{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:49:49Z","timestamp":1789609789282,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019415","name":"H Wilhelm Schaumann Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019415","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jnutbio.2025.109881","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T16:26:36Z","timestamp":1740241596000},"page":"109881","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Alteration of the microbiota with vancomycin and high-fiber diet affects short-chain fatty acid\/free fatty acid receptor signaling in rat caecum"],"prefix":"10.1016","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4502-1687","authenticated-orcid":false,"given":"Jasmin","family":"Ballout","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5731-1019","authenticated-orcid":false,"given":"Yasutada","family":"Akiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Kaunitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schwiertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Mazzuoli-Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Breves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-4636","authenticated-orcid":false,"given":"Martin","family":"Diener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jnutbio.2025.109881_bib0001","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00424-017-2105-9","article-title":"A look at the smelly side of physiology: transport of short chain fatty acids","volume":"470","author":"Stumpff","year":"2018","journal-title":"Pflugers Arch"},{"issue":"11","key":"10.1016\/j.jnutbio.2025.109881_bib0002","doi-asserted-by":"crossref","first-page":"C979","DOI":"10.1152\/ajpcell.00228.2014","article-title":"From microbe to man: the role of microbial short chain fatty acid metabolites in host cell biology","volume":"307","author":"Natarajan","year":"2014","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"10.1016\/j.jnutbio.2025.109881_bib0003","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/j.2040-4603.2018.tb00038.x","article-title":"Role of short chain fatty acid receptors in intestinal Physiology and Pathophysiology","volume":"8","author":"Priyadarshini","year":"2018","journal-title":"Compr Physiol"},{"issue":"2","key":"10.1016\/j.jnutbio.2025.109881_bib0004","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0016-5085(82)80339-9","article-title":"Utilization of nutrients by isolated epithelial cells of the rat colon","volume":"83","author":"Roediger","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2025.109881_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174292","article-title":"Short-chain fatty acid receptors involved in epithelial acetylcholine release in rat caecum","volume":"906","author":"Ballout","year":"2021","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"10.1016\/j.jnutbio.2025.109881_bib0006","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1124\/mol.115.102301","article-title":"The pharmacology and function of receptors for short-chain fatty acids","volume":"89","author":"Bolognini","year":"2016","journal-title":"Mol Pharmacol"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.109881_bib0007","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.jnutbio.2025.109881_bib0008","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1158\/0008-5472.CAN-08-4466","article-title":"GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon","volume":"69","author":"Thangaraju","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2025.109881_bib0009","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.jnutbio.2025.109881_bib0010","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1017\/S0007114508888733","article-title":"Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability","volume":"100","author":"Suzuki","year":"2008","journal-title":"Br J Nutr"},{"issue":"10","key":"10.1016\/j.jnutbio.2025.109881_bib0011","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.3945\/jn.116.232538","article-title":"Dietary fermentable Fiber reduces intestinal barrier defects and inflammation in colitic mice","volume":"146","author":"van Hung","year":"2016","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2025.109881_bib0012","doi-asserted-by":"crossref","first-page":"4969","DOI":"10.3389\/fphys.2019.00329","article-title":"Impact of sensitization and inflammation on the interaction of mast cells with the intestinal epithelium in rats","volume":"10","author":"Becker","year":"2019","journal-title":"Front. Physiol."},{"issue":"10","key":"10.1016\/j.jnutbio.2025.109881_bib0013","doi-asserted-by":"crossref","first-page":"e196","DOI":"10.1038\/ctg.2016.54","article-title":"Human intestinal barrier function in health and disease","volume":"7","author":"K\u00f6nig","year":"2016","journal-title":"Clin Transl Gastroenterol"},{"issue":"12","key":"10.1016\/j.jnutbio.2025.109881_bib0014","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1097\/MIB.0000000000000504","article-title":"Mechanisms underlying dysregulation of electrolyte absorption in inflammatory bowel disease-associated diarrhea","volume":"21","author":"Priyamvada","year":"2015","journal-title":"Inflamm Bowel Dis"},{"issue":"8","key":"10.1016\/j.jnutbio.2025.109881_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220642","article-title":"The long-term consequences of antibiotic therapy: role of colonic short-chain fatty acids (SCFA) system and intestinal barrier integrity","volume":"14","author":"Holota","year":"2019","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jnutbio.2025.109881_bib0016","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00424-017-2104-x","article-title":"Segmental differences in the non-neuronal cholinergic system in rat caecum","volume":"470","author":"Bader","year":"2018","journal-title":"Pflugers Arch"},{"issue":"4","key":"10.1016\/j.jnutbio.2025.109881_bib0017","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00424-018-2236-7","article-title":"Robustness of the non-neuronal cholinergic system in rat large intestine against luminal challenges","volume":"471","author":"Bader","year":"2019","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jnutbio.2025.109881_bib0018","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3389\/fmicb.2017.01076","article-title":"Incubation temperature, but not Pequi oil supplementation, affects methane production, and the ruminal microbiota in a Rumen Simulation Technique (Rusitec) System","volume":"8","author":"Duarte","year":"2017","journal-title":"Front Microbiol"},{"issue":"6","key":"10.1016\/j.jnutbio.2025.109881_bib0019","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00424-021-02565-8","article-title":"The role of HCO3- in propionate-induced anion secretion across rat caecal epithelium","volume":"473","author":"Ballout","year":"2021","journal-title":"Pflugers Arch"},{"issue":"21","key":"10.1016\/j.jnutbio.2025.109881_bib0020","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1111\/bph.15928","article-title":"Ionotropic P2X4 and P2X7 receptors in the regulation of ion transport across rat colon","volume":"179","author":"Ballout","year":"2022","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/j.jnutbio.2025.109881_bib0021","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1113\/jphysiol.2014.280792","article-title":"Short-chain fatty acid sensing in rat duodenum","volume":"593","author":"Akiba","year":"2015","journal-title":"J Physiol"},{"issue":"15","key":"10.1016\/j.jnutbio.2025.109881_bib0022","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","article-title":"Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets","volume":"64","author":"Andersen","year":"2004","journal-title":"Cancer Res"},{"issue":"9","key":"10.1016\/j.jnutbio.2025.109881_bib0023","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.jnutbio.2025.109881_bib0024","doi-asserted-by":"crossref","first-page":"433","DOI":"10.33549\/physiolres.930967","article-title":"Effect of pectin and amidated pectin on cholesterol homeostasis and cecal metabolism in rats fed a high-cholesterol diet","volume":"56","author":"Marounek","year":"2007","journal-title":"Physiol Res"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.109881_bib0025","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1476-5381.2009.00421.x","article-title":"Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3","volume":"158","author":"Milligan","year":"2009","journal-title":"Br J Pharmacol"},{"issue":"12","key":"10.1016\/j.jnutbio.2025.109881_bib0026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144854","article-title":"Antibiotic treatment affects intestinal permeability and gut microbial composition in Wistar rats dependent on antibiotic class","volume":"10","author":"Tulstrup","year":"2015","journal-title":"PLoS One"},{"issue":"Pt 4","key":"10.1016\/j.jnutbio.2025.109881_bib0027","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1113\/jphysiol.2010.199976","article-title":"Non-neuronal release of ACh plays a key role in secretory response to luminal propionate in rat colon","volume":"589","author":"Yajima","year":"2011","journal-title":"J Physiol"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.109881_bib0028","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1152\/physrev.00007.2018","article-title":"Structure, gating, and regulation of the CFTR anion channel","volume":"99","author":"Csan\u00e1dy","year":"2019","journal-title":"Physiol Rev"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.109881_bib0029","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0167-0115(89)90250-4","article-title":"Antisecretory effects of somatostatin and vasopressin in the rat colon descendens in vitro","volume":"25","author":"Knobloch","year":"1989","journal-title":"Regul Pept"},{"issue":"10","key":"10.1016\/j.jnutbio.2025.109881_bib0030","doi-asserted-by":"crossref","first-page":"5803","DOI":"10.3390\/ijms23105803","article-title":"Regulator of G-protein signaling-4 attenuates cardiac adverse remodeling and neuronal norepinephrine release-promoting free fatty acid receptor FFAR3 signaling","volume":"23","author":"Carbone","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.jnutbio.2025.109881_bib0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218384","article-title":"Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy","volume":"14","author":"Feng","year":"2019","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jnutbio.2025.109881_bib0032","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.ajpath.2013.01.013","article-title":"Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis","volume":"182","author":"Bergmann","year":"2013","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.109881_bib0033","doi-asserted-by":"crossref","first-page":"74","DOI":"10.5152\/tjg.2022.20691","article-title":"Subepithelial serotonin reduces small intestinal epithelial cell tightness via reduction of occluding expression","volume":"33","author":"Horie","year":"2022","journal-title":"Turk J Gastroenterol"},{"issue":"11","key":"10.1016\/j.jnutbio.2025.109881_bib0034","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1007\/s00535-016-1195-z","article-title":"Serotonin disrupts esophageal mucosal integrity: an investigation using a stratified squamous epithelial model","volume":"51","author":"Wu","year":"2016","journal-title":"J Gastroenterol"},{"issue":"8","key":"10.1016\/j.jnutbio.2025.109881_bib0035","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1111\/all.14254","article-title":"Butyrate inhibits human mast cell activation via epigenetic regulation of fc\u03b5ri-mediated signaling","volume":"75","author":"Folkerts","year":"2020","journal-title":"Allergy"},{"issue":"19","key":"10.1016\/j.jnutbio.2025.109881_bib0036","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1111\/jcmm.17924","article-title":"Epigenetic histone modification by butyrate downregulates KIT and attenuates mast cell function","volume":"27","author":"Gudneppanavar","year":"2023","journal-title":"J Cell Mol Med"},{"issue":"10","key":"10.1016\/j.jnutbio.2025.109881_bib0037","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1210\/en.2013-1142","article-title":"GPR41\/FFAR3 and GPR43\/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes","volume":"154","author":"N\u00f8hr","year":"2013","journal-title":"Endocrinology"},{"issue":"49","key":"10.1016\/j.jnutbio.2025.109881_bib0038","doi-asserted-by":"crossref","first-page":"41195","DOI":"10.1074\/jbc.M112.396259","article-title":"Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3","volume":"287","author":"Hudson","year":"2012","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.jnutbio.2025.109881_bib0039","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1124\/mol.114.093294","article-title":"Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands","volume":"86","author":"Hudson","year":"2014","journal-title":"Mol Pharmacol"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.109881_bib0040","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1074\/jbc.M115.687939","article-title":"Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands","volume":"291","author":"Sergeev","year":"2016","journal-title":"J Biol Chem"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325000440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325000440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T16:35:00Z","timestamp":1746376500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286325000440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":40,"alternative-id":["S0955286325000440"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.109881","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alteration of the microbiota with vancomycin and high-fiber diet affects short-chain fatty acid\/free fatty acid receptor signaling in rat caecum","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.109881","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109881"}}