{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:42:43Z","timestamp":1793727763237,"version":"4.6.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860792"],"award-info":[{"award-number":["81860792"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360871"],"award-info":[{"award-number":["82360871"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009102","name":"Education Department of Jiangxi Province","doi-asserted-by":"publisher","award":["GJJ2200913"],"award-info":[{"award-number":["GJJ2200913"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009102","name":"Education Department of Jiangxi Province","doi-asserted-by":"publisher","award":["GJJ201267"],"award-info":[{"award-number":["GJJ201267"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009102","name":"Education Department of Jiangxi Province","doi-asserted-by":"publisher","award":["GJJ2200965"],"award-info":[{"award-number":["GJJ2200965"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20224ACB206040"],"award-info":[{"award-number":["20224ACB206040"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20232ACB206054"],"award-info":[{"award-number":["20232ACB206054"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jnutbio.2025.109880","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T19:12:55Z","timestamp":1740597175000},"page":"109880","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Ginsenoside Rg1 alleviated experimental colitis in obesity mice by regulating memory follicular T cells via Bcl-6\/Blimp-1 pathway"],"prefix":"10.1016","volume":"140","author":[{"given":"Zeyun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-2811","authenticated-orcid":false,"given":"Duanyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2025.109880_bib0001","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/jama.2023.15389","article-title":"Ulcerative Colitis in adults: a review","volume":"330","author":"Gros","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0002","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.3748\/wjg.v27.i22.2963","article-title":"Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: a review","volume":"27","author":"Sun","year":"2021","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0003","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.cgh.2022.06.030","article-title":"Global hospitalization trends for Crohn's Disease and Ulcerative Colitis in the 21st century: a systematic review with temporal analyses","volume":"21","author":"Buie","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0004","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/ibd\/izab219","article-title":"Racial and ethnic distribution of inflammatory bowel disease in the United States","volume":"28","author":"Barnes","year":"2022","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5217\/ir.2018.16.1.26","article-title":"Immunological pathogenesis of inflammatory bowel disease","volume":"16","author":"Lee","year":"2018","journal-title":"Intest Res"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0006","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S2468-1253(22)00021-8","article-title":"Lifestyle, behaviour, and environmental modification for the management of patients with inflammatory bowel diseases: an International Organization for Study of Inflammatory Bowel Diseases consensus","volume":"7","author":"Ananthakrishnan","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0007","doi-asserted-by":"crossref","first-page":"832","DOI":"10.14309\/ajg.0000000000000608","article-title":"Effect of lifestyle factors on outcomes in patients with inflammatory bowel diseases","volume":"115","author":"Rozich","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0008","doi-asserted-by":"crossref","first-page":"7868","DOI":"10.3748\/wjg.v22.i35.7868","article-title":"Interaction of obesity and inflammatory bowel disease","volume":"22","author":"Harper","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0009","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.3748\/wjg.v29.i36.5226","article-title":"Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory Th\/tfh subset balance","volume":"29","author":"Zheng","year":"2023","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0010","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12979-024-00425-4","article-title":"Role of germinal center and CD39(high)CD73(+) B cells in the age-related tonsillar involution","volume":"21","author":"Pastor","year":"2024","journal-title":"Immun Ageing"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0011","article-title":"Mechanism of sishen-pill-regulated special memory T and mTfh cell via involving JAK\/STAT5 pathway in Colitis mice","volume":"2022","author":"Wang","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0012","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1142\/S0192415X22500100","article-title":"Curcumin inhibits T follicular helper cell differentiation in mice with dextran sulfate sodium (DSS)-induced colitis","volume":"50","author":"Wang","year":"2022","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0013","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9621738","article-title":"The role of T follicular helper cells and interleukin-21 in the pathogenesis of inflammatory bowel disease","volume":"2021","author":"Sun","year":"2021","journal-title":"Gastroenterol Res Pract"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0014","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jgr.2016.08.004","article-title":"Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases","volume":"41","author":"Kim","year":"2017","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0015","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000484578","article-title":"Ginsenoside Rg1 protects cardiomyocytes against hypoxia\/reoxygenation injury via activation of Nrf2\/HO-1 signaling and inhibition of JNK","volume":"44","author":"Li","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155474","article-title":"Ginsenosides from Panax ginseng as potential therapeutic candidates for the treatment of inflammatory bowel disease","volume":"127","author":"Niu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0017","article-title":"Ginsenoside-Rg1 rescues stress-induced depression-like behaviors via suppression of oxidative stress and neural inflammation in rats","volume":"2020","author":"Li","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.817600","article-title":"Ginsenoside Rg1 alleviates acute ulcerative colitis by modulating gut microbiota and microbial tryptophan metabolism","volume":"13","author":"Cheng","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2017.06.002","article-title":"Ginsenoside Rg1 attenuates the inflammatory response in DSS-induced mice colitis","volume":"50","author":"Zhu","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0020","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ejphar.2015.06.011","article-title":"Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20(S)-protopanaxatriol in mice with TNBS-induced colitis","volume":"762","author":"Lee","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0021","doi-asserted-by":"crossref","first-page":"590","DOI":"10.31083\/ph.2020.0696","article-title":"Ginsenoside regulates treg\/Th17 cell ratio and inhibits inflammation to treat COPD","volume":"75","author":"Xu","year":"2020","journal-title":"Pharmazie"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0022","doi-asserted-by":"crossref","first-page":"20073","DOI":"10.1021\/acs.jafc.3c04811","article-title":"Ginsenoside Rg1 alleviates ulcerative colitis in obese mice by regulating the gut microbiota-lipid metabolism-Th1\/Th2\/Th17 cells axis","volume":"71","author":"Zhong","year":"2023","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0023","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1053\/gast.2003.50050","article-title":"Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis","volume":"124","author":"Totsuka","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0024","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5536679","article-title":"Sishen pill maintained colonic mucosal barrier integrity to treat ulcerative colitis via Rho\/ROCK signaling pathway","volume":"2021","author":"Zhang","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0025","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1136\/gut.2009.203554","article-title":"Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis","volume":"59","author":"Schmidt","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0026","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/JLB.5MR0321-145R","article-title":"Stem cell-like memory T cells: the generation and application","volume":"110","author":"Wang","year":"2021","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0027","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S2468-1253(23)00011-0","article-title":"Inflammation and malnutrition in inflammatory bowel disease","volume":"8","author":"Massironi","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0028","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/imcb.12280","article-title":"Immunological memory","volume":"97","author":"Kirman","year":"2019","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0029","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-immunol-041015-055605","article-title":"Follicular helper T cells","volume":"34","author":"Vinuesa","year":"2016","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0030","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00281-019-00733-8","article-title":"The pathogenicity of Th17 cells in autoimmune diseases","volume":"41","author":"Yasuda","year":"2019","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0031","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00281-019-00741-8","article-title":"Treg cells in autoimmunity: from identification to Treg-based therapies","volume":"41","author":"G\u00f6schl","year":"2019","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0032","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41591-022-01680-y","article-title":"Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity","volume":"28","author":"Uzzan","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0033","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/ni.1837","article-title":"Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation","volume":"11","author":"Crotty","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0034","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1126\/science.1175870","article-title":"Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation","volume":"325","author":"Johnston","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.110969","article-title":"Astragalus polysaccharides ameliorates experimental colitis by regulating memory B cells metabolism","volume":"394","author":"Deng","year":"2024","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109108","article-title":"Astragalus polysaccharide alleviates ulcerative colitis by regulating the balance of tfh\/treg cells","volume":"111","author":"Zhong","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0037","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9839474","article-title":"Gut microbiota-mediated NLRP12 expression drives the attenuation of dextran sulphate sodium-induced ulcerative colitis by Qingchang Wenzhong decoction","volume":"2019","author":"Sun","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0038","article-title":"Case Report: IL-21 and Bcl-6 regulate the proliferation and secretion of tfh and tfr cells in the intestinal germinal center of patients with inflammatory bowel disease","volume":"11","author":"Yang","year":"2020","journal-title":"Front Pharmacol"},{"issue":"7","key":"10.1016\/j.jnutbio.2025.109880_bib0039","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.4049\/jimmunol.1700106","article-title":"Integrated STAT3 and Ikaros Zinc finger transcription factor activities regulate bcl-6 expression in CD4+ Th cells","volume":"199","author":"Read","year":"2017","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.jnutbio.2025.109880_bib0040","doi-asserted-by":"crossref","first-page":"e903","DOI":"10.1002\/iid3.903","article-title":"AhR agonist tapinarof ameliorates lupus autoimmunity by suppressing Tfh cell differentiation via regulation of the JAK2-STAT3 signaling pathway","volume":"11","author":"Zhang","year":"2023","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.jnutbio.2025.109880_bib0041","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.998693","article-title":"FOXO1 inhibits FSL-1 regulation of integrin \u03b26 by blocking STAT3 binding to the integrin \u03b26 gene promoter","volume":"12","author":"Xu","year":"2022","journal-title":"Front Cell Infect Microbiol"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325000439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325000439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:22:21Z","timestamp":1778779341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286325000439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":41,"alternative-id":["S0955286325000439"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.109880","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ginsenoside Rg1 alleviated experimental colitis in obesity mice by regulating memory follicular T cells via Bcl-6\/Blimp-1 pathway","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.109880","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109880"}}