{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:21:03Z","timestamp":1773966063085,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013225","name":"Academy of Scientific and Innovative Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004507","name":"Central Drug Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jnutbio.2025.110238","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T16:17:50Z","timestamp":1765988270000},"page":"110238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Naringenin prevents osteoblast senescence in d-galactose-induced aging conditions via estrogen receptor-mediated pathway"],"prefix":"10.1016","volume":"150","author":[{"given":"Saurabh Kumar","family":"Kaushal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devendra Pratap","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankita","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megha","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2487-4082","authenticated-orcid":false,"given":"Divya","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2025.110238_bib0001","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10522-021-09910-5","article-title":"Aging and age-related diseases: from mechanisms to therapeutic strategies","volume":"22","author":"Li","year":"2021","journal-title":"Biogerontology"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0002","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13551","article-title":"NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation","volume":"21","author":"Hu","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0003","doi-asserted-by":"crossref","first-page":"e188","DOI":"10.1097\/MD.0000000000000188","article-title":"Fracture as an independent risk factor of dementia: a nationwide population-based cohort study","volume":"93","author":"Tsai","year":"2014","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0004","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00026.2006","article-title":"Estrogen receptors: how do they signal and what are their targets","volume":"87","author":"Heldring","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0005","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1359\/jbmr.081011","article-title":"Ethanol impairs estrogen receptor signaling resulting in accelerated activation of senescence pathways, whereas estradiol attenuates the effects of ethanol in osteoblasts","volume":"24","author":"Chen","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0006","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1365-2672.2011.05070.x","article-title":"Antibacterial activity of naringin derivatives against pathogenic strains","volume":"111","author":"C\u00e9liz","year":"2011","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0007","article-title":"Naringenin and its derivatives-health-promoting phytobiotic against resistant bacteria and fungi in humans","volume":"11","author":"Duda-Madej","year":"2022","journal-title":"Antibiot (Basel, Switzerland)"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2025.109894","article-title":"Naringenin alleviates heat stress-induced liver injury in Ningdu yellow chickens by decreasing RIPK3 and PDC binding","volume":"140","author":"Liu","year":"2025","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/biom9110690","article-title":"On the neuroprotective effects of naringenin: pharmacological targets, signaling pathways, molecular mechanisms, and clinical perspective","volume":"9","author":"Nouri","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10071686","article-title":"Naringin and naringenin: their mechanisms of action and the potential anticancer activities","volume":"10","author":"Stabrauskiene","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0011","article-title":"Naringenin is a potential anabolic treatment for bone loss by modulating osteogenesis, osteoclastogenesis, and macrophage polarization","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0012","doi-asserted-by":"crossref","first-page":"ziae101","DOI":"10.1093\/jbmrpl\/ziae101","article-title":"IL-33 prevents age-related bone loss and memory impairment by suppression of Th17 response: evidence in a d-galactose-induced aging mouse model","volume":"8","author":"Kaushal","year":"2024","journal-title":"JBMR Plus"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0013","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1002\/jcb.30313","article-title":"Maintenance of increased bone mass after PTH withdrawal by sequential medicarpin treatment via augmentation of cAMP-PKA pathway","volume":"123","author":"Sharma","year":"2022","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0014","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1002\/jcp.26233","article-title":"Estrogen regulates stemness and senescence of bone marrow stromal cells to prevent osteoporosis via er\u03b2-SATB2 pathway","volume":"233","author":"Wu","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0015","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.freeradbiomed.2022.08.028","article-title":"Cladrin alleviates dexamethasone-induced apoptosis of osteoblasts and promotes bone formation through autophagy induction via AMPK\/mTOR signaling","volume":"190","author":"Rai","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0016","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.12659\/MSM.902396","article-title":"Effect of naringin on monosodium iodoacetate-induced osteoarthritis pain in rats","volume":"23","author":"Xu","year":"2017","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0017","first-page":"1","article-title":"Naringenin is a potential anabolic treatment for bone loss by modulating osteogenesis, osteoclastogenesis, and macrophage polarization","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0018","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/j.1476-5381.2011.01637.x","article-title":"A naturally occurring naringenin derivative exerts potent bone anabolic effects by mimicking oestrogen action on osteoblasts","volume":"165","author":"Swarnkar","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0019","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.977347","article-title":"MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling pathway","volume":"13","author":"Tripathi","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153750","article-title":"Extract and fraction of Musa paradisiaca flower have osteogenic effect and prevent ovariectomy induced osteopenia","volume":"93","author":"Rai","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0021","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1210\/jc.2014-4370","article-title":"Brief report: does PTH increase with age, independent of 25-hydroxyvitamin D, phosphate, renal function, and ionized calcium?","volume":"100","author":"Carrivick","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0022","first-page":"1073","article-title":"Effect of dietary flavonoid naringenin on bones in rats with ovariectomy-induced osteoporosis","volume":"73","author":"Kaczmarczyk-Sedlak","year":"2016","journal-title":"Acta Pol Pharm"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0023","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s00011-018-1195-y","article-title":"Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and nf\u03bab","volume":"67","author":"Manchope","year":"2018","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.623175","article-title":"Is senescence-associated \u03b2-galactosidase a reliable in vivo marker of cellular senescence during embryonic development?","volume":"9","author":"de Mera-Rodr\u00edguez","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/biom10030420","article-title":"Role of p53 in the regulation of cellular senescence","volume":"10","author":"Mijit","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0026","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3389\/fphar.2019.01344","article-title":"Therapeutic anabolic and anticatabolic benefits of natural Chinese medicines for the treatment of osteoporosis","volume":"10","author":"He","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0027","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2174\/1389450118666170321105425","article-title":"Therapeutic potential and outlook of alternative medicine for osteoporosis","volume":"18","author":"Wang","year":"2017","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0028","article-title":"Naringin promotes osteoblast differentiation and ameliorates osteoporosis in ovariectomized mice","volume":"15","author":"Cui","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0029","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1016\/j.febslet.2011.07.046","article-title":"Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-\u03bab and ERK activation","volume":"585","author":"Ang","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2023.1158198","article-title":"Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases","volume":"11","author":"Chaudhary","year":"2023","journal-title":"Front Chem"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0031","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.toxrep.2021.02.007","article-title":"Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect","volume":"8","author":"Mahmoud","year":"2021","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0032","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1172\/JCI6610","article-title":"Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone","volume":"104","author":"Jilka","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0033","doi-asserted-by":"crossref","first-page":"21913","DOI":"10.3390\/ijms151221913","article-title":"The inhibition of RANKL-induced osteoclastogenesis through the suppression of p38 signaling pathway by naringenin and attenuation of titanium-particle-induced osteolysis","volume":"15","author":"Wang","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0034","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00441-021-03496-7","article-title":"Estrogen prevents cellular senescence and bone loss through Usp10-dependent p53 degradation in osteocytes and osteoblasts: the role of estrogen in bone cell senescence","volume":"386","author":"Wei","year":"2021","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jnutbio.2025.110238_bib0035","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1172\/JCI125755","article-title":"Impact of estrogens in males and androgens in females","volume":"129","author":"Hammes","year":"2019","journal-title":"J Clin Invest"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325004000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286325004000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:14:47Z","timestamp":1773958487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286325004000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":35,"alternative-id":["S0955286325004000"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110238","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Naringenin prevents osteoblast senescence in d-galactose-induced aging conditions via estrogen receptor-mediated pathway","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110238","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110238"}}