{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:32:06Z","timestamp":1793802726483,"version":"4.6.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902857"],"award-info":[{"award-number":["81902857"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jnutbio.2026.110487","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T08:52:09Z","timestamp":1787388729000},"page":"110487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["HACD3 integrates central leptin sensitivity and peripheral thermogenesis to oppositely regulate energy balance"],"prefix":"10.1016","volume":"159","author":[{"given":"Qindan","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-5255","authenticated-orcid":false,"given":"Xiaoying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jnutbio.2026.110487_bib0001","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(01)00240-9","article-title":"Obesity and the regulation of energy balance","volume":"104","author":"Spiegelman","year":"2001","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110487_bib0002","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/CIRCULATIONAHA.111.087213","article-title":"Energy balance and obesity","volume":"126","author":"Hill","year":"2012","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110487_bib0003","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1210\/er.2017-00111","article-title":"Obesity pathogenesis: an Endocrine Society scientific statement","volume":"38","author":"Schwartz","year":"2017","journal-title":"Endocr Rev"},{"issue":"6836","key":"10.1016\/j.jnutbio.2026.110487_bib0004","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/35078085","article-title":"Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus","volume":"411","author":"Cowley","year":"2001","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jnutbio.2026.110487_bib0005","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s42255-019-0095-y","article-title":"Leptin and the endocrine control of energy balance","volume":"1","author":"Friedman","year":"2019","journal-title":"Nat Metab"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110487_bib0006","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1210\/en.2007-1132","article-title":"Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion","volume":"149","author":"van de Wall","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2026.110487_bib0007","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.physiol.70.113006.100707","article-title":"Mechanisms of leptin action and leptin resistance","volume":"70","author":"Myers","year":"2008","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110487_bib0008","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol Rev"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110487_bib0009","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.cmet.2015.09.007","article-title":"Brown and beige fat: physiological roles beyond heat generation","volume":"22","author":"Kajimura","year":"2015","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110487_bib0010","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cell.2012.05.016","article-title":"Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human","volume":"150","author":"Wu","year":"2012","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jnutbio.2026.110487_bib0011","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81410-5","article-title":"A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis","volume":"92","author":"Puigserver","year":"1998","journal-title":"Cell"},{"issue":"6778","key":"10.1016\/j.jnutbio.2026.110487_bib0012","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/35007527","article-title":"Towards a molecular understanding of adaptive thermogenesis","volume":"404","author":"Lowell","year":"2000","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.jnutbio.2026.110487_bib0013","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.febslet.2008.06.007","article-title":"Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis","volume":"582","author":"Ikeda","year":"2008","journal-title":"Febs Lett"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110487_bib0014","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4062\/biomolther.2014.017","article-title":"Metabolism of very long-chain fatty acids: genes and pathophysiology","volume":"22","author":"Sassa","year":"2014","journal-title":"Biomol Ther (Seoul)"},{"issue":"37","key":"10.1016\/j.jnutbio.2026.110487_bib0015","doi-asserted-by":"crossref","first-page":"15538","DOI":"10.1074\/jbc.M117.803171","article-title":"The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways","volume":"292","author":"Sawai","year":"2017","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.jnutbio.2026.110487_bib0016","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/jb\/mvq092","article-title":"Characterization of HACD1 K64Q mutant found in arrhythmogenic right ventricular dysplasia patients","volume":"148","author":"Konishi","year":"2010","journal-title":"J Biochem"},{"issue":"7503","key":"10.1016\/j.jnutbio.2026.110487_bib0017","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature13478","article-title":"The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes","volume":"510","author":"Perry","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110487_bib0018","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.metabol.2014.09.010","article-title":"Structure, production and signaling of leptin","volume":"64","author":"Munzberg","year":"2015","journal-title":"Metabolism"},{"issue":"6925","key":"10.1016\/j.jnutbio.2026.110487_bib0019","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nature01388","article-title":"STAT3 signalling is required for leptin regulation of energy balance but not reproduction","volume":"421","author":"Bates","year":"2003","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jnutbio.2026.110487_bib0020","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1172\/JCI200113914","article-title":"Selective deletion of leptin receptor in neurons leads to obesity","volume":"108","author":"Cohen","year":"2001","journal-title":"J Clin Invest"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326002299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326002299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:23:51Z","timestamp":1793802231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286326002299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":20,"alternative-id":["S0955286326002299"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110487","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HACD3 integrates central leptin sensitivity and peripheral thermogenesis to oppositely regulate energy balance","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110487","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110487"}}