{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:31:57Z","timestamp":1793971917640,"version":"4.8.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30803"],"award-info":[{"award-number":["2023JJ30803"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.jnutbio.2026.110517","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:49:23Z","timestamp":1791503363000},"page":"110517","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dietary zeaxanthin attenuates cigarette smoke-induced COPD by suppressing ERK-driven apoptosis"],"prefix":"10.1016","volume":"160","author":[{"given":"Ziyi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinshi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiru","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2026.110517_bib0001","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.76","article-title":"Chronic obstructive pulmonary disease","volume":"1","author":"Barnes","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"9","key":"10.1016\/j.jnutbio.2026.110517_bib0002","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3390\/antiox8090390","article-title":"Zeaxanthin: metabolism, properties, and antioxidant protection of Eyes, Heart, Liver, and Skin","volume":"8","author":"Murillo","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jnutbio.2026.110517_bib0003","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.preteyeres.2015.10.003","article-title":"Lutein, zeaxanthin, and meso-zeaxanthin: the basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease","volume":"50","author":"Bernstein","year":"2016","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110517_bib0004","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3390\/nu14040827","article-title":"Lutein and zeaxanthin and their roles in age-related macular degeneration-neurodegenerative disease","volume":"14","author":"Mrowicka","year":"2022","journal-title":"Nutrients"},{"issue":"Pt 2","key":"10.1016\/j.jnutbio.2026.110517_bib0005","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.foodres.2017.03.003","article-title":"Additional consumption of one egg per day increases serum lutein plus zeaxanthin concentration and lowers oxidized low-density lipoprotein in moderately hypercholesterolemic males","volume":"99","author":"Kishimoto","year":"2017","journal-title":"Food Res Int"},{"key":"10.1016\/j.jnutbio.2026.110517_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.109957","article-title":"Zeaxanthin impairs angiogenesis and tumor growth of glioblastoma: an in vitro and in vivo study","volume":"754","author":"Lu","year":"2024","journal-title":"Arch Biochem Biophys"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110517_bib0007","article-title":"Zeaxanthin prevents ferroptosis by promoting mitochondrial function and inhibiting the p53 pathway in free fatty acid-induced HepG2 cells","volume":"1868","author":"Liu","year":"2023","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"21","key":"10.1016\/j.jnutbio.2026.110517_bib0008","doi-asserted-by":"crossref","DOI":"10.3390\/foods13213388","article-title":"Effects of Zeaxanthin on the insulin resistance and gut microbiota of high-fat-diet-induced obese mice","volume":"13","author":"Jin","year":"2024","journal-title":"Foods"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110517_bib0009","doi-asserted-by":"crossref","DOI":"10.1002\/clt2.70039","article-title":"Improvement of glucocorticoid sensitivity and attenuation of pulmonary allergic reactions by exogenous supplementation with betaine in HDM and LPS-induced allergic mouse model","volume":"15","author":"Wang","year":"2025","journal-title":"Clin Transl Allergy"},{"issue":"5","key":"10.1016\/j.jnutbio.2026.110517_bib0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.15586\/aei.v50i5.664","article-title":"Zeaxanthin attenuates OVA-induced allergic asthma in mice by regulating the p38 MAPK\/\u03b2-catenin signaling pathway","volume":"50","author":"Jin","year":"2022","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110517_bib0011","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.phrs.2012.04.005","article-title":"ERK1\/2 MAP kinases: structure, function, and regulation","volume":"66","author":"Roskoski","year":"2012","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jnutbio.2026.110517_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108818","article-title":"LncRNA-CCAT1\/miR-152-3p is involved in CSE-induced inflammation in HBE cells via regulating ERK signaling pathway","volume":"109","author":"Zong","year":"2022","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110517_bib0013","doi-asserted-by":"crossref","first-page":"C330","DOI":"10.1152\/ajpcell.00182.2017","article-title":"Notch1 regulates endothelial apoptosis via the ERK pathway in chronic obstructive pulmonary disease","volume":"315","author":"Zong","year":"2018","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110517_bib0014","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/asi.20317","article-title":"CiteSpace II: detecting and visualizing emerging trends and transient patterns in scientific literature","volume":"57","author":"Chen","year":"2006","journal-title":"J Am Soc Inf Sci Technol"},{"issue":"6","key":"10.1016\/j.jnutbio.2026.110517_bib0015","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/0272989X06295361","article-title":"Decision curve analysis: a novel method for evaluating prediction models","volume":"26","author":"Vickers","year":"2006","journal-title":"Med Decis Making"},{"issue":"5","key":"10.1016\/j.jnutbio.2026.110517_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v059.i05","article-title":"mediation: R package for Causal mediation analysis","volume":"59","author":"Tingley","year":"2014","journal-title":"J Stat Softw"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110517_bib0017","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nbt1284","article-title":"Relating protein pharmacology by ligand chemistry","volume":"25","author":"Keiser","year":"2007","journal-title":"Nat Biotechnol"},{"issue":"D1","key":"10.1016\/j.jnutbio.2026.110517_bib0018","doi-asserted-by":"crossref","first-page":"D1257","DOI":"10.1093\/nar\/gkac833","article-title":"Comparative Toxicogenomics Database (CTD): update 2023","volume":"51","author":"Davis","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"10.1016\/j.jnutbio.2026.110517_bib0019","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"10.1016\/j.jnutbio.2026.110517_bib0020","doi-asserted-by":"crossref","first-page":"W356","DOI":"10.1093\/nar\/gkx374","article-title":"PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2026.110517_bib0021","doi-asserted-by":"crossref","first-page":"1.30.1","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards Suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr Protoc Bioinformatics"},{"issue":"D1","key":"10.1016\/j.jnutbio.2026.110517_bib0022","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"10.1016\/j.jnutbio.2026.110517_bib0023","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110517_bib0024","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"issue":"Suppl 4","key":"10.1016\/j.jnutbio.2026.110517_bib0025","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst Biol"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110517_bib0026","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"10.1016\/j.jnutbio.2026.110517_bib0027","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2026.110517_bib0028","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1613\/jair.953","article-title":"SMOTE: synthetic minority over-sampling technique","volume":"16","author":"Chawla","year":"2002","journal-title":"J Artif Intell Res"},{"key":"10.1016\/j.jnutbio.2026.110517_bib0029","first-page":"4765","article-title":"A unified approach to interpreting model predictions","volume":"30","author":"Lundberg","year":"2017","journal-title":"Adv Neural Inf Process Syst"},{"issue":"7","key":"10.1016\/j.jnutbio.2026.110517_bib0030","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.jnutbio.2026.110517_bib0031","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat Methods"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110517_bib0032","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat Biotechnol"},{"issue":"D1","key":"10.1016\/j.jnutbio.2026.110517_bib0033","doi-asserted-by":"crossref","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","article-title":"PubChem 2023 update","volume":"51","author":"Kim","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"10.1016\/j.jnutbio.2026.110517_bib0034","doi-asserted-by":"crossref","first-page":"D464","DOI":"10.1093\/nar\/gky1004","article-title":"RCSB Protein Data Bank: biological macromolecular structures enabling research and education in fundamental biology, biomedicine, biotechnology and energy","volume":"47","author":"Burley","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110517_bib0035","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110517_bib0036","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3109\/01902148.2012.745910","article-title":"Intraperitoneal injection of cigarette smoke extract induced emphysema, and injury of cardiac and skeletal muscles in BALB\/C mice","volume":"39","author":"Zhang","year":"2013","journal-title":"Exp Lung Res"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110517_bib0037","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12971-015-0033-z","article-title":"Comparison between cigarette smoke-induced emphysema and cigarette smoke extract-induced emphysema","volume":"13","author":"He","year":"2015","journal-title":"Tob Induc Dis"},{"issue":"7","key":"10.1016\/j.jnutbio.2026.110517_bib0038","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jnutbio.2026.110517_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117104","article-title":"Xanthophyll: health benefits and therapeutic insights","volume":"240","author":"Aziz","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.jnutbio.2026.110517_bib0040","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.abb.2018.04.008","article-title":"Lutein, zeaxanthin and mammalian development: Metabolism, functions and implications for health","volume":"647","author":"Giordano","year":"2018","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2026.110517_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104477","article-title":"Mechanistic insights into the effect of lutein on atherosclerosis, vascular dysfunction, and related risk factors: a systematic review of in vivo, ex vivo and in vitro studies","volume":"149","author":"Hajizadeh-Sharafabad","year":"2019","journal-title":"Pharmacol Res"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110517_bib0042","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3233\/JAD-210384","article-title":"The Associations of plasma\/serum carotenoids with Alzheimer's Disease: a systematic review and meta-analysis","volume":"82","author":"Qu","year":"2021","journal-title":"J Alzheimers Dis"},{"issue":"21","key":"10.1016\/j.jnutbio.2026.110517_bib0043","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000200289","article-title":"Association of serum antioxidant vitamins and carotenoids with incident Alzheimer disease and all-cause dementia among US adults","volume":"98","author":"Beydoun","year":"2022","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.jnutbio.2026.110517_bib0044","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.1039\/D1FO04064B","article-title":"Antiobesity drug-likeness properties and pancreatic lipase inhibition of a novel low molecular weight lutein oxidized product, LOP6","volume":"13","author":"Shamarao","year":"2022","journal-title":"Food Funct"},{"issue":"6","key":"10.1016\/j.jnutbio.2026.110517_bib0045","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3177\/jnsv.69.402","article-title":"Association of Dietary Carotenoids Intakes with obesity in adults: NHANES 2007-2018","volume":"69","author":"Yu","year":"2023","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"issue":"8","key":"10.1016\/j.jnutbio.2026.110517_bib0046","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1080\/01635581.2020.1801779","article-title":"Serum concentrations of carotenoids and fat-soluble vitamins in relation to nutritional status of patients with ovarian cancer","volume":"73","author":"Terlikowska","year":"2021","journal-title":"Nutr Cancer"},{"issue":"8","key":"10.1016\/j.jnutbio.2026.110517_bib0047","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1002\/cam4.1639","article-title":"Renal cell carcinoma risk associated with lower intake of micronutrients","volume":"7","author":"Bock","year":"2018","journal-title":"Cancer Med"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110517_bib0048","article-title":"Dietary lutein plus zeaxanthin intake and DICER1 rs3742330 A >G polymorphism relative to colorectal cancer risk","volume":"9","author":"Kim","year":"2019","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110517_bib0049","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/advances\/nmz120","article-title":"Carotenoid intake and circulating carotenoids are inversely associated with the risk of bladder cancer: a dose-response meta-analysis","volume":"11","author":"Wu","year":"2020","journal-title":"Adv Nutr"},{"issue":"6","key":"10.1016\/j.jnutbio.2026.110517_bib0050","doi-asserted-by":"crossref","DOI":"10.3390\/nu15061459","article-title":"Effects of Astaxanthin, Lutein, and Zeaxanthin on eye-hand coordination and smooth-pursuit eye movement after visual display terminal operation in healthy subjects: a randomized, double-blind placebo-controlled intergroup trial","volume":"15","author":"Yoshida","year":"2023","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.jnutbio.2026.110517_bib0051","article-title":"Effect of lutein on ocular goblet cell, IFN-\u03b3, and IL-17 concentration in dry eye-induced mice model","volume":"15","author":"Faustine","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.jnutbio.2026.110517_bib0052","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1522302","article-title":"The effects of lutein\/zeaxanthin (Lute-gen\u00ae) on eye health, eye strain, sleep quality, and attention in high electronic screen users: a randomized, double-blind, placebo-controlled study","volume":"12","author":"Lopresti","year":"2025","journal-title":"Front Nutr"},{"key":"10.1016\/j.jnutbio.2026.110517_bib0053","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.hrtlng.2024.02.010","article-title":"Association between carotenoids and the prevalence of chronic obstructive pulmonary disease in the United States","volume":"65","author":"Huang","year":"2024","journal-title":"Heart Lung"},{"issue":"1\u20132","key":"10.1016\/j.jnutbio.2026.110517_bib0054","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11481-021-09989-0","article-title":"Synergistic effect and mechanism of apoptosis induction by morphine and the HIV-1gp120V3 loop in hippocampal neurons","volume":"17","author":"Yan","year":"2022","journal-title":"J Neuroimmune Pharmacol"},{"key":"10.1016\/j.jnutbio.2026.110517_bib0055","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ijsu.2020.07.009","article-title":"Impact of hyperglycemia on neuronal apoptosis after subarachnoid hemorrhage in rodent brain: an experimental research","volume":"83","author":"Huang","year":"2020","journal-title":"Int J Surg"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110517_bib0056","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.jcmgh.2022.10.011","article-title":"Vitamin D receptor activation targets ROS-mediated crosstalk between autophagy and apoptosis in hepatocytes in cholestasic mice","volume":"15","author":"Zheng","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jnutbio.2026.110517_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117666","article-title":"Euscaphic acid and tormentic acid protect vascular endothelial cells against hypoxia-induced apoptosis via PI3K\/AKT or ERK 1\/2 signaling pathway","volume":"252","author":"Shi","year":"2020","journal-title":"Life Sci"},{"issue":"4\u20135","key":"10.1016\/j.jnutbio.2026.110517_bib0058","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3109\/01902148.2013.788234","article-title":"Change of extracellular signal-regulated kinase expression in pulmonary arteries from smokers with and without chronic obstructive pulmonary disease","volume":"39","author":"Liu","year":"2013","journal-title":"Exp Lung Res"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110517_bib0059","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2131\/jts.35.33","article-title":"Extracellular signal-regulated kinase (ERK) inhibition attenuates cigarette smoke extract (CSE) induced-death inducing signaling complex (DISC) formation in human lung fibroblasts (MRC-5) cells","volume":"35","author":"Park","year":"2010","journal-title":"J Toxicol Sci"},{"issue":"3","key":"10.1016\/j.jnutbio.2026.110517_bib0060","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.3390\/ijms24032462","article-title":"Anti-inflammatory activity and mechanism of sweet corn extract on IL-1\u03b2-induced inflammation in a Human retinal pigment epithelial cell line (ARPE-19)","volume":"24","author":"Koraneeyakijkulchai","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110517_bib0061","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/molecules26020333","article-title":"Zeaxanthin-rich extract from superfood lycium barbarum selectively modulates the cellular adhesion and MAPK signaling in melanoma versus normal skin cells In vitro","volume":"26","author":"Cenariu","year":"2021","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.jnutbio.2026.110517_bib0062","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095214","article-title":"Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway","volume":"9","author":"Xiao","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jnutbio.2026.110517_bib0063","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/jnc.15472","article-title":"Wolfberry-derived zeaxanthin dipalmitate delays retinal degeneration in a mouse model of retinitis pigmentosa through modulating STAT3, CCL2 and MAPK pathways","volume":"158","author":"Liu","year":"2021","journal-title":"J Neurochem"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326002597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326002597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:22:35Z","timestamp":1793971355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286326002597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":63,"alternative-id":["S0955286326002597"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110517","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary zeaxanthin attenuates cigarette smoke-induced COPD by suppressing ERK-driven apoptosis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110517","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110517"}}