{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T22:48:35Z","timestamp":1762814915044,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005918","name":"Christian Medical College Vellore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005918","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jnutbio.2025.110048","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T15:54:33Z","timestamp":1753977273000},"page":"110048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The presence of a H. pylori infection blunted the upregulation of iron-related duodenal proteins in response to anemia"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4725-3227","authenticated-orcid":false,"given":"Jagadish","family":"Ramasamy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7656-7941","authenticated-orcid":false,"given":"Monica","family":"Peter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-3097","authenticated-orcid":false,"given":"Nikhitha Mariya","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jithu James","family":"Varghese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiny","family":"Prem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"Varghese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thenmozhi","family":"Mani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebby George","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1406-9298","authenticated-orcid":false,"given":"Molly","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"16 Suppl 1","key":"10.1016\/j.jnutbio.2025.110048_bib0001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-2036.2002.0160s1003.x","article-title":"Review article: natural history and epidemiology of Helicobacter pylori infection","author":"Go","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0002","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1128\/CMR.00011-10","article-title":"Helicobacter pylori and gastric cancer: factors that modulate disease risk","volume":"23","author":"Wroblewski","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0003","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1146\/annurev.micro.54.1.615","article-title":"The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer","volume":"54","author":"Ernst","year":"2000","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0004","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0924-8579(00)00288-0","article-title":"Iron deficiency anaemia and Helicobacter pylori infection","volume":"16","author":"Annibale","year":"2000","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0005","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1572-0241.2005.30252.x","article-title":"Iron-deficiency anemia and Helicobacter pylori infection: a review of the evidence","volume":"100","author":"DuBois","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068833","article-title":"Iron Status and Helicobacter pylori Infection in Symptomatic Children: An International Multi-Centered Study","volume":"8","author":"Queiroz","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0007","first-page":"886","article-title":"Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis","volume":"16","author":"Qu","year":"2010","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0008","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3109\/00365521003663670","article-title":"Iron deficiency anemia in Helicobacter pylori infection: meta-analysis of randomized controlled trials","volume":"45","author":"Yuan","year":"2010","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0009","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.3748\/wjg.v19.i26.4166","article-title":"Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin","volume":"19","author":"Monz\u00f3n","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0010","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1136\/gut.52.4.496","article-title":"Concomitant alterations in intragastric pH and ascorbic acid concentration in patients with Helicobacter pylori gastritis and associated iron deficiency anaemia","volume":"52","author":"Annibale","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0011","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1001\/jama.1997.03540380049030","article-title":"Pervasive occult gastrointestinal bleeding in an alaska native population with prevalent iron deficiency: role of helicobacter pylori gastritis","volume":"277","author":"Yip","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0012","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1086\/526784","article-title":"Enhanced Fe Ion-uptake activity in helicobacter pylori strains isolated from patients with iron-deficiency anemia","volume":"46","author":"Yokota","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0013","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1046\/j.1365-2958.2000.01987.x","article-title":"Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high-affinity ferrous iron transporter","volume":"37","author":"Velayudhan","year":"2000","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002050","article-title":"Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface","volume":"7","author":"Tan","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0015","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1136\/gut.34.8.1038","article-title":"Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrations","volume":"34","author":"Sobala","year":"1993","journal-title":"Gut"},{"year":"2018","series-title":"Chapter 52. Plasma Proteins & Immunoglobulins. Harper\u2019s Illustrated Biochemistry","author":"Kenelly","key":"10.1016\/j.jnutbio.2025.110048_bib0016"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0017","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0018","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/gut.2011.241208","article-title":"Hepcidin is localised in gastric parietal cells, regulates acid secretion and is induced by Helicobacter pylori infection","volume":"61","author":"Schwarz","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0019","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1073\/pnas.95.3.1148","article-title":"Nramp2 is mutated in the anemic Belgraderat: evidence of a role for Nramp2 in endosomal iron transport","volume":"95","author":"Fleming","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0020","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ng0897-383","article-title":"Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene","volume":"16","author":"Fleming","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0021","doi-asserted-by":"crossref","first-page":"G598","DOI":"10.1152\/ajpgi.00371.2001","article-title":"Intestinal expression of genes involved in iron absorption in humans","volume":"282","author":"Rolfs","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0022","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1152\/physiolgenomics.00211.2003","article-title":"Adaptive changes of duodenal iron transport proteins in celiac disease","volume":"17","author":"Barisani","year":"2004","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0023","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s004240000319","article-title":"Gastrointestinal function, divalent metal transporter-1 expression and intestinal iron absorption","volume":"440","author":"Oates","year":"2000","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059538","article-title":"Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2\u03b1 and altered expression of iron absorption genes in mice","volume":"8","author":"Matak","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0025","doi-asserted-by":"crossref","first-page":"C477","DOI":"10.1152\/ajpcell.00168.2009","article-title":"Iron supply determines apical\/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1","volume":"298","author":"N\u00fa\u00f1ez","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0026","doi-asserted-by":"crossref","first-page":"G1153","DOI":"10.1152\/ajpgi.00107.2003","article-title":"DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption","volume":"285","author":"Leong","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0027","doi-asserted-by":"crossref","DOI":"10.1111\/hel.12330","article-title":"An updated systematic review and meta-analysis on the association between Helicobacter pylori infection and iron deficiency anemia","volume":"22","author":"Hudak","year":"2017","journal-title":"Helicobacter"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0028","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cmet.2008.12.012","article-title":"Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency","volume":"9","author":"Shah","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0029","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1053\/gast.2002.35353","article-title":"Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats","volume":"123","author":"Frazer","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0030","doi-asserted-by":"crossref","first-page":"359S","DOI":"10.3945\/ajcn.116.141762","article-title":"Adjusting ferritin concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project","volume":"106","author":"Namaste","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0031","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/MOG.0b013e32831ef1cd","article-title":"Iron deficiency anemia: diagnosis and management","volume":"25","author":"Clark","year":"2009","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0032","article-title":"Divalent metal-ion transporter 1 is decreased in intestinal epithelial cells and contributes to the anemia in inflammatory bowel disease","volume":"5","author":"Wu","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0033","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1053\/j.gastro.2010.12.037","article-title":"Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation","volume":"140","author":"Brasse-Lagnel","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0034","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.pedneo.2018.02.007","article-title":"Hepcidin correlates with interleukin-1\u03b2 and interleukin-6 but not iron deficiency in children with Helicobacter pylori infection","volume":"59","author":"Chen","year":"2018","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0035","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00508-016-0961-5","article-title":"The impact of Helicobacter pylori eradication on serum hepcidin-25 level and iron parameters in patients with iron deficiency anemia","volume":"128","author":"Sapmaz","year":"2016","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0036","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/MOG.0000000000000308","article-title":"Gastric acid secretion","volume":"32","author":"Schubert","year":"2016","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0037","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3945\/ajcn.114.097394","article-title":"Is achlorhydria a cause of iron deficiency anemia?","volume":"102","author":"Betesh","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0038","first-page":"1554","article-title":"High prevalence and persistence of cytotoxin-positive Helicobacter pylori strains in a population with high prevalence of atrophic gastritis","volume":"87","author":"Fox","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0039","first-page":"146","article-title":"Gastric histopathology, iron status and iron deficiency anemia in children with helicobacter pylori infection","volume":"38","author":"Baysoy","year":"2004","journal-title":"J Pediat Gastroenterol Nutr"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0040","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.3945\/jn.112.160358","article-title":"Duodenal reductase activity and spleen iron stores are reduced and erythropoiesis is abnormal in Dcytb knockout mice exposed to hypoxic conditions","volume":"142","author":"Choi","year":"2012","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2025.110048_bib0041","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1172\/JCI64373","article-title":"Iron deficiency accelerates helicobacter pylori-induced carcinogenesis in rodents and humans","volume":"123","author":"Noto","year":"2013","journal-title":"J Clin Invest"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325002116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325002116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T22:44:36Z","timestamp":1762814676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286325002116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":41,"alternative-id":["S0955286325002116"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110048","relation":{},"ISSN":["0955-2863"],"issn-type":[{"type":"print","value":"0955-2863"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The presence of a H. pylori infection blunted the upregulation of iron-related duodenal proteins in response to anemia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110048"}}