{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:28:38Z","timestamp":1787801318483,"version":"build-2784847793"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jnutbio.2023.109566","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T10:43:24Z","timestamp":1704278604000},"page":"109566","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Obesity phenotype induced by high-fat diet promotes diethylnitrosamine (DEN)-induced precancerous lesions by M1 macrophage polarization in mice liver"],"prefix":"10.1016","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3064-335X","authenticated-orcid":false,"given":"Li","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du","family":"Zuoqin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Jiaqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xiaomeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Youkun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-9717","authenticated-orcid":false,"given":"Wu","family":"Jianbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2023.109566_bib0001","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"Ca Cancer J Clin"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0002","doi-asserted-by":"crossref","first-page":"704","DOI":"10.5858\/2010-0524-RA.1","article-title":"Update on precursor and early lesions of hepatocellular carcinomas","volume":"135","author":"Park","year":"2011","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1019772","article-title":"Interim efficacy and safety of PD-1 inhibitors in preventing recurrence of hepatocellular carcinoma after interventional therapy","volume":"13","author":"Qiao","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0004","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/hep.22709","article-title":"Consensus group for hepatocellular neoplasia. Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia","volume":"49","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0005","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1053\/jhep.2002.33713","article-title":"Is obesity an independent risk factor for hepatocellular carcinoma in cirrhosis?","volume":"36","author":"Nair","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0006","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.cbi.2019.02.024","article-title":"Diethylnitrosamine enhances hepatic tumorigenic pathways in mice fed with high fat diet (Hfd)","volume":"303","author":"Arboatti","year":"2019","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0007","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41420-019-0198-y","article-title":"Hyperglycemia exacerbates acetaminophen-induced acute liver injury by promoting liver-resident macrophage proinflammatory response via AMPK\/PI3K\/AKT-mediated oxidative stress","volume":"5","author":"Wang","year":"2019","journal-title":"Cell Death Discov"},{"issue":"2","key":"10.1016\/j.jnutbio.2023.109566_bib0008","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cld.2015.01.012","article-title":"Nonalcoholic fatty liver disease, diabetes, obesity, and hepatocellular carcinoma","volume":"19","author":"Noureddin","year":"2015","journal-title":"Clin liver Dis"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.808526","article-title":"Hepatocellular carcinoma and obesity, type 2 diabetes mellitus, cardiovascular disease: causing factors, molecular links, and treatment options","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0010","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.cell.2020.11.009","article-title":"Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity","volume":"183","author":"Ringel","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.590568","article-title":"PD-1 blockade reverses obesity-mediated T cell priming impairment","volume":"11","author":"Le","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0012","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","article-title":"Hepatocellular carcinoma","volume":"391","author":"Forner","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0013","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41420-022-01201-3","article-title":"MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling","volume":"8","author":"Zhou","year":"2022","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0014","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0015","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3389\/fimmu.2014.00430","article-title":"Hepatic localization of macrophage phenotypes during fibrogenesis and resolution of fibrosis in mice and humans","volume":"5","author":"Beljaars","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0016","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/s41420-021-00756-x","article-title":"The METTL3\/MALAT1\/PTBP1\/USP8\/TAK1 axis promotes pyroptosis and M1 polarization of macrophages and contributes to liver fibrosis","volume":"7","author":"Shu","year":"2021","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0017","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101634","article-title":"Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH","volume":"36","author":"Xu","year":"2020","journal-title":"Redox Biol"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0019","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13045-020-00991-2","article-title":"Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer","volume":"13","author":"Zhao","year":"2020","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0020","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jhep.2017.05.022","article-title":"Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice","volume":"67","author":"Ma","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.803037","article-title":"Macrophage polarization and its role in liver disease","volume":"12","author":"Wang","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0022","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.canlet.2013.11.013","article-title":"CD68(+)HLA-DR(+) M1-like macrophages promote motility of HCC cells via NF-\u03baB\/FAK pathway","volume":"345","author":"Wang","year":"2014","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0023","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.3389\/fimmu.2019.01643","article-title":"M1 macrophages induce PD-L1 expression in hepatocellular carcinoma cells through IL-1\u03b2 signaling","volume":"10","author":"Zong","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117121","article-title":"Survival of endogenous hepatic stem\/progenitor cells in liver tissues during liver cirrhosis","volume":"241","author":"Chen","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0025","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1007\/s00268-017-4453-1","article-title":"Surgical management of intrahepatic cholangiocarcinoma in patients with cirrhosis: impact of lymphadenectomy on peri-operative outcomes","volume":"42","author":"Bagante","year":"2018","journal-title":"World J Surg"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0026","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1136\/gutjnl-2011-301116","article-title":"Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer","volume":"61","author":"Schneider","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0027","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/bs.mcb.2020.08.006","article-title":"Diethylnitrosamine-induced liver tumorigenesis in mice","volume":"163","author":"Schulien","year":"2021","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0028","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jhep.2011.09.020","article-title":"Obesity, inflammation, and liver cancer","volume":"56","author":"Sun","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0029","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0030","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1073\/pnas.90.5.2065","article-title":"Trans-activation of glutathione transferase P gene during chemical hepatocarcinogenesis of the rat","volume":"90","author":"Morimura","year":"1993","journal-title":"Proc Nati Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0031","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1136\/gutjnl-2013-306294","article-title":"CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis","volume":"63","author":"Ehling","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0032","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1136\/gutjnl-2013-304564","article-title":"Hepatocellular carcinoma and sorafenib: too many resistance mechanisms?","volume":"62","author":"Berasain","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0033","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/hep.30811","article-title":"Clinical impact of genomic diversity from early to advanced hepatocellular carcinoma","volume":"71","author":"Nault","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0034","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/cncr.21607","article-title":"Dysplastic nodules frequently develop into hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis","volume":"106","author":"Kobayashi","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114611","article-title":"Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice","volume":"378","author":"Fuentes-Hern\u00e1ndez","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0036","first-page":"22","article-title":"Establishment and optimization of a mouse model of primary liver cancer","volume":"29","author":"Sun","year":"2019","journal-title":"Chinese J Comp Med"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0037","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3389\/fphys.2018.00197","article-title":"Tissue improves blood flow and reduces inflammation in high fat fed mice with hindlimb ischemia","volume":"9","author":"Liyuan","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0038","doi-asserted-by":"crossref","first-page":"T255","DOI":"10.1530\/ERC-14-0070","article-title":"Obesity and thyroid cancer","volume":"21","author":"Marcello","year":"2014","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2018.02.015","article-title":"The role of the lipidome in obesity-mediated colon cancer risk","volume":"59","author":"Jain","year":"2018","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109119","article-title":"Maternal soybean diet on prevention of obesity-related breast cancer through early-life gut microbiome and epigenetic regulation","volume":"110","author":"Chen","year":"2022","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0041","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.120.316101","article-title":"Obesity phenotypes, diabetes, and cardiovascular diseases","volume":"126","author":"Pich\u00e9","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109021","article-title":"Successful correction of hyperglycemia is critical for weight loss and a decrease in cardiovascular risk in obese patients","volume":"106","author":"Zalejska-Fiolka","year":"2022","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0043","first-page":"4623","article-title":"Proliferation of human hepatocellular carcinoma cells from surgically resected specimens under conditionally reprogrammed culture","volume":"19","author":"Wang","year":"2019","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0044","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0045","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.hbpd.2020.03.006","article-title":"Therapeutic effect of hydrogen peroxide via altered expression of glutathione S-transferase and peroxiredoxin-2 in hepatocellular carcinoma","volume":"19","author":"Hashim","year":"2020","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0046","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3390\/cancers13040778","article-title":"Pancreatic tumorigenesis: oncogenic KRAS and the vulnerability of the pancreas to obesity","volume":"13","author":"Luo","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0047","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.902114","article-title":"An evidence review of the association of immune and inflammatory markers with obesity-related eating behaviors","volume":"13","author":"Meng","year":"2022","journal-title":"Front immunol"},{"key":"10.1016\/j.jnutbio.2023.109566_bib0048","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41420-021-00711-w","article-title":"Role of RAGE in obesity-induced adipose tissue inflammation and insulin resistance","volume":"7","author":"Feng","year":"2021","journal-title":"Cell Death Discov"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286323002991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286323002991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:42:08Z","timestamp":1760629328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286323002991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":48,"alternative-id":["S0955286323002991"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109566","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Obesity phenotype induced by high-fat diet promotes diethylnitrosamine (DEN)-induced precancerous lesions by M1 macrophage polarization in mice liver","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109566","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109566"}}