{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:34:06Z","timestamp":1793126046478,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002668","name":"Abant Izzet Baysal \u00dcniversitesi","doi-asserted-by":"publisher","award":["2021.08.02.1532"],"award-info":[{"award-number":["2021.08.02.1532"]}],"id":[{"id":"10.13039\/501100002668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002668","name":"Abant Izzet Baysal \u00dcniversitesi","doi-asserted-by":"publisher","award":["2021\/26"],"award-info":[{"award-number":["2021\/26"]}],"id":[{"id":"10.13039\/501100002668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jnutbio.2024.109800","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T15:25:47Z","timestamp":1731425147000},"page":"109800","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Proposed receptor-mediated mechanisms of melatonin in nitroglycerin-induced migraine-like hyperalgesic conditions in rats"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9261-2634","authenticated-orcid":false,"given":"Erkan","family":"Kilinc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7035-3336","authenticated-orcid":false,"given":"Ibrahim Ethem","family":"Torun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Baranoglu Kilinc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"T\u00f6re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.jnutbio.2024.109800_bib0001","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1177\/0333102418771350","article-title":"Current understanding of meningeal and cerebral vascular function underlying migraine headache","volume":"39","author":"Levy","year":"2019","journal-title":"Cephalalgia"},{"issue":"7","key":"10.1016\/j.jnutbio.2024.109800_bib0002","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S1474-4422(09)70090-0","article-title":"Origin of pain in migraine: evidence for peripheral sensitisation","volume":"8","author":"Olesen","year":"2009","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109800_bib0003","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00221-009-1756-y","article-title":"Migraine: where and how does the pain originate?","volume":"196","author":"Messlinger","year":"2009","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.jnutbio.2024.109800_bib0004","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neuropharm.2016.12.024","article-title":"Serotonergic mechanisms of trigeminal meningeal nociception: implications for migraine pain","volume":"116","author":"Kilinc","year":"2017","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.jnutbio.2024.109800_bib0005","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1111\/head.14618","article-title":"Mitochondrial metabolism related markers GDF-15, FGF-21, and HIF-1\u03b1 are elevated in pediatric migraine attacks","volume":"63","author":"Kilinc","year":"2023","journal-title":"Headache"},{"key":"10.1016\/j.jnutbio.2024.109800_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynpai.2022.100091","article-title":"Cortical spreading depression and meningeal nociception","volume":"11","author":"Carneiro-Nascimento","year":"2022","journal-title":"Neurobiol Pain"},{"issue":"2","key":"10.1016\/j.jnutbio.2024.109800_bib0007","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nm0202-136","article-title":"Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model","volume":"8","author":"Bolay","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2024.109800_bib0008","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fncel.2019.00136","article-title":"Shared fate of meningeal mast cells and sensory neurons in migraine","volume":"13","author":"Koyuncu Irmak","year":"2019","journal-title":"Front Cell Neurosci"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109800_bib0009","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1046\/j.1468-2982.1997.1703166.x","article-title":"Release of histamine from dural mast cells by substance P and calcitonin gene-related peptide","volume":"17","author":"Ottosson","year":"1997","journal-title":"Cephalalgia"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109800_bib0010","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S1474-4422(21)00409-9","article-title":"Calcitonin gene-related peptide-targeting drugs for migraine: how pharmacology might inform treatment decisions","volume":"21","author":"Al-Hassany","year":"2022","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jnutbio.2024.109800_bib0011","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbi.2021.01.034","article-title":"Anti-inflammatory effects of melatonin: a systematic review and meta-analysis of clinical trials","volume":"93","author":"Cho","year":"2021","journal-title":"Brain Behav Immun"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109800_bib0012","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3390\/antiox11030532","article-title":"Melatonin and related compounds: antioxidant and anti-inflammatory actions","volume":"11","author":"Bantounou","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109800_bib0013","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1600-079X.2011.00895.x","article-title":"Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies","volume":"51","author":"Wilhelmsen","year":"2011","journal-title":"J Pineal Res"},{"issue":"5","key":"10.1016\/j.jnutbio.2024.109800_bib0014","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.3390\/jcm13051278","article-title":"Non-pharmacological treatments in paediatric migraine","volume":"13","author":"Baglioni","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.jnutbio.2024.109800_bib0015","doi-asserted-by":"crossref","first-page":"e6877","DOI":"10.7717\/peerj.6877","article-title":"Distribution and colocalization of melatonin 1a-receptor and NADPH-d in the trigeminal system of rat","volume":"7","author":"He","year":"2019","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109800_bib0016","doi-asserted-by":"crossref","first-page":"e12575","DOI":"10.1111\/jpi.12575","article-title":"MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations","volume":"67","author":"Klosen","year":"2019","journal-title":"J Pineal Res"},{"issue":"4","key":"10.1016\/j.jnutbio.2024.109800_bib0017","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1600-079X.1995.tb00186.x","article-title":"Melatonin receptors in the rat brain and pituitary","volume":"19","author":"Williams","year":"1995","journal-title":"J Pineal Res"},{"issue":"5","key":"10.1016\/j.jnutbio.2024.109800_bib0018","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.anl.2011.09.007","article-title":"Immunohistochemical and biomolecular identification of melatonin 1a and 1b receptors in rat vestibular nuclei","volume":"39","author":"Ahn","year":"2012","journal-title":"Auris Nasus Larynx"},{"issue":"7","key":"10.1016\/j.jnutbio.2024.109800_bib0019","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1007\/s00429-017-1439-6","article-title":"Melatonin receptors: distribution in mammalian brain and their respective putative functions","volume":"222","author":"Ng","year":"2017","journal-title":"Brain Struct Funct"},{"issue":"13","key":"10.1016\/j.jnutbio.2024.109800_bib0020","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1177\/0333102419868187","article-title":"Current understanding of pineal gland structure and function in headache","volume":"39","author":"Peres","year":"2019","journal-title":"Cephalalgia"},{"issue":"6","key":"10.1016\/j.jnutbio.2024.109800_bib0021","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1136\/jnnp.71.6.747","article-title":"Hypothalamic involvement in chronic migraine","volume":"71","author":"Peres","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2","key":"10.1016\/j.jnutbio.2024.109800_bib0022","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1046\/j.1468-2982.1995.015002136.x","article-title":"Nocturnal melatonin excretion is decreased in patients with migraine without aura attacks associated with menses","volume":"15","author":"Brun","year":"1995","journal-title":"Cephalalgia"},{"issue":"4","key":"10.1016\/j.jnutbio.2024.109800_bib0023","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10194-008-0047-5","article-title":"Low urinary 6-sulphatoxymelatonin concentrations in acute migraine","volume":"9","author":"Masruha","year":"2008","journal-title":"J Headache Pain"},{"key":"10.1016\/j.jnutbio.2024.109800_bib0024","first-page":"619","article-title":"Regulation of CGRP release from rat trigeminal nucleus caudalis by melatonin: B068","volume":"27","author":"Amado","year":"2007","journal-title":"Cephalalgia"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109800_bib0025","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s13760-017-0803-x","article-title":"The effect of melatonin on gene expression of calcitonin gene-related peptide and some proinflammatory mediators in patients with pure menstrual migraine","volume":"117","author":"Ansari","year":"2017","journal-title":"Acta Neurol Belg"},{"issue":"9","key":"10.1016\/j.jnutbio.2024.109800_bib0026","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1111\/ejn.15888","article-title":"Meningeal mast cell-mediated mechanisms of cholinergic system modulation in neurogenic inflammation underlying the pathophysiology of migraine","volume":"59","author":"Kilinc","year":"2024","journal-title":"Eur J Neurosci"},{"issue":"6","key":"10.1016\/j.jnutbio.2024.109800_bib0027","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/ejn.16106","article-title":"D2 dopamine receptor-mediated mechanisms of dopaminergic system modulation in in vivo and in vitro experimental models of migraine","volume":"59","author":"Baranoglu Kilinc","year":"2024","journal-title":"Eur J Neurosci"},{"issue":"6","key":"10.1016\/j.jnutbio.2024.109800_bib0028","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1007\/s10753-017-0645-y","article-title":"Melatonin Attenuates Pain Hypersensitivity and Decreases Astrocyte-Mediated Spinal Neuroinflammation in a Rat Model of Oxaliplatin-Induced Pain","volume":"40","author":"Wang","year":"2017","journal-title":"Inflammation"},{"issue":"7","key":"10.1016\/j.jnutbio.2024.109800_bib0029","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.7150\/thno.19500","article-title":"Melatonin Suppresses Neuropathic Pain via MT2-Dependent and -Independent Pathways in Dorsal Root Ganglia Neurons of Mice","volume":"7","author":"Lin","year":"2017","journal-title":"Theranostics"},{"issue":"10","key":"10.1016\/j.jnutbio.2024.109800_bib0030","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.3390\/ijms20102452","article-title":"Melatonin MT1 and MT2 receptors exhibit distinct effects in the modulation of body temperature across the light\/dark cycle","volume":"20","author":"L\u00f3pez-Canul","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109800_bib0031","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ana.21994","article-title":"Thalamic sensitization transforms localized pain into widespread allodynia","volume":"68","author":"Burstein","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jnutbio.2024.109800_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynpai.2022.100105","article-title":"Nitroglycerin as a model of migraine: clinical and preclinical review","volume":"12","author":"Sureda-Gibert","year":"2022","journal-title":"Neurobiol Pain"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109800_bib0033","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1468-2982.2009.01924.x","article-title":"Alterations of the endocannabinoid system in an animal model of migraine: evaluation in cerebral areas of rat","volume":"30","author":"Greco","year":"2010","journal-title":"Cephalalgia"},{"issue":"13","key":"10.1016\/j.jnutbio.2024.109800_bib0034","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1177\/03331024221114773","article-title":"The effects of certain TRP channels and voltage-gated KCNQ\/Kv7 channel opener retigabine on calcitonin gene-related peptide release in the trigeminovascular system","volume":"42","author":"Citak","year":"2022","journal-title":"Cephalalgia"},{"issue":"183","key":"10.1016\/j.jnutbio.2024.109800_bib0035","doi-asserted-by":"crossref","DOI":"10.3791\/63723","article-title":"Ex vivo release of calcitonin gene-related peptide from the trigeminovascular system in rodents","author":"Rasmussen","year":"2022","journal-title":"J Vis Exp"},{"issue":"1-2","key":"10.1016\/j.jnutbio.2024.109800_bib0036","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pain.2007.03.012","article-title":"Mast cell degranulation activates a pain pathway underlying migraine headache","volume":"130","author":"Levy","year":"2007","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.jnutbio.2024.109800_bib0037","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1097\/j.pain.0000000000001481","article-title":"Intact mast cell content during mild head injury is required for development of latent pain sensitization: implications for mechanisms underlying post-traumatic headache","volume":"160","author":"Bree","year":"2019","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.jnutbio.2024.109800_bib0038","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1097\/j.pain.0000000000001801","article-title":"Lasmiditan inhibits calcitonin gene-related peptide release in the rodent trigeminovascular system","volume":"161","author":"Labastida-Ram\u00edrez","year":"2020","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109800_bib0039","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s10753-019-01115-w","article-title":"Thymoquinone inhibits neurogenic inflammation underlying migraine through modulation of calcitonin gene-related peptide release and stabilization of meningeal mast cells in glyceryltrinitrate-induced migraine model in rats","volume":"43","author":"Kilinc","year":"2020","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109800_bib0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1124\/jpet.114.218263","article-title":"Melatonin receptors trigger cAMP production and inhibit chloride movements in nonpigmented ciliary epithelial cells","volume":"352","author":"Huete-Toral","year":"2015","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109800_bib0041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40122-016-0049-y","article-title":"Melatonin in chronic pain syndromes","volume":"5","author":"Danilov","year":"2016","journal-title":"Pain Ther"},{"issue":"2","key":"10.1016\/j.jnutbio.2024.109800_bib0042","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1177\/0333102413502735","article-title":"Nitric oxide synthase, calcitonin gene-related peptide and NK-1 receptor mechanisms are involved in GTN-induced neuronal activation","volume":"34","author":"Ramachandran","year":"2014","journal-title":"Cephalalgia"},{"issue":"7","key":"10.1016\/j.jnutbio.2024.109800_bib0043","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.3390\/ijms25073706","article-title":"Differences in neuropathology between nitroglycerin-induced mouse models of episodic and chronic migraine","volume":"25","author":"Park","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109800_bib0044","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s10194-019-0963-6","article-title":"Behavioral and cognitive animal models in headache research","volume":"20","author":"Vuralli","year":"2019","journal-title":"J Headache Pain"},{"issue":"14","key":"10.1016\/j.jnutbio.2024.109800_bib0045","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1177\/0333102415574846","article-title":"Mechanisms of glyceryl trinitrate provoked mast cell degranulation","volume":"35","author":"Pedersen","year":"2015","journal-title":"Cephalalgia"},{"issue":"6","key":"10.1016\/j.jnutbio.2024.109800_bib0046","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/1440-1681.12915","article-title":"Salmon calcitonin ameliorates migraine pain through modulation of CGRP release and dural mast cell degranulation in rats","volume":"45","author":"Kilinc","year":"2018","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"4","key":"10.1016\/j.jnutbio.2024.109800_bib0047","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/ejn.14897","article-title":"Receptor mechanisms mediating the anti-neuroinflammatory effects of endocannabinoid system modulation in a rat model of migraine","volume":"55","author":"Kilinc","year":"2022","journal-title":"Eur J Neurosci"},{"issue":"4","key":"10.1016\/j.jnutbio.2024.109800_bib0048","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1177\/0271678X17733655","article-title":"Neurovascular mechanisms of migraine and cluster headache","volume":"39","author":"Hoffmann","year":"2019","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"10.1016\/j.jnutbio.2024.109800_bib0049","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10194-009-0097-3","article-title":"Melatonin treatment decreases c-fos expression in a headache model induced by capsaicin","volume":"10","author":"Tanuri","year":"2009","journal-title":"J Headache Pain"},{"key":"10.1016\/j.jnutbio.2024.109800_bib0050","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-neuro-080422-105509","article-title":"Meningeal mechanisms and the migraine connection","volume":"46","author":"Levy","year":"2023","journal-title":"Annu Rev Neurosci"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109800_bib0051","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3390\/biomedicines10010076","article-title":"Neurogenic inflammation: the participant in migraine and recent advancements in translational research","volume":"10","author":"Spekker","year":"2021","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109800_bib0052","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00281-018-0676-y","article-title":"Neurogenic inflammation and its role in migraine","volume":"40","author":"Ramachandran","year":"2018","journal-title":"Semin Immunopathol"},{"issue":"8","key":"10.1016\/j.jnutbio.2024.109800_bib0053","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1002\/jcb.25491","article-title":"Possible involvement of the inhibition of NF-\u03baB factor in anti-inflammatory actions that melatonin exerts on mast cells","volume":"117","author":"Maldonado","year":"2016","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jnutbio.2024.109800_bib0054","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jss.2016.11.055","article-title":"Melatonin reduces changes to small intestinal microvasculature during systemic inflammation","volume":"211","author":"Lansink","year":"2017","journal-title":"J Surg Res"},{"issue":"9","key":"10.1016\/j.jnutbio.2024.109800_bib0055","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1111\/bph.14971","article-title":"Adreno-melatonin receptor complexes control ion homeostasis and intraocular pressure - their disruption contributes to hypertensive glaucoma","volume":"177","author":"Alkozi","year":"2020","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10.1016\/j.jnutbio.2024.109800_bib0056","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2174\/157015912800604489","article-title":"Melatonin in antinociception: its therapeutic applications","volume":"10","author":"Srinivasan","year":"2012","journal-title":"Curr Neuropharmacol"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109800_bib0057","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.pain.2004.01.027","article-title":"Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats","volume":"109","author":"Tu","year":"2004","journal-title":"Pain"},{"issue":"1-3","key":"10.1016\/j.jnutbio.2024.109800_bib0058","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejphar.2007.09.006","article-title":"Melatonin reduces formalin-induced nociception and tactile allodynia in diabetic rats","volume":"577","author":"Arreola-Espino","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jnutbio.2024.109800_bib0059","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ejphar.2015.07.010","article-title":"Antinociceptive properties of selective MT(2) melatonin receptor partial agonists","volume":"764","author":"L\u00f3pez-Canul","year":"2015","journal-title":"Eur J Pharmacol"},{"issue":"32","key":"10.1016\/j.jnutbio.2024.109800_bib0060","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.2174\/0929867324666170209104926","article-title":"Targeting melatonin MT2 receptors: a novel pharmacological avenue for inflammatory and neuropathic pain","volume":"25","author":"Posa","year":"2018","journal-title":"Curr Med Chem"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109800_bib0061","doi-asserted-by":"crossref","first-page":"e12671","DOI":"10.1111\/jpi.12671","article-title":"Nociceptive responses in melatonin MT2 receptor knockout mice compared to MT1 and double MT1 \/MT2 receptor knockout mice","volume":"69","author":"Posa","year":"2020","journal-title":"J Pineal Res"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109800_bib0062","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.phrs.2009.11.014","article-title":"Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation","volume":"62","author":"Maldonado","year":"2010","journal-title":"Pharmacol Res"},{"issue":"2","key":"10.1016\/j.jnutbio.2024.109800_bib0063","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/med.21628","article-title":"Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation","volume":"40","author":"Ma","year":"2020","journal-title":"Med Res Rev"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109800_bib0064","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3390\/ijms23010471","article-title":"Membrane melatonin receptors activated cell signaling in physiology and disease","volume":"23","author":"Nikolaev","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109800_bib0065","doi-asserted-by":"crossref","first-page":"e12952","DOI":"10.1111\/jpi.12952","article-title":"Melatonin receptor structure and signaling","volume":"76","author":"Okamoto","year":"2024","journal-title":"J Pineal Res"},{"issue":"2","key":"10.1016\/j.jnutbio.2024.109800_bib0066","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1152\/physrev.00059.2021","article-title":"CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond","volume":"103","author":"Russo","year":"2023","journal-title":"Physiol Rev"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324002316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324002316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:35:42Z","timestamp":1777595742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286324002316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":66,"alternative-id":["S0955286324002316"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109800","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proposed receptor-mediated mechanisms of melatonin in nitroglycerin-induced migraine-like hyperalgesic conditions in rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109800","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109800"}}