{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:52:10Z","timestamp":1783511530490,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MH215"],"award-info":[{"award-number":["ZR2020MH215"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2023-WJZD174"],"award-info":[{"award-number":["2023-WJZD174"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273626"],"award-info":[{"award-number":["82273626"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jnutbio.2025.109896","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T05:51:54Z","timestamp":1741240314000},"page":"109896","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Folic acid intervention ameliorates hepatic steatosis after long-term alcohol exposure by alleviating endoplasmic reticulum stress"],"prefix":"10.1016","volume":"141","author":[{"given":"Huichao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5968-5701","authenticated-orcid":false,"given":"Yiqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0675-6963","authenticated-orcid":false,"given":"Hui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jnutbio.2025.109896_bib0001","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/jama.2021.7683","article-title":"Diagnosis and treatment of alcohol-associated liver disease: a review","volume":"326","author":"Singal","year":"2021","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.jnutbio.2025.109896_bib0002","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1111\/jgh.16282","article-title":"Alcohol and the mechanisms of liver disease","volume":"38","author":"Chen","year":"2023","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.109896_bib0003","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-pathmechdis-031521-030435","article-title":"Recent advances in understanding of pathogenesis of alcohol-associated liver disease","volume":"18","author":"Wu","year":"2023","journal-title":"Ann Rev Pathol"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.109896_bib0004","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s12967-023-04166-8","article-title":"Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease","volume":"21","author":"Yan","year":"2023","journal-title":"J Translat Med"},{"key":"10.1016\/j.jnutbio.2025.109896_bib0005","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.freeradbiomed.2022.10.322","article-title":"FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease","volume":"193","author":"You","year":"2022","journal-title":"Free Radical Biol Med"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.109896_bib0006","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41572-018-0014-7","article-title":"Alcoholic liver disease","volume":"4","author":"Seitz","year":"2018","journal-title":"Nat Rev Dis Prim"},{"issue":"2","key":"10.1016\/j.jnutbio.2025.109896_bib0007","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.tips.2021.11.011","article-title":"ER stress in obesity pathogenesis and management","volume":"43","author":"Ajoolabady","year":"2022","journal-title":"Trends Pharmacolog Sci"},{"issue":"2","key":"10.1016\/j.jnutbio.2025.109896_bib0008","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/jcp.25098","article-title":"Endoplasmic reticulum stress interacts with inflammation in Human diseases","volume":"231","author":"Cao","year":"2015","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.109896_bib0009","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-012513-104649","article-title":"The role of endoplasmic reticulum stress in Human pathology","volume":"10","author":"Oakes","year":"2015","journal-title":"Ann Rev Pathol"},{"issue":"12","key":"10.1016\/j.jnutbio.2025.109896_bib0010","doi-asserted-by":"crossref","first-page":"G965","DOI":"10.1152\/ajpgi.00132.2015","article-title":"Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat\/sugar diet","volume":"309","author":"Liu","year":"2015","journal-title":"Am J Physiol-Gastrointestin Liver Physiol"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.109896_bib0011","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev-arplant-042817-040331","article-title":"Protein quality control in the endoplasmic reticulum of plants","volume":"69","author":"Strasser","year":"2018","journal-title":"Ann Rev Plant Biol"},{"key":"10.1016\/j.jnutbio.2025.109896_bib0012","article-title":"Endoplasmic reticulum stress and protein degradation in chronic liver disease","volume":"161","author":"Xia","year":"2020","journal-title":"Pharmacolog Res"},{"issue":"5","key":"10.1016\/j.jnutbio.2025.109896_bib0013","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/S0016-5085(03)00276-2","article-title":"Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice","volume":"124","author":"Ji","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2025.109896_bib0014","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.intimp.2018.10.013","article-title":"Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism","volume":"65","author":"Wang","year":"2018","journal-title":"Int Immunopharmacol"},{"issue":"42","key":"10.1016\/j.jnutbio.2025.109896_bib0015","doi-asserted-by":"crossref","first-page":"16314","DOI":"10.1073\/pnas.0808517105","article-title":"PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation","volume":"105","author":"Bobrovnikova-Marjon","year":"2008","journal-title":"Proceed Natl Acad Sci"},{"issue":"3","key":"10.1016\/j.jnutbio.2025.109896_bib0016","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1515\/cclm-2012-0308","article-title":"B-vitamin dependent methionine metabolism and alcoholic liver disease","volume":"51","author":"Halsted","year":"2013","journal-title":"Clin Chem Lab Med"},{"issue":"3","key":"10.1016\/j.jnutbio.2025.109896_bib0017","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/biof.1154","article-title":"Novel insights on interactions between folate and lipid metabolism","volume":"40","author":"Da Silva R","year":"2013","journal-title":"BioFactors"},{"issue":"5","key":"10.1016\/j.jnutbio.2025.109896_bib0018","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1016\/j.clnu.2017.06.021","article-title":"Serum folic acid levels are associated with the presence and severity of liver steatosis in Chinese adults","volume":"37","author":"Xia","year":"2018","journal-title":"Clin Nutr"},{"issue":"50","key":"10.1016\/j.jnutbio.2025.109896_bib0019","doi-asserted-by":"crossref","first-page":"13162","DOI":"10.1021\/acs.jafc.8b05193","article-title":"Folic acid reduced triglycerides deposition in primary chicken hepatocytes","volume":"66","author":"Liu","year":"2018","journal-title":"J Agric Food Chem"},{"issue":"6","key":"10.1016\/j.jnutbio.2025.109896_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108005","article-title":"Activation of a specific gut Bacteroides-folate-liver axis benefits for the alleviation of nonalcoholic hepatic steatosis","volume":"32","author":"Qiao","year":"2020","journal-title":"Cell Rep"},{"issue":"39","key":"10.1016\/j.jnutbio.2025.109896_bib0021","doi-asserted-by":"crossref","first-page":"14276","DOI":"10.1021\/acs.jafc.3c01851","article-title":"Folic acid protects against ethanol-induced hepatic mitophagy imbalance by ROS scavenging and attenuating the elevated hcy levels","volume":"71","author":"Zhao","year":"2023","journal-title":"J Agric Food Chem"},{"issue":"12","key":"10.1016\/j.jnutbio.2025.109896_bib0022","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.3390\/nu16121872","article-title":"Role of folate in liver diseases","volume":"16","author":"Yang","year":"2024","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.jnutbio.2025.109896_bib0023","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1093\/ajcn\/33.12.2727","article-title":"Nutritional anemia in alcoholism","volume":"33","author":"Lindenbaum","year":"1980","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"10.1016\/j.jnutbio.2025.109896_bib0024","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/mnfr.201200077","article-title":"Folate, alcohol, and liver disease","volume":"57","author":"Medici","year":"2012","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jnutbio.2025.109896_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155437","article-title":"Rutin ameliorated lipid metabolism dysfunction of diabetic NAFLD via AMPK\/SREBP1 pathway","volume":"126","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.jnutbio.2025.109896_bib0026","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.3945\/jn.114.193128","article-title":"Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice","volume":"144","author":"Liu","year":"2014","journal-title":"J Nutr"},{"issue":"6","key":"10.1016\/j.jnutbio.2025.109896_bib0027","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.3390\/ijms24065531","article-title":"Role of Stearoyl-CoA Desaturase 1 in cardiovascular physiology","volume":"24","author":"Balatskyi","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jnutbio.2025.109896_bib0028","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3390\/nu9040346","article-title":"Homocysteine induces hepatic steatosis involving ER stress response in high methionine diet-fed mice","volume":"9","author":"Ai","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.109896_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2022.101198","article-title":"Endoplasmic reticulum stress and lipids in health and diseases","volume":"89","author":"Celik","year":"2023","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.jnutbio.2025.109896_bib0030","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.lfs.2014.11.019","article-title":"Chronic intermittent hypobaric hypoxia ameliorates endoplasmic reticulum stress mediated liver damage induced by fructose in rats","volume":"121","author":"Yuan","year":"2015","journal-title":"Life Sci"},{"key":"10.1016\/j.jnutbio.2025.109896_bib0031","article-title":"Endoplasmic reticulum stress: bridging inflammation and obesity-associated adipose tissue","volume":"15","author":"Ma","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2025.109896_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2022.101198","article-title":"Endoplasmic reticulum stress and lipids in health and diseases","volume":"89","author":"Celik","year":"2023","journal-title":"Prog Lipid Res"},{"issue":"12","key":"10.1016\/j.jnutbio.2025.109896_bib0033","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.3109\/10715762.2015.1078461","article-title":"Endoplasmic reticulum stress and oxidative stress in the pathogenesis of non-alcoholic fatty liver disease","volume":"49","author":"Ashraf","year":"2015","journal-title":"Free Radical Res"},{"issue":"4","key":"10.1016\/j.jnutbio.2025.109896_bib0034","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2018.06.008","article-title":"Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease","volume":"69","author":"Lebeaupin","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.jnutbio.2025.109896_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2021.107067","article-title":"The relationship with the stability between GRP78, CHOP and human carotid atherosclerotic plaque","volume":"212","author":"Wang","year":"2022","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.jnutbio.2025.109896_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110375","article-title":"Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy","volume":"129","author":"Pang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jnutbio.2025.109896_bib0037","doi-asserted-by":"crossref","unstructured":"Almeida L. M., Pinho B. R. The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases. 2022, 97(5): 1737-48.","DOI":"10.1111\/brv.12860"},{"key":"10.1016\/j.jnutbio.2025.109896_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118740","article-title":"The molecular mechanism and functional diversity of UPR signaling sensor IRE1","volume":"265","author":"Bashir","year":"2021","journal-title":"Life Sci"},{"issue":"12","key":"10.1016\/j.jnutbio.2025.109896_bib0039","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s41419-022-05444-x","article-title":"Endoplasmic reticulum stress-mediated cell death in liver injury","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis"},{"issue":"Pt A","key":"10.1016\/j.jnutbio.2025.109896_bib0040","article-title":"Explore the mechanism and substance basis of Mahuang FuziXixin Decoction for the treatment of lung cancer based on network pharmacology and molecular docking","volume":"151","author":"Zhang","year":"2022","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.jnutbio.2025.109896_bib0041","doi-asserted-by":"crossref","first-page":"105737","DOI":"10.1016\/j.bioorg.2022.105737","article-title":"Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress","volume":"122","author":"Li","year":"2022","journal-title":"Bioorganic Chem"},{"issue":"12","key":"10.1016\/j.jnutbio.2025.109896_bib0042","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s41419-022-05444-x","article-title":"Endoplasmic reticulum stress-mediated cell death in liver injury","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis"},{"issue":"14","key":"10.1016\/j.jnutbio.2025.109896_bib0043","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.7150\/ijbs.86608","article-title":"Broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane (MAM) dysfunction in diabetic kidney disease","volume":"19","author":"Liu","year":"2023","journal-title":"Int J Biol Sci"},{"issue":"5","key":"10.1016\/j.jnutbio.2025.109896_bib0044","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jmb.2017.01.017","article-title":"Regulation of calcium homeostasis by ER redox: a close-up of the ER\/mitochondria connection","volume":"429","author":"Chernorudskiy","year":"2017","journal-title":"J Mol Biol"},{"issue":"49","key":"10.1016\/j.jnutbio.2025.109896_bib0045","doi-asserted-by":"crossref","first-page":"19531","DOI":"10.1021\/acs.jafc.3c05529","article-title":"Astaxanthin protects against alcoholic liver injury via regulating mitochondrial redox balance and calcium homeostasis","volume":"71","author":"Wang","year":"2023","journal-title":"J Agric Food Chem"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325000592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325000592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:35:15Z","timestamp":1777595715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286325000592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":45,"alternative-id":["S0955286325000592"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.109896","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Folic acid intervention ameliorates hepatic steatosis after long-term alcohol exposure by alleviating endoplasmic reticulum stress","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.109896","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109896"}}