{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:03:45Z","timestamp":1784559825220,"version":"3.55.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000148","name":"Canadian Anesthesiologists' Society","doi-asserted-by":"publisher","award":["QYZDB-SSW-SLH046"],"award-info":[{"award-number":["QYZDB-SSW-SLH046"]}],"id":[{"id":"10.13039\/501100000148","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011811","name":"Inner Mongolia Agricultural University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011811","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472060"],"award-info":[{"award-number":["82472060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB1610000"],"award-info":[{"award-number":["XDB1610000"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jnutbio.2026.110446","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:29:25Z","timestamp":1781105365000},"page":"110446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Lactobacillus casei Zhang modulates hippocampal metabolism and cognition in T2DM rats: a microbiota-gut-brain axis study"],"prefix":"10.1016","volume":"157","author":[{"given":"Yue","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-5015","authenticated-orcid":false,"given":"Huili","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3916-6774","authenticated-orcid":false,"given":"Haodong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2282-6474","authenticated-orcid":false,"given":"Fuchun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2026.110446_bib0001","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11892-013-0375-y","article-title":"Diabetes mellitus and inflammation","volume":"13","author":"Lontchi-Yimagou","year":"2013","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0002","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.2337\/dc23-S002","article-title":"Classification and diagnosis of diabetes: standards of care in diabetes-2023","volume":"46","author":"El-Sayed","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0003","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0004","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00125-007-0602-7","article-title":"Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes","volume":"50","author":"Gold","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0005","doi-asserted-by":"crossref","first-page":"7036","DOI":"10.1073\/pnas.1000645107","article-title":"Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes","volume":"107","author":"Takeda","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0006","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.2337\/db13-1954","article-title":"Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease","volume":"63","author":"De Felice","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0007","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S2213-8587(14)70148-2","article-title":"Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review","volume":"3","author":"Geijselaers","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0008","article-title":"High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0009","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s11011-015-9670-4","article-title":"Patients with type 2 diabetes exhibit cognitive impairment with changes of metabolite concentration in the left hippocampus","volume":"30","author":"Wang","year":"2015","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0010","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bbadis.2016.11.003","article-title":"Cognitive decline in type 2 diabetic db\/db mice may be associated with brain region-specific metabolic disorders","volume":"1863","author":"Zheng","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0011","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1177\/0271678X15626154","article-title":"Analysis of neuron-astrocyte metabolic cooperation in the brain of db\/db mice with cognitive decline using 13C NMR spectroscopy","volume":"37","author":"Zheng","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0012","first-page":"304","article-title":"Metabolic alterations associated to brain dysfunction in diabetes","volume":"6","author":"Duarte","year":"2015","journal-title":"Aging Dis"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0013","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s11011-020-00541-2","article-title":"A novel hippocampus metabolite signature in diabetes mellitus rat model of diabetic encephalopathy","volume":"35","author":"Chen","year":"2020","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0014","doi-asserted-by":"crossref","first-page":"154712","DOI":"10.1016\/j.metabol.2021.154712","article-title":"Role of the gut microbiota in type 2 diabetes and related diseases","volume":"117","author":"Yang","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0015","article-title":"The impact of gut microbial dysbiosis on the atrophy of the hippocampus and abnormal metabolism of N-acetyl aspartate in type 2 diabetic rats","volume":"10","author":"Zhu","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0016","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.3390\/molecules26196076","article-title":"Probiotics regulate gut microbiota: an effective method to improve immunity","volume":"26","author":"Wang","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0017","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.neuroimage.2015.11.018","article-title":"Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate","volume":"125","author":"Janik","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0018","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/nutrit\/nuac113","article-title":"Probiotic supplements are effective in people with cognitive impairment: a meta-analysis of randomized controlled trials","volume":"81","author":"Liu","year":"2023","journal-title":"Nutr Rev"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0019","doi-asserted-by":"crossref","first-page":"149407","DOI":"10.1016\/j.brainres.2024.149407","article-title":"Lactobacillus casei Zhang prevents hippocampal atrophy and cognitive impairment in rats with type 2 diabetes by regulating blood glucose levels","volume":"1850","author":"Cai","year":"2025","journal-title":"Brain Res"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0020","doi-asserted-by":"crossref","first-page":"127307","DOI":"10.1016\/j.ijbiomac.2023.127307","article-title":"White hyacinth bean polysaccharide ameliorates diabetes via microbiota-gut-brain axis in type 2 diabetes mellitus rats","volume":"253","author":"Chen","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0021","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00394-013-0519-5","article-title":"Probiotic Lactobacillus casei Zhang ameliorates high-fructose-induced impaired glucose tolerance in hyperinsulinemia rats","volume":"53","author":"Zhang","year":"2014","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0022","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1038\/srep05654","article-title":"Lactobacillus casei reduces susceptibility to type 2 diabetes via microbiota-mediated body chloride ion influx","volume":"4","author":"Zhang","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0023","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1007\/s00394-021-02764-0","article-title":"Lactobacillus casei Zhang exerts anti-obesity effect to obese glut1 and gut-specific-glut1 knockout mice via gut microbiota modulation mediated different metagenomic pathways","volume":"61","author":"He","year":"2022","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0024","series-title":"The rat brain in stereotaxic coordinates: hard cover edition","author":"Paxinos","year":"2006"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0025","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn Process"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0026","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4939-8994-2_10","article-title":"The Y-maze for assessment of spatial working and reference memory in mice","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0027","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.biopha.2018.02.084","article-title":"Investigation of insulin resistance in the popularly used four rat models of type-2 diabetes","volume":"101","author":"Chao","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0028","doi-asserted-by":"crossref","first-page":"104941","DOI":"10.1016\/j.neuint.2020.104941","article-title":"Region-specific metabolic characterization of the type 1 diabetic brain in mice with and without cognitive impairment","volume":"143","author":"Xu","year":"2021","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0029","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V","article-title":"Proton NMR chemical shifts and coupling constants for brain metabolites","volume":"13","author":"Govindaraju","year":"2000","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0030","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1186\/s12909-024-05822-3","article-title":"Longitudinal variation of correlations between different components of assessment within a medical school","volume":"24","author":"Matos Sousa","year":"2024","journal-title":"BMC Med Educ"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0031","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1037\/0033-2909.87.2.245","article-title":"Tests for comparing elements of a correlation matrix","volume":"87","author":"Steiger","year":"1980","journal-title":"Psychol Bull"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0032","doi-asserted-by":"crossref","first-page":"734158","DOI":"10.3389\/fnins.2021.734158","article-title":"Hippocampal function is impaired by a short-term high-fat diet in mice: increased blood-brain barrier permeability and neuroinflammation as triggering events","volume":"15","author":"de Paula","year":"2021","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0033","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1053\/meta.2000.17721","article-title":"A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat","volume":"49","author":"Reed","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0034","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.phrs.2005.05.004","article-title":"Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening","volume":"52","author":"Srinivasan","year":"2005","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0035","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11892-016-0775-x","volume":"16","author":"Zilliox","year":"2016","journal-title":"Diabetes and cognitive impairment. Curr Diab Rep"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0036","first-page":"1118","article-title":"Effect of type 2 diabetes mellitus on brain metabolites by using proton magnetic resonance spectroscopy-a systematic review","volume":"5","author":"Santhakumari","year":"2014","journal-title":"Int J Pharma Bio Sci"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0037","doi-asserted-by":"crossref","first-page":"738971","DOI":"10.3389\/fnagi.2021.738971","article-title":"Meta-analysis of neurochemical changes estimated via magnetic resonance spectroscopy in mild cognitive impairment and Alzheimer\u2019s disease","volume":"13","author":"Liu","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0038","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3389\/fneur.2019.01068","article-title":"Correlation between diabetic cognitive impairment and diabetic retinopathy in patients with T2DM by (1)H-MRS","volume":"10","author":"Lu","year":"2019","journal-title":"Front Neurol"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0039","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/biom15030399","article-title":"Role of gamma-aminobutyric acid (GABA) as an inhibitory neurotransmitter in diabetes management: mechanisms and therapeutic implications","volume":"15","author":"Barakat","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0040","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s10571-022-01214-7","article-title":"Function of the GABAergic system in diabetic encephalopathy","volume":"43","author":"Zhou","year":"2023","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0041","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.3390\/nu14061292","article-title":"Taurine supplementation as a neuroprotective strategy upon brain dysfunction in metabolic syndrome and diabetes","volume":"14","author":"Rafiee","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0042","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1080\/1028415X.2022.2131062","article-title":"Taurine and N-acetylcysteine treatments prevent memory impairment and metabolite profile alterations in the hippocampus of high-fat diet-fed female mice","volume":"26","author":"Garcia-Serrano","year":"2023","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0043","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1074\/mcp.RA118.000690","article-title":"Metabolomic analysis identifies lactate as an important pathogenic factor in diabetes-associated cognitive decline rats","volume":"17","author":"Zhao","year":"2018","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0044","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.psychres.2017.05.017","article-title":"Negative correlation between CSF lactate levels and MoCA scores in male Chinese subjects","volume":"255","author":"Wang","year":"2017","journal-title":"Psychiat Res"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0045","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3389\/fncel.2018.00527","article-title":"Analysis of metabolic alterations related to pathogenic process of diabetic encephalopathy rats","volume":"12","author":"Dong","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0046","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.3390\/ijms23095173","article-title":"Continuous ingestion of Lacticasei bacillus rhamnosus JB-1 during chronic stress ensures neurometabolic and behavioural stability in rats","volume":"23","author":"Chudzik","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0047","doi-asserted-by":"crossref","first-page":"34","DOI":"10.20517\/mrr.2025.56","article-title":"GABA-producing lactococcus lactis alleviates gut dysfunction and neurobehavioral abnormalities associated with irritable bowel syndrome","volume":"4","author":"Jin","year":"2025","journal-title":"Microbiome Res Rep"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12020-023-03640-z","article-title":"Gut microbiota and type 2 diabetes mellitus: a focus on the gut-brain axis","volume":"84","author":"Pan","year":"2024","journal-title":"Endocrine"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0049","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12967-023-04088-5","article-title":"The roles of dietary lipids and lipidomics in gut-brain axis in type 2 diabetes mellitus","volume":"21","author":"Agagunduz","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0050","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3390\/nu16111698","article-title":"Astragalus polysaccharide modulates the gut microbiota and metabolites of patients with type 2 diabetes in an In vitro fermentation model","volume":"16","author":"Zhang","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0051","doi-asserted-by":"crossref","first-page":"1135343","DOI":"10.3389\/fnut.2023.1135343","article-title":"Fecal metabolomics combined with 16S rRNA gene sequencing to analyze the effect of Jiaotai pill intervention in type 2 diabetes mellitus rats","volume":"10","author":"Liu","year":"2023","journal-title":"Front Nutr"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0052","doi-asserted-by":"crossref","first-page":"16791","DOI":"10.1038\/s41598-018-35014-1","article-title":"The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: a randomized, double-blinded, placebo-controlled trial","volume":"8","author":"Hsieh","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0053","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1002\/jsfa.12267","article-title":"Lactobacillus paracasei IMC 502 ameliorates type 2 diabetes by mediating gut microbiota-SCFA-hormone\/inflammation pathway in mice","volume":"103","author":"Gu","year":"2023","journal-title":"J Sci Food Agric"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0054","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40168-019-0713-7","article-title":"Dietary fructose-induced gut dysbiosis promotes mouse hippocampal neuroinflammation: a benefit of short-chain fatty acids","volume":"7","author":"Li","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0055","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1186\/s12967-022-03609-y","article-title":"Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions","volume":"20","author":"Agagunduz","year":"2022","journal-title":"J Transl Med"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0056","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.cmet.2021.08.015","article-title":"The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease","volume":"33","author":"Zhu","year":"2021","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0057","doi-asserted-by":"crossref","first-page":"6840","DOI":"10.1039\/D3FO01518A","article-title":"The probiotic Lactobacillus casei Zhang-mediated correction of gut dysbiosis ameliorates peritoneal fibrosis by suppressing macrophage-related inflammation via the butyrate\/PPAR-gamma\/NF-kappaB pathway","volume":"14","author":"Wu","year":"2023","journal-title":"Food Funct"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0058","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1039\/C6FO01147K","article-title":"A comparative study of the antidiabetic effects exerted by live and dead multi-strain probiotics in the type 2 diabetes model of mice","volume":"7","author":"Li","year":"2016","journal-title":"Food Funct"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0059","doi-asserted-by":"crossref","first-page":"114308","DOI":"10.1016\/j.biopha.2023.114308","article-title":"Butyrate ameliorates chronic alcoholic central nervous damage by suppressing microglia-mediated neuroinflammation and modulating the microbiome-gut-brain axis","volume":"160","author":"Wei","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jnutbio.2026.110446_bib0060","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1002\/ptr.7827","article-title":"Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4\/NF-small ka, CyrillicB pathway through microbiota-gut-brain axis","volume":"37","author":"Zhang","year":"2023","journal-title":"Phytother Res"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326001889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326001889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:32:01Z","timestamp":1784557921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286326001889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":60,"alternative-id":["S0955286326001889"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110446","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactobacillus casei Zhang modulates hippocampal metabolism and cognition in T2DM rats: a microbiota-gut-brain axis study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110446","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110446"}}