{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:58:01Z","timestamp":1787497081974,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013840","name":"Biocenter Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013840","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015738","name":"Mary and Georg C Ehrnrooth Foundation","doi-asserted-by":"publisher","award":["202200015"],"award-info":[{"award-number":["202200015"]}],"id":[{"id":"10.13039\/100015738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["314925"],"award-info":[{"award-number":["314925"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004012","name":"Jane and Aatos Erkko Fundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jnutbio.2024.109692","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T13:43:34Z","timestamp":1718286214000},"page":"109692","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Exploration of dietary interventions to treat mitochondrial fatty acid disorders in a mouse model"],"prefix":"10.1016","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9398-7649","authenticated-orcid":false,"given":"Kaija J.","family":"Autio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hennariikka","family":"Koivisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Puronurmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Tanila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-9214","authenticated-orcid":false,"given":"Alexander J.","family":"Kastaniotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2024.109692_bib0001","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12966-023-01463-9","article-title":"Practical dietary interventions to prevent cardiovascular disease suitable for implementation in primary care: an ADAPTE-guided systematic review of international clinical guidelines","volume":"20","author":"Le Goff","year":"2023","journal-title":"Intl J Behavl Nutr Physical Act"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0002","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/PSY.0000000000000673","article-title":"The effects of dietary improvement on symptoms of depression and anxiety: a meta-analysis of randomized controlled trials","volume":"81","author":"Firth","year":"2019","journal-title":"Psychosom Med"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0003","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.3390\/nu14204261","article-title":"Dietary interventions in inflammatory bowel disease","volume":"14","author":"Godala","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2023.103408","article-title":"Namdar Ahmadabad H. Intermittent fasting: a promising dietary intervention for autoimmune diseases","volume":"22","author":"Barati","year":"2023","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0005","doi-asserted-by":"crossref","first-page":"10672","DOI":"10.3390\/ijms241310672","article-title":"New insights and potential therapeutic interventions in metabolic diseases","volume":"24","author":"Clemente-Su\u00e1rez","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0006","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ymgme.2016.09.002","article-title":"Nutritional interventions in primary mitochondrial disorders: developing an evidence base","volume":"119","author":"Camp","year":"2016","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0007","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s11940-009-0046-0","article-title":"A modern approach to the treatment of mitochondrial disease","volume":"11","author":"Parikh","year":"2009","journal-title":"Curr Treat Options Neurol"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0008","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbalip.2016.08.011","article-title":"Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology","volume":"1862","author":"Kastaniotis","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0009","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.ajhg.2016.09.021","article-title":"MECR mutations cause childhood-onset dystonia and optic atrophy, a mitochondrial fatty acid synthesis disorder","volume":"99","author":"Heimer","year":"2016","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1136\/jmg-2023-109340","article-title":"Recessive MECR pathogenic variants cause an LHON-like optic neuropathy","volume":"61","author":"Fiorini","year":"2024","journal-title":"J Med Genet"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0011","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/hmg\/ddz311","article-title":"Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy","volume":"29","author":"Li","year":"2020","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0012","doi-asserted-by":"crossref","unstructured":"Webb BD, Nowinski SM, Solmonson A, Ganesh J, Rodenburg RJ, Leandro J, et al. Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency 2023;12:68047. https:\/\/doi.org\/10.7554\/eLife.","DOI":"10.7554\/eLife.68047"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0013","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1093\/hmg\/ddx105","article-title":"Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA\/ACP reductase in placental development in mice","volume":"26","author":"Nair","year":"2017","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0014","doi-asserted-by":"crossref","first-page":"9781","DOI":"10.1523\/JNEUROSCI.3514-17.2018","article-title":"Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice","volume":"38","author":"Nair","year":"2018","journal-title":"J Neurosci"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0015","doi-asserted-by":"crossref","first-page":"7522","DOI":"10.1074\/jbc.TM117.000259","article-title":"Lipoic acid metabolism and mitochondrial redox regulation","volume":"293","author":"Solmonson","year":"2018","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0016","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3390\/biom9080356","article-title":"Insights on the use of \u03b1-lipoic acid for therapeutic purposes","volume":"9","author":"Salehi","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0017","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1007\/s11064-022-03598-w","article-title":"Abdel-Daim MM. \u03b1-Lipoic acid, an organosulfur biomolecule a novel therapeutic agent for neurodegenerative disorders: an mechanistic perspective","volume":"47","author":"Khan","year":"2022","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0018","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1038\/s41467-023-39151-8","article-title":"Chemoproteomic target deconvolution reveals histone deacetylases as targets of (R)-lipoic acid","volume":"14","author":"Lechner","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101948","article-title":"Htd2 deficiency-associated suppression of alpha-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes","volume":"41","author":"Zeng","year":"2021","journal-title":"Redox Biol"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0020","doi-asserted-by":"crossref","first-page":"17184","DOI":"10.1074\/jbc.M114.550806","article-title":"4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function","volume":"289","author":"Chen","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2019.118540","article-title":"Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function","volume":"1866","author":"Masud","year":"2019","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0022","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/1073858420936162","article-title":"Mitochondrial fatty acids and neurodegenerative disorders","volume":"27","author":"Kastaniotis","year":"2021","journal-title":"Neuroscientist"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0023","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12915-021-00951-3","article-title":"Genetic dissection of the mitochondrial lipoylation pathway in yeast","volume":"19","author":"Pietik\u00e4inen","year":"2021","journal-title":"BMC Biol"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0024","series-title":"GeneReviews","article-title":"MECR-related neurologic disorder","author":"Heimer","year":"1993"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/gene.20062","article-title":"Highly restricted expression of Cre recombinase in cerebellar Purkinje cells","volume":"40","author":"Zhang","year":"2004","journal-title":"Genesis"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0026","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1471-4159.1988.tb02958.x","article-title":"Fatty acid transport through the blood-brain barrier","volume":"50","author":"Spector","year":"1988","journal-title":"J Neurochem"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0027","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13041-015-0101-6","article-title":"Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in rats","volume":"8","author":"Choi","year":"2015","journal-title":"Mol Brain"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0028","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0306-3623(96)00474-0","article-title":"The pharmacology of the antioxidant lipoic acid","volume":"29","author":"Biewenga","year":"1997","journal-title":"Gen Pharmac"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0029","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.idairyj.2006.06.015","article-title":"Medium-chain triglycerides","volume":"16","author":"Marten","year":"2006","journal-title":"Int Dairy J"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0030","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1194\/jlr.R067629","article-title":"Short- and medium-chain fatty acids in energy metabolism: the cellular perspective","volume":"57","author":"Sch\u00f6nfeld","year":"2016","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0031","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/mmi.12402","article-title":"Defects in mitochondrial fatty acid synthesis result in failure of multiple aspects of mitochondrial biogenesis in Saccharomyces cerevisiae","volume":"90","author":"Kursu","year":"2013","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0032","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.molcel.2018.06.039","article-title":"ACP acylation is an acetyl-CoA-dependent modification required for electron transport chain assembly","volume":"71","author":"Van","year":"2018","journal-title":"Mol Cell"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0033","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41467-023-36358-7","article-title":"An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration","volume":"14","author":"Rahman","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0034","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/taap.2002.9437","article-title":"Antioxidant and prooxidant activities of \u03b1-lipoic acid and dihydrolipoic acid","volume":"182","author":"Moini","year":"2002","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0035","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s11064-007-9403-0","article-title":"The effects and mechanisms of mitochondrial nutrient \u03b1-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview","volume":"33","author":"Liu","year":"2008","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0036","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1042\/EBC20170114","article-title":"Emerging therapies for mitochondrial diseases","volume":"62","author":"Hirano","year":"2018","journal-title":"Essays Biochem"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0037","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/MOP.0000000000000954","article-title":"Mitochondrial medicine therapies: rationale, evidence, and dosing guidelines","volume":"32","author":"Barcelos","year":"2020","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0038","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/jnr.490180407","article-title":"Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture","volume":"18","author":"Edmond","year":"1987","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0039","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000508054","article-title":"Brain fuel utilization in the developing brain","volume":"75","author":"Steiner","year":"2020","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.jnutbio.2024.109692_bib0040","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev-genom-091416-035340","article-title":"On the evolution of lactase persistence in humans","volume":"8","author":"S\u00e9gurel","year":"2017","journal-title":"Annu Rev Genomics Hum Genet"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324001256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324001256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T22:00:56Z","timestamp":1728338456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286324001256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":40,"alternative-id":["S0955286324001256"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109692","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploration of dietary interventions to treat mitochondrial fatty acid disorders in a mouse model","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109692","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109692"}}