{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:45:59Z","timestamp":1785462359578,"version":"3.56.0"},"reference-count":113,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["MKB-YRF 2020\/21"],"award-info":[{"award-number":["MKB-YRF 2020\/21"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jnutbio.2025.110050","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:08:54Z","timestamp":1754438934000},"page":"110050","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Fisetin ameliorates neurobehavioral deficits in bile duct ligated rat model by restoring spine density and memory gene expression"],"prefix":"10.1016","volume":"146","author":[{"given":"Shiwangi","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Rishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aanchal","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2025.110050_bib0001","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1007\/s11064-021-03372-4","article-title":"Hepatic encephalopathy: from metabolic to neurodegenerative","volume":"46","author":"Ochoa-Sanchez","year":"2021","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0002","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cld.2012.03.009","article-title":"Hepatic encephalopathy","volume":"16","author":"Khungar","year":"2012","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0003","doi-asserted-by":"crossref","first-page":"170","DOI":"10.55544\/jrasb.3.3.27","article-title":"A comprehensive review on hepatic encephalopathy: pathophysiology, symptoms, epidemiology, classification, diagnosis and treatment","volume":"3","author":"Tejpal","year":"2024","journal-title":"J Res Appl Sci Biotechnol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0004","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/apt.16831","article-title":"Current and emerging therapies for the management of cirrhosis and its complications","volume":"55","author":"Tapper","year":"2022","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0005","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.jhep.2016.07.046","article-title":"Cerebrospinal fluid metabolomics highlights dysregulation of energy metabolism in overt hepatic encephalopathy","volume":"65","author":"Weiss","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0006","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1053\/j.gastro.2020.02.020","article-title":"Metabolic inflammation\u2014A role for hepatic inflammatory pathways as drivers of comorbidities in nonalcoholic fatty liver disease?","volume":"158","author":"Gehrke","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0007","unstructured":"Tamnanloo F. Implications of neuronal cell loss in chronic liver disease. 2024."},{"key":"10.1016\/j.jnutbio.2025.110050_bib0008","first-page":"1","article-title":"Ammonia-induced stress response in liver disease progression and hepatic encephalopathy","author":"Gallego-Dur\u00e1n","year":"2024","journal-title":"Nature Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0009","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22735","article-title":"Sirtuin-3 activation by honokiol restores mitochondrial dysfunction in the hippocampus of the hepatic encephalopathy rat model of ammonia neurotoxicity","volume":"35","author":"Anamika","year":"2021","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2022.114795","article-title":"Overview of oxidative stress findings in hepatic encephalopathy: from cellular and ammonium-based animal models to human data","volume":"654","author":"Simicic","year":"2022","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2022.114766","article-title":"Low cerebral energy metabolism in hepatic encephalopathy reflects low neuronal energy demand. Role of ammonia-induced increased GABAergic tone","volume":"654","author":"S\u00f8rensen","year":"2022","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.578922","article-title":"Disturbance of the glutamate-glutamine cycle, secondary to hepatic damage, compromises memory function","volume":"15","author":"Lim\u00f3n","year":"2021","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0013","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.cgh.2022.04.034","article-title":"Hepatic encephalopathy: current and emerging treatment modalities","volume":"20","author":"Fallahzadeh","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0014","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cld.2024.01.004","article-title":"Minimal hepatic encephalopathy","volume":"28","author":"Redfield","year":"2024","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0015","series-title":"Phytochemistry, the Military and Health","first-page":"257","article-title":"Prevention of liver problems from adverse chemical agents by healthy nutrition and Unani dietotherapy","author":"Ansari","year":"2021"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0016","first-page":"01","article-title":"Critical overview of probiotics efficacy on health and its safety","author":"Deka","year":"2021","journal-title":"Pharmaceut Biosci J"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0017","doi-asserted-by":"crossref","first-page":"370","DOI":"10.2307\/j.ctt1q1cr8b.33","article-title":"Interactions between supplements and medications","author":"Sultan","year":"2018","journal-title":"Iatrogenicity"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0018","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1515\/rjdnmd-2016-0020","article-title":"Metabolic interplay of hepatic enzymes\u2013a case report","volume":"23","author":"Ungurianu","year":"2016","journal-title":"Roman J Diabetes Nutr Metab Dis"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0019","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9966750","article-title":"Gon\u00e7alves-de-Albuquerque CF. Flavonols and flavones as potential anti-inflammatory, antioxidant, and antibacterial compounds","volume":"2022","author":"Chagas","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0020","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1080\/1028415X.2022.2028058","article-title":"A role for flavonoids in the prevention and\/or treatment of cognitive dysfunction, learning, and memory deficits: a review of preclinical and clinical studies","volume":"26","author":"Ramezani","year":"2023","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0021","article-title":"A comprehensive review of the pharmacological importance of dietary flavonoids as hepatoprotective agents","volume":"2023","author":"Gajender","year":"2023","journal-title":"Evid-Based Compl Alternat Med"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0022","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tifs.2021.03.030","article-title":"Food flavonols: nutraceuticals with complex health benefits and functionalities","volume":"117","author":"Barreca","year":"2021","journal-title":"Trends Food Sci Technol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0023","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1007\/s12035-016-9795-4","article-title":"Neuroprotective effect of fisetin against amyloid-beta-induced cognitive\/synaptic dysfunction, neuroinflammation, and neurodegeneration in adult mice","volume":"54","author":"Ahmad","year":"2017","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0024","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/jnc.15370","article-title":"Flavonoid fisetin reverses impaired hippocampal synaptic plasticity and cognitive function by regulating the function of AMPARs in a male rat model of schizophrenia","volume":"158","author":"Zhan","year":"2021","journal-title":"J Neurochem"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0025","article-title":"Bioactive flavonoid fisetin\u2013a molecule of pharmacological interest","volume":"5","author":"Jash","year":"2014","journal-title":"Cardiovasc Dis"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0026","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3390\/jcm8060850","article-title":"Phytomedicine-based potent antioxidant, fisetin protects CNS-insult LPS-induced oxidative stress-mediated neurodegeneration and memory impairment","volume":"8","author":"Ahmad","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0027","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11011-012-9351-5","article-title":"Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy","volume":"28","author":"Bosoi","year":"2013","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0028","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5607\/en.2015.24.4.325","article-title":"The role of oxidative stress in neurodegenerative diseases","volume":"24","author":"Kim","year":"2015","journal-title":"Exp Neurobiol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0029","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11064-011-0583-2","article-title":"Thioacetamide-induced fulminant hepatic failure induces cerebral mitochondrial dysfunction by altering the electron transport chain complexes","volume":"37","author":"Chadipiralla","year":"2012","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0030","first-page":"376","article-title":"Oxidative stress in neurodegenerative diseases\u2606","volume":"7","author":"Chen","year":"2012","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0031","doi-asserted-by":"crossref","first-page":"16568","DOI":"10.1073\/pnas.0607822103","article-title":"Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory","volume":"103","author":"Maher","year":"2006","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0032","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ejphar.2014.06.065","article-title":"Fisetin improves glucose homeostasis through the inhibition of gluconeogenic enzymes in hepatic tissues of streptozotocin induced diabetic rats","volume":"740","author":"Prasath","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.113783","article-title":"Fisetin, a dietary flavonoid, promotes transintestinal cholesterol excretion through the activation of ppar\u03b4","volume":"175","author":"Guo","year":"2024","journal-title":"Food Res Int"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0034","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jff.2014.11.025","article-title":"Fisetin, a dietary flavonoid, attenuates hyperammonemia and improves circadian locomotor deficits, redox balance, and astrocytic markers in rats","volume":"12","author":"Subramanian","year":"2015","journal-title":"J Funct Foods"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0035","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.pharep.2014.06.018","article-title":"Chronotherapeutic effect of fisetin on expression of urea cycle enzymes and inflammatory markers in hyperammonaemic rats","volume":"66","author":"Subramanian","year":"2014","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0036","article-title":"The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: focus on the role of oxidative stress","volume":"13","author":"Hassan","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0037","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1007\/s10753-021-01434-x","article-title":"Neuroprotective effect of fisetin against the cerebral ischemia-reperfusion damage via suppression of oxidative stress and inflammatory parameters","volume":"44","author":"Zhang","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110824","article-title":"Fisetin improves lead-induced neuroinflammation, apoptosis and synaptic dysfunction in mice associated with the AMPK\/SIRT1 and autophagy pathway","volume":"134","author":"Yang","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0039","doi-asserted-by":"crossref","first-page":"19","DOI":"10.17085\/apm.2020.15.1.19","article-title":"Bile duct ligation of C57BL\/6 mice as a model of hepatic encephalopathy","volume":"15","author":"Cho","year":"2020","journal-title":"Anesth Pain Med"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-22423-6","article-title":"A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation","volume":"12","author":"Claeys","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0041","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bionut.2012.04.005","article-title":"Anticonvulsant effect of fisetin by modulation of endogenous biomarkers","volume":"2","author":"Raygude","year":"2012","journal-title":"Biomed Prevent Nutr"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0042","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3233\/BPL-200104","article-title":"Preventing and treating neurological disorders with the flavonol fisetin","volume":"6","author":"Maher","year":"2020","journal-title":"Brain Plasticity"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0043","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1039\/C7FO00809K","article-title":"Protective effects of fisetin and other berry flavonoids in Parkinson's disease","volume":"8","author":"Maher","year":"2017","journal-title":"Food Funct"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0044","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuint.2015.08.003","article-title":"Cell and brain tissue imaging of the flavonoid fisetin using label-free two-photon microscopy","volume":"89","author":"Krasieva","year":"2015","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/gerona\/glx104","article-title":"Fisetin reduces the impact of aging on behavior and physiology in the rapidly aging SAMP8 mouse","volume":"73","author":"Currais","year":"2018","journal-title":"J Gerontol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0046","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jphs.2017.12.008","article-title":"Oral administration of fisetin promotes the induction of hippocampal long-term potentiation in vivo","volume":"136","author":"He","year":"2018","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0047","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neuroscience.2018.03.008","article-title":"Fisetin exerts antioxidant and neuroprotective effects in multiple mutant hSOD1 models of amyotrophic lateral sclerosis by activating ERK","volume":"379","author":"Wang","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0048","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/jcbfm.2011.189","article-title":"The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice","volume":"32","author":"Gelderblom","year":"2012","journal-title":"J Cerebral Blood Flow Metab"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0049","first-page":"305","article-title":"Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat","volume":"65","author":"Kountouras","year":"1984","journal-title":"Br J Exp Pathol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0050","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0051","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1101\/lm.334306","article-title":"Spatial and nonspatial escape strategies in the Barnes maze","volume":"13","author":"Harrison","year":"2006","journal-title":"Learning Memory"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0052","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.neubiorev.2004.06.006","article-title":"The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory","volume":"28","author":"Hughes","year":"2004","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0053","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3329\/ajmbr.v2i2.29006","article-title":"Changes in hepatosomatic index and histoarchitecture of liver in common carp exposed to organophosphate insecticide sumithion","volume":"2","author":"Hossain","year":"2016","journal-title":"Asian J Med Biol Res"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0054","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0095-4543(05)70347-X","article-title":"Evaluation of tests used to screen patients with liver disorders","volume":"23","author":"Scheig","year":"1996","journal-title":"Primary Care"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0055","first-page":"3642","article-title":"Blood-brain barrier permeability is exacerbated in experimental model of hepatic encephalopathy via MMP-9 activation and downregulation of tight junction proteins","volume":"55","author":"Dhanda","year":"2018","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0056","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fnana.2016.00038","article-title":"Golgi-Cox staining step by step","volume":"10","author":"Zaqout","year":"2016","journal-title":"Front Neuroanat"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0057","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proceed Natl Acad Sci"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0058","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000027464","article-title":"Use of bile acids as potential markers of liver dysfunction in humans: a systematic review","volume":"100","author":"Azer","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0059","doi-asserted-by":"crossref","first-page":"428","DOI":"10.14218\/JCTH.2023.00446","article-title":"Subnormal serum liver enzyme levels: a review of pathophysiology and clinical significance","volume":"12","author":"Youssef","year":"2024","journal-title":"J Clin Transl Hepatol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0060","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1515\/hsz-2021-0209","article-title":"Acute-phase protein synthesis: a key feature of innate immune functions of the liver","volume":"402","author":"Ehlting","year":"2021","journal-title":"Biol Chem"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0061","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1134\/S002209302106020X","article-title":"Integrative role of albumin: evolutionary, biochemical and pathophysiological aspects","volume":"57","author":"Belinskaia","year":"2021","journal-title":"J Evol Biochem Physiol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0062","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.13737","article-title":"Changes in Protein Metabolism and Early Development of Sarcopenia in Mice With Cholestatic Liver Disease","volume":"16","author":"Agrifoglio","year":"2025","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0063","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.nut.2014.03.016","article-title":"Ammonia and amino acid profiles in liver cirrhosis: effects of variables leading to hepatic encephalopathy","volume":"31","author":"Holecek","year":"2015","journal-title":"Nutrition"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0064","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4939-8994-2_10","article-title":"The Y-maze for assessment of spatial working and reference memory in mice","author":"Kraeuter","year":"2019","journal-title":"Pre-Clin Models"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.pneurobio.2014.12.002","article-title":"Synaptic clustering within dendrites: an emerging theory of memory formation","volume":"126","author":"Kastellakis","year":"2015","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0066","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.cell.2019.09.011","article-title":"Neuromodulator signaling bidirectionally controls vesicle numbers in human synapses","volume":"179","author":"Patzke","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0067","doi-asserted-by":"crossref","first-page":"19902","DOI":"10.1073\/pnas.0609924104","article-title":"PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating","volume":"103","author":"Lin","year":"2006","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0068","doi-asserted-by":"crossref","first-page":"24534","DOI":"10.1016\/S0021-9258(17)31422-9","article-title":"Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle","volume":"269","author":"Calakos","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0069","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1083\/jcb.134.5.1219","article-title":"Synaptic vesicle recycling in synapsin I knock-out mice","volume":"134","author":"Ryan","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0070","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1016-8478(23)17545-5","article-title":"Altered complexin expression in psychiatric and neurological disorders: cause or consequence?","volume":"25","author":"Brose","year":"2008","journal-title":"Mol Cells"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0071","doi-asserted-by":"crossref","first-page":"18664","DOI":"10.1073\/pnas.0509153102","article-title":"Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1","volume":"102","author":"Rhee","year":"2005","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0072","doi-asserted-by":"crossref","first-page":"14","DOI":"10.61186\/nl.3.2.14","article-title":"Neuroprotective role of Fisetin in Alzheimer's disease: an overview of potential mechanism and clinical findings","volume":"3","author":"Nabizadeh","year":"2024","journal-title":"Neurol Lett"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0073","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.1007\/s12035-023-03469-7","article-title":"The neuroprotective role of Fisetin in different neurological diseases: a systematic review","volume":"60","author":"Jiang","year":"2023","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0074","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.nutres.2017.03.008","article-title":"Coffee consumption prevents fibrosis in a rat model that mimics secondary biliary cirrhosis in humans","volume":"40","author":"Arauz","year":"2017","journal-title":"Nutr Res"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0075","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00268-003-7209-z","article-title":"Obstructive jaundice in rats: cause of spatial memory deficits with recovery after biliary decompression","volume":"28","author":"Huang","year":"2004","journal-title":"World J Surg"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0076","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/08923973.2022.2047198","article-title":"Fisetin alleviates thioacetamide-induced hepatic fibrosis in rats by inhibiting wnt\/\u03b2-catenin signaling pathway","volume":"44","author":"El-Fadaly","year":"2022","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0077","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuint.2011.09.007","article-title":"Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy","volume":"60","author":"Rao","year":"2012","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0078","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.14309\/01.ajg.0000582124.67482.93","article-title":"P: 37 probiotics combined with Rifaximin for the treatment of chronic hepatic encephalopathy: a longitudinal In vivo 1H-MRS study of brain metabolism using BDL rats","volume":"114","author":"Flatt","year":"2019","journal-title":"Off J Am Coll Gastroenterol ACG"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0079","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1007\/s11064-012-0803-4","article-title":"The role of glutamine synthetase and glutamate dehydrogenase in cerebral ammonia homeostasis","volume":"37","author":"Cooper","year":"2012","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2022.114696","article-title":"Amino acids, ammonia, and hepatic encephalopathy","volume":"649","author":"Kroupina","year":"2022","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0081","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s11064-016-2014-x","article-title":"Neurotoxicity of ammonia","volume":"42","author":"Oja","year":"2017","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0082","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0022-510X(99)00169-0","article-title":"Hepatic encephalopathy: molecular mechanisms underlying the clinical syndrome","volume":"170","author":"Albrecht","year":"1999","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0083","first-page":"33","article-title":"Antihyperammonemic effect of fisetin on hyperammonemic rats: a biochemical study","volume":"2","author":"Jayakumar","year":"2013","journal-title":"Int J Mod Res Rev"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0084","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bbi.2018.03.002","article-title":"Systemic inflammation without gliosis mediates cognitive deficits through impaired BDNF expression in bile duct ligation model of hepatic encephalopathy","volume":"70","author":"Dhanda","year":"2018","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0085","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1001\/jama.2019.7437","article-title":"Associations of amyloid, tau, and neurodegeneration biomarker profiles with rates of memory decline among individuals without dementia","volume":"321","author":"Jack","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0086","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139739","article-title":"Spatial and working memory is linked to spine density and mushroom spines","volume":"10","author":"Mahmmoud","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0087","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41467-017-02751-2","article-title":"Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory","volume":"9","author":"Frank","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0088","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/jnc.15290","article-title":"Bile-duct ligation renders the brain susceptible to hypotension-induced neuronal degeneration: implications of ammonia","volume":"157","author":"Cl\u00e9ment","year":"2021","journal-title":"J Neurochem"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0089","doi-asserted-by":"crossref","unstructured":"Raviz E.K., Noormand F., Kermani A.S., Galedari A., Esmaeilpour K., Maneshian M., et al. Promising effects of naringenin and melatonin against hepatic encephalopathy impairments induced by bile duct ligation in male rats. Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Central Nervous System Agents). 2022;22:31-8.","DOI":"10.2174\/1871524922666220314123052"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0090","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3389\/fnins.2020.00241","article-title":"Fisetin prevents HT22 cells from high glucose-induced neurotoxicity via PI3K\/Akt\/CREB signaling pathway","volume":"14","author":"Zhang","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0091","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0074-7742(09)85026-5","article-title":"Role of Akt and ERK signaling in the neurogenesis following brain ischemia","volume":"85","author":"Shioda","year":"2009","journal-title":"Int Rev Neurobiol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0092","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1016\/j.bmc.2011.05.021","article-title":"Neuroprotective effects of linarin through activation of the PI3K\/akt pathway in amyloid-\u03b2-induced neuronal cell death","volume":"19","author":"Lou","year":"2011","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0093","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/toxsci\/kfx093","article-title":"Insulin resistance disrupts the interaction between AKT and the NMDA receptor and the inactivation of the CaMKIV\/CREB pathway in minimal hepatic encephalopathy","volume":"159","author":"Ding","year":"2017","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0094","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuro.2022.08.005","article-title":"SB332235, a CXCR2 antagonist, ameliorates thioacetamide-induced hepatic encephalopathy through modulation of the PI3K\/AKT pathways in rats","volume":"92","author":"Abdelaziz","year":"2022","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0095","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1007\/s12035-023-03264-4","article-title":"Sustained hyperammonemia activates NF-\u03baB in Purkinje neurons through activation of the TrkB-PI3K-AKT pathway by microglia-derived BDNF in a rat model of minimal hepatic encephalopathy","volume":"60","author":"Arenas","year":"2023","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0096","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2202-15-15","article-title":"Morphological changes of cortical pyramidal neurons in hepatic encephalopathy","volume":"15","author":"Chen","year":"2014","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0097","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116504","article-title":"Unveiling the protective potential of mirabegron against thioacetamide-induced hepatic encephalopathy in rats: insights into cAMP\/PPAR-\u03b3\/p-ERK1\/2\/p S536 NF-\u03bab p 65 and p-CREB\/BDNF\/TrkB in parallel with oxidative and apoptotic trajectories","volume":"229","author":"Hassan","year":"2024","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0098","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00213-018-4833-8","article-title":"Baicalin reverses the impairment of synaptogenesis induced by dopamine burden via the stimulation of GABA AR\u2013TrkB interaction in minimal hepatic encephalopathy","volume":"235","author":"Ding","year":"2018","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0099","doi-asserted-by":"crossref","first-page":"20953","DOI":"10.1073\/pnas.0811025106","article-title":"Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development","volume":"105","author":"Elias","year":"2008","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0100","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1124\/mol.106.026062","article-title":"Interaction of the \u00b5-opioid receptor with synaptophysin influences receptor trafficking and signaling","volume":"71","author":"Liang","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0101","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1038\/s41467-019-12015-w","article-title":"Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin","volume":"10","author":"Courtney","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0102","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.3390\/ijms24021384","article-title":"Tricarboxylic acid metabolite imbalance in rats with acute thioacetamide-induced hepatic encephalopathy indicates incomplete recovery","volume":"24","author":"Shurubor","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0103","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/cr.2014.81","article-title":"TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites","volume":"24","author":"Yang","year":"2014","journal-title":"Cell Res"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0104","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a013102","article-title":"Mitochondrial metabolism, sirtuins, and aging","volume":"4","author":"Sack","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0105","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5522708","article-title":"Role of SIRT1 in hepatic encephalopathy: in vivo and in vitro studies focusing on the NLRP3 inflammasome","volume":"2021","author":"Jiao","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0106","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-61639-6","article-title":"Neuroprotective and cognitive enhancing effects of herbecetin against thioacetamide induced hepatic encephalopathy in rats via upregulation of AMPK and SIRT1 signaling pathways","volume":"14","author":"Sedik","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0107","doi-asserted-by":"crossref","DOI":"10.1177\/11779322231155068","article-title":"New insight into mechanisms of hepatic encephalopathy: an integrative analysis approach to identify molecular markers and therapeutic targets","volume":"17","author":"Sepehrinezhad","year":"2023","journal-title":"Bioinform Biol Insights"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0108","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0304-3940(00)01312-4","article-title":"Long-term treatment with haloperidol decreases the mRNA levels of complexin I, but not complexin II, in rat prefrontal cortex, nucleus accumbens and ventral tegmental area","volume":"290","author":"Nakahara","year":"2000","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0109","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/cns.12202","article-title":"Increased activation of synapsin 1 and mitogen-activated protein kinases\/extracellular signal-regulated kinase in the amygdala of maternal separation rats","volume":"20","author":"Park","year":"2014","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0110","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/syn.20840","article-title":"Prenatal exposure to perfluorooctanesulfonate in rat resulted in long-lasting changes of expression of synapsins and synaptophysin","volume":"65","author":"Zeng","year":"2011","journal-title":"Synapse"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0111","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/cne.21908","article-title":"Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain","volume":"512","author":"Mittelsteadt","year":"2009","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0112","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1365-2990.2007.00917.x","article-title":"Spatiotemporal patterns of postsynaptic density (PSD)-95 expression after rat spinal cord injury","volume":"34","author":"Cheng","year":"2008","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.jnutbio.2025.110050_bib0113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12868-019-0546-0","article-title":"The bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression","volume":"20","author":"Louis Sam Titus","year":"2019","journal-title":"BMC Neurosci"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095528632500213X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095528632500213X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:23:32Z","timestamp":1778563412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095528632500213X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":113,"alternative-id":["S095528632500213X"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110050","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fisetin ameliorates neurobehavioral deficits in bile duct ligated rat model by restoring spine density and memory gene expression","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110050"}}