{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:10:26Z","timestamp":1778566226401,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["242300421292"],"award-info":[{"award-number":["242300421292"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["202300410080"],"award-info":[{"award-number":["202300410080"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["242102310557"],"award-info":[{"award-number":["242102310557"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U2004104"],"award-info":[{"award-number":["U2004104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jnutbio.2026.110266","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T16:17:37Z","timestamp":1768493857000},"page":"110266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dietary naringenin alleviates experimental autoimmune encephalomyelitis in mice partially via estrogen receptor-mediated pathway"],"prefix":"10.1016","volume":"151","author":[{"given":"Chaolei","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaozhen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zejin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinli","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5464-7884","authenticated-orcid":false,"given":"Junpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2026.110266_bib0001","doi-asserted-by":"crossref","first-page":"ITC81","DOI":"10.7326\/AITC202106150","article-title":"Multiple sclerosis","volume":"174","author":"Olek","year":"2021","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0002","first-page":"25","article-title":"The neuropathobiology of multiple sclerosis","author":"Marcel","year":"2024","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0003","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/jama.2020.26858","article-title":"Diagnosis and treatment of multiple sclerosis: a review","volume":"325","author":"McGinley","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0004","article-title":"What can we learn from sex differences in MS?","volume":"11","author":"Patricia","year":"2021","journal-title":"J Pers Med"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0005","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1056\/NEJM199807303390501","article-title":"Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in Multiple sclerosis group","volume":"339","author":"Confavreux","year":"1998","journal-title":"New Engl J Med"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0006","first-page":"103","article-title":"Neuroprotection in cerebral cortex induced by the pregnancy hormone estriol","author":"Cassandra","year":"2023","journal-title":"Lab Invest"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0007","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.4049\/jimmunol.1101578","article-title":"Estrogen receptor \u03b1 signaling in T lymphocytes is required for estradiol-mediated inhibition of Th1 and Th17 cell differentiation and protection against experimental autoimmune encephalomyelitis","volume":"187","author":"L\u00e9lu","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0008","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1196\/annals.1386.021","article-title":"A potential role for estrogen in experimental autoimmune encephalomyelitis and multiple sclerosis","volume":"1089","author":"Offner","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0009","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1080\/1547691X.2016.1223768","article-title":"Medium-dose estrogen ameliorates experimental autoimmune encephalomyelitis in ovariectomized mice","volume":"13","author":"Haghmorad","year":"2016","journal-title":"J Immunotoxicol"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0010","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.70235","article-title":"Ospemifene, a selective estrogen receptor modulator, enhances oligodendrocyte myelination and preserves neurofunctions against injuries","volume":"169","author":"Liu","year":"2025","journal-title":"J Neurochem"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0011","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.contraception.2012.12.011","article-title":"Ethinyl estradiol and 17\u03b2-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment","volume":"87","author":"Stanczyk","year":"2013","journal-title":"Contraception"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0012","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ejphar.2014.07.057","article-title":"Phytoestrogens and their effects","volume":"741","author":"Sirotkin","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0013","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.freeradbiomed.2013.10.004","article-title":"Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS\/p38 MAPK pathway and epigenetic regulation","volume":"67","author":"Hsieh","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0014","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nrd3248","article-title":"Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis","volume":"9","author":"Brinkmann","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0015","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/brain\/awq386","article-title":"Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway","volume":"134","author":"Linker","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0016","article-title":"Naringenin: a flavanone with anti-inflammatory and anti-infective properties","volume":"164","author":"Ji","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2024.100791","article-title":"Selected fruit pomaces: nutritional profile, health benefits, and applications in functional foods and feeds","volume":"9","author":"Kumar","year":"2024","journal-title":"Curr Res Food Sci"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0018","article-title":"Naringenin nanoliposomes alleviate hyperuricemia by inhibiting NLRP3 inflammasome: effects of rigidity","volume":"14","author":"Feng","year":"2025","journal-title":"Food Sci Human Well"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0019","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.fshw.2022.10.043","article-title":"Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and vitro","volume":"12","author":"Cai","year":"2023","journal-title":"Food Sci Human Wellness"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0020","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","article-title":"Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta","volume":"139","author":"Kuiper","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0021","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3390\/antiox12030586","article-title":"Naringenin and hesperidin as promising alternatives for prevention and Co-adjuvant therapy for breast cancer","volume":"12","author":"Maria Beatriz","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0022","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10571-017-0519-8","article-title":"Protective role of Naringenin against a\u03b2-caused damage via ER and PI3K\/akt-mediated pathways","volume":"38","author":"Zhang","year":"2018","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0023","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jnutbio.2017.12.004","article-title":"Dietary naringenin supplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmune inflammatory responses in mice","volume":"54","author":"Wang","year":"2018","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109448","article-title":"Naringenin confers protection against experimental autoimmune encephalomyelitis through modulating the gut-brain axis: a multiomics analysis","volume":"122","author":"Liu","year":"2023","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0025","doi-asserted-by":"crossref","first-page":"11026","DOI":"10.1080\/10408398.2022.2092054","article-title":"Naringenin as a natural immunomodulator against T cell-mediated autoimmune diseases: literature review and network-based pharmacology study","volume":"63","author":"Liu","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2020.108560","article-title":"Naringenin attenuates experimental autoimmune encephalomyelitis by protecting the intact of blood-brain barrier and controlling inflammatory cell migration","volume":"89","author":"Niu","year":"2021","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2023.100537","article-title":"Green tea EGCG inhibits na\u00efve CD4(+) T cell division and progression in mice: an integration of network pharmacology, molecular docking and experimental validation","volume":"7","author":"Niu","year":"2023","journal-title":"Curr Res Food Sci"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0028","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1007\/s10753-023-01829-y","article-title":"Ivermectin protects against experimental autoimmune encephalomyelitis in mice by modulating the Th17\/Treg balance involved in the IL-2\/STAT5 pathway","volume":"46","author":"Xie","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155722","article-title":"Naringin as a natural candidate for anti-autoimmune hepatitis: inhibitory potency and hepatoprotective mechanism","volume":"129","author":"Zhu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0030","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/jnr.1183","article-title":"17 beta-estradiol inhibits cytokine, chemokine, and chemokine receptor mRNA expression in the central nervous system of female mice with experimental autoimmune encephalomyelitis","volume":"65","author":"Matejuk","year":"2001","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0031","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1194\/jlr.M087387","article-title":"Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr(-\/-) mice","volume":"59","author":"Burke","year":"2018","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0032","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a029025","article-title":"Effector T cells in multiple sclerosis","volume":"8","author":"Kaskow","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0033","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s00281-022-00926-8","article-title":"T-cell surveillance of the human brain in health and multiple sclerosis","volume":"44","author":"Joost","year":"2022","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0034","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1476-5381.2011.01302.x","article-title":"Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)","volume":"164","author":"Constantinescu","year":"2011","journal-title":"Brit J Pharmacol"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0035","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1742-2094-11-32","article-title":"Cerebrospinal fluid detection of interleukin-1\u03b2 in phase of remission predicts disease progression in multiple sclerosis","volume":"11","author":"Rossi","year":"2014","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0036","article-title":"Autoimmune neuroinflammatory diseases: role of interleukins","volume":"24","author":"Abdul Waheed","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0037","doi-asserted-by":"crossref","first-page":"9041","DOI":"10.1073\/pnas.0802218105","article-title":"IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis","volume":"105","author":"Serada","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0038","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.cytogfr.2014.07.016","article-title":"TNF and TNF-receptors: from mediators of cell death and inflammation to therapeutic giants - past, present and future","volume":"25","author":"Sedger","year":"2014","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0039","article-title":"Estrogen receptor alpha signaling in dendritic cells modulates autoimmune disease phenotype in mice","volume":"24","author":"Yee Ming","year":"2023","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0040","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0960-0760(02)00119-X","article-title":"Cell type-specificity of nonclassical estrogen signaling in the developing midbrain","volume":"81","author":"Beyer","year":"2002","journal-title":"J Steroid Biochem Molec Biol"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0041","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.4049\/jimmunol.171.11.6267","article-title":"Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol","volume":"171","author":"Soldan","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0042","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jneuroim.2014.10.004","article-title":"Pregnancy level of estrogen attenuates experimental autoimmune encephalomyelitis in both ovariectomized and pregnant C57BL\/6 mice through expansion of treg and Th2 cells","volume":"277","author":"Haghmorad","year":"2014","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0043","first-page":"23","article-title":"Mechanism underlying Naringenin hypocholesterolemic effects: involvement of estrogen receptor alpha subtype","author":"Pallottini","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-2797(01)00285-X","article-title":"Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450","volume":"139","author":"Hodek","year":"2002","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0045","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00253-011-3449-2","article-title":"Metabolic engineering of flavonoids in plants and microorganisms","volume":"91","author":"Wang","year":"2011","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0046","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1128\/MCB.25.8.2957-2968.2005","article-title":"17beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization","volume":"25","author":"Ghisletti","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0047","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1210\/er.2007-0001","article-title":"The complex role of estrogens in inflammation","volume":"28","author":"Straub","year":"2007","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0048","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1007\/s11011-017-0063-8","article-title":"Estrogen protects both sexes against EAE by promoting common regulatory cell subtypes independent of endogenous estrogen","volume":"32","author":"Seifert","year":"2017","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0049","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12974-019-1588-z","article-title":"Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE","volume":"16","author":"Seifert","year":"2019","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jnutbio.2026.110266_bib0050","doi-asserted-by":"crossref","first-page":"9614","DOI":"10.1073\/pnas.1531957100","article-title":"Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol","volume":"100","author":"Vegeto","year":"2003","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326000082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326000082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:23:23Z","timestamp":1778563403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286326000082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":50,"alternative-id":["S0955286326000082"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110266","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary naringenin alleviates experimental autoimmune encephalomyelitis in mice partially via estrogen receptor-mediated pathway","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110266","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110266"}}