{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:29:35Z","timestamp":1788913775015,"version":"build-2803163510"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jnutbio.2024.109803","type":"journal-article","created":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T20:44:46Z","timestamp":1731876286000},"page":"109803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Sulforaphane suppresses A\u03b2 accumulation and tau hyperphosphorylation in vascular cognitive impairment(VCI)"],"prefix":"10.1016","volume":"136","author":[{"given":"Cong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irum","family":"Ejaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Mesbah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1639-1283","authenticated-orcid":false,"given":"Feifei","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2024.109803_bib0001","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association\/american stroke association","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0002","article-title":"Vascular cognitive impairment","volume":"4","author":"Van der Flier","year":"2018","journal-title":"Nat Rev Dis Pri"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0003","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1016\/j.jacc.2019.04.034","article-title":"Vascular cognitive impairment and dementia","volume":"73","author":"Iadecola","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(15)00463-8","article-title":"Vascular dementia","volume":"386","author":"O'Brien","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0005","article-title":"Vascular cognitive impairment","author":"Dichgans","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0006","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1007\/s00415-020-10262-2","article-title":"Cognitive evaluation in cerebral small vessel disease: towards an evidence-based identification of the reference standards. Part 1. A systematic review and qualitative data synthesis","volume":"268","author":"Salvadori","year":"2021","journal-title":"J Neurol"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0007","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s13311-021-01170-y","article-title":"Vascular cognitive impairment (VCI)","volume":"19","author":"Rundek","year":"2022","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0008","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/WCO.0000000000000913","article-title":"Cerebral small vessel disease and vascular cognitive impairment: from diagnosis to management","volume":"34","author":"Zanon Zotin","year":"2021","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0009","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","article-title":"Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges","volume":"9","author":"Pantoni","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0010","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1177\/23969873241229612","article-title":"Association of covert brain infarct phenotype with stroke recurrence in first-ever manifest ischemic stroke according to etiology","volume":"9","author":"Meinel","year":"2024","journal-title":"Eur Stroke J"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0011","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/jamaneurol.2018.3122","article-title":"Clinical significance of magnetic resonance imaging markers of vascular brain injury: A systematic review and meta-analysis","volume":"76","author":"Debette","year":"2019","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0012","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1474-4422(07)70170-9","article-title":"Silent brain infarcts: a systematic review","volume":"6","author":"Vermeer","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0013","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/ana.23802","article-title":"Diffusion changes predict cognitive and functional outcome: the LADIS study","volume":"73","author":"Jokinen","year":"2013","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0014","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1159\/000334498","article-title":"2001\u20132011: A decade of the LADIS (Leukoaraiosis And DISability) study: what have we learned about white matter changes and small-vessel disease?","volume":"32","year":"2011","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0015","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/STROKEAHA.119.026170","article-title":"Global burden of small vessel disease\u2013Related brain changes on MRI predicts cognitive and functional decline","volume":"51","author":"Jokinen","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0016","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1017\/S0033291709990857","article-title":"Relationship between baseline white-matter changes and development of late-life depressive symptoms: 3-year results from the LADIS study","volume":"40","author":"Teodorczuk","year":"2010","journal-title":"Psychol Med"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0017","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/gps.4368","article-title":"White matter microstructural damage and depressive symptoms in patients with mild cognitive impairment and cerebral small vessel disease: the VMCI-Tuscany Study","volume":"31","author":"Pasi","year":"2016","journal-title":"Int J Geriat Psychiatry"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0018","first-page":"280","article-title":"Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study","volume":"14","author":"Skrobot","year":"2018","journal-title":"Dementia"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0019","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1136\/jnnp.2008.160440","article-title":"Location of lacunar infarcts correlates with cognition in a sample of non-disabled subjects with age-related white-matter changes: the LADIS study","volume":"80","author":"Benisty","year":"2009","journal-title":"Neurosurgery & Psychiatry"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0020","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1161\/STROKEAHA.112.662593","article-title":"White matter lesion progression in LADIS: frequency, clinical effects, and sample size calculations","volume":"43","author":"Schmidt","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0021","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1212\/WNL.0b013e31821d752f","article-title":"Incident lacunes influence cognitive decline: the LADIS study","volume":"76","author":"Jokinen","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/8154969","article-title":"Correlation between motor Cortex excitability changes and cognitive impairment in vascular depression: pathophysiological insights from a longitudinal TMS study","volume":"2016","author":"Pennisi","year":"2016","journal-title":"Neural Plast"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0023","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.neuroimage.2005.06.066","article-title":"The prediction of rapid conversion to Alzheimer's disease in mild cognitive impairment using regional cerebral blood flow SPECT","volume":"28","author":"Hirao","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0024","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/17474930221137019","article-title":"The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis","volume":"18","author":"Lam","year":"2023","journal-title":"Int J Stroke"},{"issue":"2","key":"10.1016\/j.jnutbio.2024.109803_bib0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/jmf.2018.0024","article-title":"Isothiocyanate from broccoli, sulforaphane, and its properties","volume":"22","author":"Vanduchova","year":"2019","journal-title":"J Med Food"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0026","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s12272-020-01225-2","article-title":"Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems","volume":"43","author":"Kamal","year":"2020","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0027","doi-asserted-by":"crossref","first-page":"8637","DOI":"10.3390\/ijms21228637","article-title":"Efficacy of Sulforaphane in neurodegenerative diseases","volume":"21","author":"Schepici","year":"2020","journal-title":"IJMS"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0028","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1177\/0271678X18764083","article-title":"Protective effects of sulforaphane in experimental vascular cognitive impairment: contribution of the Nrf2 pathway","volume":"39","author":"Mao","year":"2019","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0029","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/pcn.13276","article-title":"Efficacy and safety of sulforaphane for treatment of mild to moderate depression in patients with history of cardiac interventions: A randomized, double-blind, placebo-controlled clinical trial","volume":"75","author":"Ghazizadeh-Hashemi","year":"2021","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0030","doi-asserted-by":"crossref","first-page":"6902","DOI":"10.3390\/molecules28196902","article-title":"Sulforaphane's multifaceted potential: from neuroprotection to anticancer action","volume":"28","author":"Otoo","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0031","first-page":"10010","article-title":"Sulforaphane's nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent and -independent mechanism of Anti-SARS-CoV-2 activity","volume":"1","author":"Yan","year":"2024","journal-title":"J Respir Biol Transl Med"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109803_bib0032","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresrev.2007.01.003","article-title":"Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases","volume":"54","author":"Farkas","year":"2007","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0033","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.neuroscience.2011.02.031","article-title":"Heme oxygenase 1, beneficial role in permanent ischemic stroke and in Gingko biloba (EGb 761) neuroprotection","volume":"180","author":"Shah","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0034","doi-asserted-by":"crossref","DOI":"10.1111\/j.1471-4159.1999.721187.x","article-title":"Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice","volume":"72","author":"Panahian","year":"1999","journal-title":"J Neurochem"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0035","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/cns.13496","article-title":"The novel Nrf2 activator CDDO-EA attenuates cerebral ischemic injury by promoting microglia\/macrophage polarization toward M2 phenotype in mice","volume":"27","author":"Lei","year":"2021","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jare.2021.09.002","article-title":"Oxyphylla A ameliorates cognitive deficits and alleviates neuropathology via the akt-GSK3 beta and Nrf2-Keap1-HO-1 pathways in vitro and in vivo murine models of Alzheimer's disease","volume":"34","author":"Bian","year":"2021","journal-title":"J Adv Res"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108335","article-title":"Inhibition of GPR17 with cangrelor improves cognitive impairment and synaptic deficits induced by A beta(1-42) through Nrf2\/HO-1 and NF-kappa B signaling pathway in mice","volume":"101","author":"Jin","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0038","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.arr.2011.12.009","article-title":"Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies","volume":"11","author":"Sabayan","year":"2012","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0039","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0040","article-title":"Toxic tau: structural origins of tau aggregation in Alzheimer's disease","volume":"15","author":"A","year":"2020","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0041","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3233\/JAD-180772","article-title":"Tau protein dysfunction after brain ischemia","volume":"66","author":"Pluta","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0042","doi-asserted-by":"crossref","DOI":"10.1038\/mp.2017.171","article-title":"Tau-mediated iron export prevents ferroptotic damage after ischemic stroke","volume":"22","author":"Tuo","year":"2017","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0043","doi-asserted-by":"crossref","DOI":"10.1111\/j.1471-4159.2007.05194.x","article-title":"The GSK3 hypothesis of Alzheimer's disease","volume":"104","author":"Hooper","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0044","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3233\/JAD-2009-0960","article-title":"Accumulated amyloid-beta peptide and hyperphosphorylated tau protein: relationship and links in Alzheimer's disease","volume":"16","author":"Huang","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0045","article-title":"Mangostanaxanthone IV ameliorates streptozotocin-induced neuro-inflammation, amyloid deposition, and tau hyperphosphorylation via modulating PI3K\/Akt\/GSK-3 beta pathway","volume":"10","author":"Abdallah","year":"2021","journal-title":"Bio-Basel"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2020.118664","article-title":"Glycogen synthase kinase-3 signaling in Alzheimer's disease","author":"Lauretti","year":"2020","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0047","doi-asserted-by":"crossref","DOI":"10.1038\/s41593-020-0687-6","article-title":"Synergy between amyloid-beta and tau in Alzheimer's disease","volume":"23","author":"Busche","year":"2020","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0048","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2016.00061","article-title":"Analysis of amyloid precursor protein function in drosophila melanogaster","volume":"9","author":"Cassar","year":"2016","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0049","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrn.2017.29","article-title":"Not just amyloid: physiological functions of the amyloid precursor protein family","volume":"18","author":"M\u00fcller","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0050","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1097\/WNR.0b013e32832d2e6a","article-title":"Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia","volume":"20","author":"Okamoto","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0051","author":"Pluta","year":"2011","journal-title":"Cognitive Impairment with Vascular Impairment and Degene"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0052","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/hbm.20586","article-title":"White matter hyperintensities in the forties: their prevalence and topography in an epidemiological sample aged 44\u201348","volume":"30","author":"Wen","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0053","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1007\/s11095-011-0500-z","article-title":"Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice","volume":"28","author":"Clarke","year":"2011","journal-title":"Pharm Res"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0054","doi-asserted-by":"crossref","DOI":"10.1002\/ptr.6427","article-title":"The neuroprotective activities of natural products through the Nrf2 upregulation","author":"Tavakkoli","year":"2019","journal-title":"Phytother Res"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0055","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13229-021-00447-5","article-title":"Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder","volume":"12","author":"Zimmerman","year":"2021","journal-title":"Mol Autism"},{"issue":"3","key":"10.1016\/j.jnutbio.2024.109803_bib0056","doi-asserted-by":"crossref","first-page":"718","DOI":"10.3390\/nu15030718","article-title":"Sulforaphane treatment in children with autism: A prospective randomized double-blind study","volume":"31","author":"Magner","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0057","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1443604","article-title":"Vicious cycle of oxidative stress and neuroinflammation in pathophysiology of chronic vascular encephalopathy","volume":"15","author":"Dmytriv","year":"2024","journal-title":"Front Physiol"},{"issue":"4","key":"10.1016\/j.jnutbio.2024.109803_bib0058","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00204-011-0674-5","article-title":"The cytoprotective role of the Keap1-Nrf2 pathway","volume":"85","author":"Baird","year":"2011","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0059","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.29219","article-title":"Nrf2-ARE signaling in cellular protection: mechanism of action and the regulatory mechanisms","author":"Shaw","year":"2020","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228637","article-title":"Efficacy of Sulforaphane in neurodegenerative diseases","volume":"21","author":"Schepici","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0061","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.freeradbiomed.2013.08.190","article-title":"Sulforaphane preconditioning of the Nrf2\/HO-1 defense pathway protects the cerebral vasculature against blood\u2013brain barrier disruption and neurological deficits in stroke","volume":"65","author":"Alfieri","year":"2013","journal-title":"Free Radical Bio Med"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0062","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1080\/10408398.2018.1546669","article-title":"Bioactivity of dietary polyphenols: the role of metabolites","volume":"60","author":"Luca","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0063","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3945\/an.116.012138","article-title":"Mediterranean diet, cognitive function, and dementia: A systematic review of the evidence","volume":"7","author":"Petersson","year":"2016","journal-title":"Adv Nut"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0064","article-title":"Mediterranean diet and mild cognitive impairment","volume":"66","author":"Scarmeas","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0065","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1080\/09637486.2022.2050999","article-title":"Daily mocha coffee intake and psycho-cognitive status in non-demented non-smokers subjects with subcortical ischaemic vascular disease","volume":"73","author":"Fisicaro","year":"2022","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0066","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3390\/nu13020536","article-title":"Moderate mocha coffee consumption is associated with higher cognitive and mood status in a non-demented elderly population with subcortical ischemic vascular disease","volume":"13","author":"Fisicaro","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0067","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2024.112498","article-title":"Combined effect of red wine and mocha pot coffee in mild vascular cognitive impairment","volume":"194","author":"Pennisi","year":"2024","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0068","doi-asserted-by":"crossref","first-page":"e15688","DOI":"10.7717\/peerj.15688","article-title":"Tea intake or consumption and the risk of dementia: a meta-analysis of prospective cohort studies","volume":"11","author":"Jiang","year":"2023","journal-title":"PeerJ"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0069","doi-asserted-by":"crossref","first-page":"8330","DOI":"10.1039\/D4FO01750A","article-title":"Tea, coffee, and caffeine intake and risk of dementia and Alzheimer's disease: a systematic review and meta-analysis of cohort studies","volume":"15","author":"Li","year":"2024","journal-title":"Food Funct"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0070","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41398-022-01923-z","article-title":"Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants","volume":"12","author":"Hu","year":"2022","journal-title":"Transl Psychiatry"},{"issue":"6791","key":"10.1016\/j.jnutbio.2024.109803_bib0071","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35017574","article-title":"Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation","volume":"6","author":"Hoeflich","year":"2000","journal-title":"Nature"},{"issue":"38","key":"10.1016\/j.jnutbio.2024.109803_bib0072","doi-asserted-by":"crossref","first-page":"39541","DOI":"10.1074\/jbc.M403449200","article-title":"Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44\/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor","volume":"17","author":"Takada","year":"2004","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109803_bib0073","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12035-021-02611-7","article-title":"Implications of phosphoinositide 3-kinase-akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer's disease","volume":"59","author":"Kumar","year":"2022","journal-title":"Mol Neurobiol"},{"issue":"8","key":"10.1016\/j.jnutbio.2024.109803_bib0074","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/hipo.20805","article-title":"GSK3\u03b2 overexpression induces neuronal death and a depletion of the neurogenic niches in the dentate gyrus","volume":"21","author":"Sirerol-Piquer","year":"2011","journal-title":"Hippocampus"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0075","article-title":"GSK-3\u03b2 in DNA repair, apoptosis, and resistance of chemotherapy, radiotherapy of cancer","author":"Lin","year":"2020","journal-title":"BBA - Molecular Cell Research"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0076","doi-asserted-by":"crossref","first-page":"9098","DOI":"10.3390\/ijms22169098","article-title":"GSK-3\u03b2, FYN, and DYRK1A: master regulators in neurodegenerative pathways","volume":"22","author":"Demuro","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0077","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fnmol.2011.00032","article-title":"GSK-3 inhibitors: preclinical and clinical focus on CNS","volume":"4","author":"Eldar-Finkelman","year":"2011","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"10.1016\/j.jnutbio.2024.109803_bib0078","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s12017-022-08731-0","article-title":"Tau and GSK-3\u03b2 are critical contributors to \u03b1-synuclein-mediated post-stroke brain damage","volume":"25","author":"Mehta","year":"2023","journal-title":"Neuromolecular Med"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0079","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1159\/000447799","article-title":"Sulforaphane prevents neuronal apoptosis and memory impairment in diabetic rats","volume":"39","author":"Wang","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0080","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.3390\/molecules27175422","article-title":"Sulforaphane regulates eNOS activation and NO production via src-mediated PI3K\/akt signaling in Human endothelial EA.hy926 cells","volume":"27","author":"Zhang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0081","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1007\/s10787-023-01373-z","article-title":"A mechanistic overview of sulforaphane and its derivatives application in diabetes and its complications","volume":"31","author":"Mohamadi","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0082","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jnutbio.2019.01.019","article-title":"Sulforaphane triggers a functional elongation of microglial process via the Akt signal","volume":"67","author":"Wu","year":"2019","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0083","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1160\/TH12-09-0636","article-title":"Sulforaphane prevents human platelet aggregation through inhibiting the phosphatidylinositol 3-kinase\/akt pathway","volume":"109","author":"Chuang","year":"2013","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0084","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1158\/1535-7163.MCT-06-0404","article-title":"Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells","volume":"6","author":"Chaudhuri","year":"2007","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.jnutbio.2024.109803_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153062","article-title":"The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner","volume":"86","author":"Zhang","year":"2021","journal-title":"Phytomedicine"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324002341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286324002341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T11:37:06Z","timestamp":1733571426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286324002341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":85,"alternative-id":["S0955286324002341"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109803","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sulforaphane suppresses A\u03b2 accumulation and tau hyperphosphorylation in vascular cognitive impairment(VCI)","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109803","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109803"}}