{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:45:46Z","timestamp":1791747946053,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007707","name":"University of California, Davis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007707","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK034854"],"award-info":[{"award-number":["P30DK034854"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jnutbio.2026.110516","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:32:28Z","timestamp":1791387148000},"page":"110516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut microbiota-derived indole-3-propionic acid suppresses hepatic CYP2E1 expression in mice"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2751-5832","authenticated-orcid":false,"given":"Yige","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6407-9891","authenticated-orcid":false,"given":"Pan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7651-6765","authenticated-orcid":false,"given":"Vladimir","family":"Yeliseyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongwei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7780-5470","authenticated-orcid":false,"given":"Guodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jnutbio.2026.110516_bib0001","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1021\/tx700079z","article-title":"Cytochrome p450 and chemical toxicology","volume":"21","author":"Guengerich","year":"2008","journal-title":"Chemical research in toxicology"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110516_bib0002","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.pharmtox.44.101802.121704","article-title":"Oxidative stress, toxicology, and pharmacology of CYP2E1","volume":"44","author":"Caro","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"23","key":"10.1016\/j.jnutbio.2026.110516_bib0003","first-page":"8435","article-title":"Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol","volume":"61","author":"Sohn","year":"2001","journal-title":"Cancer research"},{"issue":"10","key":"10.1016\/j.jnutbio.2026.110516_bib0004","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1093\/carcin\/13.10.1789","article-title":"Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes","volume":"13","author":"Yamazaki","year":"1992","journal-title":"Carcinogenesis"},{"issue":"43","key":"10.1016\/j.jnutbio.2026.110516_bib0005","doi-asserted-by":"crossref","first-page":"5725","DOI":"10.3748\/wjg.v13.i43.5725","article-title":"CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking","volume":"13","author":"Gao","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2026.110516_bib0006","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1186\/1471-2407-10-575","article-title":"The PstI\/RsaI and DraI polymorphisms of CYP2E1 and head and neck cancer risk: a meta-analysis based on 21 case-control studies","volume":"10","author":"Tang","year":"2010","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110516_bib0007","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1517\/17425250903540238","article-title":"CYP2E1 and risk of chemically mediated cancers","volume":"6","author":"Trafalis","year":"2010","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"16","key":"10.1016\/j.jnutbio.2026.110516_bib0008","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1093\/jnci\/89.16.1207","article-title":"CYP2E1 Genetic Polymorphisms and Risk of Nasopharyngeal Carcinoma in Taiwan","volume":"89","author":"Hildesheim","year":"1997","journal-title":"JNCI: Journal of the National Cancer Institute"},{"issue":"9","key":"10.1016\/j.jnutbio.2026.110516_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044478","article-title":"Functional PstI\/RsaI polymorphism in CYP2E1 is associated with the development, progression and poor outcome of gastric cancer","volume":"7","author":"Feng","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jnutbio.2026.110516_bib0010","first-page":"8927","article-title":"Cytochrome P450 2E1 RsaI\/PstI polymorphism is associated with urologic cancer risk: evidence from a meta-analysis","volume":"8","author":"Lin","year":"2015","journal-title":"Int J Clin Exp Med"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110516_bib0011","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/03602532.2011.602688","article-title":"Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity","volume":"44","author":"Jaeschke","year":"2012","journal-title":"Drug metabolism reviews"},{"issue":"12","key":"10.1016\/j.jnutbio.2026.110516_bib0012","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1124\/dmd.117.077313","article-title":"RNA-Seq profiling of intestinal expression of xenobiotic processing genes in germ-free mice","volume":"45","author":"Fu","year":"2017","journal-title":"Drug Metabolism and Disposition"},{"issue":"6","key":"10.1016\/j.jnutbio.2026.110516_bib0013","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s12223-017-0517-8","article-title":"Colonization by non-pathogenic bacteria alters mRNA expression of cytochromes P450 in originally germ-free mice","volume":"62","author":"Jourov\u00e1","year":"2017","journal-title":"Folia microbiologica"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110516_bib0014","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/toxsci\/kfv110","article-title":"Developmental regulation of drug-processing genes in livers of germ-free mice","volume":"147","author":"Selwyn","year":"2015","journal-title":"Toxicological Sciences"},{"issue":"10","key":"10.1016\/j.jnutbio.2026.110516_bib0015","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1124\/dmd.115.063545","article-title":"RNA-Seq quantification of hepatic drug processing genes in germ-free mice","volume":"43","author":"Selwyn","year":"2015","journal-title":"Drug metabolism and disposition"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110516_bib0016","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13099-023-00540-5","article-title":"Gut microbiota and host cytochrome P450 characteristics in the pseudo germ-free model: co-contributors to a diverse metabolic landscape","volume":"15","author":"Wang","year":"2023","journal-title":"Gut Pathogens"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110516_bib0017","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1124\/dmd.122.001173","article-title":"Antibiotics-Induced Depletion of Rat Microbiota Induces Changes in the Expression of Host Drug-Processing Genes and Pharmacokinetic Behaviors of CYPs Probe Drugs","volume":"51","author":"Yang","year":"2023","journal-title":"Drug metabolism and disposition: the biological fate of chemicals"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110516_bib0018","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00271-10","article-title":"Colonization-induced host-gut microbial metabolic interaction","volume":"2","author":"Claus","year":"2011","journal-title":"mBio"},{"issue":"6","key":"10.1016\/j.jnutbio.2026.110516_bib0019","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet\u2013induced obesity and diabetes in mice","volume":"57","author":"Cani","year":"2008","journal-title":"Diabetes"},{"issue":"5975","key":"10.1016\/j.jnutbio.2026.110516_bib0020","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.1179721","article-title":"Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5","volume":"328","author":"Vijay-Kumar","year":"2010","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110516_bib0021","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41467-021-27762-y","article-title":"Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract","volume":"13","author":"Zhang","year":"2022","journal-title":"Nature communications"},{"issue":"20","key":"10.1016\/j.jnutbio.2026.110516_bib0022","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.1073\/pnas.1721711115","article-title":"Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation","volume":"115","author":"Wang","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110516_bib0023","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41467-021-27762-y","article-title":"Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110516_bib0024","doi-asserted-by":"crossref","DOI":"10.1093\/ecco-jcc\/jjae148","article-title":"Oxidized Polyunsaturated Fatty Acid Promotes Colitis and Colitis-Associated Tumorigenesis in Mice","volume":"19","author":"Wang","year":"2025","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jnutbio.2026.110516_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110338","article-title":"The gut microbiota mediates epoxy eicosanoid metabolism in the colon","author":"Jing","year":"2025","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110516_bib0026","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2019.1690364","article-title":"Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involved","volume":"12","author":"Yang","year":"2020","journal-title":"Gut Microbes"},{"issue":"11","key":"10.1016\/j.jnutbio.2026.110516_bib0027","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","article-title":"The gut-liver axis and gut microbiota in health and liver disease","volume":"21","author":"Hsu","year":"2023","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110516_bib0028","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1038\/s41467-018-05470-4","article-title":"Microbial tryptophan catabolites in health and disease","volume":"9","author":"Roager","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2026.110516_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.crtox.2024.100195","article-title":"Subcellular expression of CYP2E1 in HepG2 cells impacts response to free oleic and palmitic acid","volume":"7","author":"Killingsworth","year":"2024","journal-title":"Curr Res Toxicol"},{"issue":"10","key":"10.1016\/j.jnutbio.2026.110516_bib0030","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/S0006-2952(03)00586-0","article-title":"Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice","volume":"66","author":"Cheung","year":"2003","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"10.1016\/j.jnutbio.2026.110516_bib0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107913","article-title":"HBx inhibits CYP2E1 gene expression via downregulating HNF4\u03b1 in human hepatoma cells","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110516_bib0032","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/dna.1995.14.285","article-title":"Role of the liver-enriched transcription factor HNF-1\u03b1 in expression of the CYP2E1 gene","volume":"14","author":"Liu","year":"1995","journal-title":"DNA and cell biology"},{"issue":"7","key":"10.1016\/j.jnutbio.2026.110516_bib0033","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.bcp.2004.06.003","article-title":"Determination of interleukin-4-responsive region in the human cytochrome P450 2E1 gene promoter","volume":"68","author":"Abdel-Razzak","year":"2004","journal-title":"Biochemical pharmacology"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110516_bib0034","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1124\/pr.55.4.2","article-title":"Induction of drug metabolism: the role of nuclear receptors","volume":"55","author":"Handschin","year":"2003","journal-title":"Pharmacological reviews"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110516_bib0035","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bbrc.2005.08.162","article-title":"Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes","volume":"338","author":"Fujii-Kuriyama","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2026.110516_bib0036","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12876-014-0189-7","article-title":"Intestinal permeability\u2013a new target for disease prevention and therapy","volume":"14","author":"Bischoff","year":"2014","journal-title":"BMC Gastroenterol"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110516_bib0037","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jhep.2013.07.044","article-title":"Pathological bacterial translocation in liver cirrhosis","volume":"60","author":"Wiest","year":"2014","journal-title":"Journal of Hepatology"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110516_bib0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2006.03.012","article-title":"The regulation of cytochrome P450 2E1 during LPS-induced inflammation in the rat","volume":"216","author":"Abdulla","year":"2006","journal-title":"Toxicol Appl Pharmacol"},{"issue":"16","key":"10.1016\/j.jnutbio.2026.110516_bib0039","doi-asserted-by":"crossref","first-page":"15734","DOI":"10.1074\/jbc.M311850200","article-title":"Lipopolysaccharide induces CYP2E1 in astrocytes through MAP kinase kinase-3 and C\/EBPbeta and -delta","volume":"279","author":"Kelicen","year":"2004","journal-title":"J Biol Chem"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326002585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326002585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T18:47:09Z","timestamp":1791744429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286326002585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":39,"alternative-id":["S0955286326002585"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110516","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut microbiota-derived indole-3-propionic acid suppresses hepatic CYP2E1 expression in mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110516","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110516"}}