{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:07:00Z","timestamp":1792192020421,"version":"4.4.0"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"CAMS Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jnutbio.2023.109548","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T15:09:37Z","timestamp":1702652977000},"page":"109548","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Metabolome implies increased fatty acid utilization and histone methylation in the follicles from hyperandrogenic PCOS women"],"prefix":"10.1016","volume":"125","author":[{"given":"Yue","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaochen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hefeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiexue","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2023.109548_bib0001","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0002","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0003","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fertnstert.2008.06.035","article-title":"The androgen excess and PCOS society criteria for the polycystic ovary syndrome: the complete task force report","volume":"91","author":"Azziz","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0004","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/er.2015-1018","article-title":"Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome","volume":"36","author":"Dumesic","year":"2015","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0005","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1210\/jcem-63-5-1204","article-title":"Determination of the source(s) of androgen overproduction in hirsutism associated with polycystic ovary syndrome by simultaneous adrenal and ovarian venous catheterization. Comparison with the dexamethasone suppression test","volume":"63","author":"Wajchenberg","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0006","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.fertnstert.2003.07.008","article-title":"Adrenocortical hyperresponsiveness to corticotropin in polycystic ovary syndrome patients with adrenal androgen excess","volume":"81","author":"Moran","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.01.001","article-title":"Metabolic dysfunction in polycystic ovary syndrome: pathogenic role of androgen excess and potential therapeutic strategies","volume":"35","author":"Sanchez-Garrido","year":"2020","journal-title":"Mol Metab"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0008","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3390\/metabo11120845","article-title":"Profile of bile acid metabolomics in the follicular fluid of PCOS patients","volume":"11","author":"Yang","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0009","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s10815-019-01428-7","article-title":"Understanding mechanisms of oocyte development by follicular fluid lipidomics","volume":"36","author":"Montani","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0010","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/humupd\/dmm040","article-title":"Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality","volume":"14","author":"Gilchrist","year":"2008","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0011","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1095\/biolreprod.109.082941","article-title":"Formation of the ovarian follicular antrum and follicular fluid","volume":"82","author":"Rodgers","year":"2010","journal-title":"Biol Reprod"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0012","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12958-021-00825-x","article-title":"UHPLC-MS-MS analysis of oxylipins metabolomics components of follicular fluid in infertile individuals with diminished ovarian reserve","volume":"19","author":"Liang","year":"2021","journal-title":"Reprod Biol Endocrinol RBE"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0013","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s12020-014-0200-7","article-title":"Prevalence and impact of hyperandrogenemia in 1,218 women with polycystic ovary syndrome","volume":"47","author":"Livadas","year":"2014","journal-title":"Endocrine"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0014","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1073\/pnas.1418216112","article-title":"Alternative splicing of the androgen receptor in polycystic ovary syndrome","volume":"112","author":"Wang","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0015","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.tcm.2019.08.010","article-title":"Polycystic ovary syndrome and cardiometabolic risk: opportunities for cardiovascular disease prevention","volume":"30","author":"Osibogun","year":"2020","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0016","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1161\/CIRCULATIONAHA.123.065827","article-title":"Polycystic ovary syndrome fuels cardiovascular inflammation and aggravates ischemic cardiac injury","volume":"148","author":"Gao","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0017","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1093\/humrep\/dep121","article-title":"Milder forms of atherogenic dyslipidemia in ovulatory versus anovulatory polycystic ovary syndrome phenotype","volume":"24","author":"Rizzo","year":"2009","journal-title":"Hum Reprod Oxf Engl"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0018","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.fertnstert.2008.12.138","article-title":"Prevalence of hyperandrogenemia in the polycystic ovary syndrome diagnosed by the National Institutes of Health 1990 criteria","volume":"93","author":"Huang","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0019","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1016\/j.fertnstert.2009.12.081","article-title":"Steroid profiles in ovarian follicular fluid in women with and without polycystic ovary syndrome, analyzed by liquid chromatography-tandem mass spectrometry","volume":"94","author":"Naessen","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0020","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nature07762","article-title":"Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression","volume":"457","author":"Sreekumar","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0021","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.fertnstert.2012.06.025","article-title":"Women with reduced ovarian reserve or advanced maternal age have an altered follicular environment","volume":"98","author":"Pacella","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0022","doi-asserted-by":"crossref","first-page":"E226","DOI":"10.1210\/jc.2013-3839","article-title":"Follicular fluid soluble receptor for advanced glycation end-products (sRAGE): a potential indicator of ovarian reserve","volume":"99","author":"Merhi","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0023","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.fertnstert.2014.11.015","article-title":"Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health","volume":"103","author":"Dumesic","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0024","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s10815-021-02105-4","article-title":"Elevated ovarian pentraxin 3 in polycystic ovary syndrome","volume":"38","author":"Pan","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0026","doi-asserted-by":"crossref","first-page":"25934","DOI":"10.1038\/srep25934","article-title":"Circulating zinc-\u03b12-glycoprotein levels and insulin resistance in polycystic ovary syndrome","volume":"6","author":"Lai","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0027","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13148-018-0442-y","article-title":"Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis","volume":"10","author":"Pan","year":"2018","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0028","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41588-018-0055-6","article-title":"Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes","volume":"50","author":"Han","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0029","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/ps.5190","article-title":"Fenoxaprop-ethyl affects mouse oocyte quality and the underlying mechanisms","volume":"75","author":"He","year":"2019","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0030","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11427-018-9379-x","article-title":"Mechanism underlying the retarded nuclear translocation of androgen receptor splice variants","volume":"62","author":"Liu","year":"2019","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0031","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.molcel.2020.09.022","article-title":"Characterization of metabolic patterns in mouse oocytes during meiotic maturation","volume":"80","author":"Li","year":"2020","journal-title":"Mol Cell"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0032","doi-asserted-by":"crossref","first-page":"W486","DOI":"10.1093\/nar\/gky310","article-title":"MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis","volume":"46","author":"Chong","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0033","doi-asserted-by":"crossref","first-page":"W652","DOI":"10.1093\/nar\/gkp356","article-title":"MetaboAnalyst: a web server for metabolomic data analysis and interpretation","volume":"37","author":"Xia","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0034","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/cem.695","article-title":"Orthogonal projections to latent structures (O-PLS)","volume":"16","author":"Trygg","year":"2002","journal-title":"J Chemom"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0035","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/cem.1187","article-title":"CV-ANOVA for significance testing of PLS and OPLS\u00ae models","volume":"22","author":"Eriksson","year":"2008","journal-title":"J Chemom"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0036","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cca.2019.11.016","article-title":"Metabolic alterations associated with polycystic ovary syndrome: a UPLC Q-Exactive based metabolomic study","volume":"502","author":"Chen","year":"2020","journal-title":"Clin Chim Acta Int J Clin Chem"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0037","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4274\/jtgga.galenos.2022.2022-2-1","article-title":"Vitamin B3 (niacin), B6, C, and iron intake are associated with the free androgen index, especially in normoandrogenic polycystic ovary syndrome","volume":"23","author":"Hestiantoro","year":"2022","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.815968","article-title":"Effects of androgen excess-related metabolic disturbances on granulosa cell function and follicular development","volume":"13","author":"Liao","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0039","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s10038-020-0819-6","article-title":"Identification of epigenetic interactions between microRNA and DNA methylation associated with polycystic ovarian syndrome","volume":"66","author":"Mao","year":"2021","journal-title":"J Hum Genet"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0040","article-title":"Molecular features of polycystic ovary syndrome revealed by transcriptome analysis of oocytes and cumulus cells","volume":"9","author":"Li","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1262\/jrd.2019-102","article-title":"Energy metabolism of follicular environment during oocyte growth and maturation","volume":"66","author":"Warzych","year":"2020","journal-title":"J Reprod Dev"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0042","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-physiol-021115-105045","article-title":"The biochemistry and physiology of mitochondrial fatty acid \u03b2-oxidation and its genetic disorders","volume":"78","author":"Houten","year":"2016","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0043","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1530\/REP-13-0251","article-title":"Lipids and oocyte developmental competence: the role of fatty acids and \u03b2-oxidation","volume":"148","author":"Dunning","year":"2014","journal-title":"Reprod Camb Engl"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0044","doi-asserted-by":"crossref","first-page":"e10074","DOI":"10.1371\/journal.pone.0010074","article-title":"Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes","volume":"5","author":"Igosheva","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.114.126409","article-title":"Developmental programming by androgen affects the circadian timing system in female mice1","volume":"92","author":"Mereness","year":"2015","journal-title":"Biol Reprod"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0046","doi-asserted-by":"crossref","first-page":"e49217","DOI":"10.1371\/journal.pone.0049217","article-title":"High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation\/brain defects","volume":"7","author":"Luzzo","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0047","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12958-021-00749-6","article-title":"Correlation between steroid levels in follicular fluid and hormone synthesis related substances in its exosomes and embryo quality in patients with polycystic ovary syndrome","volume":"19","author":"Yu","year":"2021","journal-title":"Reprod Biol Endocrinol RBE"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0048","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1530\/REP-07-0061","article-title":"Carbohydrate metabolism by murine ovarian follicles and oocytes grown in vitro","volume":"134","author":"Harris","year":"2007","journal-title":"Reprod Camb Engl"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0049","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1530\/rep.0.1260027","article-title":"Influence of oocyte-secreted factors and culture duration on the metabolic activity of bovine cumulus cell complexes","volume":"126","author":"Sutton","year":"2003","journal-title":"Reprod Camb Engl"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0050","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1530\/rep.0.1240675","article-title":"Activity of key enzymes involved in glucose and triglyceride catabolism during bovine oocyte maturation in vitro","volume":"124","author":"Cetica","year":"2002","journal-title":"Reprod Camb Engl"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0051","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/(SICI)1098-2795(199605)44:1<121::AID-MRD14>3.0.CO;2-7","article-title":"Glucose utilization during gonadotropin-induced meiotic maturation in cumulus cell-enclosed mouse oocytes","volume":"44","author":"Downs","year":"1996","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0052","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1095\/biolreprod58.4.1084","article-title":"Meiotic induction in cumulus cell-enclosed mouse oocytes: involvement of the pentose phosphate pathway","volume":"58","author":"Downs","year":"1998","journal-title":"Biol Reprod"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0053","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1042\/BCJ20160822","article-title":"Amino acid homeostasis and signalling in mammalian cells and organisms","volume":"474","author":"Br\u00f6er","year":"2017","journal-title":"Biochem J"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0054","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/intimm\/dxaa019","article-title":"Amino acids: key sources for immunometabolites and immunotransmitters","volume":"32","author":"Miyajima","year":"2020","journal-title":"Int Immunol"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0055","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.904942","article-title":"Abnormal endometrial receptivity and oxidative stress in polycystic ovary syndrome","volume":"13","author":"Shan","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0056","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1126\/science.1227166","article-title":"Suppression of oxidative stress by \u03b2-hydroxybutyrate, an endogenous histone deacetylase inhibitor","volume":"339","author":"Shimazu","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0057","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/s41598-018-36941-9","article-title":"Prominent action of butyrate over \u03b2-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule","volume":"9","author":"Chriett","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0058","doi-asserted-by":"crossref","first-page":"13766","DOI":"10.1038\/s41598-018-31822-7","article-title":"Metabolic gene expression and epigenetic effects of the ketone body \u03b2-hydroxybutyrate on H3K9ac in bovine cells, oocytes and embryos","volume":"8","author":"Sangalli","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0059","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1373\/clinchem.2011.176396","article-title":"Metabolic heterogeneity in polycystic ovary syndrome is determined by obesity: plasma metabolomic approach using GC-MS","volume":"58","author":"Escobar-Morreale","year":"2012","journal-title":"Clin Chem"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0060","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1007\/s00216-015-8670-x","article-title":"Serum metabolomics study of polycystic ovary syndrome based on UPLC-QTOF-MS coupled with a pattern recognition approach","volume":"407","author":"Dong","year":"2015","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0061","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.plefa.2017.09.001","article-title":"Metabolic pathways of oleic and palmitic acid are intensified in PCOS patients with normal androgen levels","volume":"126","author":"Szczuko","year":"2017","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0062","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.988767","article-title":"Arachidonic acid in follicular fluid of PCOS induces oxidative stress in a human ovarian granulosa tumor cell line (KGN) and upregulates GDF15 expression as a response","volume":"13","author":"Ma","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0063","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1210\/clinem\/dgac281","article-title":"Elevated levels of follicular fatty acids induce ovarian inflammation via ERK1\/2 and inflammasome activation in PCOS","volume":"107","author":"Lai","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0064","doi-asserted-by":"crossref","first-page":"E2269","DOI":"10.1210\/jc.2013-3942","article-title":"Associations between insulin resistance, free fatty acids, and oocyte quality in polycystic ovary syndrome during in vitro fertilization","volume":"99","author":"Niu","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0065","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1001\/jamainternmed.2016.2925","article-title":"\u03c9-3 polyunsaturated fatty acid biomarkers and coronary heart disease: pooling project of 19 cohort studies","volume":"176","author":"Del Gobbo","year":"2016","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.jnutbio.2023.109548_bib0066","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3390\/ijms17081257","article-title":"Docosahexaenoic acid induces oxidative DNA damage and apoptosis, and enhances the chemosensitivity of cancer cells","volume":"17","author":"Song","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0067","doi-asserted-by":"crossref","first-page":"pyw078","DOI":"10.1093\/ijnp\/pyw078","article-title":"N-3 polyunsaturated fatty acids through the lifespan: implication for psychopathology","volume":"19","author":"Pusceddu","year":"2016","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0068","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1095\/biolreprod.109.076851","article-title":"The effect of linolenic acid on bovine oocyte maturation and development","volume":"81","author":"Marei","year":"2009","journal-title":"Biol Reprod"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0069","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/(SICI)1099-0895(199812)14:4<263::AID-DMR233>3.0.CO;2-C","article-title":"Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years","volume":"14","author":"Randle","year":"1998","journal-title":"Diabetes Metab Rev"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0070","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1039\/C6MB00420B","article-title":"Serum metabolomics of Indian women with polycystic ovary syndrome using 1H NMR coupled with a pattern recognition approach","volume":"12","author":"RoyChoudhury","year":"2016","journal-title":"Mol Biosyst"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0071","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.rbmo.2021.11.012","article-title":"Amino acid signatures in relation to polycystic ovary syndrome and increased risk of different metabolic disturbances","volume":"44","author":"Ye","year":"2022","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0072","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1021\/pr3000317","article-title":"Metabonomics reveals plasma metabolic changes and inflammatory marker in polycystic ovary syndrome patients","volume":"11","author":"Sun","year":"2012","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0073","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1741-7015-10-153","article-title":"Metabolic profiles characterizing different phenotypes of polycystic ovary syndrome: plasma metabolomics analysis","volume":"10","author":"Zhao","year":"2012","journal-title":"BMC Med"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0074","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2174\/2213235X01666131203230512","article-title":"Metabolic evidence of diminished lipid oxidation in women with polycystic ovary syndrome","volume":"2","author":"Whigham","year":"2014","journal-title":"Curr Metabolomics"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0075","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jsbmb.2018.10.012","article-title":"Identification of the metabolic fingerprints in women with polycystic ovary syndrome using the multiplatform metabolomics technique","volume":"186","author":"Buszewska-Forajta","year":"2019","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104492","article-title":"PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome","volume":"89","author":"Mu","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0077","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1093\/jas\/sky154","article-title":"Glycine treatment enhances developmental potential of porcine oocytes and early embryos by inhibiting apoptosis","volume":"96","author":"Li","year":"2018","journal-title":"J Anim Sci"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0078","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/mrd.22618","article-title":"Glycine supplementation in vitro enhances porcine preimplantation embryo cell number and decreases apoptosis but does not lead to live births","volume":"83","author":"Redel","year":"2016","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0079","doi-asserted-by":"crossref","first-page":"37262","DOI":"10.1038\/srep37262","article-title":"Glycine increases preimplantation development of mouse oocytes following vitrification at the germinal vesicle stage","volume":"6","author":"Cao","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119756","article-title":"Glycine ameliorates MBP-induced meiotic abnormalities and apoptosis by regulating mitochondrial-endoplasmic reticulum interactions in porcine oocytes","volume":"309","author":"Gao","year":"2022","journal-title":"Environ Pollut"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0081","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s43032-019-00015-6","article-title":"Methionine adenosyltransferase 2\u03b2 participates in mouse oocyte maturation by regulating the MAPK pathway","volume":"27","author":"An","year":"2020","journal-title":"Reprod Sci Thousand Oaks Calif"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0082","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.fertnstert.2015.04.005","article-title":"Genome-wide screen of ovary-specific DNA methylation in polycystic ovary syndrome","volume":"104","author":"Yu","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0083","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ebiom.2017.01.011","article-title":"Prevalence of prediabetes risk in offspring born to mothers with hyperandrogenism","volume":"16","author":"Tian","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0084","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.220211","article-title":"Inhibition of EED activity enhances cell survival of female germline stem cell and improves the oocytes production during oogenesis in vitro","volume":"13","author":"Wang","year":"2023","journal-title":"Open Biol"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0085","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/humupd\/dmy021","article-title":"Epigenetic regulation in development: is the mouse a good model for the human?","volume":"24","author":"Hanna","year":"2018","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0086","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature23262","article-title":"Maternal H3K27me3 controls DNA methylation-independent imprinting","volume":"547","author":"Inoue","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0087","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41588-021-00821-2","article-title":"Distinct dynamics and functions of H2AK119ub1 and H3K27me3 in mouse preimplantation embryos","volume":"53","author":"Chen","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0088","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1126\/science.aam5339","article-title":"Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition","volume":"357","author":"Zenk","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2023.109548_bib0089","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.molcel.2016.08.032","article-title":"Resetting epigenetic memory by reprogramming of histone modifications in mammals","volume":"63","author":"Zheng","year":"2016","journal-title":"Mol Cell"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286323002814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286323002814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:41:26Z","timestamp":1760629286000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286323002814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":89,"alternative-id":["S0955286323002814"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109548","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolome implies increased fatty acid utilization and histone methylation in the follicles from hyperandrogenic PCOS women","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109548","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109548"}}