jbc.275.6.4127","article-title":"Interaction of Pex5p, the type 1 peroxisome targeting signal receptor, with the peroxisomal membrane proteins Pex14p and Pex13p","volume":"275","author":"Urquhart","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0040","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1073\/pnas.1423951112","article-title":"Acyl-CoA oxidase complexes control the chemical message produced by Caenorhabditis elegans","volume":"112","author":"Zhang","year":"2015","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1997.00001.x","article-title":"The mitochondrial carnitine palmitoyltransferase system\u2014from concept to molecular analysis","volume":"244","author":"McGarry","year":"1997","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0042","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.bbamcr.2006.09.006","article-title":"Peroxisomes and oxidative stress","volume":"1763","author":"Schrader","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0043","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1242\/dmm.007708","article-title":"Deletion of a single allele of the Pex11\u03b2 gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain","volume":"5","author":"Ahlemeyer","year":"2012","journal-title":"Dis Models Mech"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0044","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.etp.2009.08.008","article-title":"Peroxisomes and peroxisomal disorders: the main facts","volume":"62","author":"Fidaleo","year":"2010","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0045","doi-asserted-by":"crossref","first-page":"25918","DOI":"10.1038\/srep25918","article-title":"SOD2 deregulation enhances migration, invasion and has poor prognosis in salivary adenoid cystic carcinoma","volume":"6","author":"Chang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0046","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.freeradbiomed.2012.07.011","article-title":"Reactive oxygen species regulation of autophagy in cancer: implications for cancer treatment","volume":"53","author":"Li","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0047","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.bbrc.2018.05.050","article-title":"Catalase inhibition induces pexophagy through ROS accumulation","volume":"501","author":"Lee","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0048","first-page":"939","article-title":"NBR1 acts as an autophagy receptor for peroxisomes","volume":"126","author":"Deosaran","year":"2013","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0049","doi-asserted-by":"crossref","first-page":"7349","DOI":"10.1111\/jcmm.14594","article-title":"Sigma-1 receptor protects against ferroptosis in hepatocellular carcinoma cells","volume":"23","author":"Bai","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0050","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41392-020-0149-3","article-title":"Erianin, a novel dibenzyl compound in dendrobium extract, inhibits lung cancer cell growth and migration via calcium\/calmodulin-dependent ferroptosis","volume":"5","author":"Chen","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0051","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fphar.2014.00151","article-title":"Glutathione and mitochondria","volume":"5","author":"Ribas","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2023.109432_bib0052","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286323001651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286323001651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:39:31Z","timestamp":1760629171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286323001651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":52,"alternative-id":["S0955286323001651"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109432","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal protein deficiency impairs peroxisome biogenesis and leads to oxidative stress and ferroptosis in liver of fetal growth restriction offspring","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109432","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109432"}}