{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:25:24Z","timestamp":1792725924754,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jnutbio.2024.109788","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T06:56:38Z","timestamp":1729752998000},"page":"109788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Lipidomic profiling of serum and liver tissue reveals hepatoprotective mechanism of taxifolin in rats with CCl4-induced subacute hepatic injury based on LC-MS\/MS"],"prefix":"10.1016","volume":"136","author":[{"given":"Yiming","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1172-7323","authenticated-orcid":false,"given":"Long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingmei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2024.109788_bib0001","article-title":"Zerumbone protects against carbon tetrachloride (CCl(4))-induced acute liver injury in mice via inhibiting oxidative stress and the inflammatory response: involving the TLR4\/NF-\u03baB\/COX-2 pathway","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0002","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/cphy.c120027","article-title":"Bile formation and secretion","volume":"3","author":"Boyer","year":"2013","journal-title":"Comprehensive Physiol"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0003","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver regeneration: biological and pathological mechanisms and implications","volume":"18","author":"Michalopoulos","year":"2021","journal-title":"Nat Rev. Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0004","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Current biology\u202f: CB"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0005","article-title":"Inhibition of oxidative stress and ALOX12 and NF-\u03baB pathways contribute to the protective effect of baicalein on carbon tetrachloride-induced acute liver injury","volume":"10","author":"Dai","year":"2021","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0006","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12906-017-1604-8","article-title":"Hepatoprotective effect of Coreopsis tinctoria flowers against carbon tetrachloride-induced liver damage in mice","volume":"17","author":"Tsai","year":"2017","journal-title":"BMC Compl Altern Med"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0007","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21091209","article-title":"Detection of 191 taxifolin metabolites and their distribution in rats using HPLC-ESI-IT-TOF-MS(n)","volume":"21","author":"Yang","year":"2016","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2019.112066","article-title":"An insight into the health-promoting effects of taxifolin (dihydroquercetin)","volume":"166","author":"Sunil","year":"2019","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071546","article-title":"Taxifolin activates the Nrf2 anti-oxidative stress pathway in mouse skin epidermal JB6 P+ cells through epigenetic modifications","volume":"18","author":"Kuang","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116939","article-title":"5,7,3\u2032,4\u2032-flavan-on-ol (taxifolin) protects against acetaminophen-induced liver injury by regulating the glutathione pathway","volume":"236","author":"Hu","year":"2019","journal-title":"Life sciences"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0011","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/S0022-2275(20)32358-0","article-title":"Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid","volume":"41","author":"Theriault","year":"2000","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0012","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2147\/DDDT.S281369","article-title":"Taxifolin, extracted from waste larix olgensis roots, attenuates CCl(4)-induced liver fibrosis by regulating the PI3K\/AKT\/mTOR and TGF-\u03b21\/Smads signaling pathways","volume":"15","author":"Liu","year":"2021","journal-title":"Drug Design, Develop Ther"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0013","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12944-016-0244-1","article-title":"Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats","volume":"15","author":"Ishikawa","year":"2016","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2022.105341","article-title":"Hepatic lipidomics and proteomics analysis reveals the mechanism of Cyclocarya paliurus flavonoids in preventing non-alcoholic steatohepatitis in mice","volume":"99","author":"Wang","year":"2022","journal-title":"J Funct Foods"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0015","first-page":"1","article-title":"Triglyceride metabolism in the liver","volume":"8","author":"Alves-Bezerra","year":"2017","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114527","article-title":"Acute liver injury induced by carbon tetrachloride reversal by Gandankang aqueous extracts through nuclear factor erythroid 2-related factor 2 signaling pathway","volume":"251","author":"Wei","year":"2023","journal-title":"Ecotoxicol Environment Safety"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0017","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/BJ20111451","article-title":"Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling","volume":"441","author":"Lee","year":"2012","journal-title":"Biochem J"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0018","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jep.2017.02.018","article-title":"Protective effect of a polysaccharide from Anoectochilus roxburghii against carbon tetrachloride-induced acute liver injury in mice","volume":"200","author":"Zeng","year":"2017","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0019","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084429","article-title":"S-acetyl-glutathione attenuates carbon tetrachloride-induced liver injury by modulating oxidative imbalance and inflammation","volume":"23","author":"Di Paola","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0020","article-title":"Pharmacological basis and new insights of taxifolin: a comprehensive review","volume":"142","author":"Das","year":"2021","journal-title":"Biomed Pharmacother = Biomed & pharmacother"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0021","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1016\/j.fshw.2023.03.034","article-title":"Fabrication of taxifolin loaded zein-caseinate nanoparticles and its bioavailability in rats","volume":"12","author":"Li","year":"2023","journal-title":"Food Sci Human Wellness"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0022","article-title":"Metabolism, tissue distribution and excretion of taxifolin in rat","volume":"150","author":"Li","year":"2022","journal-title":"Biomed Pharmacother = Biomed pharmacother"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0023","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijbiomac.2020.02.027","article-title":"In vitro and in vivo inhibitory activity of taxifolin on three digestive enzymes","volume":"150","author":"Su","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0024","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201606","article-title":"Lipid metabolism and cancer","volume":"218","author":"Bian","year":"2021","journal-title":"J Exp Med"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0025","doi-asserted-by":"crossref","first-page":"35037","DOI":"10.1038\/srep35037","article-title":"Comprehensive plasma metabolomic analyses of atherosclerotic progression reveal alterations in glycerophospholipid and sphingolipid metabolism in apolipoprotein E-deficient mice","volume":"6","author":"Dang","year":"2016","journal-title":"Scientific Rep"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0026","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ecoenv.2017.08.028","article-title":"Cell metabolomics reveals the neurotoxicity mechanism of cadmium in PC12 cells","volume":"147","author":"Zong","year":"2018","journal-title":"Ecotoxicol Environment safety"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0027","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jgg.2019.11.009","article-title":"Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression","volume":"47","author":"Wang","year":"2020","journal-title":"J Genetics Genomics = Yi chuan xue bao"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0028","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease","volume":"1859","author":"van der Veen","year":"2017","journal-title":"Biochimica et biophysica acta. Biomembranes"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0029","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1039\/D0FO02632H","article-title":"Effect of different phosphatidylcholines on high fat diet-induced insulin resistance in mice","volume":"12","author":"Gao","year":"2021","journal-title":"Food Funct"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0030","first-page":"2546","article-title":"Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing akt membrane binding","volume":"110","author":"Koeberle","year":"2013"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.708978","article-title":"Hepatic macrophage as a key player in fatty liver disease","volume":"12","author":"Xu","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0032","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.prostaglandins.2009.04.009","article-title":"Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol","volume":"89","author":"Makide","year":"2009","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0033","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/acer.13558","article-title":"Applications and challenges for the use of phosphatidylethanol testing in liver disease patients (mini review)","volume":"42","author":"Nguyen","year":"2018","journal-title":"Alcohol, Clin Exp Res"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0034","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1038\/s41467-021-21669-4","article-title":"Metabolomics of sebum reveals lipid dysregulation in Parkinson's disease","volume":"12","author":"Sinclair","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021034","article-title":"Phosphatidylethanolamines are associated with nonalcoholic fatty liver disease (NAFLD) in obese adults and induce liver cell metabolic perturbations and hepatic stellate cell activation","volume":"24","author":"Shama","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0036","doi-asserted-by":"crossref","DOI":"10.3390\/biom10111497","article-title":"Sphingomyelinases and liver diseases","volume":"10","author":"Insausti-Urkia","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0037","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.tips.2017.04.004","article-title":"Roles of diacylglycerols and ceramides in hepatic insulin resistance","volume":"38","author":"Petersen","year":"2017","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0038","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.freeradbiomed.2019.05.029","article-title":"Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease","volume":"144","author":"Svegliati-Baroni","year":"2019","journal-title":"Free Radical Biol Med"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0039","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010040","article-title":"Sphingolipids in non-alcoholic fatty liver disease and hepatocellular carcinoma: ceramide turnover","volume":"21","author":"Simon","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0040","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1515\/hsz-2014-0296","article-title":"Sphingolipids in liver injury, repair and regeneration","volume":"396","author":"Nojima","year":"2015","journal-title":"Biol Chem"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0041","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12944-018-0952-9","article-title":"Plasma lipidomic signatures of spontaneous obese rhesus monkeys","volume":"18","author":"Wang","year":"2019","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0042","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0163-7827(03)00051-1","article-title":"Enzymes of triacylglycerol synthesis and their regulation","volume":"43","author":"Coleman","year":"2004","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.jnutbio.2024.109788_bib0043","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s10886-021-01337-z","article-title":"Survival of plants during short-term BOA-OH exposure: ROS related gene expression and detoxification reactions are accompanied with fast membrane lipid repair in root tips","volume":"48","author":"Laschke","year":"2022","journal-title":"J Chem Ecol"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324002195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324002195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T11:36:40Z","timestamp":1733571400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286324002195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":43,"alternative-id":["S0955286324002195"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109788","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipidomic profiling of serum and liver tissue reveals hepatoprotective mechanism of taxifolin in rats with CCl4-induced subacute hepatic injury based on LC-MS\/MS","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109788","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109788"}}