{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:54:19Z","timestamp":1792068859104,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019396","name":"Anhui Province Key Laboratory of Medical Physics and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2023xkjd04"],"award-info":[{"award-number":["2023xkjd04"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jnutbio.2025.110174","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:24:30Z","timestamp":1762388670000},"page":"110174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["High-fat diet mediates the formation of nonalcoholic fatty liver by modulating the AhR\/miR-132\/SIRT1 axis"],"prefix":"10.1016","volume":"148","author":[{"given":"Qing","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongdeng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2025.110174_bib0001","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0002","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0003","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S2468-1253(22)00317-X","article-title":"Global prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in the overweight and obese population: a systematic review and meta-analysis","volume":"8","author":"Quek","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109199","article-title":"High fat diet-triggered non-alcoholic fatty liver disease: a review of proposed mechanisms","volume":"330","author":"Lian","year":"2020","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114220","article-title":"Aryl hydrocarbon receptor (AHR)-mediated inflammation and resolution: non-genomic and genomic signaling","volume":"182","author":"Bock","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.08.022","article-title":"Functions of aryl hydrocarbon receptor (AHR) and CD38 in NAD metabolism and nonalcoholic steatohepatitis (NASH)","volume":"169","author":"Bock","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0007","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1016\/j.apsb.2021.10.014","article-title":"Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver","volume":"11","author":"Jin","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0008","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1136\/gutjnl-2018-318146","article-title":"miRNAs and NAFLD: from pathophysiology to therapy","volume":"68","author":"Gjorgjieva","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0009","doi-asserted-by":"crossref","first-page":"11964","DOI":"10.1073\/pnas.1311087110","article-title":"Aryl hydrocarbon receptor-mediated induction of the microRNA-132\/212 cluster promotes interleukin-17-producing T-helper cell differentiation","volume":"110","author":"Nakahama","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0010","doi-asserted-by":"crossref","unstructured":"Personnaz J., Piccolo E., Dortignac A., Iacovoni J.S., Mariette J., Rocher V., et al. Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor. Sci Adv n.d.;8:eabg9055. https:\/\/doi.org\/10.1126\/sciadv.abg9055.","DOI":"10.1126\/sciadv.abg9055"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0011","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1136\/gutjnl-2016-312869","article-title":"miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression","volume":"67","author":"Hanin","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.107037","article-title":"SIRT1\/SREBPs-mediated regulation of lipid metabolism","volume":"199","author":"Shen","year":"2024","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0013","article-title":"Regulation of SIRT1 and its roles in inflammation","volume":"13","author":"Yang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0014","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/15548627.2020.1860541","article-title":"SIRT1 - a new mammalian substrate of nuclear autophagy","volume":"17","author":"Wang","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0015","doi-asserted-by":"crossref","first-page":"852","DOI":"10.7150\/ijbs.19370","article-title":"Emerging roles of SIRT1 in fatty liver diseases","volume":"13","author":"Ding","year":"2017","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0016","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1186\/s12967-023-04790-4","article-title":"Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis","volume":"21","author":"Yang","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0017","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3892\/ijmm.2023.5219","article-title":"Gene therapy targeting miR\u2011212\u20113p exerts therapeutic effects on MAFLD similar to those of exercise","volume":"51","author":"Sun","year":"2023","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0018","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11010-021-04269-0","article-title":"Acetylation of H3K27 activated lncRNA NEAT1 and promoted hepatic lipid accumulation in non-alcoholic fatty liver disease via regulating miR-212-5p\/GRIA3","volume":"477","author":"Hu","year":"2022","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0019","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/jcmm.12733","article-title":"miR-212 downregulation contributes to the protective effect of exercise against non-alcoholic fatty liver via targeting FGF-21","volume":"20","author":"Xiao","year":"2016","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0020","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1530\/JME-16-0179","article-title":"miR-212-5p suppresses lipid accumulation by targeting FAS and SCD1","volume":"59","author":"Guo","year":"2017","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101092","article-title":"Dysregulated lipid metabolism links NAFLD to cardiovascular disease","volume":"42","author":"Deprince","year":"2020","journal-title":"Mol Metab"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109199","article-title":"High fat diet-triggered non-alcoholic fatty liver disease: a review of proposed mechanisms","volume":"330","author":"Lian","year":"2020","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101122","article-title":"Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans","volume":"50","author":"Pafili","year":"2021","journal-title":"Mol Metab"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0024","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/TP.0000000000002480","article-title":"Nonalcoholic fatty liver disease: basic pathogenetic mechanisms in the progression from NAFLD to NASH","volume":"103","author":"Pierantonelli","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914653","article-title":"Histone modifications in NAFLD: mechanisms and potential therapy","volume":"24","author":"Shi","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0026","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of ppar\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116658","article-title":"A current understanding of FXR in NAFLD: the multifaceted regulatory role of FXR and novel lead discovery for drug development","volume":"175","author":"Tang","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0028","article-title":"Abdominal obesity and insulin resistance in people exposed to moderate-to-high levels of dioxin","volume":"11","author":"Chang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0029","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.taap.2016.03.011","article-title":"Inhibition of the aryl hydrocarbon receptor prevents western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2\/4, tgf\u03b2, and IDO1","volume":"300","author":"Moyer","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0030","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.3390\/nu14153145","article-title":"Ketone bodies and SIRT1, synergic epigenetic regulators for metabolic health: a narrative review","volume":"14","author":"Tozzi","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.779177","article-title":"SIRT1: a potential therapeutic target in autoimmune diseases","volume":"12","author":"Shen","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0032","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1007\/s12035-016-0073-2","article-title":"P66Shc-SIRT1 Regulation of oxidative stress protects against cardio-cerebral vascular disease","volume":"54","author":"Kong","year":"2017","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177693","article-title":"Dimethyl fumarate improves non-alcoholic fatty liver disease by regulating SIRT1 signal to inhibit MAMs over-enrichment","volume":"1000","author":"Zhang","year":"2025","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0034","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jare.2024.12.047","article-title":"Dimeric guaianolide sesquiterpenoids from the flowers of Chrysanthemum indicum ameliorate hepatic steatosis through mitigating SIRT1-mediated lipid accumulation and ferroptosis","volume":"76","author":"Liu","year":"2025","journal-title":"J Adv Res"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107155","article-title":"SIRT1: harnessing multiple pathways to hinder NAFLD","volume":"203","author":"Tian","year":"2024","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155285","article-title":"Formononetin promotes fatty acid \u03b2-oxidation to treat non-alcoholic steatohepatitis through SIRT1\/PGC-1\u03b1\/ppar\u03b1 pathway","volume":"124","author":"Liao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0037","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0038","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s10020-019-0085-2","article-title":"miR-122 promotes hepatic lipogenesis via inhibiting the LKB1\/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease","volume":"25","author":"Long","year":"2019","journal-title":"Mol Med"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108642","article-title":"miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload","volume":"695","author":"Wang","year":"2020","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0040","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1672-0229(08)60044-3","article-title":"A brief review on the mechanisms of miRNA regulation","volume":"7","author":"Cai","year":"2009","journal-title":"Genomics Proteomics Bioinformat"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0041","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.3390\/nu13082590","article-title":"Plasma free fatty acid concentration as a modifiable risk factor for metabolic disease","volume":"13","author":"Henderson","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0042","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s41065-020-00136-y","article-title":"Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population","volume":"157","author":"Zong","year":"2020","journal-title":"Hereditas"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0043","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2036.2010.04366.x","article-title":"Differential expression of miRNAs in the visceral adipose tissue of patients with non-alcoholic fatty liver disease","volume":"32","author":"Estep","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jnutbio.2025.110174_bib0044","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1021\/acs.jafc.9b04259","article-title":"Pterostilbene improves hepatic lipid accumulation via the MiR-34a\/Sirt1\/SREBP-1 pathway in fructose-fed rats","volume":"68","author":"Wu","year":"2020","journal-title":"J Agric Food Chem"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325003365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325003365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:43:11Z","timestamp":1766140991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286325003365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":44,"alternative-id":["S0955286325003365"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110174","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-fat diet mediates the formation of nonalcoholic fatty liver by modulating the AhR\/miR-132\/SIRT1 axis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110174","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110174"}}