{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:54:55Z","timestamp":1793663695455,"version":"4.5.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","award":["2023FSYYZQ03"],"award-info":[{"award-number":["2023FSYYZQ03"]}],"id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","award":["2023ZL038"],"award-info":[{"award-number":["2023ZL038"]}],"id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","award":["2025ZR122"],"award-info":[{"award-number":["2025ZR122"]}],"id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016105","name":"Quzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023K161"],"award-info":[{"award-number":["2023K161"]}],"id":[{"id":"10.13039\/501100016105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016105","name":"Quzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023K155"],"award-info":[{"award-number":["2023K155"]}],"id":[{"id":"10.13039\/501100016105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jnutbio.2025.110140","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T04:46:42Z","timestamp":1760071602000},"page":"110140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["UPP1 as a potential target for astilbin in ameliorating high-fat diet-induced bone loss via MAPK signaling: a study incorporating gut microbiota and metabolomics"],"prefix":"10.1016","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4458-0193","authenticated-orcid":false,"given":"Hui","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zechen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianze","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenXuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujie","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jnutbio.2025.110140_bib0001","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41584-024-01094-9","article-title":"Evidence-based guideline for the management of osteoporosis in men","volume":"20","author":"Fuggle","year":"2024","journal-title":"Nat Rev Rheumatol"},{"issue":"39","key":"10.1016\/j.jnutbio.2025.110140_bib0002","doi-asserted-by":"crossref","first-page":"E1333","DOI":"10.1503\/cmaj.221647","article-title":"Clinical practice guideline for management of osteoporosis and fracture prevention in Canada: 2023 update","volume":"195","author":"Morin","year":"2023","journal-title":"CMAJ"},{"issue":"4","key":"10.1016\/j.jnutbio.2025.110140_bib0003","doi-asserted-by":"crossref","first-page":"101122","DOI":"10.1016\/j.gendis.2023.101122","article-title":"The role of lipid metabolism in osteoporosis: clinical implication and cellular mechanism","volume":"11","author":"Zhang","year":"2024","journal-title":"Genes Dis"},{"issue":"23","key":"10.1016\/j.jnutbio.2025.110140_bib0004","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242316920","article-title":"Comparison of the therapeutic effects of adipose- and bone marrow-derived mesenchymal stem cells on renal fibrosis","volume":"24","author":"Yoshida","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"Pt A","key":"10.1016\/j.jnutbio.2025.110140_bib0005","article-title":"12-deoxyphorbol 13-acetate inhibits RANKL-induced osteoclastogenesis via the attenuation of MAPK signaling and NFATc1 activation","volume":"101","author":"Chen","year":"2021","journal-title":"Int Immunopharmacol"},{"issue":"7","key":"10.1016\/j.jnutbio.2025.110140_bib0006","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1089\/jmf.2022.K.0131","article-title":"Inhibitory effects of wheat sprouts extract on RANKL-induced osteoclast differentiation via suppressing MAPK and NFATc1 signaling pathways","volume":"26","author":"Han","year":"2023","journal-title":"J Med Food"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.110140_bib0007","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/s41467-024-45340-w","article-title":"UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment","volume":"15","author":"Li","year":"2024","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.jnutbio.2025.110140_bib0008","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/01.mpa.0000151581.45156.e4","article-title":"RPL38, FOSL1, and UPP1 are predominantly expressed in the pancreatic ductal epithelium","volume":"30","author":"Sahin","year":"2005","journal-title":"Pancreas"},{"issue":"5","key":"10.1016\/j.jnutbio.2025.110140_bib0009","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.14336\/AD.2022.0218","article-title":"UPP1 promotes lung adenocarcinoma progression through epigenetic regulation of glycolysis","volume":"13","author":"Wang","year":"2022","journal-title":"Aging Dis"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.110140_bib0010","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1186\/s12935-024-03598-6","article-title":"Intestinal metaplasia key molecules and UPP1 activation via Helicobacter pylori\/NF-kB: drivers of malignant progression in gastric cancer","volume":"24","author":"Chen","year":"2024","journal-title":"Cancer Cell Int"},{"issue":"11","key":"10.1016\/j.jnutbio.2025.110140_bib0011","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1038\/s41418-021-00810-2","article-title":"CBF\u03b2 promotes colorectal cancer progression through transcriptionally activating OPN, FAM129A, and UPP1 in a RUNX2-dependent manner","volume":"28","author":"Wang","year":"2021","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jnutbio.2025.110140_bib0012","doi-asserted-by":"crossref","first-page":"155628","DOI":"10.1016\/j.phymed.2024.155628","article-title":"Morinda officinalis-derived extracellular vesicle-like particles: anti-osteoporosis effect by regulating MAPK signaling pathway","volume":"129","author":"Cao","year":"2024","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.jnutbio.2025.110140_bib0013","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.7150\/ijbs.94863","article-title":"Fgf9 regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis by PI3K\/AKT\/Hippo and MEK\/ERK signaling","volume":"20","author":"Chen","year":"2024","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jnutbio.2025.110140_bib0014","doi-asserted-by":"crossref","first-page":"1417348","DOI":"10.3389\/fvets.2024.1417348","article-title":"Nucleotide metabolism-related host proteins RNA polymerase II subunit and uridine phosphorylase 1 interacting with porcine epidemic diarrhea virus N proteins affect viral replication","volume":"11","author":"Xu","year":"2024","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.jnutbio.2025.110140_bib0015","article-title":"Uridine phosphorylase 1 as a biomarker associated with glycolysis in acute lung injury","author":"Song","year":"2025","journal-title":"Inflammation"},{"issue":"10","key":"10.1016\/j.jnutbio.2025.110140_bib0016","doi-asserted-by":"crossref","DOI":"10.3390\/ph16101438","article-title":"Morroniside inhibits inflammatory bone loss through the TRAF6-mediated NF-\u03baB\/MAPK signalling pathway","volume":"16","author":"Xiao","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.jnutbio.2025.110140_bib0017","doi-asserted-by":"crossref","first-page":"156144","DOI":"10.1016\/j.phymed.2024.156144","article-title":"Astilbin alleviates hepatic fibrosis through PXR-PINK1\/Parkin pathway: a new strategy by regulating hepatic stellate cells-macrophage crosstalk","volume":"135","author":"Dou","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.110140_bib0018","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s13287-024-04025-3","article-title":"Astilbin improves the therapeutic effects of mesenchymal stem cells in AKI-CKD mice by regulating macrophage polarization through PTGS2-mediated pathway","volume":"15","author":"Geng","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jnutbio.2025.110140_bib0019","doi-asserted-by":"crossref","first-page":"116697","DOI":"10.1016\/j.biopha.2024.116697","article-title":"Vitamin K2 ameliorates osteoarthritis by suppressing ferroptosis and extracellular matrix degradation through activation GPX4\u2019s dual functions","volume":"175","author":"He","year":"2024","journal-title":"Biomed Pharmacother"},{"issue":"30","key":"10.1016\/j.jnutbio.2025.110140_bib0020","doi-asserted-by":"crossref","first-page":"16739","DOI":"10.1021\/acs.jafc.4c02798","article-title":"Dendrobine ameliorates glucocorticoid-induced osteoporosis by promoting osteogenesis through JNK\/p38 MAPK pathway activation and GR nuclear translocation inhibition","volume":"72","author":"Li","year":"2024","journal-title":"J Agric Food Chem"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.110140_bib0021","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1186\/s12891-024-08068-8","article-title":"The link between osteoporosis and frozen shoulder: exploring the therapeutic effect of TAK715 on reversing fibrosis and protecting against osteoporosis via the p38 MAPK signaling pathway","volume":"25","author":"Li","year":"2024","journal-title":"BMC Musculoskelet Disord"},{"issue":"9","key":"10.1016\/j.jnutbio.2025.110140_bib0022","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202302508R","article-title":"Carboxypeptidase M modulates BMSCs osteogenesis-adipogenesis via the MAPK\/ERK pathway: an integrated single-cell and bulk transcriptomic study","volume":"38","author":"Liao","year":"2024","journal-title":"Faseb j"},{"key":"10.1016\/j.jnutbio.2025.110140_bib0023","doi-asserted-by":"crossref","first-page":"1405173","DOI":"10.3389\/fphar.2024.1405173","article-title":"Caffeine regulates both osteoclast and osteoblast differentiation via the AKT, NF-\u03baB, and MAPK pathways","volume":"15","author":"Miao","year":"2024","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110140_bib0024","doi-asserted-by":"crossref","first-page":"116571","DOI":"10.1016\/j.biopha.2024.116571","article-title":"Restoring bone-fat equilibrium: baicalin\u2019s impact on P38 MAPK pathway for treating diabetic osteoporosis","volume":"175","author":"Qin","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jnutbio.2025.110140_bib0025","doi-asserted-by":"crossref","first-page":"847401","DOI":"10.3389\/fendo.2022.847401","article-title":"The role of depletion of gut microbiota in osteoporosis and osteoarthritis: a narrative review","volume":"13","author":"Guan","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"9","key":"10.1016\/j.jnutbio.2025.110140_bib0026","doi-asserted-by":"crossref","first-page":"8583","DOI":"10.18632\/aging.103168","article-title":"Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis","volume":"12","author":"He","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"9","key":"10.1016\/j.jnutbio.2025.110140_bib0027","doi-asserted-by":"crossref","first-page":"2004831","DOI":"10.1002\/advs.202004831","article-title":"Extracellular vesicles from child gut microbiota enter into bone to preserve bone mass and strength","volume":"8","author":"Liu","year":"2021","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.110140_bib0028","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1136\/ard-2022-223626","article-title":"L-arginine metabolism inhibits arthritis and inflammatory bone loss","volume":"83","author":"Cao","year":"2024","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"10.1016\/j.jnutbio.2025.110140_bib0029","doi-asserted-by":"crossref","first-page":"e1369","DOI":"10.1002\/ctm2.1369","article-title":"Arginine methylation of PPP1CA by CARM1 regulates glucose metabolism and affects osteogenic differentiation and osteoclastic differentiation","volume":"13","author":"Zhang","year":"2023","journal-title":"Clin Transl Med"},{"issue":"1","key":"10.1016\/j.jnutbio.2025.110140_bib0030","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13099-023-00553-0","article-title":"Gut microbiota signatures and fecal metabolites in postmenopausal women with osteoporosis","volume":"15","author":"Wang","year":"2023","journal-title":"Gut Pathog"},{"issue":"12","key":"10.1016\/j.jnutbio.2025.110140_bib0031","doi-asserted-by":"crossref","first-page":"8355","DOI":"10.1111\/jcmm.14713","article-title":"Astilbin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis","volume":"23","author":"Jin","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jnutbio.2025.110140_bib0032","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3389\/fphar.2019.01344","article-title":"Therapeutic anabolic and anticatabolic benefits of natural Chinese medicines for the treatment of osteoporosis","volume":"10","author":"He","year":"2019","journal-title":"Front Pharmacol"},{"issue":"9","key":"10.1016\/j.jnutbio.2025.110140_bib0033","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2174\/1389450118666170321105425","article-title":"Therapeutic potential and outlook of alternative medicine for osteoporosis","volume":"18","author":"Wang","year":"2017","journal-title":"Curr Drug Targets"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095528632500302X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095528632500302X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:30:10Z","timestamp":1773325810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095528632500302X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":33,"alternative-id":["S095528632500302X"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110140","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"UPP1 as a potential target for astilbin in ameliorating high-fat diet-induced bone loss via MAPK signaling: a study incorporating gut microbiota and metabolomics","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110140"}}