{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:39:02Z","timestamp":1792132742756,"version":"4.4.0"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ40569"],"award-info":[{"award-number":["2023JJ40569"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","award":["22A0300"],"award-info":[{"award-number":["22A0300"]}],"id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jnutbio.2025.110232","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T17:25:14Z","timestamp":1765473914000},"page":"110232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The role of folic acid and vitamin B12 in gestational diabetes mellitus and offspring development: A narrative review"],"prefix":"10.1016","volume":"150","author":[{"given":"Jiayue","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenran","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5255-7269","authenticated-orcid":false,"given":"Xueqiong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2025.110232_bib0001","doi-asserted-by":"crossref","unstructured":"Kautzky-Willer A, Winhofer Y, Kiss H, Falcone V, Berger A, Lechleitner M, et al. [Gestational diabetes mellitus (Update 2023)]. 2023;135:115\u201328. https:\/\/doi.org\/10.1007\/s00508-023-02181-9.","DOI":"10.1007\/s00508-023-02181-9"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0002","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-019-0098-8","article-title":"Gestational diabetes mellitus","volume":"5","author":"Mcintyre","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109050","article-title":"IDF Diabetes Atlas: estimation of global and regional gestational Diabetes mellitus prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group's criteria","volume":"183","author":"Wang","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0004","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81498","article-title":"The genetic risk of gestational diabetes in South Asian women","volume":"11","author":"Lamri","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0005","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1186\/s12889-024-18024-9","article-title":"National and regional prevalence of gestational diabetes mellitus in India: a systematic review and meta-analysis","volume":"24","author":"Mantri","year":"2024","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0006","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/17446651.2018.1476135","article-title":"Gestational diabetes risk factors and long-term consequences for both mother and offspring: a literature review","volume":"14","author":"Farahvar","year":"2019","journal-title":"Expert Rev Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0007","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1186\/s12884-018-2131-4","article-title":"Prevalence and risk factors of gestational diabetes mellitus in Asia: a systematic review and meta-analysis","volume":"18","author":"Lee","year":"2018","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0008","doi-asserted-by":"crossref","first-page":"742","DOI":"10.5114\/aoms.2020.94433","article-title":"Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis","volume":"16","author":"Wang","year":"2020","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/nu8120768","article-title":"Vitamin B12 status among pregnant women in the UK and its association with obesity and gestational diabetes","volume":"8","author":"Sukumar","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0010","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12940-020-00668-w","article-title":"Climate factors and gestational diabetes mellitus risk - a systematic review","volume":"19","author":"Preston","year":"2020","journal-title":"Environ Health"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0011","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4093\/dmj.2021.0335","article-title":"Gestational diabetes mellitus: diagnostic approaches and maternal-offspring complications","volume":"46","author":"Moon","year":"2022","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0012","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2337\/dc18-1646","article-title":"Hyperglycemia and adverse pregnancy outcome follow-up study (HAPO FUS): maternal gestational diabetes mellitus and childhood glucose metabolism","volume":"42","author":"Lowe","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0013","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1210\/clinem\/dgaa180","article-title":"The joint associations of maternal BMI and glycemia with childhood adiposity","volume":"105","author":"Josefson","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0014","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12974-017-0859-9","article-title":"Exposure to gestational diabetes mellitus induces neuroinflammation, derangement of hippocampal neurons, and cognitive changes in rat offspring","volume":"14","author":"Vuong","year":"2017","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0015","doi-asserted-by":"crossref","first-page":"e3532","DOI":"10.1002\/dmrr.3532","article-title":"Maternal metabolic factors and the association with gestational diabetes: a systematic review and meta-analysis","volume":"38","author":"Habibi","year":"2022","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0016","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1042\/CS20171432","article-title":"Endoplasmic reticulum stress\/autophagy pathway is involved in diabetes-induced neuronal apoptosis and cognitive decline in mice","volume":"132","author":"Kong","year":"2018","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.619176","article-title":"Maternal vitamin B12 status during pregnancy and its association with outcomes of pregnancy and health of the offspring: a systematic review and implications for policy in India","volume":"12","author":"Behere","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0018","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s43032-020-00161-2","article-title":"Maternal folic acid supplementation mediates offspring health via DNA methylation","volume":"27","author":"Liu","year":"2020","journal-title":"Reprod Sci"},{"issue":"12","key":"10.1016\/j.jnutbio.2025.110232_bib0019","volume":"383","author":"Wolffenbuttel","year":"2023","journal-title":"Bmj"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/nu16081217","article-title":"Gestational diabetes mellitus: what can medical nutrition therapy do?","volume":"16","author":"Wei","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0021","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000337684","article-title":"Folate and vitamin B12: function and importance in cognitive development","volume":"70","author":"Troen","year":"2012","journal-title":"Nestle Nutr Inst Workshop Ser"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0022","doi-asserted-by":"crossref","DOI":"10.3390\/nu12092867","article-title":"Vitamins and one-carbon metabolism: implications in human health and disease","volume":"12","author":"Lyon","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0023","first-page":"141","article-title":"The relationship between folate, vitamin B12 and gestational diabetes mellitus with proposed mechanisms and foetal implications","volume":"15","author":"Maher","year":"2021","journal-title":"J Family Reprod Health"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0024","first-page":"523","article-title":"Determining the effect of folate diets during pregnancy and lactation on neurobehavioural changes in the adult life of offspring","volume":"14","author":"Vinaykumar","year":"2019","journal-title":"J Taibah Univ Med Sci"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00125-007-0793-y","article-title":"Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune maternal nutrition study","volume":"51","author":"Yajnik","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0026","doi-asserted-by":"crossref","first-page":"11024","DOI":"10.21037\/apm-21-2940","article-title":"LncRNA RPL13p5 gene expression promotes insulin resistance in patients with gestational diabetes","volume":"10","author":"Li","year":"2021","journal-title":"Ann Palliat Med"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0027","doi-asserted-by":"crossref","first-page":"688","DOI":"10.2337\/db13-0558","article-title":"Developmental programming by maternal insulin resistance: hyperinsulinemia, glucose intolerance, and dysregulated lipid metabolism in male offspring of insulin-resistant mice","volume":"63","author":"Isganaitis","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0028","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13148-025-01923-y","article-title":"Insulin levels at 18-20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood","volume":"17","author":"Maguolo","year":"2025","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0029","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2174\/1389201017666160127105926","article-title":"An interplay between obesity and inflammation in gestational diabetes mellitus","volume":"17","author":"Sk\u00f3rzy\u0144ska-Dziduszko","year":"2016","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111315","article-title":"Adipose tissue and insulin resistance in obese","volume":"137","author":"Ahmed","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0031","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s12020-021-02933-5","article-title":"Adiponectin ameliorates placental injury in gestational diabetes mice by correcting fatty acid oxidation\/peroxide imbalance-induced ferroptosis via restoration of CPT-1 activity","volume":"75","author":"Zheng","year":"2022","journal-title":"Endocrine"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0032","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11092433","article-title":"Significance of serum-plasma leptin profile during pregnancy in gestational diabetes mellitus: a systematic review and meta-analysis","volume":"11","author":"Roca-Rodr\u00edguez","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0033","first-page":"747","article-title":"Measuring visfatin levels in saliva: an alternative approach to gestational diabetes screening","volume":"65","author":"Eroglu","year":"2021","journal-title":"Arch Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0034","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.peptides.2018.01.005","article-title":"Circulating adipokines and mRNA expression in adipose tissue and the placenta in women with gestational diabetes mellitus","volume":"101","author":"Tsiotra","year":"2018","journal-title":"Peptides"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0035","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1096\/fj.08-116889","article-title":"High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57\/BL6 mice","volume":"23","author":"Jones","year":"2009","journal-title":"Faseb j"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000322038","article-title":"Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood","volume":"93","author":"Sullivan","year":"2011","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0037","article-title":"Role of oxidative stress and inflammation in gestational diabetes mellitus","volume":"12","author":"Saucedo","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0038","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/jcp.27164","article-title":"A review of the molecular mechanisms of hyperglycemia-induced free radical generation leading to oxidative stress","volume":"234","author":"Yaribeygi","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0039","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s10020-018-0060-3","article-title":"The role of advanced glycation end-products in the development of coronary artery disease in patients with and without diabetes mellitus: a review","volume":"24","author":"Fishman","year":"2018","journal-title":"Mol Med"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8091385","article-title":"Relationship between oxidative stress, ER stress, and inflammation in type 2 diabetes: the battle continues","volume":"8","author":"Burgos-Mor\u00f3n","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0041","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/610950","article-title":"Nutritionally mediated oxidative stress and inflammation","author":"Mu\u00f1oz","year":"2013","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0042","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-3-030-12668-1_12","article-title":"The role of inflammation in the development of GDM and the use of markers of inflammation in GDM screening","volume":"1134","author":"Khambule","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0043","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252212195","article-title":"Oxidative stress and placental pathogenesis: a contemporary overview of potential biomarkers and emerging therapeutics","volume":"25","author":"Vornic","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0044","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9962860","article-title":"The role of oxidative stress and antioxidant balance in pregnancy","volume":"2021","author":"Hussain","year":"2021","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0045","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1210\/en.2016-1889","article-title":"Gestational diabetes alters functions in offspring's umbilical cord cells with implications for cardiovascular health","volume":"158","author":"Amrithraj","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0046","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","article-title":"The endoplasmic reticulum: structure, function and response to cellular signaling","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0047","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mam.2018.11.001","article-title":"Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity","volume":"66","author":"Villalobos-Labra","year":"2019","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0048","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12040793","article-title":"Impact of obesity-related endoplasmic reticulum stress on cancer and associated molecular targets","volume":"12","author":"Albashtawi","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0049","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.placenta.2023.08.070","article-title":"Regulatory mechanisms underlying endoplasmic reticulum stress involvement in the development of gestational diabetes mellitus entail the CHOP-ppar\u03b1-NF-\u03bab pathway","volume":"142","author":"He","year":"2023","journal-title":"Placenta"},{"issue":"Suppl 1","key":"10.1016\/j.jnutbio.2025.110232_bib0050","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3109\/09513590.2012.651933","article-title":"Neuroendocrine aspects of placenta and pregnancy","volume":"28","author":"De Bonis","year":"2012","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0051","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1007\/s00125-016-4040-2","article-title":"Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants","volume":"59","author":"Yung","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0052","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1525189","article-title":"A stress paradox: the dual role of the unfolded protein response in the placenta","volume":"15","author":"Chowdhury","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0053","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/biolre\/ioaf071","article-title":"Endoplasmic reticulum stress: an emerging therapeutic target for preeclampsia\u2020","volume":"113","author":"Chen","year":"2025","journal-title":"Biol Reprod"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0054","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1399694","article-title":"Genetic and inflammatory factors underlying gestational diabetes mellitus: a review","volume":"15","author":"Ray","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0055","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1210\/clinem\/dgab657","article-title":"Decreased monocyte count is associated with gestational diabetes mellitus development, macrosomia, and inflammation","volume":"107","author":"Huang","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0056","doi-asserted-by":"crossref","first-page":"bvac134","DOI":"10.1210\/jendso\/bvac134","article-title":"Predictive gestational diabetes biomarkers with sustained alterations throughout pregnancy","volume":"6","author":"Heath","year":"2022","journal-title":"J Endocr Soc"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0057","article-title":"Immunobiology of gestational diabetes mellitus in post-Medawar era","volume":"12","author":"Sharma","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0058","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41598-018-19263-8","article-title":"Periconception onset diabetes is associated with embryopathy and fetal growth retardation, reproductive tract hyperglycosylation and impaired immune adaptation to pregnancy","volume":"8","author":"Brown","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0059","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s12640-019-00070-6","article-title":"Inflammatory consequences of maternal diabetes on the offspring brain: a hippocampal organotypic culture study","volume":"36","author":"G\u0142ombik","year":"2019","journal-title":"Neurotox Res"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0060","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13071627","article-title":"The role of IL-6 and TNF-\u03b1 as early biomarkers in the prediction and diagnosis of gestational diabetes mellitus","volume":"13","author":"Varthaliti","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0061","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252111641","article-title":"Cellular and molecular pathophysiology of gestational diabetes","volume":"25","author":"Torres-Torres","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0062","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-981-15-3449-2_1","article-title":"Epigenetics in health and disease","volume":"1253","author":"Zhang","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0063","doi-asserted-by":"crossref","first-page":"R247","DOI":"10.1530\/EJE-16-1017","article-title":"MECHANISMS IN ENDOCRINOLOGY: epigenetic modifications and gestational diabetes: a systematic review of published literature","volume":"176","author":"Moen","year":"2017","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0064","article-title":"Deciphering the genetic code of DNA methylation","volume":"22","author":"Wang","year":"2021","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0065","doi-asserted-by":"crossref","DOI":"10.3390\/nu15010070","article-title":"Maternal and placental DNA methylation changes associated with the pathogenesis of gestational diabetes mellitus","volume":"15","author":"Xu","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0066","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13148-024-01738-3","article-title":"Methylation alterations of imprinted genes in different placental diseases","volume":"16","author":"Wang","year":"2024","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0067","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13148-023-01554-1","article-title":"Associations between nutrients in one-carbon metabolism and fetal DNA methylation in pregnancies with or without gestational diabetes mellitus","volume":"15","author":"Kadam","year":"2023","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0068","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/bs.afnr.2017.12.006","article-title":"Recent developments in folate nutrition","volume":"83","author":"Naderi","year":"2018","journal-title":"Adv Food Nutr Res"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0069","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41387-024-00282-6","article-title":"Folic acid supplementation on inflammation and homocysteine in type 2 diabetes mellitus: systematic review and meta-analysis of randomized controlled trials","volume":"14","author":"Mokgalaboni","year":"2024","journal-title":"Nutr Diabetes"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12929-014-0077-z","article-title":"Folic acid supplementation in pregnancy and implications in health and disease","volume":"21","author":"Barua","year":"2014","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0071","doi-asserted-by":"crossref","first-page":"6884","DOI":"10.1080\/14767058.2021.1929158","article-title":"Periconceptional folate and gestational diabetes mellitus: a systematic review and meta-analysis of cohort studies","volume":"35","author":"Liu","year":"2022","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0072","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1039\/C5CS00165J","article-title":"Vitamin B12 catalysed reactions","volume":"44","author":"Giedyk","year":"2015","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0073","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2022.102490","article-title":"Methylations in vitamin B(12) biosynthesis and catalysis","volume":"77","author":"Mathur","year":"2022","journal-title":"Curr Opin Struct Biol"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0074","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jimd.12009","article-title":"Vitamin B(12), folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation","volume":"42","author":"Froese","year":"2019","journal-title":"J Inherit Metab Dis"},{"issue":"Suppl 1","key":"10.1016\/j.jnutbio.2025.110232_bib0075","doi-asserted-by":"crossref","first-page":"S141","DOI":"10.1016\/j.dsx.2016.12.023","article-title":"Implication of homocysteine in diabetes and impact of folate and vitamin B12 in diabetic population","volume":"11","author":"Mursleen","year":"2017","journal-title":"Diabetes Metab Syndr"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105457","article-title":"Regulatory mechanisms of one-carbon metabolism enzymes","volume":"299","author":"Petrova","year":"2023","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0077","doi-asserted-by":"crossref","DOI":"10.3390\/nu13124562","article-title":"Methylenetetrahydrofolate (MTHFR), the one-carbon cycle, and cardiovascular risks","volume":"13","author":"Raghubeer","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0078","doi-asserted-by":"crossref","DOI":"10.3390\/nu14193930","article-title":"High folate, perturbed one-carbon metabolism and gestational diabetes mellitus","volume":"14","author":"Williamson","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0079","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3945\/an.111.000992","article-title":"Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role","volume":"3","author":"Crider","year":"2012","journal-title":"Adv Nutr"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0080","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2337\/dc20-1607","article-title":"Association of maternal folate and vitamin B(12) in early pregnancy with gestational diabetes mellitus: a prospective cohort study","volume":"44","author":"Chen","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0081","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12020-019-02053-1","article-title":"Vitamin B12 insufficiency is associated with increased risk of gestational diabetes mellitus: a systematic review and meta-analysis","volume":"66","author":"Kouroglou","year":"2019","journal-title":"Endocrine"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0082","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.2147\/DMSO.S391888","article-title":"The effects of serum folic acid and vitamin B12 on the risk of gestational diabetes mellitus","volume":"15","author":"Cheng","year":"2022","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0083","article-title":"Associations of maternal rs1801131 genotype in MTHFR and serum folate and vitamin B(12) with gestational diabetes mellitus in Chinese pregnant women","volume":"14","author":"Li","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0084","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/1753-0407.12899","article-title":"Joint effects of folate and vitamin B(12) imbalance with maternal characteristics on gestational diabetes mellitus","volume":"11","author":"Li","year":"2019","journal-title":"J Diabetes"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0085","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.clnu.2017.03.022","article-title":"High folate and low vitamin B12 status during pregnancy is associated with gestational diabetes mellitus","volume":"37","author":"Lai","year":"2018","journal-title":"Clin Nutr"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0086","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1221259","article-title":"Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis","volume":"14","author":"Ulloque-Badaracco","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0087","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000515085","article-title":"Changes of serum sex hormone-binding globulin, homocysteine, and hypersensitive CRP levels during pregnancy and their relationship with gestational diabetes mellitus","volume":"86","author":"Liu","year":"2021","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0088","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1007\/s10528-023-10659-4","article-title":"Global DNA methylation levels viz-a-viz genetic and biochemical variations in one carbon metabolic pathway: an exploratory study from North India","volume":"62","author":"Chaudhary","year":"2024","journal-title":"Biochem Genet"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0089","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2337\/db22-1044","article-title":"\u03b2-cell miRNA-503-5p induced by hypomethylation and inflammation promotes insulin resistance and \u03b2-cell decompensation","volume":"73","author":"Zhou","year":"2024","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0090","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.602477","article-title":"Genetics and epigenetics: new insight on gestational diabetes mellitus","volume":"11","author":"Dalfr\u00e0","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0091","doi-asserted-by":"crossref","first-page":"89","DOI":"10.7812\/TPP\/21.204","article-title":"Vitamins: functions and uses in medicine","volume":"26","author":"Hanna","year":"2022","journal-title":"Perm J"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0092","article-title":"Is supplementation with micronutrients still necessary during pregnancy? A review","volume":"13","author":"Ballest\u00edn","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0093","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-068076","article-title":"Serum folate deficiency and associated factors among pregnant women in Haramaya District, Eastern Ethiopia: a community-based study","volume":"13","author":"Mamme","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0094","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgph.0001828","article-title":"The prevalence and risk factors associated with iron, vitamin B12 and folate deficiencies in pregnant women: a cross-sectional study in Mbeya, Tanzania","volume":"3","author":"John","year":"2023","journal-title":"PLOS Glob Public Health"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0095","doi-asserted-by":"crossref","DOI":"10.3390\/nu12010247","article-title":"Folic acid fortification and neural tube defect risk: analysis of the food Fortification Initiative dataset","volume":"12","author":"Murphy","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0096","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fnut.2019.00093","article-title":"Vitamin B12 intake from animal foods, biomarkers, and health aspects","volume":"6","author":"Obeid","year":"2019","journal-title":"Front Nutr"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0097","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1177\/15648265080292S117","article-title":"Effects of vitamin B12 and folate deficiency on brain development in children","volume":"29","author":"Black","year":"2008","journal-title":"Food Nutr Bull"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0098","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/cga.12233","article-title":"Nutritional role of folate","volume":"57","author":"Ebara","year":"2017","journal-title":"Congenit Anom (Kyoto)"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0099","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1093\/hmg\/ddx164","article-title":"Exploring a causal role of DNA methylation in the relationship between maternal vitamin B12 during pregnancy and child's IQ at age 8, cognitive performance and educational attainment: a two-step mendelian randomization study","volume":"26","author":"Caramaschi","year":"2017","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033290","article-title":"Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12","volume":"7","author":"Mckay","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0101","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13148-019-0712-3","article-title":"Placenta-specific epimutation at H19-DMR among common pregnancy complications: its frequency and effect on the expression patterns of H19 and IGF2","volume":"11","author":"Yamaguchi","year":"2019","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0102","doi-asserted-by":"crossref","first-page":"928","DOI":"10.4161\/epi.6.7.16263","article-title":"Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy","volume":"6","author":"Hoyo","year":"2011","journal-title":"Epigenetics"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0103","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/ng1629","article-title":"Epimutation of the telomeric imprinting center region on chromosome 11p15 in silver-Russell syndrome","volume":"37","author":"Gicquel","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0104","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/ejcn.2010.294","article-title":"Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood","volume":"65","author":"Ba","year":"2011","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0105","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6652231","article-title":"A novel review of homocysteine and pregnancy complications","volume":"2021","author":"Dai","year":"2021","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0106","doi-asserted-by":"crossref","first-page":"394","DOI":"10.4161\/epi.4.6.9766","article-title":"LINE-1 DNA methylation is inversely correlated with cord plasma homocysteine in man: a preliminary study","volume":"4","author":"Fryer","year":"2009","journal-title":"Epigenetics"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0107","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.3945\/ajcn.2009.28858","article-title":"Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects","volume":"91","author":"Wang","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0108","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nrn1986","article-title":"Neural tube defects and folate: case far from closed","volume":"7","author":"Blom","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0109","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s13224-022-01645-8","article-title":"Association between maternal birth weight and gestational diabetes mellitus: a systematic review and meta-analysis","volume":"72","author":"Shokri","year":"2022","journal-title":"J Obstet Gynaecol India"},{"key":"10.1016\/j.jnutbio.2025.110232_bib0110","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2024.1432033","article-title":"Risk factors and prediction model for low-birth-weight infants born to women with gestational diabetes mellitus","volume":"12","author":"Pan","year":"2024","journal-title":"Front Public Health"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325003948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325003948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:14:27Z","timestamp":1773958467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286325003948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":110,"alternative-id":["S0955286325003948"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110232","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of folic acid and vitamin B12 in gestational diabetes mellitus and offspring development: A narrative review","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110232","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110232"}}