{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:03:25Z","timestamp":1772773405678,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270396"],"award-info":[{"award-number":["82270396"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273919"],"award-info":[{"award-number":["82273919"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jnutbio.2024.109584","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T01:49:26Z","timestamp":1705801766000},"page":"109584","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Identification of potential pathogenic hepatic super-enhancers regulatory network in high-fat diet induced hyperlipidemia"],"prefix":"10.1016","volume":"126","author":[{"given":"Yingying","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Run","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuxiu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menghan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhouxiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2024.109584_bib0001","doi-asserted-by":"crossref","first-page":"7629","DOI":"10.1021\/acs.jafc.1c01813","article-title":"Flavonoids from whole-grain oat alleviated high-fat diet-induced hyperlipidemia via regulating bile acid metabolism and gut microbiota in mice","volume":"69","author":"Duan","year":"2021","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0002","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12944-019-1171-8","article-title":"Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review","volume":"19","author":"Yao","year":"2020","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0003","doi-asserted-by":"crossref","first-page":"77","DOI":"10.31083\/j.rcm.2018.03.908","article-title":"Alteration of lipid metabolism in chronic kidney disease, the role of novel antihyperlipidemic agents, and future directions","volume":"19","author":"Sudhakaran","year":"2018","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0004","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/s41591-020-01150-3","article-title":"A shift in cholesterol geography","volume":"26","author":"Stower","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0005","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1210\/clinem\/dgab876","article-title":"New therapies for primary hyperlipidemia","volume":"107","author":"Aguilar-Salinas","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0006","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-981-15-1792-1_5","article-title":"Exercise and hyperlipidemia","volume":"1228","author":"He","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0007","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222011107","article-title":"Atorvastatin ester regulates lipid metabolism in hyperlipidemia rats via the PPAR-signaling pathway and HMGCR expression in the liver","volume":"22","author":"Hu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0008","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1023\/A:1005661516165","article-title":"Fatty infiltration of liver in hyperlipidemic patients","volume":"45","author":"Assy","year":"2000","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0009","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00041433-200008000-00006","article-title":"Serum triglycerides, the liver and the pancreas","volume":"11","author":"Miller","year":"2000","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0010","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrg3207","article-title":"Transcription factors: from enhancer binding to developmental control","volume":"13","author":"Spitz","year":"2012","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0011","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cell.2013.03.035","article-title":"Master transcription factors and mediator establish super-enhancers at key cell identity genes","volume":"153","author":"Whyte","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0012","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.stem.2015.04.001","article-title":"Tex10 coordinates epigenetic control of super-enhancer activity in pluripotency and reprogramming","volume":"16","author":"Ding","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0013","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.bbrc.2004.04.136","article-title":"A constitutive super-enhancer: homologous region 3 of Bombyx mori nucleopolyhedrovirus","volume":"318","author":"Chen","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0014","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2013.09.053","article-title":"Super-enhancers in the control of cell identity and disease","volume":"155","author":"Hnisz","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0015","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.trecan.2017.03.006","article-title":"Super-enhancer-driven transcriptional dependencies in cancer","volume":"3","author":"Sengupta","year":"2017","journal-title":"Trends Cancer"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0016","first-page":"506","article-title":"Targeting super-enhancers for disease treatment and diagnosis","volume":"41","author":"Shin","year":"2018","journal-title":"Mol Cells"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0017","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s10038-018-0422-2","article-title":"Integrative functional analysis of super enhancer SNPs for coronary artery disease","volume":"63","author":"Gong","year":"2018","journal-title":"J Hum Genet"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0018","doi-asserted-by":"crossref","first-page":"e14780","DOI":"10.7717\/peerj.14780","article-title":"Targeting super enhancers for liver disease: a review","volume":"11","author":"Yang","year":"2023","journal-title":"PeerJ"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0019","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0020","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/s41467-020-14796-x","article-title":"Alterations in promoter interaction landscape and transcriptional network underlying metabolic adaptation to diet","volume":"11","author":"Qin","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0021","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1126\/science.abn9886","article-title":"An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice","volume":"378","author":"Nikkanen","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0022","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0023","article-title":"Liraglutide alleviates hepatic steatosis and liver injury in T2MD rats via a GLP-1R dependent AMPK pathway","volume":"11","author":"Zhou","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0024","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12920-018-0438-7","article-title":"Genomics of lipid-laden human hepatocyte cultures enables drug target screening for the treatment of non-alcoholic fatty liver disease","volume":"11","author":"Breher-Esch","year":"2018","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0025","doi-asserted-by":"crossref","first-page":"11799","DOI":"10.1038\/s41598-021-91284-2","article-title":"BET inhibitor suppresses migration of human hepatocellular carcinoma by inhibiting SMARCA4","volume":"11","author":"Choi","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0026","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/bioinformatics\/btr064","article-title":"FIMO: scanning for occurrences of a given motif","volume":"27","author":"Grant","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0027","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cell.2013.03.036","article-title":"Selective inhibition of tumor oncogenes by disruption of super-enhancers","volume":"153","author":"Loven","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0028","article-title":"Nintedanib alleviates experimental colitis by inhibiting CEBPB\/PCK1 and CEBPB\/EFNA1 pathways","volume":"13","author":"Li","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0029","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.metabol.2016.07.001","article-title":"BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver","volume":"65","author":"Yamada","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041297","article-title":"Inhibition of bromodomain and extraterminal domain (BET) proteins by JQ1 unravels a novel epigenetic modulation to control lipid homeostasis","volume":"21","author":"Tonini","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0031","first-page":"985-99 e9","article-title":"HNF4 regulates fatty acid oxidation and is required for renewal of intestinal stem cells in mice","volume":"158","author":"Chen","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0032","doi-asserted-by":"crossref","first-page":"29501","DOI":"10.1074\/jbc.M111.263509","article-title":"Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression","volume":"286","author":"Gokey","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0033","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bbalip.2009.12.009","article-title":"alpha(1)-fetoprotein transcription factor (FTF)\/liver receptor homolog-1 (LRH-1) is an essential lipogenic regulator","volume":"1801","author":"Xu","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0034","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cell.2020.12.023","article-title":"Cholesterol transport through lysosome-peroxisome membrane contacts","volume":"184","author":"Chu","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0035","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s11427-013-4585-y","article-title":"Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue","volume":"57","author":"Wu","year":"2014","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0036","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1074\/jbc.M115.701094","article-title":"Differential roles of cell death-inducing DNA fragmentation factor-alpha-like effector (CIDE) proteins in promoting lipid droplet fusion and growth in subpopulations of hepatocytes","volume":"291","author":"Xu","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0037","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1194\/jlr.M077941","article-title":"Amelioration of diet-induced steatohepatitis in mice following combined therapy with ASO-Fsp27 and fenofibrate","volume":"58","author":"Rajamoorthi","year":"2017","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2022.101193","article-title":"CD36 favours fat sensing and transport to govern lipid metabolism","volume":"88","author":"Li","year":"2022","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0039","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.taap.2016.12.019","article-title":"Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice","volume":"316","author":"Choi","year":"2017","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbrc.2014.03.103","article-title":"Rapamycin-mediated CD36 translational suppression contributes to alleviation of hepatic steatosis","volume":"447","author":"Wang","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0041","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41419-020-03003-w","article-title":"Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?","volume":"11","author":"Rada","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0042","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1111\/jcmm.14108","article-title":"Pex11a deficiency causes dyslipidaemia and obesity in mice","volume":"23","author":"Chen","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0043","doi-asserted-by":"crossref","first-page":"E187","DOI":"10.1152\/ajpendo.00425.2012","article-title":"Pex11alpha deficiency impairs peroxisome elongation and division and contributes to nonalcoholic fatty liver in mice","volume":"304","author":"Weng","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0044","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/mmi.12060","article-title":"Mitochondrial beta-oxidation regulates organellar integrity and is necessary for conidial germination and invasive growth in Magnaporthe oryzae","volume":"86","author":"Patkar","year":"2012","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0045","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.bbrc.2018.03.052","article-title":"Enoyl coenzyme A hydratase 1 protects against high-fat-diet-induced hepatic steatosis and insulin resistance","volume":"499","author":"Huang","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0046","doi-asserted-by":"crossref","first-page":"6152","DOI":"10.1158\/1078-0432.CCR-04-0285","article-title":"Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms","volume":"10","author":"Hansel","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2020.108365","article-title":"The modulation of Luffa cylindrica (L.) Roem supplementation on gene expression and amino acid profiles in liver for alleviating hepatic steatosis via gut microbiota in high-fat diet-fed mice: insight from hepatic transcriptome analysis","volume":"80","author":"Zhang","year":"2020","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0048","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.jcmgh.2021.07.016","article-title":"Liver-specific deletion of mouse CTCF leads to hepatic steatosis via augmented PPARgamma signaling","volume":"12","author":"Choi","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2024.109584_bib0049","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.gde.2020.02.021","article-title":"CTCF and CTCFL in cancer","volume":"61","author":"Debaugny","year":"2020","journal-title":"Curr Opin Genet Dev"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324000172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324000172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:41:13Z","timestamp":1760629273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286324000172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":49,"alternative-id":["S0955286324000172"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109584","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of potential pathogenic hepatic super-enhancers regulatory network in high-fat diet induced hyperlipidemia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109584","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109584"}}