{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:18:59Z","timestamp":1775686739964,"version":"3.50.1"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018973","name":"Lovely Professional University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018973","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jnutbio.2026.110335","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T20:31:20Z","timestamp":1772483480000},"page":"110335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dietary organosulfur compounds and the H2S\u2013polysulfide redox axis: Current evidence and limitations"],"prefix":"10.1016","volume":"153","author":[{"given":"Nikky","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tejasvi","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6354-9525","authenticated-orcid":false,"given":"Vivek","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2026.110335_bib0001","article-title":"Therapeutic uses of dietary organosulfur compounds in response to viral (SARS-CoV-2)\/bacterial infection, inflammation, cancer, oxidative stress, cardiovascular diseases, obesity, and diabetes","volume":"26","author":"Barman","year":"2025","journal-title":"Chem Biodivers"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0002","doi-asserted-by":"crossref","DOI":"10.2174\/0118715273386239250706125440","article-title":"Organosulfur compounds: potential therapeutics for Parkinson\u2019s disease","author":"Egbujor","year":"2025","journal-title":"CNS Neurol Disord-Drug Targets"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110335_bib0003","article-title":"Antiferroptotic properties of allicin and related organosulfur compounds diallyl disulfide and diallyl trisulfide from garlic","volume":"195","author":"Hirata","year":"2025","journal-title":"Food Chem Toxicol"},{"issue":"28","key":"10.1016\/j.jnutbio.2026.110335_bib0004","doi-asserted-by":"crossref","first-page":"6065","DOI":"10.1021\/acs.orglett.4c02256","article-title":"Desulfurization of thiols for nucleophilic substitution","volume":"26","author":"Fu","year":"2024","journal-title":"Org Lett"},{"issue":"41","key":"10.1016\/j.jnutbio.2026.110335_bib0005","doi-asserted-by":"crossref","DOI":"10.1002\/ange.202407308","article-title":"Development of a fluorescent probe with high selectivity based on thiol-ene click nucleophilic cascade reactions for delving into the action mechanism of serotonin in depression","volume":"136","author":"Yue","year":"2024","journal-title":"Angew Chem"},{"issue":"39","key":"10.1016\/j.jnutbio.2026.110335_bib0006","doi-asserted-by":"crossref","first-page":"21283","DOI":"10.1039\/D5CP02976G","article-title":"Modeling CH 3 SOH\u2013aromatic complexes to probe cysteine sulfenic acid\u2013aromatic interactions in proteins","volume":"27","author":"Orabi","year":"2025","journal-title":"Phys Chem Phys"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110335_bib0007","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202300595","article-title":"Thiol-disulfide exchange kinetics and redox potential of the coenzyme M and coenzyme B heterodisulfide, an electron acceptor coupled to energy conservation in methanogenic archaea","volume":"25","author":"Laird","year":"2024","journal-title":"ChemBioChem"},{"issue":"6","key":"10.1016\/j.jnutbio.2026.110335_bib0008","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.3390\/ijms25063521","article-title":"Electrophilic compounds in the human diet and their role in the induction of the transcription factor NRF2","volume":"25","author":"Andr\u00e9s","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110335_bib0009","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s44371-025-00286-w","article-title":"A review of sulfur-containing compounds of natural origin with insights into their pharmacological and toxicological impacts","volume":"2","author":"Nwankwo","year":"2025","journal-title":"Discov Chem"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0010","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.niox.2025.03.006","article-title":"From methionine to sulfide: exploring the diagnostic and therapeutic potential of sulfur-containing biomolecules in hypertension","volume":"156","author":"Misak","year":"2025","journal-title":"Nitric Oxide"},{"issue":"24","key":"10.1016\/j.jnutbio.2026.110335_bib0011","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1039\/D5CC00252D","article-title":"Synthetic organic polysulfanes as H 2 S donors and anticancer agents","volume":"61","author":"Sufian","year":"2025","journal-title":"Chem Commun"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1534000","article-title":"Natural sulfur compounds in mental health and neurological disorders: insights from observational and intervention studies","volume":"12","author":"Rana","year":"2025","journal-title":"Front Nutr"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2024.106664","article-title":"Anticancer effects of alpha-lipoic acid, a potent organosulfur compound by modulating matrix metalloproteinases and apoptotic markers in osteosarcoma MG-63 cells","volume":"247","author":"Ahmadi","year":"2025","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"10.1016\/j.jnutbio.2026.110335_bib0014","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s10534-025-00716-3","article-title":"Modification of human metallothioneins by garlic organosulfur compounds, allicin and ajoene: direct effect on zinc homeostasis with relevance to immune regulation","volume":"38","author":"Mosna","year":"2025","journal-title":"BioMetals"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0015","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.niox.2024.01.004","article-title":"Hydrogen sulfide (H2S) metabolism: unraveling cellular regulation, disease implications, and therapeutic prospects for precision medicine","volume":"144","author":"Pandey","year":"2024","journal-title":"Nitric Oxide"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110335_bib0016","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jphs.2024.04.007","article-title":"Sulfide and polysulfide as pronociceptive mediators: focus on Cav3. 2 function enhancement and TRPA1 activation","volume":"155","author":"Sekiguchi","year":"2024","journal-title":"J Pharmacol Sci"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110335_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-024-01996-x","article-title":"Hydrogen sulfide induces regulatory B cells via glycolysis and mitochondrial ROS, attenuating LPS-induced lung injury","volume":"23","author":"Jeong","year":"2025","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102514","article-title":"Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress","volume":"57","author":"Akiyama","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103265","article-title":"Endogenous hydrogen sulfide accelerated trauma-induced heterotopic ossification through the Ca2+\/ERK pathway-enhanced aberrant osteogenic activity","volume":"75","author":"Yuan","year":"2024","journal-title":"Redox Biol"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.937956","article-title":"Dietary organosulfur compounds: emerging players in the regulation of bone homeostasis by plant-derived molecules","volume":"13","author":"Gambari","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0021","doi-asserted-by":"crossref","unstructured":"Wang J, Su X, Huang J, Qin L, Jiang X A Real-time in situ enzymatic strategy to stabilize garlic bioactive compounds for enhanced therapeutic efficacy. Available at SSRN 5771955. http:\/\/dx.doi.org\/10.2139\/ssrn.5771955.","DOI":"10.2139\/ssrn.5771955"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0022","author":"Ali"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0023","series-title":"Structure and chemical reactivity of bacterial reactive sulfur species (RSS)-Sensing transcriptional repressors","author":"Fakhoury","year":"2023"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.135610","article-title":"Development of methods for quantitative determination of the total and reactive polysulfides: reactive polysulfide profiling in vegetables","volume":"413","author":"Kasamatsu","year":"2023","journal-title":"Food Chem"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110335_bib0025","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1089\/ars.2019.7888","article-title":"Organic isothiocyanates as hydrogen sulfide donors","volume":"32","author":"Martelli","year":"2020","journal-title":"Antioxid Redox Signal"},{"issue":"19","key":"10.1016\/j.jnutbio.2026.110335_bib0026","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.3390\/molecules25194537","article-title":"Glucosinolates: natural occurrence, biosynthesis, accessibility, isolation, structures, and biological activities","volume":"25","author":"Nguyen","year":"2020","journal-title":"Molecules"},{"issue":"17","key":"10.1016\/j.jnutbio.2026.110335_bib0027","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.3390\/molecules25173804","article-title":"Health benefits of plant-derived sulfur compounds, glucosinolates, and organosulfur compounds","volume":"25","author":"Mi\u0119kus","year":"2020","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110335_bib0028","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2174\/1872312814666211210111820","article-title":"Physiological and pathophysiological role of cysteine metabolism in human metabolic syndrome","volume":"14","author":"Muthuraman","year":"2021","journal-title":"Drug Metab Lett"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0029","doi-asserted-by":"crossref","unstructured":"Aliyev IA, Trofimov BA, Oparina LA Aromatic disulfides, sulfoxides, sulfones, and other derivatives of aromatic thiols. (pp. 89\u2013147). Cham: Springer International Publishing.","DOI":"10.1007\/978-3-030-69621-4_3"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110335_bib0030","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev-food-052720-010127","article-title":"Dietary organosulfur-containing compounds and their health-promotion mechanisms","volume":"13","author":"Lu","year":"2022","journal-title":"Annu Rev Food Sci Technol"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0031","first-page":"1","article-title":"Developing organosulfur compounds in Allium as the next-generation flavor and bioactive ingredients for food and medicine","volume":"8","author":"Dai","year":"2025","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0032","unstructured":"Delbaere S, Van Loey A Processing to control (bio) chemical reactions influencing volatile profiles in Brassica and Allium vegetables\u2013an integrated food chain approach."},{"issue":"6","key":"10.1016\/j.jnutbio.2026.110335_bib0033","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3390\/molecules26061505","article-title":"Allicin, the odor of freshly crushed garlic: a review of recent progress in understanding allicin\u2019s effects on cells","volume":"26","author":"Borlinghaus","year":"2021","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110335_bib0034","doi-asserted-by":"crossref","DOI":"10.1111\/1541-4337.13389","article-title":"Mechanisms underlying the formation of main volatile odor sulfur compounds in foods during thermal processing","volume":"23","author":"Luo","year":"2024","journal-title":"Compr Rev Food Sci Food Saf"},{"issue":"12","key":"10.1016\/j.jnutbio.2026.110335_bib0035","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.3390\/antiox11122487","article-title":"Generation and physiology of hydrogen sulfide and reactive sulfur species in bacteria","volume":"11","author":"Han","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0036","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1130208","article-title":"Glucosinolates, a natural chemical arsenal: more to tell than the myrosinase story","volume":"14","author":"Abdel-Massih","year":"2023","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0037","doi-asserted-by":"crossref","unstructured":"Chokumnoyporn N, Samakradhamrongthai RS The stability. Inaroma and flavor in product development: characterization, perception, and application 2024 31 (pp. 229\u2013252). Cham: Springer Nature Switzerland.","DOI":"10.1007\/978-3-031-62612-8_7"},{"issue":"9","key":"10.1016\/j.jnutbio.2026.110335_bib0038","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3390\/cimb47090765","article-title":"Reactive sulfur species and protein persulfidation: an emerging redox axis in Human health and disease","volume":"47","author":"Curieses Andr\u00e9s","year":"2025","journal-title":"Curr Issues Mol Biol"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0039","article-title":"Allicin in digestive system cancer: from biological effects to clinical treatment","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0040","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fnut.2020.00064","article-title":"Organosulfur compounds: a review of their anti-inflammatory effects in human health","volume":"7","author":"Ruhee","year":"2020","journal-title":"Front Nutr"},{"issue":"16","key":"10.1016\/j.jnutbio.2026.110335_bib0041","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.3390\/molecules27165252","article-title":"Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation","volume":"27","author":"Pot\u0119ga","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0042","first-page":"363","volume":"22","author":"Castro","year":"2023"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110335_bib0043","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3390\/antiox14030341","article-title":"The role of hydrogen sulfide in the regulation of the pulmonary vasculature in health and disease","volume":"14","author":"Aaronson","year":"2025","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110335_bib0044","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41579-024-01104-3","article-title":"Diversity and ecology of microbial sulfur metabolism","volume":"23","author":"Zhou","year":"2025","journal-title":"Nat Rev Microbiol"},{"issue":"8","key":"10.1016\/j.jnutbio.2026.110335_bib0045","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.3390\/foods10081680","article-title":"Beneficial effects of organosulfur compounds from Allium cepa on gut health: a systematic review","volume":"10","author":"Guillamon","year":"2021","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110335_bib0046","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6459585","article-title":"Mitochondrial-endoplasmic reticulum communication-mediated oxidative stress and autophagy","volume":"2022","author":"Liu","year":"2022","journal-title":"BioMed Res Int"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110335_bib0047","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3390\/antiox12030603","article-title":"Role of 3-mercaptopyruvate sulfurtransferase (3-MST) in physiology and disease","volume":"12","author":"Rao","year":"2023","journal-title":"Antioxidants"},{"issue":"18","key":"10.1016\/j.jnutbio.2026.110335_bib0048","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.3390\/molecules25184111","article-title":"Prevailing knowledge on the bioavailability and biological activities of sulphur compounds from Alliums: a potential drug candidate","volume":"25","author":"Subramanian","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0049","first-page":"445","volume":"25","author":"Walag","year":"2020"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0050","author":"Kusza"},{"issue":"4\u20136","key":"10.1016\/j.jnutbio.2026.110335_bib0051","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/ars.2021.0170","article-title":"Chemical biology of reactive sulfur species: hydrolysis-driven equilibrium of polysulfides as a determinant of physiological functions","volume":"36","author":"Sawa","year":"2022","journal-title":"Antioxid Redox Signal"},{"issue":"5","key":"10.1016\/j.jnutbio.2026.110335_bib0052","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1021\/acs.accounts.3c00626","article-title":"Sulfur switches for responsive peptide materials","volume":"57","author":"Deming","year":"2024","journal-title":"Acc Chem Res"},{"issue":"39","key":"10.1016\/j.jnutbio.2026.110335_bib0053","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202403435","article-title":"Advances in electrocatalyst design and mechanism for sulfide oxidation reaction in hydrogen sulfide splitting","volume":"34","author":"Yu","year":"2024","journal-title":"Adv Funct Mater"},{"issue":"14","key":"10.1016\/j.jnutbio.2026.110335_bib0054","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1089\/ars.2019.7880","article-title":"Prodrugs of persulfides, sulfur dioxide, and carbon disulfide: important tools for studying sulfur signaling at various oxidation states","volume":"33","author":"Yu","year":"2020","journal-title":"Antioxid Redox Signal"},{"issue":"18","key":"10.1016\/j.jnutbio.2026.110335_bib0055","doi-asserted-by":"crossref","first-page":"9845","DOI":"10.3390\/ijms25189845","article-title":"Post-translational modifications to cysteine residues in plant proteins and their impact on the regulation of metabolism and signal transduction","volume":"25","author":"Boutin","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.jnutbio.2026.110335_bib0056","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.3390\/antiox12091737","article-title":"Hydrogen sulfide: an emerging regulator of oxidative stress and cellular homeostasis a comprehensive one-year review","volume":"12","author":"Munteanu","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0057","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/B978-0-12-821038-3.00054-9","article-title":"Organosulfur compounds as nutraceuticals","volume":"1","author":"Goncharov","year":"2021","journal-title":"Nutraceuticals"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110335_bib0058","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/s41467-017-01311-y","article-title":"Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics","volume":"8","author":"Akaike","year":"2017","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.jnutbio.2026.110335_bib0059","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3390\/biom10050697","article-title":"Cystathionine-\u03b2-synthase: molecular regulation and pharmacological inhibition","volume":"10","author":"Zuhra","year":"2020","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110335_bib0060","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1515\/hsz-2020-0266","article-title":"Thiol switches in membrane proteins-extracellular redox regulation in cell biology","volume":"402","author":"Lorenzen","year":"2021","journal-title":"Biol Chem"},{"issue":"1\u20133","key":"10.1016\/j.jnutbio.2026.110335_bib0061","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/ars.2023.0352","article-title":"Emerging chemical biology of protein persulfidation","volume":"39","author":"Vignane","year":"2023","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110335_bib0063","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1021\/bi1010893","article-title":"Pre-steady-state kinetic analysis of enzyme-monitored turnover during cystathionine \u03b2-synthase-catalyzed H2S generation","volume":"50","author":"Singh","year":"2011","journal-title":"Biochemistry"},{"issue":"7","key":"10.1016\/j.jnutbio.2026.110335_bib0064","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1089\/ars.2017.7224","article-title":"Redox-dependent regulation of sulfur metabolism in biomolecules: implications for cardiovascular health","volume":"30","author":"Mistry","year":"2019","journal-title":"Antioxid Redox Signal"},{"issue":"14","key":"10.1016\/j.jnutbio.2026.110335_bib0065","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1089\/ars.2020.8060","article-title":"SG1002 and catenated divalent organic sulfur compounds as promising hydrogen sulfide prodrugs","volume":"33","author":"Gojon","year":"2020","journal-title":"Antioxid Redox Signal"},{"issue":"9","key":"10.1016\/j.jnutbio.2026.110335_bib0066","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3390\/cimb47090765","article-title":"Reactive sulfur species and protein persulfidation: an emerging redox axis in human health and disease","volume":"47","author":"Andr\u00e9s","year":"2025","journal-title":"Curr Issues Mol Biol"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110335_bib0067","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s11101-019-09634-y","article-title":"Modulation of hydrogen sulfide gasotransmitter limits the proven benefits of garlic","volume":"18","author":"Yagdi Efe","year":"2019","journal-title":"Phytochem Rev"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102519","article-title":"Cystathionine \u03b3 lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction","volume":"58","author":"Wu","year":"2022","journal-title":"Redox Biol"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110335_bib0069","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41467-024-55661-5","article-title":"Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice","volume":"16","author":"Nishimura","year":"2025","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.jnutbio.2026.110335_bib0070","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3390\/life15050757","article-title":"Integrative strategies for preventing and managing metabolic syndrome: the impact of exercise and diet on oxidative stress reduction a review","volume":"15","author":"Onu","year":"2025","journal-title":"Life"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0071","author":"Flori"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0072","series-title":"Cruciferous vegetables, isothiocyanates, indoles, and cancer prevention. Inbioactive compounds and cancer","first-page":"535","author":"Thomson","year":"2010"},{"issue":"7","key":"10.1016\/j.jnutbio.2026.110335_bib0073","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3390\/antiox11071255","article-title":"The role of organosulfur compounds as Nrf2 activators and their antioxidant effects","volume":"11","author":"Egbujor","year":"2022","journal-title":"Antioxidants"},{"issue":"16","key":"10.1016\/j.jnutbio.2026.110335_bib0074","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1089\/ars.2020.8077","article-title":"Measuring reactive sulfur species and thiol oxidation states: challenges and cautions in relation to alkylation-based protocols","volume":"33","author":"Nagy","year":"2020","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0075","article-title":"Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs","volume":"12","author":"Cirino","year":"2022","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0076","series-title":"In vitro and in vivo activities of Allium-derived alk (en) ylmercaptocysteines","author":"Le","year":"2020"},{"issue":"6","key":"10.1016\/j.jnutbio.2026.110335_bib0077","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3390\/biomedicines12061169","article-title":"Anti-inflammatory therapeutic mechanisms of isothiocyanates: insights from sulforaphane","volume":"12","author":"Habtemariam","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0079","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1387903","article-title":"Gut redox and microbiome: charting the roadmap to T-cell regulation","volume":"15","author":"Prasad","year":"2024","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.jnutbio.2026.110335_bib0080","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.3390\/molecules27113389","article-title":"Hydrogen sulfide biology and its role in cancer","volume":"27","author":"Khattak","year":"2022","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.jnutbio.2026.110335_bib0081","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s12032-023-02124-4","article-title":"The mechanistic insights of the antioxidant Keap1-Nrf2 pathway in oncogenesis: a deadly scenario","volume":"40","author":"Mukherjee","year":"2023","journal-title":"Med Oncol"},{"issue":"5","key":"10.1016\/j.jnutbio.2026.110335_bib0082","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1013164","article-title":"Hydrogen sulfide (H2S) coordinates redox balance, carbon metabolism, and mitochondrial bioenergetics to suppress SARS-CoV-2 infection","volume":"21","author":"Agrawal","year":"2025","journal-title":"PLoS Pathog"},{"issue":"7","key":"10.1016\/j.jnutbio.2026.110335_bib0083","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.3390\/nu11071581","article-title":"Natural hydrogen sulfide donors from Allium sp. as a nutraceutical approach in type 2 diabetes prevention and therapy","volume":"11","author":"Melino","year":"2019","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110335_bib0084","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1002\/j.2040-4603.2021.tb00187.x","article-title":"Hydrogen sulfide actions in the vasculature","volume":"11","author":"Mendiola","year":"2021","journal-title":"Compr Physiol"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110335_bib0085","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3390\/nu17030428","article-title":"Protective effects of sulforaphane preventing inflammation and oxidative stress to enhance metabolic health: a narrative review","volume":"17","author":"Alves","year":"2025","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.jnutbio.2026.110335_bib0086","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.3390\/ijms26073131","article-title":"Hydrogen sulfide (H2S-or H2Sn-Polysulfides) in synaptic plasticity: modulation of NMDA receptors and neurotransmitter release in learning and memory","volume":"26","author":"Munteanu","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.jnutbio.2026.110335_bib0087","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/s42255-022-00656-z","article-title":"Bacterial hydrogen sulfide drives cryptic redox chemistry in gut microbial communities","volume":"4","author":"Wolfson","year":"2022","journal-title":"Nat Metab"},{"issue":"21","key":"10.1016\/j.jnutbio.2026.110335_bib0088","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262110807","article-title":"Natural sulfur compounds in mineral waters: implications for human health and disease","volume":"26","author":"Vaccarezza","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110335_bib0089","doi-asserted-by":"crossref","first-page":"G125","DOI":"10.1152\/ajpgi.00261.2020","article-title":"Production of hydrogen sulfide by the intestinal microbiota and epithelial cells and consequences for the colonic and rectal mucosa","volume":"320","author":"Blachier","year":"2021","journal-title":"Am J Physiol-Gastrointest Liver Physiol"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110240","article-title":"Antihypertensive effects of allicin on spontaneously hypertensive rats via vasorelaxation and hydrogen sulfide mechanisms","volume":"128","author":"Cui","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"10.1016\/j.jnutbio.2026.110335_bib0091","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.tips.2015.05.007","article-title":"The role of H2S bioavailability in endothelial dysfunction","volume":"36","author":"Wang","year":"2015","journal-title":"Trends Pharmacol Sci"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110335_bib0092","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/j.2040-4603.2019.tb00084.x","article-title":"Nitric oxide and hydrogen sulfide regulation of ischemic vascular growth and remodeling","volume":"9","author":"Rajendran","year":"2019","journal-title":"Compr Physiol"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110335_bib0093","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11906-019-1009-9","article-title":"Effect of garlic\u2019s active constituents in inflammation, obesity and cardiovascular disease","volume":"22","author":"Quesada","year":"2020","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0094","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2025.1599154","article-title":"The therapeutic effects of natural organosulfur compounds on atherosclerosis and their potential mechanisms: a comprehensive review","volume":"12","author":"Tang","year":"2025","journal-title":"Front Cardiovasc Med"},{"issue":"10","key":"10.1016\/j.jnutbio.2026.110335_bib0095","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1089\/ars.2017.7096","article-title":"Beyond a gasotransmitter: hydrogen sulfide and polysulfide in cardiovascular health and immune response","volume":"27","author":"Yuan","year":"2017","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0096","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66795-5","article-title":"Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and H2S in biological samples","author":"Miljkovic","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0097","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbpa.2018.08.012","article-title":"Reactive sulfur species (RSS): persulfides, polysulfides, potential, and problems","volume":"49","author":"Lau","year":"2019","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0098","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.aca.2017.03.027","article-title":"Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach","volume":"969","author":"Ikeda","year":"2017","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0099","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.redox.2018.07.016","article-title":"A selective and sensitive method for quantification of endogenous polysulfide production in biological samples","volume":"18","author":"Bibli","year":"2018","journal-title":"Redox Biol"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110335_bib0100","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ncomms1506","article-title":"Selective fluorescent probes for live-cell monitoring of sulphide","volume":"2","author":"Qian","year":"2011","journal-title":"Nat Commun"},{"issue":"17","key":"10.1016\/j.jnutbio.2026.110335_bib0101","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1021\/acs.accounts.5c00483","article-title":"Activity-based fluorescent probes for reactive sulfur species","volume":"58","author":"Xian","year":"2025","journal-title":"Acc Chem Res"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110335_bib0102","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3390\/antiox12040925","article-title":"Bioavailability of organosulfur compounds after the ingestion of black garlic by healthy humans","volume":"12","author":"Moreno-Ortega","year":"2023","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110335_bib0103","article-title":"New method for quantification of gasotransmitter hydrogen sulfide in biological matrices by LC-MS\/MS","volume":"7","author":"Tan","year":"2017","journal-title":"Sci Rep"},{"issue":"44","key":"10.1016\/j.jnutbio.2026.110335_bib0104","doi-asserted-by":"crossref","first-page":"30422","DOI":"10.1021\/jacs.4c10266","article-title":"Simultaneous quantitation of persulfides, biothiols, and hydrogen sulfide through sulfur exchange reaction with trityl spin probes","volume":"146","author":"Tan","year":"2024","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102401","article-title":"Stable isotope dilution mass spectrometry quantification of hydrogen sulfide and thiols in biological matrices","volume":"55","author":"Malaeb","year":"2022","journal-title":"Redox biol"},{"key":"10.1016\/j.jnutbio.2026.110335_bib0106","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.111140","article-title":"Forensic analysis of hydrogen sulfide poisoning cases: innovative LC-MS\/MS methodology for accurate detection in human blood","volume":"204","author":"Qin","year":"2024","journal-title":"Microchem J"},{"issue":"16","key":"10.1016\/j.jnutbio.2026.110335_bib0107","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1093\/jxb\/erz260","article-title":"Sulphur systems biology\u2014Making sense of omics data","volume":"70","author":"Watanabe","year":"2019","journal-title":"J Exp Bot"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095528632600077X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095528632600077X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T21:25:21Z","timestamp":1775683521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095528632600077X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":105,"alternative-id":["S095528632600077X"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110335","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary organosulfur compounds and the H2S\u2013polysulfide redox axis: Current evidence and limitations","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110335","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110335"}}