{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:03:12Z","timestamp":1793286192834,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073538"],"award-info":[{"award-number":["82073538"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CNS-BMSG2021-07"],"award-info":[{"award-number":["CNS-BMSG2021-07"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CNS-DSM2018A30"],"award-info":[{"award-number":["CNS-DSM2018A30"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jnutbio.2023.109484","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T00:24:08Z","timestamp":1697847848000},"page":"109484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["n-3 polyunsaturated fatty acids in phospholipid or triacylglycerol form attenuate nonalcoholic fatty liver disease via mediating cannabinoid receptor 1\/adiponectin\/ceramide pathway"],"prefix":"10.1016","volume":"123","author":[{"given":"Yan-fang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-kai","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4674-0317","authenticated-orcid":false,"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-fei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5227-5565","authenticated-orcid":false,"given":"Duo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2023.109484_bib0001","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: a multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0002","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3390\/nu11040872","article-title":"Oxidative stress and non-alcoholic fatty liver disease: effects of omega-3 fatty acid supplementation","volume":"11","author":"Yang","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0003","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.metabol.2016.05.003","article-title":"Non-alcoholic fatty liver disease and dyslipidemia: an update","volume":"65","author":"Katsiki","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0004","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0005","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jhep.2017.09.003","article-title":"Genetics and epigenetics of NAFLD and NASH: clinical impact","volume":"68","author":"Eslam","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0006","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1053\/j.gastro.2020.01.052","article-title":"Nonalcoholic fatty liver disease 2020: the state of the disease","volume":"158","author":"Cotter","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0007","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ijo.2015.135","article-title":"Dietary DHA reduces downstream endocannabinoid and inflammatory gene expression and epididymal fat mass while improving aspects of glucose use in muscle in C57BL\/6J mice","volume":"40","author":"Kim","year":"2016","journal-title":"Int J Obes"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0008","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.nut.2010.11.003","article-title":"Endocannabinoid signaling and energy metabolism: a target for dietary intervention","volume":"27","author":"Kim","year":"2011","journal-title":"Nutrition"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0009","first-page":"1506","article-title":"The endocannabinoid system: directing eating behavior and macronutrient metabolism","volume":"5","author":"Watkins","year":"2014","journal-title":"Front Psychol"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0010","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fphys.2014.00100","article-title":"Docosahexaenoyl ethanolamide improves glucose uptake and alters endocannabinoid system gene expression in proliferating and differentiating C2C12 myoblasts","volume":"5","author":"Kim","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0011","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1124\/pr.58.3.2","article-title":"The endocannabinoid system as an emerging target of pharmacotherapy","volume":"58","author":"Pacher","year":"2006","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0012","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/j.gastro.2020.03.087","article-title":"Role of cannabis and its derivatives in gastrointestinal and hepatic disease","volume":"159","author":"Gotfried","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0013","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.bbrc.2004.02.139","article-title":"AICAR stimulates adiponectin and inhibits cytokines in adipose tissue","volume":"316","author":"Lihn","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2019.154028","article-title":"Adiponectin and leptin in the diagnosis and therapy of NAFLD","volume":"103","author":"Boutari","year":"2020","journal-title":"Metabolism"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0015","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1002\/hep.27695","article-title":"Altered hepatic gene expression in nonalcoholic fatty liver disease is associated with lower hepatic n-3 and n-6 polyunsaturated fatty acids","volume":"61","author":"Arendt","year":"2015","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0016","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mam.2018.03.001","article-title":"Omega-3 fatty acids and non-alcoholic fatty liver disease: evidence of efficacy and mechanism of action","volume":"64","author":"Scorletti","year":"2018","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0017","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.pharmthera.2017.07.007","article-title":"Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease","volume":"181","author":"Jump","year":"2018","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0018","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3390\/md17030155","article-title":"Correlation between fatty acid profile and anti-inflammatory activity in common Australian seafood by-products","volume":"17","author":"Ahmad","year":"2019","journal-title":"Mar Drugs"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0019","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.3390\/nu13082836","article-title":"Krill oil treatment increases distinct pufas and oxylipins in adipose tissue and liver and attenuates obesity-associated inflammation via direct and indirect mechanisms","volume":"13","author":"Gart","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0020","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3390\/nu13020437","article-title":"Krill oil supplementation reduces exacerbated hepatic steatosis induced by thermoneutral housing in mice with diet-induced obesity","volume":"13","author":"Sistilli","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0021","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jfca.2008.02.004","article-title":"Analysis of DHA-rich phospholipids from egg of squid Sthenoteuthis oualaniensis","volume":"21","author":"Wang","year":"2008","journal-title":"J Food Compos Anal"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0022","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.foodchem.2017.04.138","article-title":"Comparison of solvents for extraction of krill oil from krill meal: lipid yield, phospholipids content, fatty acids composition and minor components","volume":"233","author":"Xie","year":"2017","journal-title":"Food Chem"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0023","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/BF02540369","article-title":"Effects on plasma lipids and fatty acid composition of very low fat diets enriched with fish or kangaroo meat","volume":"22","author":"Sinclair","year":"1987","journal-title":"Lipids"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0024","doi-asserted-by":"crossref","first-page":"E1023","DOI":"10.1152\/ajpendo.00397.2009","article-title":"Comparison between surrogate indexes of insulin sensitivity\/resistance and Hyperinsulinemic euglycemic clamp estimates in rats","volume":"297","author":"Muniyappa","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0025","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00125-009-1305-z","article-title":"n-3 fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet","volume":"52","author":"Kuda","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0026","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1093\/jn\/138.10.1915","article-title":"Long-chain (n-3) polyunsaturated fatty acids prevent metabolic and vascular disorders in fructose-fed rats","volume":"138","author":"Robbez Masson","year":"2008","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0027","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.metabol.2009.02.013","article-title":"Fish oil and argan oil intake differently modulate insulin resistance and glucose intolerance in a rat model of dietary-induced obesity","volume":"58","author":"Samane","year":"2009","journal-title":"Metabolism"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0028","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.3945\/jn.110.125732","article-title":"Eicosapentaenoic acid prevents and reverses insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation","volume":"140","author":"Kalupahana","year":"2010","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0029","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.plefa.2017.09.011","article-title":"Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice","volume":"136","author":"Guo","year":"2018","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0030","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/j.2040-4603.2014.tb00548.x","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101238","article-title":"Metabolic-associated fatty liver disease and lipoprotein metabolism","volume":"50","author":"Heeren","year":"2021","journal-title":"Mol Metab"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0032","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/1541-4337.12427","article-title":"Antarctic Krill (Euphausia superba) oil: a comprehensive review of chemical composition, extraction technologies, health benefits, and current applications","volume":"18","author":"Xie","year":"2019","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0033","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.nut.2019.03.021","article-title":"Differential plasma postprandial lipidomic responses to krill oil and fish oil supplementations in women: a randomized crossover study","volume":"65","author":"Sung","year":"2019","journal-title":"Nutrition"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0034","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.lfs.2014.09.027","article-title":"Beneficial effects of phosphatidylcholine on high-fat diet-induced obesity, hyperlipidemia and fatty liver in mice","volume":"118","author":"Lee","year":"2014","journal-title":"Life Sci"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0035","doi-asserted-by":"crossref","first-page":"e38834","DOI":"10.1371\/journal.pone.0038834","article-title":"Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids","volume":"7","author":"Rossmeisl","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2019.100997","article-title":"Health benefits of dietary marine DHA\/EPA-enriched glycerophospholipids","volume":"75","author":"Zhang","year":"2019","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0037","doi-asserted-by":"crossref","first-page":"9177","DOI":"10.1039\/D0FO01462A","article-title":"Effect of dietary EPA and DHA on murine blood and liver fatty acid profile and liver oxylipin pattern depending on high and low dietary n6-PUFA","volume":"11","author":"Kutzner","year":"2020","journal-title":"Food & function"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0038","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1111\/bph.15099","article-title":"Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21\/PGC-1\u03b1 pathway","volume":"177","author":"Wu","year":"2020","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0039","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jnutbio.2015.09.015","article-title":"Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL\/6J mice via activation of peroxisome proliferator-activated receptor (PPAR) alpha and inhibition of PPAR gamma and Akt","volume":"28","author":"Jia","year":"2016","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0040","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0167-7799(03)00078-7","article-title":"Haematococcus astaxanthin: applications for human health and nutrition","volume":"21","author":"Guerin","year":"2003","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0041","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-3-030-60204-8_13","article-title":"Biological functions of plasmalogens","volume":"1299","author":"Hossain","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0042","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/lipd.12335","article-title":"Enrichment of n-3 containing ether phospholipids in plasma after 30\u2009days of krill oil compared with fish oil supplementation","volume":"57","author":"Sung","year":"2022","journal-title":"Lipids"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0043","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/MOL.0b013e3282f9b54d","article-title":"Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism","volume":"19","author":"Flowers","year":"2008","journal-title":"Curr Opin Lipidol"},{"issue":"suppl 1","key":"10.1016\/j.jnutbio.2023.109484_bib0044","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2826.2008.01671.x","article-title":"Cannabinoid receptors: where they are and what they do","volume":"20","author":"Mackie","year":"2008","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0045","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.3945\/jn.109.104844","article-title":"Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats","volume":"139","author":"Batetta","year":"2009","journal-title":"J Nutr"},{"issue":"suppl 1","key":"10.1016\/j.jnutbio.2023.109484_bib0046","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1365-2826.2008.01690.x","article-title":"Endocannabinoids, adipose tissue and lipid metabolism","volume":"20","author":"Pagano","year":"2008","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0047","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/j.biochi.2006.07.019","article-title":"Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol","volume":"88","author":"Spoto","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0048","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/oby.2007.581","article-title":"Identification of endocannabinoids and related compounds in human fat cells","volume":"15","author":"Gonthier","year":"2007","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0049","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jnutbio.2014.03.012","article-title":"Cannabinoid receptor antagonists and fatty acids alter endocannabinoid system gene expression and COX activity","volume":"25","author":"Kim","year":"2014","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0050","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.metabol.2010.09.003","article-title":"Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis","volume":"60","author":"Polyzos","year":"2011","journal-title":"Metabolism"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115157","article-title":"Ceramide de novo synthesis in non-alcoholic fatty liver disease: pathogenic mechanisms and therapeutic perspectives","volume":"202","author":"Yu","year":"2022","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0052","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.cmet.2014.08.002","article-title":"Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance","volume":"20","author":"Turpin","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0053","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1039\/C6FO00589F","article-title":"Protective effects of fish oil on pre-diabetes: a lipidomic analysis of liver ceramides in rats","volume":"7","author":"Taltavull","year":"2016","journal-title":"Food Funct"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0054","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-physiol-031620-093815","article-title":"Ceramides in metabolism: key lipotoxic players","volume":"83","author":"Chaurasia","year":"2021","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0055","first-page":"1","article-title":"Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases","volume":"51","author":"Kim","year":"2019","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0056","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2337\/db08-1228","article-title":"Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance","volume":"58","author":"Haus","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0057","doi-asserted-by":"crossref","first-page":"7357","DOI":"10.1007\/s00216-013-7166-9","article-title":"Development and validation of LC-MS\/MS method for determination of very long acyl chain (C22:0 and C24:0) ceramides in human plasma","volume":"405","author":"Jiang","year":"2013","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0058","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cmet.2014.09.015","article-title":"CerS2 haploinsufficiency inhibits \u03b2-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance","volume":"20","author":"Raichur","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0059","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI200523057","article-title":"Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity","volume":"115","author":"Osei-Hyiaman","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0060","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cmet.2014.01.002","article-title":"Peroxisomes: a nexus for lipid metabolism and cellular signaling","volume":"19","author":"Lodhi","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0061","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1126\/science.aay0542","article-title":"An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis","volume":"367","author":"Zhao","year":"2020","journal-title":"Science (New York, NY)."},{"key":"10.1016\/j.jnutbio.2023.109484_bib0062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/endocr\/bqz046","article-title":"CPT1A-mediated fat oxidation, mechanisms, and therapeutic potential","volume":"161","author":"Schlaepfer","year":"2020","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0063","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/01.RES.0000256090.42690.05","article-title":"AMP-activated protein kinase in metabolic control and insulin signaling","volume":"100","author":"Towler","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0064","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbadis.2017.10.002","article-title":"n-3 fatty acids combined with flavan-3-ols prevent steatosis and liver injury in a murine model of NAFLD","volume":"1864","author":"Vauzour","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0065","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nm.2277","article-title":"Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin","volume":"17","author":"Holland","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2023.109484_bib0066","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12944-017-0450-5","article-title":"Hydroxytyrosol prevents reduction in liver activity of \u0394-5 and \u0394-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice","volume":"16","author":"Valenzuela","year":"2017","journal-title":"Lipids Health Dis"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286323002176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286323002176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:22:06Z","timestamp":1778516526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286323002176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":66,"alternative-id":["S0955286323002176"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109484","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"n-3 polyunsaturated fatty acids in phospholipid or triacylglycerol form attenuate nonalcoholic fatty liver disease via mediating cannabinoid receptor 1\/adiponectin\/ceramide pathway","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109484","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109484"}}