{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:52:43Z","timestamp":1784386363524,"version":"3.55.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006300","name":"University of Illinois Urbana-Champaign College of Agricultural Consumer and Environmental Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["HD0880833"],"award-info":[{"award-number":["HD0880833"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005302","name":"University of Illinois at Urbana-Champaign","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jnutbio.2025.110234","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:08:34Z","timestamp":1766189314000},"page":"110234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Prebiotic fructan chain length influences enteric microbiota-host GABAergic signaling and intestinal motility"],"prefix":"10.1016","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6422-8006","authenticated-orcid":false,"given":"Benjamin A.","family":"Levine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis J.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8830-7506","authenticated-orcid":false,"given":"Brett R.","family":"Loman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2025.110234_bib0001","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3945\/an.115.009696","article-title":"Perspective: closing the dietary Fiber gap: an ancient solution for a 21st century Problem12","volume":"7","author":"Thompson","year":"2016","journal-title":"Adv Nutr"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0002","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.clnu.2023.11.005","article-title":"Dietary fiber intake and all-cause and cause-specific mortality: an updated systematic review and meta-analysis of prospective cohort studies","volume":"43","author":"Ramezani","year":"2024","journal-title":"Clin Nutrit"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0003","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S2468-1253(24)00238-3","article-title":"Dietary management of irritable bowel syndrome: considerations, challenges, and solutions","volume":"9","author":"Whelan","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0004","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/apt.17894","article-title":"Worldwide population prevalence and impact of sub-diagnostic gastrointestinal symptoms","volume":"59","author":"Palsson","year":"2024","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0005","unstructured":"What is a Disorder of Gut-Brain Interaction (DGBI) [Online]. Rome Foundation: [date unknown]. https:\/\/theromefoundation.org\/what-is-a-disorder-of-gut-brain-interaction-dgbi\/ accessed 3 December 2025."},{"key":"10.1016\/j.jnutbio.2025.110234_bib0006","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1017\/S0029665120006990","article-title":"Challenges of the low FODMAP diet for managing irritable bowel syndrome and approaches to their minimisation and mitigation","volume":"80","author":"Wilson","year":"2021","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0007","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/apt.13706","article-title":"Randomised clinical trial: the efficacy of gut-directed hypnotherapy is similar to that of the low FODMAP diet for the treatment of irritable bowel syndrome","volume":"44","author":"Peters","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0008","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S2468-1253(24)00045-1","article-title":"A low FODMAP diet plus traditional dietary advice versus a low-carbohydrate diet versus pharmacological treatment in irritable bowel syndrome (CARIBS): a single-centre, single-blind, randomised controlled trial","volume":"9","author":"Nybacka","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0009","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jand.2019.01.017","article-title":"Nutrient intake, diet quality, and diet diversity in irritable bowel syndrome and the impact of the low FODMAP diet","volume":"120","author":"Staudacher","year":"2020","journal-title":"J Acad Nutrit Dietet"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0010","article-title":"Long-term impact of the low-FODMAP diet on gastrointestinal symptoms, dietary intake, patient acceptability, and healthcare utilization in irritable bowel syndrome","volume":"30","author":"O\u2019Keeffe","year":"2018","journal-title":"Neurogastroenterol Motilit"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0011","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/s41395-018-0195-4","article-title":"A systematic review and meta-analysis evaluating the efficacy of a gluten-free diet and a low FODMAPS diet in treating symptoms of irritable bowel syndrome","volume":"113","author":"Dionne","year":"2018","journal-title":"Offic J Am Coll Gastroenterol | ACG"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0012","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.3390\/molecules28041613","article-title":"Structural characterisation, and bioactivities of fructans: a review","volume":"28","author":"Wang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0013","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00180-20","article-title":"Subtle variations in dietary-Fiber fine structure differentially influence the composition and metabolic function of gut microbiota","volume":"5","author":"Tuncil","year":"2020","journal-title":"mSphere"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0014","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/ajg.2013.105","article-title":"Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life","volume":"108","author":"B\u00f6hn","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0015","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s11894-013-0370-0","article-title":"Dietary fructose intolerance, fructan intolerance and FODMAPs","volume":"16","author":"Fedewa","year":"2014","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0016","doi-asserted-by":"crossref","unstructured":"Waclawikov\u00e1 B., Codutti A., Alim K., El Aidy S. Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in silico studies. Gut Microbes 14: 1997296. doi: 10.1080\/19490976.2021.1997296.","DOI":"10.1080\/19490976.2021.1997296"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0017","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3945\/jn.115.227504","article-title":"Nondigestible fructans alter gastrointestinal barrier function, gene expression, histomorphology, and the microbiota profiles of diet-induced obese C57BL\/6J Mice123","volume":"146","author":"Liu","year":"2016","journal-title":"J Nutrit"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0018","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.nutres.2008.02.014","article-title":"Fructooligosaccharides exhibit more rapid fermentation than long-chain inulin in an in vitro fermentation system","volume":"28","author":"Stewart","year":"2008","journal-title":"Nutrit Res"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0019","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40168-021-01061-6","article-title":"Gut microbiome variation modulates the effects of dietary fiber on host metabolism","volume":"9","author":"Murga-Garrido","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0020","article-title":"Non-SCFA microbial metabolites associated with fiber fermentation and host health","volume":"0","author":"Grant","year":"2024","journal-title":"Trends Endocrinol Metabol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0021","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.3390\/nu13062099","article-title":"Regulation of neurotransmitters by the gut microbiota and effects on cognition in neurological disorders","volume":"13","author":"Chen","year":"2021","journal-title":"Nutrients"},{"issue":"16","key":"10.1016\/j.jnutbio.2025.110234_bib0022","article-title":"Gamma-aminobutyric acid as a potential postbiotic mediator in the gut\u2013brain axis","volume":"8","author":"Braga","year":"2024","journal-title":"NPJ Sci Food"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0023","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1093\/brain\/awae413","article-title":"From bugs to brain: unravelling the GABA signalling networks in the brain-gut-microbiome axis","volume":"148","author":"Belelli","year":"2025","journal-title":"Brain"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.00206","article-title":"Common distribution of gad operon in Lactobacillus brevis and its GadA contributes to efficient GABA synthesis toward cytosolic near-neutral pH [Online]","volume":"8","author":"Wu","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0025","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12934-021-01729-6","article-title":"Cell factory for \u03b3-aminobutyric acid (GABA) production using Bifidobacterium adolescentis","volume":"21","author":"Altaib","year":"2022","journal-title":"Microb Cell Factor"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0026","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70986-z","article-title":"Bifidobacterium adolescentis as a key member of the human gut microbiota in the production of GABA","volume":"10","author":"Duranti","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0027","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41564-018-0307-3","article-title":"GABA-modulating bacteria of the human gut microbiota","volume":"4","author":"Strandwitz","year":"2019","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0028","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0029","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.anaerobe.2016.10.011","article-title":"GABA production and structure of gadB\/gadC genes in Lactobacillus and bifidobacterium strains from human microbiota","volume":"42","author":"Yunes","year":"2016","journal-title":"Anaerobe"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0030","doi-asserted-by":"crossref","first-page":"10361","DOI":"10.1523\/JNEUROSCI.0441-14.2014","article-title":"Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon","volume":"34","author":"Seifi","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0031","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.phrs.2014.12.001","article-title":"GABA and GABA receptors in the gastrointestinal tract: from motility to inflammation","volume":"93","author":"Auteri","year":"2015","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0032","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1476-5381.1983.tb08807.x","article-title":"GABAA and GABAB receptor-mediated effects in guinea-pig ileum","volume":"78","author":"Giotti","year":"1983","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0033","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0165-1838(94)90183-X","article-title":"[3H]GABA uptake and GABA localization in mucosal endocrine cells of the rat stomach and colon","volume":"47","author":"Krantis","year":"1994","journal-title":"J Autonom Nerv Syst"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0034","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1113\/jphysiol.2005.098962","article-title":"The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line","volume":"569","author":"Gameiro","year":"2005","journal-title":"J Physiol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0035","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1152\/physiologyonline.2000.15.6.284","article-title":"GABA in the mammalian Enteric Nervous System","volume":"15","author":"Krantis","year":"2000","journal-title":"Physiology"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0036","doi-asserted-by":"crossref","first-page":"422","DOI":"10.5056\/jnm17100","article-title":"Dysregulation of GABAergic signalling contributes in the pathogenesis of diarrhea-predominant irritable bowel syndrome","volume":"24","author":"Aggarwal","year":"2018","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0037","doi-asserted-by":"crossref","first-page":"G453","DOI":"10.1152\/ajpgi.00497.2011","article-title":"A novel role of intestine epithelial GABAergic signaling in regulating intestinal fluid secretion","volume":"303","author":"Li","year":"2012","journal-title":"Am J Physiol-Gastrointest Liver Physiol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0038","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005404","article-title":"Metacoder: an R package for visualization and manipulation of community taxonomic diversity data","volume":"13","author":"Foster","year":"2017","journal-title":"PLOS Computat Biol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0039","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0040","unstructured":"R: The R Project for Statistical Computing [Online]. https:\/\/www.r-project.org\/ accessed 3 April 2025."},{"key":"10.1016\/j.jnutbio.2025.110234_bib0041","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0042","doi-asserted-by":"crossref","first-page":"lqaa023","DOI":"10.1093\/nargab\/lqaa023","article-title":"Visualizing \u2019omic feature rankings and log-ratios using Qurro","volume":"2","author":"Fedarko","year":"2020","journal-title":"NAR Genom Bioinform"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0043","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/s41467-019-10656-5","article-title":"Establishing microbial composition measurement standards with reference frames","volume":"10","author":"Morton","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0044","unstructured":"Stability of reference genes for messenger RNA quantification by real-time PCR in mouse dextran sodium sulfate experimental colitis | PLOS one [Online].https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0156289 accessed 3 April 2025."},{"key":"10.1016\/j.jnutbio.2025.110234_bib0045","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-72673-9","article-title":"The gut microbiota of healthy individuals remains resilient in response to the consumption of various dietary fibers","volume":"14","author":"Pihelgas","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0046","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.ajcnut.2024.09.019","article-title":"The effects of chicory inulin-type fructans supplementation on weight management outcomes: systematic review, meta-analysis, and meta-regression of randomized controlled trials","volume":"120","author":"Reimer","year":"2024","journal-title":"Am J Clin Nutrit"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0047","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1136\/gut.46.3.370","article-title":"Pathways and receptors involved in peptide YY induced contraction of rat proximal colonic muscle in vitro","volume":"46","author":"Ferrier","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0048","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5056\/jnm.2011.17.1.73","article-title":"Mechanism of action of cholecystokinin on colonic motility in isolated, vascularly perfused rat colon","volume":"17","author":"Ko","year":"2011","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0049","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.coph.2013.09.002","article-title":"Gut motility and enteroendocrine secretion","volume":"13","author":"Wu","year":"2013","journal-title":"Curr Opinion Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0050","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1469-7793.1998.805bj.x","article-title":"Expression of functional GABAA receptors in cholecystokinin-secreting gut neuroendocrine murine STC-1 cells","volume":"510","author":"Glassmeier","year":"1998","journal-title":"J Physiol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0051","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/S0016-5085(88)80068-4","article-title":"Short-chain fatty acids stimulate ileal motility in humans","volume":"95","author":"Kamath","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0052","doi-asserted-by":"crossref","DOI":"10.1080\/16546628.2017.1321948","article-title":"Modulatory effect of intestinal polyamines and trace amines on the spontaneous phasic contractions of the isolated ileum and colon rings of mice","volume":"61","author":"S\u00e1nchez","year":"2017","journal-title":"Food Nutr Res"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0053","article-title":"Physiology of \u03b3-aminobutyric acid production by Akkermansia muciniphila","volume":"90","author":"Konstanti","year":"2024","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0054","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00424-024-02914-3","article-title":"Bicarbonate secretion and acid\/base sensing by the intestine","volume":"476","author":"Becker","year":"2024","journal-title":"Pflugers Arch - Eur J Physiol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0055","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fphar.2010.00124","article-title":"A gut feeling about GABA: focus on GABAB receptors","volume":"1","author":"Hyland","year":"2010","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0056","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1113\/jphysiol.2006.115279","article-title":"Interstitial cells of Cajal: a new perspective on smooth muscle function","volume":"576","author":"Sanders","year":"2006","journal-title":"J Physiol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0057","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.629391","article-title":"Small intestinal tuft cell activity associates with energy metabolism in diet-induced obesity","volume":"12","author":"Arora","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0058","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/sj.bjp.0703069","article-title":"Gamma-aminobutyric acid (GABA) transport across human intestinal epithelial (Caco-2) cell monolayers","volume":"129","author":"Thwaites","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0059","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ejpb.2012.03.007","article-title":"Carrier-mediated \u03b3-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers","volume":"81","author":"Nielsen","year":"2012","journal-title":"Eur J Pharmaceut Biopharmaceut"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0060","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01087-19","article-title":"Bifidobacterium dentium fortifies the intestinal mucus layer via autophagy and calcium signaling pathways","volume":"10","author":"Engevik","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0061","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401669R","article-title":"Limosilactobacillus reuteri promotes the expression and secretion of enteroendocrine- and enterocyte-derived hormones","volume":"39","author":"Di Rienzi","year":"2025","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0062","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1053\/gast.1996.v110.pm8566597","article-title":"\u03b3-aminobutyric acid stimulates electrolyte transport in the guinea pig ileum in vitro","volume":"110","author":"MacNaughton","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0063","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/BF00500768","article-title":"gamma-aminobutyric acid and cholinergic transmission in the guinea-pig ileum","volume":"322","author":"Kleinrok","year":"1983","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0064","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0014-2999(82)90390-9","article-title":"GABAA- and GABAB-receptor-mediated modification of intestinal motility","volume":"86","author":"Ong","year":"1982","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0065","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1254\/jphs.94.368","article-title":"Characterization of GABA(B) receptors involved in inhibition of motility associated with acetylcholine release in the dog small intestine: possible existence of a heterodimer of GABA(B1) and GABA(B2) subunits","volume":"94","author":"Kawakami","year":"2004","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0066","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/1440-1681.12824","article-title":"Furosemide suppresses ileal and colonic contractility via interactions with GABA-A receptor in mice","volume":"44","author":"Kaewsaro","year":"2017","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0067","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1139\/y95-720","article-title":"Functional evidence for the involvement of GABAA receptors in cholecystokinin-induced ileal contraction","volume":"73","author":"Alican","year":"1995","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0068","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/j.1476-5381.1989.tb12654.x","article-title":"An in vitro study of the relationship between GABA receptor function and propulsive motility in the distal colon of the rabbit","volume":"98","author":"Tonini","year":"1989","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0069","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-2999(93)90801-N","article-title":"Excitatory and inhibitory responses mediated by GABAA and GABAB receptors in guinea pig distal colon","volume":"230","author":"Minocha","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0070","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1476-5381.1985.tb17383.x","article-title":"Modulatory activity of GABAB receptors on cholinergic tone in guinea-pig distal colon","volume":"84","author":"Giotti","year":"1985","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0071","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00441-002-0566-3","article-title":"Neuronal and glial localization of GABA transporter immunoreactivity in the myenteric plexus","volume":"308","author":"Fletcher","year":"2002","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0072","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuropharm.2014.02.019","article-title":"Endogenous kynurenic acid regulates extracellular GABA levels in the rat prefrontal cortex","volume":"82","author":"Beggiato","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0073","doi-asserted-by":"crossref","first-page":"eaaf9794","DOI":"10.1126\/science.aaf9794","article-title":"Kynurenines: tryptophan\u2019s metabolites in exercise, inflammation, and mental health","volume":"357","author":"Cervenka","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147724","article-title":"Brain injury and inflammation genes common to a number of neurological diseases and the genes involved in the genesis of GABAnergic neurons are altered in monoamine oxidase B knockout mice","volume":"1774","author":"Chen","year":"2022","journal-title":"Brain Res"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0075","doi-asserted-by":"crossref","first-page":"544","DOI":"10.5056\/jnm18082","article-title":"Sex-gender differences in irritable bowel syndrome","volume":"24","author":"Kim","year":"2018","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0076","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14430","article-title":"Symptoms and health experience in irritable bowel syndrome with focus on men","volume":"34","author":"Bureychak","year":"2022","journal-title":"Neurogastroenterol Motilit"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0077","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/gutjnl-2022-328166","article-title":"Advancing human gut microbiota research by considering gut transit time","volume":"72","author":"Proch\u00e1zkov\u00e1","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0078","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2025.108094","article-title":"The sex related differences in health and disease: a systematic review of sex-specific gut microbiota and possible implications for microbial pathogenesis","volume":"209","author":"Ghaffar","year":"2025","journal-title":"Microb Pathogenes"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0079","unstructured":"Sex differences in the phylum-level human gut microbiota composition | BMC Microbiology | full text [Online]. https:\/\/bmcmicrobiol.biomedcentral.com\/articles\/10.1186\/s12866-021-02198-y accessed 26 November 2024."},{"issue":"13","key":"10.1016\/j.jnutbio.2025.110234_bib0080","article-title":"Sex differences in gut fermentation and immune parameters in rats fed an oligofructose-supplemented diet","volume":"6","author":"Shastri","year":"2015","journal-title":"Biol Sex Differ"},{"key":"10.1016\/j.jnutbio.2025.110234_bib0081","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14248","article-title":"Age-related differences of \u03b3-aminobutyric acid (GABA)ergic transmission in human colonic smooth muscle","volume":"34","author":"Zizzo","year":"2022","journal-title":"Neurogastroenterol Motility"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325003961?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325003961?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:09:44Z","timestamp":1781496584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286325003961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":81,"alternative-id":["S0955286325003961"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110234","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prebiotic fructan chain length influences enteric microbiota-host GABAergic signaling and intestinal motility","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110234","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110234"}}