{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:20:12Z","timestamp":1788844812238,"version":"build-2803163510"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009730","name":"Universidade Federal de Ouro Preto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ - 04983-22"],"award-info":[{"award-number":["APQ - 04983-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-02200-21"],"award-info":[{"award-number":["APQ-02200-21"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-02511-22"],"award-info":[{"award-number":["APQ-02511-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-02029-21"],"award-info":[{"award-number":["APQ-02029-21"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020670","name":"Cancer Council Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jnutbio.2026.110372","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T23:18:23Z","timestamp":1775690303000},"page":"110372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Small litter size attenuates adverse hepatic effects induced by a high-sucrose diet"],"prefix":"10.1016","volume":"155","author":[{"given":"Juliana Let\u00edcia","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1645-6251","authenticated-orcid":false,"given":"Isabela Jesus","family":"de Deus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Rezende Ribeiro de","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-4333","authenticated-orcid":false,"given":"Miliane Martins de Andrade","family":"Fagundes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Silveira","family":"Breguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Martins","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia","family":"Paula-Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Caldeira","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8171-435X","authenticated-orcid":false,"given":"Karina Barbosa","family":"de Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2026.110372_bib0001","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/adc.71.4.288","article-title":"Role of nutritional programming in determining adult morbidity","volume":"71","author":"Lucas","year":"1994","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0002","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41576-018-0092-0","article-title":"Genomic imprinting disorders: lessons on how genome, epigenome and environment interact","volume":"20","author":"Monk","year":"2019","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0003","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1136\/bmj.301.6761.1111","article-title":"The fetal and infant origins of adult disease","volume":"301","author":"Barker","year":"1990","journal-title":"BMJ : Br Med J"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0004","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1017\/S2040174418000892","article-title":"DOHaD in science and society: emergent opportunities and novel responsibilities","volume":"10","author":"Penkler","year":"2019","journal-title":"J Dev Orig Health Dis"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0005","series-title":"Guideline: Sugars intake for adults and children","year":"2015"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0006","doi-asserted-by":"crossref","first-page":"e1017","DOI":"10.1161\/CIR.0000000000000439","article-title":"Added sugars and cardiovascular disease risk in children: a scientific statement from the American Heart Association","volume":"135","author":"Vos","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0007","doi-asserted-by":"crossref","DOI":"10.1186\/s12889-023-17223-0","article-title":"Association between diet soft drink consumption and metabolic dysfunction-associated steatotic liver disease: findings from the NHANES","volume":"23","author":"Wu","year":"2023","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0008","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1139\/cjpp-2018-0353","article-title":"Histopathological and biochemical changes in the development of nonalcoholic fatty liver disease induced by high-sucrose diet at different times","volume":"97","author":"Acosta-Cota S de","year":"2019","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0009","doi-asserted-by":"crossref","first-page":"47","DOI":"10.20473\/bhsj.v5i1.35160","article-title":"The effect and mechanism of sucrose consumption to liver disease \u2013 a systematic literature review","volume":"5","author":"Sigma","year":"2022","journal-title":"Biomol Health Sci J"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0010","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1182\/blood.V93.5.1464","article-title":"NADPH oxidase: an update","volume":"93","author":"Babior","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0011","first-page":"142","article-title":"Reactive oxygen species: from health to disease","volume":"33","author":"Brieger","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0012","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature21363","article-title":"Inflammation, metaflammation and immunometabolic disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0013","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123034","article-title":"Arsenic induces hepatic insulin resistance via mtROS-NLRP3 inflammasome pathway","volume":"399","author":"Jia","year":"2020","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2013.00144","article-title":"Perinatal nutrition programs neuroimmune function long-term: mechanisms and implications","volume":"7","author":"Spencer","year":"2013","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0016","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.cmet.2020.07.014","article-title":"Size does matter: litter size strongly determines adult metabolism in rodents","volume":"32","author":"Parra-Vargas","year":"2020","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0017","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1055\/s-0029-1211159","article-title":"Obesity and enhanced diabetes and cardiovascular risk in adult rats due to early postnatal overfeeding","volume":"99","author":"Plagemann","year":"1992","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0018","article-title":"Neonatal overfeeding attenuates acute central pro-inflammatory effects of short-term high fat diet","volume":"9","author":"Cai","year":"2015","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0019","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1429157","article-title":"Neonatal overfeeding attenuates microgliosis and hippocampal damage in an infant rat model of pneumococcal meningitis","volume":"15","author":"Cassiano","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0020","first-page":"81","article-title":"Oxidative stress programming in a rat model of postnatal early overnutrition - role of insulin resistance","volume":"24","author":"Concei\u00e7\u00e3o","year":"2013","journal-title":"J NutrBiochem"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0021","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1113\/JP271189","article-title":"Early redox imbalance is associated with liver dysfunction at weaning in overfed rats","volume":"593","author":"Concei\u00e7\u00e3o","year":"2015","journal-title":"J Physiol"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0022","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1089\/ars.2014.5868","article-title":"Reactive oxygen species-induced TXNIP Drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation","volume":"22","author":"Zhang","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0023","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1007\/s00394-018-1730-1","article-title":"Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress","volume":"58","author":"Veli\u010dkovi\u0107","year":"2019","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0024","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1017\/S2040174425100123","article-title":"Metabolic imprinting due to small litter size mitigates insulin resistance through the interscapular brown adipose tissue activation in a high-sucrose diet model","volume":"16","author":"de Deus","year":"2025","journal-title":"J Dev Orig Health Dis"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0025","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.psyneuen.2009.02.013","article-title":"Neonatal overfeeding alters adult anxiety and stress responsiveness","volume":"34","author":"Spencer","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0026","first-page":"624","article-title":"The laboratory rat: relating its age with human\u2019s","volume":"4","author":"Sengupta","year":"2013","journal-title":"Int J Prev Med"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0027","doi-asserted-by":"crossref","first-page":"41","DOI":"10.21776\/ub.VetBioClinJ.2024.006.01.6","article-title":"Effects of euthanasia on animal research","volume":"6","author":"Maharani","year":"2024","journal-title":"Ve Biomed Clin J"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0028","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues*","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0029","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.603926","article-title":"Non-alcoholic steatohepatitis: a review of its mechanism, models and medical treatments","volume":"11","author":"Peng","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0031","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0032","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jnutbio.2016.09.013","article-title":"Dietary calcium supplementation in adult rats reverts brown adipose tissue dysfunction programmed by postnatal early overfeeding","volume":"39","author":"Concei\u00e7\u00e3o","year":"2017","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0033","first-page":"184","article-title":"Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide","volume":"35","author":"Madesh","year":"1998","journal-title":"Indian J Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0034","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0035","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","article-title":"Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent","volume":"25","author":"Sedlak","year":"1968","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0036","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0076-6879(94)33040-9","article-title":"Carbonyl assays for determination of oxidatively modified proteins","volume":"233","author":"Levine","year":"1994","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0037","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0038","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ab.2019.03.010","article-title":"Ponceau S waste: Ponceau S staining for total protein normalization","volume":"575","author":"Sander","year":"2019","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2199-7-33","article-title":"Selection of housekeeping genes for gene expression studies in human reticulocytes using real-time PCR","volume":"7","author":"Silver","year":"2006","journal-title":"BMC Mol Biol"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0040","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11745-013-3854-7","article-title":"Endurance training increases leptin expression in the retroperitoneal adipose tissue of rats fed with a high-sugar diet","volume":"49","author":"de Queiroz","year":"2014","journal-title":"Lipids"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0041","article-title":"Physical activity prevents alterations in mitochondrial ultrastructure and glucometabolic parameters in a high-sugar diet model","volume":"12","author":"de Queiroz","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2020.108519","article-title":"Liver lipidome signature and metabolic pathways in nonalcoholic fatty liver disease induced by a high-sugar diet","volume":"87","author":"Oliveira","year":"2021","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.2040-4603.2018.tb00008.x","article-title":"Triglyceride metabolism in the liver","volume":"8","author":"Alves-Bezerra","year":"2017","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0044","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/brv.12178","article-title":"De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose","volume":"91","author":"Sanders","year":"2016","journal-title":"Biol Rev Camb Philos Soc"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0045","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1007\/s10620-016-4054-0","article-title":"Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease","volume":"61","author":"Softic","year":"2016","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0046","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jnutbio.2013.10.006","article-title":"The inflammatory profile and liver damage of a sucrose-rich diet in mice","volume":"25","author":"Oliveira","year":"2014","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0047","doi-asserted-by":"crossref","first-page":"71","DOI":"10.20945\/2359-3997000000199","article-title":"High-sugar diet leads to obesity and metabolic diseases in ad libitum -fed rats irrespective of caloric intake","volume":"64","author":"de Oliveira","year":"2020","journal-title":"Arch Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0048","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/09603123.2019.1680817","article-title":"Evaluation of sucrose-enriched diet consumption in the development of risk factors associated to type 2 diabetes, atherosclerosis and non-alcoholic fatty liver disease in a murine model","volume":"31","author":"Plazas Guerrero","year":"2021","journal-title":"Int J Environ Health Res"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0049","first-page":"565","article-title":"Microvesicular steatosis\u202f: a missed item in the management of nonalcoholic fatty liver disease?","volume":"83","author":"Celebi","year":"2020","journal-title":"Acta Gastroenterol Belg"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0050","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.jhep.2022.08.028","article-title":"Mechanotransduction in the pathogenesis of non-alcoholic fatty liver disease","volume":"77","author":"Mitten","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0051","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.3748\/wjg.v21.i11.3223","article-title":"Biomarkers in nonalcoholic fatty liver disease-the emperor has no clothes?","volume":"21","author":"Sanal","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0052","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-2007-1001668","article-title":"Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity and enhanced cardiovascular risk in later life","volume":"26","author":"Dorner","year":"1994","journal-title":"Hormone Metab Res"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0053","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1096\/fj.201700717RR","article-title":"Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance","volume":"32","author":"Ramon-Krauel","year":"2018","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0054","doi-asserted-by":"crossref","DOI":"10.1590\/0001-3765201920170971","article-title":"Litter size reduction induces metabolic and histological adjustments in dams throughout lactation with early effects on offspring","volume":"91","author":"Xavier","year":"2019","journal-title":"An Acad Bras Cienc"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0055","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1590\/S1415-52732012000300002","article-title":"Efeito da redu\u00e7\u00e3o de ninhada sobre as respostas auton\u00f4micas e metab\u00f3licas de ratos Wistar","volume":"25","author":"Rinaldi","year":"2012","journal-title":"Rev Nutr"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0056","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9719584","article-title":"Nutrients and oxidative stress: friend or foe?","volume":"2018","author":"Tan","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0057","first-page":"2020","article-title":"Influ\u00eancia do \u00edndice glic\u00eamico dos alimentos sobre a concentra\u00e7\u00e3o de marcadores pr\u00f3-inflamat\u00f3rios","volume":"9","author":"de","year":"2020","journal-title":"Arch Health Investig"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0058","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41423-022-00858-1","article-title":"NADPH oxidase family proteins: signaling dynamics to disease management","volume":"19","author":"Begum","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0059","doi-asserted-by":"crossref","first-page":"E34","DOI":"10.1152\/ajpendo.00436.2013","article-title":"FFA-induced hepatic insulin resistance in vivo is mediated by PKC\u03b4, NADPH oxidase, and oxidative stress","volume":"307","author":"Pereira","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0060","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1155\/2012\/819310","article-title":"Characterization of blood oxidative stress in type 2 diabetes mellitus patients: increase in lipid peroxidation and SOD Activity","volume":"2012","author":"Bandeira","year":"2012","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0061","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-024-76527-2","article-title":"Antioxidant and anticoagulant properties of myo-inositol determined in an ex vivo studies and gas chromatography analysis","volume":"14","author":"Rolnik","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0063","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/oby.22821","article-title":"High glucose-aggravated hepatic insulin resistance: role of the NLRP3 Inflammasome in Kupffer cells","volume":"28","author":"Zheng","year":"2020","journal-title":"Obesity"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0062","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.freeradbiomed.2024.06.011","article-title":"Activation of the ROS\/TXNIP\/NLRP3 pathway disrupts insulin-dependent glucose uptake in skeletal muscle of insulin-resistant obese mice","volume":"222","author":"Russell-Guzm\u00e1n","year":"2024","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0064","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/imr.12285","article-title":"NLRP3 at the interface of metabolism and inflammation","volume":"265","author":"Haneklaus","year":"2015","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0065","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1124\/pharmrev.122.000629","article-title":"Pharmacological Inhibition of the NLRP3 Inflammasome: structure, molecular activation, and inhibitor-NLRP3 interaction","volume":"75","author":"Ma","year":"2023","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0066","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1402905","article-title":"Overfeeding in the early postnatal period aggravates inflammation and hepatic insulin sensitivity in the 5\u03b1-dihydrotestosterone-induced animal model of PCOS","volume":"15","author":"Veli\u010dkovi\u0107","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0067","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.numecd.2018.03.013","article-title":"Transient postnatal over nutrition induces long-term alterations in cardiac NLRP3-inflammasome pathway","volume":"28","author":"Siddeek","year":"2018","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0068","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13050","article-title":"NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice","volume":"19","author":"Mar\u00edn-Aguilar","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0069","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.metabol.2017.06.002","article-title":"Current role of the NLRP3 inflammasome on obesity and insulin resistance: a systematic review","volume":"74","author":"Rheinheimer","year":"2017","journal-title":"Metabolism"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0070","doi-asserted-by":"crossref","DOI":"10.1172\/JCI142241","article-title":"Insulin signaling in health and disease","volume":"131","author":"Saltiel","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0071","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of insulin action and insulin resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jnutbio.2026.110372_bib0072","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.971745","article-title":"Interleukin-18 in metabolism: from mice physiology to human diseases","volume":"13","author":"Somm","year":"2022","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326001142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326001142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T14:59:11Z","timestamp":1779721151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286326001142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":72,"alternative-id":["S0955286326001142"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110372","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small litter size attenuates adverse hepatic effects induced by a high-sucrose diet","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110372","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110372"}}