{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:09:59Z","timestamp":1792714199798,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jnutbio.2023.109495","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T02:39:29Z","timestamp":1697855969000},"page":"109495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Antibiotics attenuate diet-induced nonalcoholic fatty liver disease without altering intestinal barrier dysfunction"],"prefix":"10.1016","volume":"123","author":[{"given":"Annette","family":"Brandt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Csarmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica","family":"Hern\u00e1ndez-Arriaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaela","family":"Staltner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emina","family":"Halilbasic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lia","family":"Camarinha-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Bergheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jnutbio.2023.109495_bib0001","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.jnutbio.2023.109495_bib0002","doi-asserted-by":"crossref","first-page":"748-755 e3","DOI":"10.1016\/j.cgh.2018.05.057","article-title":"Nonalcoholic steatohepatitis is the fastest growing cause of hepatocellular carcinoma in liver transplant candidates","volume":"17","author":"Younossi","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"9","key":"10.1016\/j.jnutbio.2023.109495_bib0003","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/imj.14709","article-title":"Non-alcoholic fatty liver disease: a review of epidemiology, risk factors, diagnosis and management","volume":"50","author":"Huang","year":"2020","journal-title":"Intern Med J"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109495_bib0004","doi-asserted-by":"crossref","first-page":"17815","DOI":"10.1038\/s41598-021-97346-9","article-title":"Toll-like receptor 1 as a possible target in non-alcoholic fatty liver disease","volume":"11","author":"Baumann","year":"2021","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jnutbio.2023.109495_bib0005","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/hep.28356","article-title":"The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota","volume":"63","author":"Boursier","year":"2016","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109495_bib0006","doi-asserted-by":"crossref","first-page":"6668","DOI":"10.1038\/s41598-019-43228-0","article-title":"Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine","volume":"9","author":"Brandt","year":"2019","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.jnutbio.2023.109495_bib0007","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/hep.22848","article-title":"Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease","volume":"49","author":"Miele","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jnutbio.2023.109495_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101879","article-title":"Citrulline supplementation attenuates the development of non-alcoholic steatohepatitis in female mice through mechanisms involving intestinal arginase","volume":"41","author":"Rajcic","year":"2021","journal-title":"Redox Biol"},{"issue":"2","key":"10.1016\/j.jnutbio.2023.109495_bib0009","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/liv.12442","article-title":"Expression of toll-like receptors 1-5 but not TLR 6-10 is elevated in livers of patients with non-alcoholic fatty liver disease","volume":"35","author":"Kanuri","year":"2015","journal-title":"Liver Int"},{"issue":"12","key":"10.1016\/j.jnutbio.2023.109495_bib0010","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1017\/S0007114511004983","article-title":"Toll-like receptors 1-9 are elevated in livers with fructose-induced hepatic steatosis","volume":"107","author":"Wagnerberger","year":"2012","journal-title":"Br J Nutr"},{"issue":"3","key":"10.1016\/j.jnutbio.2023.109495_bib0011","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jceh.2021.11.011","article-title":"The effects of pathogen-associated molecular patterns on peripheral blood monocytes in patients with non-alcoholic fatty liver disease","volume":"12","author":"Li","year":"2022","journal-title":"J Clin Exp Hepatol"},{"issue":"7","key":"10.1016\/j.jnutbio.2023.109495_bib0012","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/labinvest.2012.75","article-title":"Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function","volume":"92","author":"Spruss","year":"2012","journal-title":"Lab Invest"},{"key":"10.1016\/j.jnutbio.2023.109495_bib0013","article-title":"Lentinan supplementation protects the gut-liver axis and prevents steatohepatitis: the role of gut microbiota involved","volume":"8","author":"Yang","year":"2021","journal-title":"Front Nutr"},{"issue":"4","key":"10.1016\/j.jnutbio.2023.109495_bib0014","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1053\/j.gastro.2019.06.028","article-title":"Microbiome signatures associated with steatohepatitis and moderate to severe fibrosis in children with nonalcoholic fatty liver disease","volume":"157","author":"Schwimmer","year":"2019","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.jnutbio.2023.109495_bib0015","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.3390\/nu9091013","article-title":"Short-term intake of a fructose-, fat- and cholesterol-rich diet causes hepatic steatosis in mice: effect of antibiotic treatment","volume":"9","author":"Brandt","year":"2017","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.jnutbio.2023.109495_bib0016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134893","article-title":"Rescue of fructose-induced metabolic syndrome by antibiotics or faecal transplantation in a rat model of obesity","volume":"10","author":"Di Luccia","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jnutbio.2023.109495_bib0017","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/hep.27982","article-title":"CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: limiting steatohepatitis by maintaining intestinal homeostasis","volume":"62","author":"Schneider","year":"2015","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109495_bib0018","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13073-016-0297-9","article-title":"Antibiotic perturbation of the murine gut microbiome enhances the adiposity, insulin resistance, and liver disease associated with high-fat diet","volume":"8","author":"Mahana","year":"2016","journal-title":"Genome Med"},{"issue":"2","key":"10.1016\/j.jnutbio.2023.109495_bib0019","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3390\/ijms20020308","article-title":"Intestinal microbiota protects against MCD diet-induced steatohepatitis","volume":"20","author":"Schneider","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.jnutbio.2023.109495_bib0020","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1097\/MEG.0000000000001232","article-title":"Rifaximin in nonalcoholic fatty liver disease: hit multiple targets with a single shot","volume":"30","author":"Abdel-Razik","year":"2018","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2023.109495_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.841132","article-title":"Rifaximin ameliorates non-alcoholic steatohepatitis in mice through regulating gut microbiome-related bile acids","volume":"13","author":"Jian","year":"2022","journal-title":"Front Pharmacol"},{"issue":"5","key":"10.1016\/j.jnutbio.2023.109495_bib0022","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600985","article-title":"Treatment with alpha-galactosylceramide protects mice from early onset of nonalcoholic steatohepatitis: Role of intestinal barrier function","volume":"61","author":"Engstler","year":"2017","journal-title":"Mol Nutr Food Res"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109495_bib0023","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1038\/s41467-022-31312-5","article-title":"Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment","volume":"13","author":"Schneider","year":"2022","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.jnutbio.2023.109495_bib0024","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1152\/advan.00017.2013","article-title":"Glucose transport into everted sacs of the small intestine of mice","volume":"37","author":"Hamilton","year":"2013","journal-title":"Adv Physiol Educ"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109495_bib0025","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/meth.1996.0074","article-title":"The use of aminoguanidine, a selective iNOS inhibitor, to evaluate the role of nitric oxide in the development of autoimmune diabetes","volume":"10","author":"Corbett","year":"1996","journal-title":"Methods"},{"issue":"8","key":"10.1016\/j.jnutbio.2023.109495_bib0026","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1093\/clinchem\/25.8.1440","article-title":"A simplified, colorimetric micromethod for xylose in serum or urine, with phloroglucinol","volume":"25","author":"Eberts","year":"1979","journal-title":"Clin Chem"},{"issue":"11","key":"10.1016\/j.jnutbio.2023.109495_bib0027","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.jnutbio.2015.05.011","article-title":"Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time","volume":"26","author":"Sellmann","year":"2015","journal-title":"J Nutr Biochem"},{"issue":"5","key":"10.1016\/j.jnutbio.2023.109495_bib0028","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.3390\/nu13051659","article-title":"Markers of intestinal permeability are rapidly improved by alcohol withdrawal in patients with alcohol-related liver disease","volume":"13","author":"Jung","year":"2021","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.jnutbio.2023.109495_bib0029","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1089\/ars.2010.3263","article-title":"Role of the inducible nitric oxide synthase in the onset of fructose-induced steatosis in mice","volume":"14","author":"Spruss","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jnutbio.2023.109495_bib0030","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.chemosphere.2019.06.080","article-title":"Intestinal barrier damage involved in intestinal microflora changes in fluoride-induced mice","volume":"234","author":"Liu","year":"2019","journal-title":"Chemosphere"},{"issue":"11","key":"10.1016\/j.jnutbio.2023.109495_bib0031","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1017\/S0007114515003621","article-title":"Supplementation of sodium butyrate protects mice from the development of non-alcoholic steatohepatitis (NASH)","volume":"114","author":"Jin","year":"2015","journal-title":"Br J Nutr"},{"issue":"3","key":"10.1016\/j.jnutbio.2023.109495_bib0032","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jnutbio.2012.01.014","article-title":"Lactobacillus casei shirota protects from fructose-induced liver steatosis: a mouse model","volume":"24","author":"Wagnerberger","year":"2013","journal-title":"J Nutr Biochem"},{"issue":"9","key":"10.1016\/j.jnutbio.2023.109495_bib0033","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3390\/microorganisms7090283","article-title":"Changes in oral microbial ecology of C57BL\/6 mice at different ages associated with sampling methodology","volume":"7","author":"Hern\u00e1ndez-Arriaga","year":"2019","journal-title":"Microorganisms"},{"issue":"17","key":"10.1016\/j.jnutbio.2023.109495_bib0034","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1128\/AEM.01043-13","article-title":"Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq illumina sequencing platform","volume":"79","author":"Kozich","year":"2013","journal-title":"Appl Environ Microb"},{"key":"10.1016\/j.jnutbio.2023.109495_bib0035","series-title":"User manual\/tutorial","first-page":"93","author":"Clarke","year":"2006"},{"issue":"8","key":"10.1016\/j.jnutbio.2023.109495_bib0036","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1007\/s00394-016-1287-9","article-title":"Oral citrulline supplementation protects female mice from the development of non-alcoholic fatty liver disease (NAFLD)","volume":"56","author":"Sellmann","year":"2017","journal-title":"Eur J Nutr"},{"issue":"4","key":"10.1016\/j.jnutbio.2023.109495_bib0037","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/jcmm.17175","article-title":"Alterations of nitric oxide homeostasis as trigger of intestinal barrier dysfunction in non-alcoholic fatty liver disease","volume":"26","author":"Baumann","year":"2022","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jnutbio.2023.109495_bib0038","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fimmu.2014.00532","article-title":"Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages","volume":"5","author":"Rath","year":"2014","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.jnutbio.2023.109495_bib0039","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109495_bib0040","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3390\/microorganisms9010199","article-title":"Fecal microbiota transplant from human to mice gives insights into the role of the gut microbiota in non-alcoholic fatty liver disease (NAFLD)","volume":"9","author":"Burz","year":"2021","journal-title":"Microorganisms"},{"issue":"12","key":"10.1016\/j.jnutbio.2023.109495_bib0041","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1136\/gutjnl-2012-303816","article-title":"Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice","volume":"62","author":"Le Roy","year":"2013","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109495_bib0042","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12944-021-01440-w","article-title":"Compositional alterations of gut microbiota in nonalcoholic fatty liver disease patients: a systematic review and Meta-analysis","volume":"20","author":"Li","year":"2021","journal-title":"Lipids Health Dis"},{"issue":"6","key":"10.1016\/j.jnutbio.2023.109495_bib0043","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jhep.2008.01.035","article-title":"Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin","volume":"48","author":"Bergheim","year":"2008","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.jnutbio.2023.109495_bib0044","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.apsb.2019.02.004","article-title":"Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters","volume":"9","author":"Sun","year":"2019","journal-title":"Acta Pharm Sin B"},{"issue":"5","key":"10.1016\/j.jnutbio.2023.109495_bib0045","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/s00394-018-1748-4","article-title":"Lack of liver steatosis in germ-free mice following hypercaloric diets","volume":"58","author":"Kaden-Volynets","year":"2019","journal-title":"Eur J Nutr"},{"issue":"5","key":"10.1016\/j.jnutbio.2023.109495_bib0046","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/dom.12637","article-title":"Effect of antibiotics on gut microbiota, glucose metabolism and body weight regulation: a review of the literature","volume":"18","author":"Mikkelsen","year":"2016","journal-title":"Diabetes Obes Metab"},{"issue":"1","key":"10.1016\/j.jnutbio.2023.109495_bib0047","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3390\/nu12010203","article-title":"Antibiotic treatment does not ameliorate the metabolic changes in rats presenting dysbiosis after consuming a high fructose diet","volume":"12","author":"Bier","year":"2020","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.jnutbio.2023.109495_bib0048","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1530\/JOE-17-0709","article-title":"The delayed effects of antibiotics in type 2 diabetes, friend or foe?","volume":"238","author":"Fu","year":"2018","journal-title":"J Endocrinol"},{"issue":"12","key":"10.1016\/j.jnutbio.2023.109495_bib0049","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1172\/JCI86674","article-title":"Antibiotic effects on gut microbiota and metabolism are host dependent","volume":"126","author":"Fujisaka","year":"2016","journal-title":"J Clin Invest"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286323002280?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286323002280?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:41:26Z","timestamp":1760629286000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286323002280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":49,"alternative-id":["S0955286323002280"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109495","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibiotics attenuate diet-induced nonalcoholic fatty liver disease without altering intestinal barrier dysfunction","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109495","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109495"}}