{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:27:34Z","timestamp":1787696854387,"version":"build-2784847793"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017949","name":"Health Commission of Shanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013318","name":"Shanxi Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jnutbio.2026.110312","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:28:08Z","timestamp":1770856088000},"page":"110312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Ketogenic diet modulates AMPK-mTOR pathway in breast cancer"],"prefix":"10.1016","volume":"153","author":[{"given":"Yaxin","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4213-7512","authenticated-orcid":false,"given":"Junjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jnutbio.2026.110312_bib0001","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3390\/nu14030476","article-title":"Breast cancer diet \u201cBCD\u201d: a review of healthy dietary patterns to prevent Breast cancer recurrence and reduce mortality","volume":"14","author":"Cava","year":"2022","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.jnutbio.2026.110312_bib0002","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.3390\/cancers15051540","article-title":"Artificial diets with selective restriction of amino acids and very low levels of lipids induce anticancer activity in mice with metastatic triple-negative breast cancer","volume":"15","author":"Guill\u00e9n-Mancina","year":"2023","journal-title":"Cancers"},{"issue":"17","key":"10.1016\/j.jnutbio.2026.110312_bib0003","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.3390\/cancers13174287","article-title":"Breast cancer\u2014epidemiology, risk factors, classification, prognostic markers, and current treatment strategies\u2014an updated review","volume":"13","author":"\u0141ukasiewicz","year":"2021","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110312_bib0004","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41392-020-00246-z","article-title":"Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus Olaparib treatment","volume":"5","author":"Perez","year":"2020","journal-title":"Sig Transduct Target Ther"},{"issue":"11","key":"10.1016\/j.jnutbio.2026.110312_bib0005","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.trecan.2019.09.007","article-title":"Lipid metabolism at the nexus of diet and tumor microenvironment","volume":"5","author":"Peck","year":"2019","journal-title":"Trends Cancer"},{"issue":"46","key":"10.1016\/j.jnutbio.2026.110312_bib0006","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2409509121","article-title":"The Warburg effect is the result of faster ATP production by glycolysis than respiration","volume":"121","author":"Kukurugya","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jnutbio.2026.110312_bib0007","series-title":"The heterogeneity of cancer metabolism. Advances in experimental medicine and biology","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-030-65768-0_1","article-title":"Glucose metabolism in cancer: the Warburg effect and beyond","volume":"1311","author":"Bose","year":"2021"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110312_bib0008","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/eci.12591","article-title":"Ketogenic diets: from cancer to mitochondrial diseases and beyond","volume":"46","author":"Branco","year":"2016","journal-title":"Eur J Clin Invest"},{"issue":"14","key":"10.1016\/j.jnutbio.2026.110312_bib0009","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1158\/1078-0432.CCR-12-0287","article-title":"Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts","volume":"19","author":"Allen","year":"2013","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110312_bib0010","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1743-7075-7-74","article-title":"The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma","volume":"7","author":"Stafford","year":"2010","journal-title":"Nutr Metab (Lond)"},{"issue":"7719","key":"10.1016\/j.jnutbio.2026.110312_bib0011","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-018-0343-4","article-title":"Suppression of insulin feedback enhances the efficacy of PI3K inhibitors","volume":"560","author":"Hopkins","year":"2018","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110312_bib0012","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3390\/medicina55040084","article-title":"Impact of different types of diet on gut microbiota profiles and cancer prevention and treatment","volume":"55","author":"Klement","year":"2019","journal-title":"Medicina"},{"issue":"6","key":"10.1016\/j.jnutbio.2026.110312_bib0013","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.ccell.2020.04.005","article-title":"Dietary approaches to cancer therapy","volume":"37","author":"Tajan","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jnutbio.2026.110312_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101154","article-title":"Critical role of AMPK in redox regulation under glucose starvation","volume":"25","author":"Ren","year":"2019","journal-title":"Redox Biol"},{"issue":"18","key":"10.1016\/j.jnutbio.2026.110312_bib0015","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1016\/j.molcel.2021.08.018","article-title":"Redox metabolism: ROS as specific molecular regulators of cell signaling and function","volume":"81","author":"Lennicke","year":"2021","journal-title":"Mol Cell"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110312_bib0016","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/cbin.10915","article-title":"Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism","volume":"42","author":"Ke","year":"2018","journal-title":"Cell Biol Int"},{"issue":"6","key":"10.1016\/j.jnutbio.2026.110312_bib0017","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/joim.12268","article-title":"AMP -activated protein kinase: a key regulator of energy balance with many roles in human disease","volume":"276","author":"Grahame Hardie","year":"2014","journal-title":"J Intern Med"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110312_bib0018","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cmet.2017.10.009","article-title":"AMPK: sensing glucose as well as cellular energy status","volume":"27","author":"Lin","year":"2018","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110312_bib0019","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cell.2017.03.035","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"169","author":"Saxton","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110312_bib0020","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jnutbio.2026.110312_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215793","article-title":"Glucose restriction induces ROS-AMPK-mediated CTR1 expression and increases cisplatin efficiency in NSCLC","volume":"543","author":"Zhang","year":"2022","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jnutbio.2026.110312_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2024.112427","article-title":"Ketogenic diet as a treatment and prevention strategy for cancer: a therapeutic alternative","volume":"124","author":"Neha","year":"2024","journal-title":"Nutrition"},{"key":"10.1016\/j.jnutbio.2026.110312_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215793","article-title":"Glucose restriction induces ROS-AMPK-mediated CTR1 expression and increases cisplatin efficiency in NSCLC","volume":"543","author":"Zhang","year":"2022","journal-title":"Cancer Lett"},{"issue":"14","key":"10.1016\/j.jnutbio.2026.110312_bib0024","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1158\/1078-0432.CCR-12-0287","article-title":"Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts","volume":"19","author":"Allen","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jnutbio.2026.110312_bib0025","doi-asserted-by":"crossref","unstructured":"Cortez N.E., Pathak S., Rodriguez Lanzi C., Hong B.V., Crone R., Sule R., et al. A Ketogenic Diet in Combination with Gemcitabine Mitigates Pancreatic Cancer-Associated Cachexia in Male and Female KPC Mice. Int J Mol Sci 24(13):10753. doi:10.3390\/ijms241310753.","DOI":"10.3390\/ijms241310753"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110312_bib0026","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.molcel.2020.12.008","article-title":"Xu F.,et al. Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53","volume":"81","author":"Jiang","year":"2021","journal-title":"Mol Cell"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110312_bib0027","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/GRF.0000000000000239","article-title":"Breast cancer epidemiology and risk factors","volume":"59","author":"Rojas","year":"2016","journal-title":"Clin Obstetr Gynecol"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110312_bib0028","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The Warburg effect: how does it benefit cancer cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem Sci"},{"issue":"8040","key":"10.1016\/j.jnutbio.2026.110312_bib0029","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/d41586-024-03830-3","article-title":"Why tumour geography matters\u2014and how to map it","volume":"635","author":"Eisenstein","year":"2024","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jnutbio.2026.110312_bib0030","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.clnu.2023.04.027","article-title":"A ketogenic diet substantially reshapes the human metabolome","volume":"42","author":"Effinger","year":"2023","journal-title":"Clin Nutr"},{"issue":"7884","key":"10.1016\/j.jnutbio.2026.110312_bib0031","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41586-021-04049-2","article-title":"Low glycaemic diets alter lipid metabolism to influence tumour growth","volume":"599","author":"Lien","year":"2021","journal-title":"Nature"},{"issue":"8028","key":"10.1016\/j.jnutbio.2026.110312_bib0032","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/s41586-024-07781-7","article-title":"Remodelling of the translatome controls diet and its impact on tumorigenesis","volume":"633","author":"Yang","year":"2024","journal-title":"Nature"},{"issue":"114","key":"10.1016\/j.jnutbio.2026.110312_bib0033","doi-asserted-by":"crossref","DOI":"10.3791\/54040","article-title":"An orthotopic mouse model of spontaneous breast cancer metastasis","author":"Paschall","year":"2016","journal-title":"J Vis Exp"},{"issue":"10","key":"10.1016\/j.jnutbio.2026.110312_bib0034","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.freeradbiomed.2009.02.019","article-title":"Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP\/ATP ratio","volume":"46","author":"Emerling","year":"2009","journal-title":"Free Radic Biol Med"},{"issue":"7","key":"10.1016\/j.jnutbio.2026.110312_bib0035","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10495-022-01731-2","article-title":"High glucose-induced ROS-accumulation in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis","volume":"27","author":"Li","year":"2022","journal-title":"Apoptosis"},{"issue":"6","key":"10.1016\/j.jnutbio.2026.110312_bib0036","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jnutbio.2026.110312_bib0037","series-title":"AMPK: methods and protocols","first-page":"195","article-title":"Compound C\/Dorsomorphin: its use and misuse as an AMPK inhibitor","author":"Dasgupta","year":"2018"},{"issue":"9","key":"10.1016\/j.jnutbio.2026.110312_bib0038","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045845","article-title":"Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling","volume":"7","author":"Saito","year":"2012","journal-title":"PloS one"},{"key":"10.1016\/j.jnutbio.2026.110312_bib0039","doi-asserted-by":"crossref","first-page":"102039","DOI":"10.1016\/j.tice.2023.102039","article-title":"Activated AMPK-mediated glucose uptake and mitochondrial dysfunction is critically involved in the glutamate-induced oxidative injury in HT22 cell","volume":"81","author":"Lin","year":"2023","journal-title":"Tissue Cell"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110312_bib0040","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41580-022-00547-x","article-title":"New insights into activation and function of the AMPK","volume":"24","author":"Steinberg","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7665","key":"10.1016\/j.jnutbio.2026.110312_bib0041","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature23275","article-title":"Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK","volume":"548","author":"Zhang","year":"2017","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jnutbio.2026.110312_bib0042","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1158\/0008-5472.CAN-23-2742","article-title":"Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint blockade therapy","volume":"84","author":"Murphy","year":"2024","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2026.110312_bib0043","doi-asserted-by":"crossref","first-page":"101637","DOI":"10.1016\/j.molmet.2022.101637","article-title":"Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages","volume":"66","author":"Calderin","year":"2022","journal-title":"Mol Metab"},{"issue":"38","key":"10.1016\/j.jnutbio.2026.110312_bib0044","doi-asserted-by":"crossref","first-page":"eadx2752","DOI":"10.1126\/sciadv.adx2752","article-title":"A long-term ketogenic diet causes hyperlipidemia, liver dysfunction, and glucose intolerance from impaired insulin secretion in mice","volume":"11","author":"Gallop","year":"2025","journal-title":"Sci Adv"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326000549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326000549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T21:24:03Z","timestamp":1775683443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286326000549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":44,"alternative-id":["S0955286326000549"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110312","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ketogenic diet modulates AMPK-mTOR pathway in breast cancer","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110312","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110312"}}