{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:39:59Z","timestamp":1793194799521,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T00:00:00Z","timestamp":1754784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006393","name":"Universidad de Granada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006393","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Government of Andalusia","doi-asserted-by":"publisher","award":["PI-0070-2024"],"award-info":[{"award-number":["PI-0070-2024"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023731","name":"Consejer\u00eda de Salud y Consumo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["C-CTS-301-UGR23"],"award-info":[{"award-number":["C-CTS-301-UGR23"]}],"id":[{"id":"10.13039\/501100023731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jnutbio.2025.110063","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T15:19:59Z","timestamp":1754925599000},"page":"110063","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Immunomodulatory effects of a short-term gluten-free diet on pediatric celiac disease: Findings from a single-cell transcriptomics study"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0113-9904","authenticated-orcid":false,"given":"Rafael","family":"Mart\u00edn-Masot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7304-2144","authenticated-orcid":false,"given":"Nerea","family":"Correa-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4093-4900","authenticated-orcid":false,"given":"Marta","family":"Herrador-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Manuel","family":"Navas-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco David","family":"Carmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Nestares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5471-5824","authenticated-orcid":false,"given":"Lara","family":"Bossini-Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2025.110063_bib0001","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1016\/S0140-6736(22)00794-2","article-title":"Coeliac disease","volume":"399","author":"Catassi","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0002","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.pcl.2021.07.007","article-title":"Celiac disease in children","volume":"68","author":"Jimenez","year":"2021","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0003","doi-asserted-by":"crossref","first-page":"eaaw7756","DOI":"10.1126\/sciadv.aaw7756","article-title":"Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease","volume":"5","author":"Goel","year":"2019","journal-title":"Sci Adv"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0004","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.humimm.2021.07.015","article-title":"Diagnosing coeliac disease: a literature review","volume":"82","author":"Gandini","year":"2021","journal-title":"Hum Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0005","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2011-301346","article-title":"The Oslo definitions for coeliac disease and related terms","volume":"62","author":"Ludvigsson","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0006","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1053\/j.gastro.2020.06.098","article-title":"Epidemiology, presentation, and diagnosis of Celiac disease","volume":"160","author":"Lebwohl","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0007","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global Prevalence of Celiac disease: systematic review and meta-analysis","volume":"16","author":"Singh","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0008","doi-asserted-by":"crossref","first-page":"507","DOI":"10.14309\/ajg.0000000000000523","article-title":"Incidence of celiac disease is increasing over time: a systematic review and meta-analysis","volume":"115","author":"King","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0009","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4291\/wjgp.v8.i2.27","article-title":"Celiac disease: from pathophysiology to treatment","volume":"8","author":"Parzanese","year":"2017","journal-title":"World J Gastrointest Pathophysiol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0010","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pathmechdis-031521-032634","article-title":"The immunobiology and pathogenesis of celiac disease","volume":"18","author":"Iversen","year":"2023","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0011","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3748\/wjg.v28.i4.449","article-title":"Celiac disease: from genetics to epigenetics","volume":"28","author":"Gnodi","year":"2022","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0012","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.jaci.2017.02.015","article-title":"Circulating gluten-specific FOXP3CD39 regulatory T cells have impaired suppressive function in patients with celiac disease","volume":"140","author":"Cook","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0013","doi-asserted-by":"crossref","DOI":"10.3390\/nu13113993","article-title":"The gluten-free diet for celiac disease and beyond","volume":"13","author":"Aljada","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197915","article-title":"Identification of peculiar gene expression profile in peripheral blood mononuclear cells (PBMC) of celiac patients on gluten free diet","volume":"13","author":"Sangineto","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.594243","article-title":"Effects of gluten challenge on PBMC gene expression profiles in diet treated celiac disease","volume":"11","author":"Yohannes","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0016","article-title":"Biomarkers to monitor gluten-free diet compliance in celiac patients","volume":"9","author":"Moreno M de","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0017","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1136\/gutjnl-2015-310148","article-title":"Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing","volume":"66","author":"Moreno M de","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0018","article-title":"The importance of an early evaluation after establishing a gluten-free diet in children with celiac disease","volume":"15","author":"Mart\u00edn-Masot","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0019","doi-asserted-by":"crossref","first-page":"186","DOI":"10.32074\/1591-951X-157","article-title":"Celiac disease: histology-differential diagnosis-complications. A practical approach","volume":"112","author":"Villanacci","year":"2020","journal-title":"Pathologica"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0020","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MPG.0000000000002497","article-title":"European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for diagnosing Coeliac disease 2020","volume":"70","author":"Husby","year":"2020","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0021","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/MOG.0000000000000436","article-title":"Seronegative coeliac disease: clearing the diagnostic dilemma","volume":"34","author":"Schiepatti","year":"2018","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0022","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1177\/2050640617751253","article-title":"Delayed celiac disease diagnosis predisposes to reduced quality of life and incremental use of health care services and medicines: a prospective nationwide study","volume":"6","author":"Fuchs","year":"2018","journal-title":"United European Gastroenterol J"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0023","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228528","article-title":"Molecular biomarkers for celiac disease: past, present and future","volume":"21","author":"Ram\u00edrez-S\u00e1nchez","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0024","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/MPG.0000000000001519","article-title":"Presymptomatic diagnosis of celiac disease in predisposed children: the role of gene expression profile","volume":"65","author":"Galatola","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0025","doi-asserted-by":"crossref","first-page":"eabl5197","DOI":"10.1126\/science.abl5197","article-title":"Cross-tissue immune cell analysis reveals tissue-specific features in humans","volume":"376","author":"Dom\u00ednguez Conde","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0026","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41588-018-0089-9","article-title":"LifeLines Cohort Study, et al. Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs","volume":"50","author":"van der Wijst","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0027","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.843086","article-title":"Single-cell RNA sequencing of peripheral blood mononuclear cells from pediatric coeliac disease patients suggests potential pre-seroconversion markers","volume":"13","author":"Ram\u00edrez-S\u00e1nchez","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0028","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1038\/s41467-022-32691-5","article-title":"Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease","volume":"13","author":"Atlasy","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0029","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/MPG.0000000000002062","article-title":"Comparison of clinical methods with the faecal gluten immunogenic peptide to assess gluten intake in coeliac disease","volume":"67","author":"Gerasimidis","year":"2018","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0030","first-page":"106","article-title":"Detection and quantification of gluten immunogenic peptides in feces of infants and their relationship with diet","volume":"111","author":"Roca","year":"2019","journal-title":"Rev Esp Enferm Dig"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0031","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.2047-6310.2012.00064.x","article-title":"Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity","volume":"7","author":"Cole","year":"2012","journal-title":"Pediatr Obes"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0032","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3945\/ajcn.111.026708","article-title":"Monitoring of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces","volume":"95","author":"Comino","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0033","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/s42003-022-04192-0","article-title":"Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility","volume":"5","author":"Cerv\u00e1n-Mart\u00edn","year":"2022","journal-title":"Commun Biol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0034","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1093\/bioinformatics\/btab358","article-title":"Cellsnp-lite: an efficient tool for genotyping single cells","volume":"37","author":"Huang","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0035","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13059-019-1865-2","article-title":"Vireo: bayesian demultiplexing of pooled single-cell RNA-seq data without genotype reference","volume":"20","author":"Huang","year":"2019","journal-title":"Genome Biol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0036","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0037","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1136\/gutjnl-2021-324984","article-title":"RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine","volume":"71","author":"Long","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0038","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0039","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/imm.12690","article-title":"High Smad7 sustains inflammatory cytokine response in refractory coeliac disease","volume":"150","author":"Sedda","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0040","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.1038\/s41598-017-07381-8","article-title":"The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages","volume":"7","author":"Kim","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0041","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1093\/nar\/gkab595","article-title":"RBFOX2 alters splicing outcome in distinct binding modes with multiple protein partners","volume":"49","author":"Zhou","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0042","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.cell.2018.12.039","article-title":"Chronic inflammation permanently reshapes tissue-resident immunity in celiac disease","volume":"176","author":"Mayassi","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0043","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1136\/gut.2008.169052","article-title":"Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling","volume":"58","author":"Trynka","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0044","doi-asserted-by":"crossref","first-page":"192","DOI":"10.34172\/mejdd.2022.272","article-title":"Introducing new potential biomarkers for celiac disease among the genes extracted from general databases","volume":"14","author":"Khalkhal","year":"2022","journal-title":"Middle East J Dig Dis"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0045","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/hmg\/ddu453","article-title":"Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels","volume":"24","author":"Kumar","year":"2015","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0046","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.immuni.2006.06.015","article-title":"CXCR4 physically associates with the T cell receptor to signal in T cells","volume":"25","author":"Kumar","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0047","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12969-018-0253-x","article-title":"The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis","volume":"16","author":"Ohl","year":"2018","journal-title":"Pediatr Rheumatol Online J"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0048","doi-asserted-by":"crossref","first-page":"9252","DOI":"10.1038\/s41598-021-86612-5","article-title":"Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells","volume":"11","author":"Bakker","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0049","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-immunol-042617-053119","article-title":"Nonclassical monocytes in health and disease","volume":"37","author":"Narasimhan","year":"2019","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0050","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3389\/fimmu.2019.01140","article-title":"The role of monocytes and macrophages in autoimmune diseases: a comprehensive review","volume":"10","author":"Ma","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0051","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184658","article-title":"The cooperative induction of CCL4 in Human monocytic cells by TNF-\u03b1 and palmitate requires MyD88 and involves MAPK\/NF-\u03baB signaling pathways","volume":"20","author":"Sindhu","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0052","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.humimm.2016.01.016","article-title":"CD4(+)HLA-G(+) regulatory T cells: molecular signature and pathophysiological relevance","volume":"77","author":"Pankratz","year":"2016","journal-title":"Hum Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0053","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13259","article-title":"Is there a role for HLA-G in the induction of regulatory T cells during the maintenance of a healthy pregnancy?","volume":"84","author":"Al-Khunaizi","year":"2020","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0054","doi-asserted-by":"crossref","first-page":"eadd6165","DOI":"10.1126\/sciadv.add6165","article-title":"RNA binding protein DDX5 restricts ror\u03b3t T suppressor function to promote intestine inflammation","volume":"9","author":"Ma","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0055","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/intimm\/dxl008","article-title":"New advances in coeliac disease: serum and intestinal expression of HLA-G","volume":"18","author":"Torres","year":"2006","journal-title":"Int Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0056","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3389\/fimmu.2014.00592","article-title":"HLA-G molecules in autoimmune diseases and infections","volume":"5","author":"Rizzo","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0057","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.humimm.2014.12.006","article-title":"HLA-G and susceptibility to develop celiac disease","volume":"76","author":"Catamo","year":"2015","journal-title":"Hum Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0058","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.796054","article-title":"HLA-G: too much or too little? Role in cancer and autoimmune disease","volume":"13","author":"Mart\u00edn-Villa","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.109923","article-title":"IL-10-producing regulatory cells impact on celiac disease evolution","volume":"260","author":"Passerini","year":"2024","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103051","article-title":"Tolerogenic IL-10-engineered dendritic cell-based therapy to restore antigen-specific tolerance in T cell mediated diseases","volume":"138","author":"Passeri","year":"2023","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0061","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-53234-x","article-title":"Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells","volume":"9","author":"Levring","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0062","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/eji.202048851","article-title":"The thioredoxin-1 inhibitor Txnip restrains effector T-cell and germinal center B-cell expansion","volume":"51","author":"Muri","year":"2021","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1016\/j.jnutbio.2025.110063_bib0063","article-title":"Immune disease variants modulate gene expression in regulatory CD4 T cells","volume":"2","author":"Bossini-Castillo","year":"2022","journal-title":"Cell Genom"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0064","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41590-018-0120-4","article-title":"Regulatory T cells in autoimmune disease","volume":"19","author":"Dominguez-Villar","year":"2018","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0065","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.704853","article-title":"Interleukin 32 promotes Foxp3 treg cell development and CD8 T cell function in Human esophageal squamous cell carcinoma microenvironment","volume":"9","author":"Han","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0066","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1038\/s41467-024-47981-3","article-title":"CD74 supports accumulation and function of regulatory T cells in tumors","volume":"15","author":"Bonnin","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0067","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/cmi.2013.38","article-title":"CD52 as both a marker and an effector molecule of T cells with regulatory action: identification of novel regulatory T cells","volume":"10","author":"Samten","year":"2013","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0068","doi-asserted-by":"crossref","first-page":"14942","DOI":"10.1073\/pnas.1520393112","article-title":"Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3","volume":"112","author":"Yan","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0069","doi-asserted-by":"crossref","DOI":"10.3390\/cells13110941","article-title":"Defining Human regulatory T cells beyond FOXP3: the need to combine phenotype with function","volume":"13","author":"Gootjes","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0070","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.4049\/jimmunol.1500821","article-title":"Transcription factor 7 limits regulatory T cell generation in the Thymus","volume":"195","author":"Barra","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0071","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jnutbio.2025.110063_bib0072","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103097","article-title":"Non-classical circulating monocytes expressing high levels of microsomal prostaglandin E2 synthase-1 tag an aberrant IFN-response in systemic sclerosis","volume":"140","author":"Villanueva-Martin","year":"2023","journal-title":"J Autoimmun"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325002256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325002256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T09:27:14Z","timestamp":1772875634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286325002256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":72,"alternative-id":["S0955286325002256"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110063","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunomodulatory effects of a short-term gluten-free diet on pediatric celiac disease: Findings from a single-cell transcriptomics study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110063"}}