{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:38:21Z","timestamp":1783057101496,"version":"3.54.6"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"am","delay-in-days":295,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005825","name":"USDA NIFA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.jnutbio.2024.109634","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T16:29:03Z","timestamp":1711816143000},"page":"109634","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Impacts of the vegetable Urtica dioica on the intestinal T and B cell phenotype and macronutrient absorption in C57BL\/6J mice with diet-induced obesity"],"prefix":"10.1016","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0367-5164","authenticated-orcid":false,"given":"Si","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samnhita","family":"Raychaudhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Opeyemi","family":"Ogedengbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Mochama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4635-7887","authenticated-orcid":false,"given":"Diana N.","family":"Obanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2024.109634_bib0001","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4024331","article-title":"Urtica dioica-derived phytochemicals for pharmacological and therapeutic applications","volume":"2022","author":"Taheri","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"issue":"7","key":"10.1016\/j.jnutbio.2024.109634_bib0002","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.3390\/molecules23071664","article-title":"Urtica spp: ordinary plants with extraordinary properties","volume":"23","author":"Kregiel","year":"2018","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109634_bib0003","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1615\/CritRevEukaryotGeneExpr.2018020389","article-title":"Investigations of phytochemical constituents and their pharmacological properties isolated from the genus Urtica: critical review and analysis","volume":"28","author":"Ibrahim","year":"2018","journal-title":"Crit Rev Eukaryotic Gene Express"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0004","doi-asserted-by":"crossref","first-page":"22222","DOI":"10.1038\/srep22222","article-title":"An extract of Urtica dioica L. mitigates obesity induced insulin resistance in mice skeletal muscle via protein phosphatase 2A (PP2A)","volume":"6","author":"Obanda","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109634_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150252","article-title":"Stinging Nettle (Urtica dioica L.) Attenuates FFA induced ceramide accumulation in 3T3-L1 Adipocytes in an adiponectin dependent manner","volume":"11","author":"Obanda","year":"2016","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.jnutbio.2024.109634_bib0006","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3390\/nu12041059","article-title":"Urtica dioica whole vegetable as a functional food targeting fat accumulation and insulin resistance-a preliminary study in a mouse pre-diabetic model","volume":"12","author":"Fan","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108594","article-title":"Metagenomic insights into the effects of Urtica dioica vegetable on the gut microbiota of C57BL\/6J obese mice, particularly the composition of Clostridia","volume":"91","author":"Fan","year":"2021","journal-title":"J. Nutri. Biochem."},{"issue":"3 (Suppl 1)","key":"10.1016\/j.jnutbio.2024.109634_bib0008","first-page":"P21","article-title":"Abundance of Clostridium butyricum in gut microbiota correlates with obesity phenotype irrespective of diet in outbred Sprague Dawley CD rats","volume":"3","author":"Obanda","year":"2019","journal-title":"Curr Dev Nutr"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.746515","article-title":"Gut microbiota composition and predicted microbial metabolic pathways of obesity prone and obesity resistant outbred Sprague-Dawley CD rats may account for differences in their phenotype","volume":"8","author":"Obanda","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jnutbio.2024.109634_bib0010","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.chom.2014.12.009","article-title":"MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health","volume":"17","author":"Kubinak","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0011","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1038\/s41467-019-11370-y","article-title":"Gut-associated IgA+ immune cells regulate obesity-related insulin resistance","volume":"10","author":"Luck","year":"2019","journal-title":"Nat Comm"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0012","doi-asserted-by":"crossref","first-page":"9351","DOI":"10.1126\/science.aat9351","article-title":"T cell-mediated regulation of the microbiota protects against obesity","volume":"365","author":"Petersen","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0013","doi-asserted-by":"crossref","first-page":"28536","DOI":"10.3402\/fnr.v60.28536","article-title":"Effect of long-term high-fat diet intake on peripheral insulin sensibility, blood pressure, and renal function in female rats","volume":"60","author":"Roza","year":"2016","journal-title":"Food Nutr Res"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0014","first-page":"54114","article-title":"Isolation and flow cytometric characterization of murine small intestinal lymphocytes","volume":"111","author":"Couter","year":"2016","journal-title":"J Vis Exp"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109634_bib0015","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/intimm\/dxm143","article-title":"CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector\/memory phenotype","volume":"20","author":"Guo","year":"2008","journal-title":"Int Immunol"},{"issue":"6","key":"10.1016\/j.jnutbio.2024.109634_bib0016","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.cmet.2016.04.022","article-title":"Direct hepatocyte insulin signaling is required for lipogenesis but is dispensable for the suppression of glucose production","volume":"23","author":"Titchenell","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0017","doi-asserted-by":"crossref","first-page":"15.25.1","DOI":"10.1002\/0471142735.im1525s104","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr Protoc Immunol"},{"issue":"5","key":"10.1016\/j.jnutbio.2024.109634_bib0018","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.immuni.2013.10.010","article-title":"The spleen in local and systemic of immunity","volume":"39","author":"Bronte","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0019","doi-asserted-by":"crossref","unstructured":"Raychaudhuri S, Shahinozzaman M, Fan S, Ogedengbe O, Subedi U, Obanda DN. Resistance to diet induced visceral fat accumulation in C57BL\/6NTac mice is associated with an enriched Lactococcus in the gut microbiota and the phenotype of immune B Cells in intestine and adipose tissue. Microorganisms. 2023;11(9):2153. 10.3390\/microorganisms11092153.","DOI":"10.3390\/microorganisms11092153"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0020","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fnut.2016.00010","article-title":"Relationships between rodent white adipose fat pads and human white adipose fat depots","volume":"3","author":"Chusyd","year":"2016","journal-title":"Front Nutr"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0021","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/s42255-021-00470-z","article-title":"Metabolic messengers: tumor necrosis factor","volume":"3","author":"Sethi","year":"2021","journal-title":"Nat Metab"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0022","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of insulin action and insulin resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.jnutbio.2024.109634_bib0023","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cmet.2015.03.001","article-title":"Regulation of obesity-related insulin resistance with gut anti-inflammatory agents","volume":"21","author":"Luck","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0024","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.3389\/fimmu.2018.02667","article-title":"Commensal bacteria-specific Cd4+ T Cell responses in health and disease","volume":"9","author":"Sorini","year":"2018","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.jnutbio.2024.109634_bib0025","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1053\/j.gastro.2017.07.047","article-title":"Circulating and tissue resident Cd4+ T Cells with reactivity to intestinal microbiota are abundant in healthy individuals and function is altered during Inflammation","volume":"153","author":"Hegazy","year":"2017","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.jnutbio.2024.109634_bib0026","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.cell.2010.02.021","article-title":"Th17 and regulatory T cells in mediating and restraining inflammation","volume":"140","author":"Littman","year":"2010","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.jnutbio.2024.109634_bib0027","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1053\/j.gastro.2017.02.016","article-title":"Gut-specific delivery of T-helper 17 cells reduces obesity and insulin resistance in mice","volume":"152","author":"Hong","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2024.109634_bib0028","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41577-023-00906-5","article-title":"The emerging family of ROR\u03b3t+ antigen-presenting cells","author":"Abramson","year":"2024","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109634_bib0029","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1038\/s41467-022-33067-5","article-title":"Interferon gamma mediates the reduction of adipose tissue regulatory T cells in human obesity","volume":"13","author":"Bradley","year":"2022","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.jnutbio.2024.109634_bib0030","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1074\/jbc.R114.635995","article-title":"Human enteroids\/colonoids and intestinal organoids functionally recapitulate normal intestinal physiology and pathophysiology","volume":"291","author":"Zachos","year":"2016","journal-title":"J. Bio Chem."},{"issue":"5","key":"10.1016\/j.jnutbio.2024.109634_bib0031","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1194\/jlr.M071340","article-title":"Using primary murine intestinal enteroids to study dietary TAG absorption, lipoprotein synthesis, and the role of apoC-III in the intestine","volume":"58","author":"Jattan","year":"2017","journal-title":"J Lipid Res"},{"issue":"6","key":"10.1016\/j.jnutbio.2024.109634_bib0032","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/j.stemcr.2017.10.013","article-title":"Development and characterization of a human and mouse intestinal epithelial cell monolayer platform","volume":"9","author":"Kozuka","year":"2017","journal-title":"Stem cells Rep"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109634_bib0033","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev-nutr-071812-161220","article-title":"Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism","volume":"34","author":"Pepino","year":"2014","journal-title":"Annu Rev Nutr"},{"issue":"41","key":"10.1016\/j.jnutbio.2024.109634_bib0034","doi-asserted-by":"crossref","first-page":"7254","DOI":"10.1021\/bi400914c","article-title":"CD36 enhances fatty acid uptake by increasing the rate of intracellular esterification but not transport across the plasma membrane","volume":"52","author":"Xu","year":"2013","journal-title":"Biochemistry"},{"issue":"9","key":"10.1016\/j.jnutbio.2024.109634_bib0035","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3748\/wjg.v16.i9.1057","article-title":"Even low-grade inflammation small intestinal function","volume":"6","author":"Peuhkuri","year":"2010","journal-title":"World J Gastroenterol"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324000676?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324000676?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T23:46:31Z","timestamp":1715643991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286324000676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":35,"alternative-id":["S0955286324000676"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109634","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impacts of the vegetable Urtica dioica on the intestinal T and B cell phenotype and macronutrient absorption in C57BL\/6J mice with diet-induced obesity","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109634","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109634"}}