{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:01:46Z","timestamp":1787868106100,"version":"build-2784847793"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jnutbio.2024.109673","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T11:36:13Z","timestamp":1718019373000},"page":"109673","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Association between flavonoid intake and rheumatoid arthritis among US adults"],"prefix":"10.1016","volume":"131","author":[{"given":"Yan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4346-7159","authenticated-orcid":false,"given":"Haoxian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4977-259X","authenticated-orcid":false,"given":"Nan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penchao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4561-4172","authenticated-orcid":false,"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4104-2402","authenticated-orcid":false,"given":"Jingtao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-0688","authenticated-orcid":false,"given":"Ling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jnutbio.2024.109673_bib0001","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1186\/ar578","article-title":"Epidemiology and genetics of rheumatoid arthritis","volume":"4","author":"Silman","year":"2002","journal-title":"Arthritis Res"},{"issue":"13","key":"10.1016\/j.jnutbio.2024.109673_bib0002","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: a review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.jnutbio.2024.109673_bib0003","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3390\/cells9040880","article-title":"Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis","volume":"9","author":"Lin","year":"2020","journal-title":"Cells"},{"issue":"10055","key":"10.1016\/j.jnutbio.2024.109673_bib0004","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.jnutbio.2024.109673_bib0005","first-page":"S128","article-title":"Epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis: a Synopsis","volume":"20","author":"Gibofsky","year":"2014","journal-title":"Am J Manag Care"},{"issue":"160","key":"10.1016\/j.jnutbio.2024.109673_bib0006","doi-asserted-by":"crossref","first-page":"210011","DOI":"10.1183\/16000617.0011-2021","article-title":"Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management","volume":"30","author":"Kadura","year":"2021","journal-title":"Eur Respir Rev"},{"issue":"2","key":"10.1016\/j.jnutbio.2024.109673_bib0007","first-page":"243","article-title":"Skin manifestations of rheumatoid arthritis","volume":"153","author":"Lora","year":"2018","journal-title":"G Ital Dermatol Venereol"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109673_bib0008","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13075-015-0601-x","article-title":"Body mass index and the risk of rheumatoid arthritis: a systematic review and dose-response meta-analysis","volume":"17","author":"Qin","year":"2015","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"10.1016\/j.jnutbio.2024.109673_bib0009","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1017\/S0007114515002093","article-title":"Low-grade inflammation, diet composition and health: current research evidence and its translation","volume":"114","author":"Minihane","year":"2015","journal-title":"Br J Nutr"},{"issue":"12","key":"10.1016\/j.jnutbio.2024.109673_bib0010","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1007\/s10067-016-3383-x","article-title":"Dietary intake and risk of rheumatoid arthritis-a cross section multicenter study","volume":"35","author":"He","year":"2016","journal-title":"Clin Rheumatol"},{"issue":"17","key":"10.1016\/j.jnutbio.2024.109673_bib0011","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.3390\/molecules26175377","article-title":"Plant flavonoids: chemical characteristics and biological activity","volume":"26","author":"Dias","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109673_bib0012","first-page":"118","article-title":"The role of polyphenols in abiotic stress response: the influence of molecular structure","volume":"10","author":"\u0160amec","year":"2021","journal-title":"Plants (Basel)"},{"key":"10.1016\/j.jnutbio.2024.109673_bib0013","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jot.2019.07.007","article-title":"Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6\/JAK2\/STAT3\/VEGF signalling pathway","volume":"22","author":"Cheng","year":"2020","journal-title":"J Orthop Translat"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109673_bib0014","first-page":"161","article-title":"Comparison of the effects of genistein and daidzein with dexamethasone and soy protein on rheumatoid arthritis in rats","volume":"1","author":"Mohammad-Shahi","year":"2011","journal-title":"Bioimpacts"},{"issue":"4","key":"10.1016\/j.jnutbio.2024.109673_bib0015","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1017\/S0007114512005594","article-title":"Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4\/NF-\u03baB signalling","volume":"110","author":"Dou","year":"2013","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jnutbio.2024.109673_bib0016","doi-asserted-by":"crossref","first-page":"392062","DOI":"10.1155\/2014\/392062","article-title":"A natural flavonoid glucoside, icariin, regulates Th17 and alleviates rheumatoid arthritis in a murine model","volume":"2014","author":"Chi","year":"2014","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.jnutbio.2024.109673_bib0017","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2147\/DDDT.S52354","article-title":"Genistein suppresses tumor necrosis factor \u03b1-induced inflammation via modulating reactive oxygen species\/Akt\/nuclear factor \u03baB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells","volume":"8","author":"Li","year":"2014","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.jnutbio.2024.109673_bib0018","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.3389\/fimmu.2018.02267","article-title":"Naringenin modifies the development of lineage-specific effector CD4(+) T Cells","volume":"9","author":"Wang","year":"2018","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.jnutbio.2024.109673_bib0019","first-page":"903","article-title":"Effects of naringenin on experimentally induced rheumatoid arthritis in Wistar rats","volume":"76","author":"Hajizadeh","year":"2021","journal-title":"Arch Razi Inst"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109673_bib0020","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s10020-022-00432-5","article-title":"Quercetin mitigates rheumatoid arthritis by inhibiting adenosine deaminase in rats","volume":"28","author":"El-Said","year":"2022","journal-title":"Mol Med"},{"issue":"8","key":"10.1016\/j.jnutbio.2024.109673_bib0021","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3390\/nu9080827","article-title":"Dietary flavonoid intake is inversely associated with cardiovascular disease risk as assessed by body mass index and waist circumference among adults in the United States","volume":"9","author":"Sebastian","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2024.109673_bib0022","doi-asserted-by":"crossref","first-page":"g14","DOI":"10.1136\/bmj.g14","article-title":"First trimester fetal growth restriction and cardiovascular risk factors in school age children: population based cohort study","volume":"348","author":"Jaddoe","year":"2014","journal-title":"BMJ"},{"issue":"10","key":"10.1016\/j.jnutbio.2024.109673_bib0023","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1093\/cid\/cix106","article-title":"A prospective study of urinary prostaglandin E2 metabolite, helicobacter pylori antibodies, and gastric cancer risk","volume":"64","author":"Wang","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"2","key":"10.1016\/j.jnutbio.2024.109673_bib0024","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1039\/D3FO02065G","article-title":"Intake of dietary flavonoids in relation to bone loss among U.S. adults: a promising strategy for improving bone health","volume":"15","author":"Zheng","year":"2024","journal-title":"Food Funct"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109673_bib0025","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12967-024-04949-7","article-title":"Association of dietary flavonoid intakes with prevalence of chronic respiratory diseases in adults","volume":"22","author":"Wu","year":"2024","journal-title":"J Transl Med"},{"key":"10.1016\/j.jnutbio.2024.109673_bib0026","doi-asserted-by":"crossref","first-page":"1287856","DOI":"10.3389\/fimmu.2023.1287856","article-title":"J-shaped association of dietary catechins intake with the prevalence of osteoarthritis and moderating effect of physical activity: an American population-based cohort study","volume":"14","author":"Fu","year":"2023","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.jnutbio.2024.109673_bib0027","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/biof.1363","article-title":"Flavanones: citrus phytochemical with health-promoting properties","volume":"43","author":"Barreca","year":"2017","journal-title":"Biofactors"},{"key":"10.1016\/j.jnutbio.2024.109673_bib0028","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.fitote.2013.07.020","article-title":"Isolation of xanthone and benzophenone derivatives from Cyclopia genistoides (L.) Vent. (honeybush) and their pro-apoptotic activity on synoviocytes from patients with rheumatoid arthritis","volume":"90","author":"Kokotkiewicz","year":"2013","journal-title":"Fitoterapia"},{"issue":"5","key":"10.1016\/j.jnutbio.2024.109673_bib0029","doi-asserted-by":"crossref","first-page":"E782","DOI":"10.1210\/jc.2010-2879","article-title":"Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome","volume":"96","author":"Rizza","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"5-6","key":"10.1016\/j.jnutbio.2024.109673_bib0030","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000439538","article-title":"Protective effects of simvastatin and hesperidin against complete freund's adjuvant-induced rheumatoid arthritis in rats","volume":"96","author":"Ahmed","year":"2015","journal-title":"Pharmacology"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109673_bib0031","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00296-012-2430-4","article-title":"Hesperidin inhibits collagen-induced arthritis possibly through suppression of free radical load and reduction in neutrophil activation and infiltration","volume":"33","author":"Umar","year":"2013","journal-title":"Rheumatol Int"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109673_bib0032","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/08923973.2012.723010","article-title":"7,3\u2032-dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis","volume":"35","author":"Li","year":"2013","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.jnutbio.2024.109673_bib0033","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.intimp.2015.11.036","article-title":"Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NF\u03baB and PCNA expression","volume":"30","author":"Bodduluru","year":"2016","journal-title":"Int Immunopharmacol"},{"issue":"14","key":"10.1016\/j.jnutbio.2024.109673_bib0034","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1080\/10408398.2020.1870035","article-title":"Citrus flavonoids and their antioxidant evaluation","volume":"62","author":"Wang","year":"2022","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"17","key":"10.1016\/j.jnutbio.2024.109673_bib0035","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1080\/10408398.2016.1246413","article-title":"The therapeutic potential of plant flavonoids on rheumatoid arthritis","volume":"57","author":"Hughes","year":"2017","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jnutbio.2024.109673_bib0036","doi-asserted-by":"crossref","first-page":"9324357","DOI":"10.1155\/2018\/9324357","article-title":"The role of flavonoids in inhibiting Th17 responses in inflammatory arthritis","volume":"2018","author":"Kelepouri","year":"2018","journal-title":"J Immunol Res"},{"issue":"5","key":"10.1016\/j.jnutbio.2024.109673_bib0037","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.phymed.2005.01.016","article-title":"Structure-activity relations of inhibitory effects of various flavonoids on lipopolysaccharide-induced prostaglandin E2 production in rat peritoneal macrophages: comparison between subclasses of flavonoids","volume":"13","author":"Takano-Ishikawa","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jnutbio.2024.109673_bib0038","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.pharmthera.2018.09.009","article-title":"The role of flavonoids in autoimmune diseases: Therapeutic updates","volume":"194","author":"Rengasamy","year":"2019","journal-title":"Pharmacol Ther"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324001062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324001062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T20:53:32Z","timestamp":1723496012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286324001062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":38,"alternative-id":["S0955286324001062"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109673","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between flavonoid intake and rheumatoid arthritis among US adults","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109673","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109673"}}