{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T05:40:13Z","timestamp":1760074813795,"version":"build-2065373602"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jnutbio.2025.109913","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T08:43:09Z","timestamp":1743756189000},"page":"109913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Linoleic acid modulates vascular reactivity, alters cyclooxygenase-2-derived products, and promotes eutrophic remodeling in small mesenteric arteries of normotensive rats"],"prefix":"10.1016","volume":"141","author":[{"given":"Dieli Oliveira","family":"Nunes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicius Bermond","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Cruz Pereira","family":"Almenara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wena Dantas","family":"Marcarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Hertel","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivanita","family":"Stefanon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-1347","authenticated-orcid":false,"given":"Alessandra Sim\u00e3o","family":"Padilha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2025.109913_bib0001","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.3390\/nu15143129","article-title":"Linoleic acid: a narrative review of the effects of increased intake in the standard American diet and associations with chronic disease","volume":"15","author":"Mercola","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0002","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/nu8010023","article-title":"Fatty acid desaturases, polyunsaturated Fatty acid regulation, and biotechnological advances","volume":"8","author":"Lee","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0003","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s12944-024-02246-2","article-title":"Beneficial effects of linoleic acid on cardiometabolic health: an update","volume":"23","author":"Jackson","year":"2024","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0004","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00125-001-0768-3","article-title":"Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity","volume":"45","author":"Summers","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0005","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3945\/ajcn.2009.28500","article-title":"Serum n\u22126 fatty acids and lipoprotein subclasses in middle-aged men: the population-based cross-sectional ERA-JUMP study","volume":"91","author":"Choo","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0006","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3945\/ajcn.111.030114","article-title":"Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial","volume":"95","author":"Bjermo","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0007","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1161\/CIRCULATIONAHA.118.038908","article-title":"Biomarkers of dietary omega-6 fatty acids and incident cardiovascular disease and mortality","volume":"139","author":"Marklund","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0008","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1161\/CIRCULATIONAHA.114.010236","article-title":"Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies","volume":"130","author":"Farvid","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0009","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/HYPERTENSIONAHA.108.112383","article-title":"Relationship of dietary linoleic acid to blood pressure","volume":"52","author":"Miura","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0010","doi-asserted-by":"crossref","DOI":"10.1161\/01.HYP.15.2_Suppl.I81","article-title":"Dietary linoleic acid prevents the development of deoxycorticosterone acetate-salt hypertension","volume":"15","author":"Kawahara","year":"1990","journal-title":"Hypertension"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0011","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jnutbio.2018.07.016","article-title":"Linoleic acid reduces vascular reactivity and improves the vascular dysfunction of the small mesentery in hypertension","volume":"62","author":"Nunes","year":"2018","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0012","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/01.HYP.31.2.615","article-title":"Linoleic acid induces relaxation and hyperpolarization of the pig coronary artery","volume":"31","author":"Pomposiello","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0013","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.metabol.2005.06.007","article-title":"Fatty acid\u2013induced changes in vascular reactivity in healthy adult rats","volume":"54","author":"Christon","year":"2005","journal-title":"Metabolism"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0014","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4196\/kjpp.2019.23.5.403","article-title":"Differential effects of saturated and unsaturated fatty acids on vascular reactivity in isolated mesenteric and femoral arteries of rats","volume":"23","author":"Vorn","year":"2019","journal-title":"Korean J Physiol Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0015","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/apha.12646","article-title":"Endothelial dysfunction and vascular disease - a 30th anniversary update","volume":"219","author":"Vanhoutte","year":"2017","journal-title":"Acta Physiologica"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0016","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12012-002-0006-3","article-title":"Linoleic acid metabolites act to increase contractility in isolated rat heart","volume":"2","author":"Mitchell","year":"2002","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0017","doi-asserted-by":"crossref","DOI":"10.1161\/01.RES.41.1.19","article-title":"Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats","author":"Mulvany","year":"1977","journal-title":"Circ Res"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0018","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.3390\/ijms20184411","article-title":"Vascular endothelial cell biology: an update","volume":"20","author":"Kr\u00fcger-Genge","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0019","first-page":"577","article-title":"[Significance of endothelial cells for the regulation of the tone of smooth muscle\u2013formation of an endothelial, relaxing factor]","volume":"75","author":"F\u00f6rstermann","year":"1986","journal-title":"Z Kardiol"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0020","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0022-2275(20)33888-8","article-title":"Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid","volume":"39","author":"Ramasamy","year":"1998","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0021","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1161\/01.HYP.26.5.764","article-title":"Oleic acid inhibits endothelial nitric oxide synthase by a protein kinase C\u2013Independent mechanism","volume":"26","author":"Davda","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0022","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.freeradbiomed.2019.09.029","article-title":"NADPH oxidase in the vasculature: expression, regulation and signalling pathways; role in normal cardiovascular physiology and its dysregulation in hypertension","volume":"145","author":"Knock","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0023","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1476-5381.2011.01276.x","article-title":"Endothelium-mediated control of vascular tone: COX-1 and COX-2 products","volume":"164","author":"F\u00e9l\u00e9tou","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0024","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00424-010-0812-6","article-title":"Vasoconstrictor prostanoids","volume":"459","author":"F\u00e9l\u00e9tou","year":"2010","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0025","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jnutbio.2008.02.004","article-title":"Role of caveolin-1 in EGCG-mediated protection against linoleic-acid-induced endothelial cell activation","volume":"20","author":"Zheng","year":"2009","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0026","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jnutbio.2006.01.005","article-title":"Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3K\/Akt and ERK1\/2 signaling","volume":"17","author":"Hennig","year":"2006","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0027","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10555-011-9302-3","article-title":"The cytochrome P450 pathway in angiogenesis and endothelial cell biology","volume":"30","author":"Fleming","year":"2011","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0028","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbapap.2010.09.009","article-title":"Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids","volume":"1814","author":"Konkel","year":"2011","journal-title":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0029","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3164\/jcbn.2008047","article-title":"Role of linoleic acid hydroperoxide preformed by cyclooxygenase-1 or -2 on the regulation of prostaglandin formation from arachidonic acid by the respective enzyme","volume":"43","author":"Fujimoto","year":"2008","journal-title":"J Clin Biochem Nutr"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0030","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1021\/np000620d","article-title":"COX-2 inhibitory effects of naturally occurring and modified fatty acids","volume":"64","author":"Ringbom","year":"2001","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0031","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0167-4889(03)00005-3","article-title":"Conjugated linoleic acid exhibits stimulatory and inhibitory effects on prostanoid production in human endothelial cells and platelets","volume":"1640","author":"Torres-Duarte","year":"2003","journal-title":"Biochimica et Biophysica Acta (BBA) - Mol Cell Res"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0032","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.toxlet.2017.07.497","article-title":"Chronic iron overload induces functional and structural vascular changes in small resistance arteries via NADPH oxidase-dependent O2[rad]\u2212 production","volume":"279","author":"Ribeiro J\u00fanior","year":"2017","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0033","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/01.HYP.36.3.312","article-title":"Structure and mechanical properties of resistance arteries in hypertension","volume":"36","author":"Intengan","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0034","first-page":"409","article-title":"Mechanical properties of arteries","volume":"19","author":"Bauer","year":"1982","journal-title":"Biorheology"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0035","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1161\/01.CIR.100.22.2267","article-title":"Resistance artery mechanics, structure, and extracellular components in spontaneously hypertensive rats","volume":"100","author":"Intengan","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0036","first-page":"149","article-title":"Influence of renal prostaglandins and dietary linoleate on hypertension in Dahl S rats","volume":"4","author":"Tobian","year":"1982","journal-title":"Hypertension"},{"key":"10.1016\/j.jnutbio.2025.109913_bib0037","doi-asserted-by":"crossref","DOI":"10.1161\/01.HYP.19.2_Suppl.II111","article-title":"Antihypertensive effect of gamma-linolenic acid in spontaneously hypertensive rats","volume":"19","author":"St Louis","year":"1992","journal-title":"Hypertension"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325000762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325000762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T05:07:10Z","timestamp":1760072830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286325000762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":37,"alternative-id":["S0955286325000762"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.109913","relation":{},"ISSN":["0955-2863"],"issn-type":[{"type":"print","value":"0955-2863"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Linoleic acid modulates vascular reactivity, alters cyclooxygenase-2-derived products, and promotes eutrophic remodeling in small mesenteric arteries of normotensive rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.109913","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109913"}}