{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:40:22Z","timestamp":1792395622690,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jnutbio.2026.110520","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:38:22Z","timestamp":1792276702000},"page":"110520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paeoniflorin Promotes Mitophagy Against Acute Kidney Injury via PRDX5-Dependent Inhibition of RACK1"],"prefix":"10.1016","author":[{"given":"Long-hao","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-xu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-rou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-xiang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9368-9379","authenticated-orcid":false,"given":"Zi-lan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-zhi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jnutbio.2026.110520_bib0001","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3390\/jcm12010375","article-title":"Acute Kidney Injury: Medical Causes and Pathogenesis","volume":"12","author":"Turgut","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0002","article-title":"Research progress of ferroptosis in acute kidney injury","volume":"13","author":"Zhang","year":"2025","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2026.124451","article-title":"Proteotoxicity and tubular epithelial cell fate in acute kidney injury: Molecular insights and treatment strategies","volume":"398","author":"Yerra","year":"2026","journal-title":"Life Sci"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0004","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2025.1643838","article-title":"Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury","volume":"12","author":"Ding","year":"2025","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0005","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.kint.2024.12.020","article-title":"Repurposing mitochondria-targeted therapeutics for kidney diseases","volume":"107","author":"Thompson","year":"2025","journal-title":"Kidney Int"},{"issue":"2","key":"10.1016\/j.jnutbio.2026.110520_bib0006","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3390\/biomedicines14020310","article-title":"Mitochondria in Renal Ischemia-Reperfusion Injury: From Mechanisms to Therapeutics","volume":"14","author":"Pan","year":"2026","journal-title":"Biomedicines"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2025.1623500","article-title":"Mitochondrial dysfunction and metabolic reprogramming in acute kidney injury: mechanisms, therapeutic advances, and clinical challenges","volume":"16","author":"Cao","year":"2025","journal-title":"Front Physiol"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0008","first-page":"32","article-title":"Mitochondrial quality control in human health and disease","volume":"11","author":"Liu","year":"2024","journal-title":"Mil Med Res"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101254","article-title":"PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation","volume":"26","author":"Lin","year":"2019","journal-title":"Redox Biol"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0010","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10495-022-01794-1","article-title":"Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1\/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury","volume":"28","author":"Zhu","year":"2023","journal-title":"Apoptosis"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0011","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1097\/IMNA-D-24-00039","article-title":"Therapeutic Application of Flavonoids in Kidney Disease and Senescence: Quercetin and Fisetin","volume":"13","author":"Li","year":"2026","journal-title":"Integrative Medicine in Nephrology and Andrology"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0012","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1097\/IMNA-D-24-00042","article-title":"The Renoprotective Effects of Radix Astragali and Salvia miltiorrhiza Bunge on Short-Term Outcomes of Acute Kidney Injury: A Retrospective Study","volume":"12","author":"He","year":"2025","journal-title":"Integrative Medicine in Nephrology and Andrology"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157429","article-title":"Naringenin alleviates endotoxin-induced acute kidney injury in chicken by inhibiting pyroptosis through PINK1-dependent mitophagy","volume":"149","author":"Chen","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1551368","article-title":"Paeoniflorin: a review of its pharmacology, pharmacokinetics and toxicity in diabetes","volume":"16","author":"Ou","year":"2025","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0015","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s12882-023-03366-0","article-title":"Paeoniflorin alleviates hypoxia\/reoxygenation injury in HK-2 cells by inhibiting apoptosis and repressing oxidative damage via Keap1\/Nrf2\/HO-1 pathway","volume":"24","author":"Xing","year":"2023","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0016","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.2147\/DDDT.S286606","article-title":"Total Glucosides of Paeony Inhibited Autophagy and Improved Acute Kidney Injury Induced by Ischemia-Reperfusion via the lncRNA TUG1\/miR-29a\/PTEN Axis","volume":"15","author":"Chang","year":"2021","journal-title":"Drug Des Devel Ther."},{"key":"10.1016\/j.jnutbio.2026.110520_bib0017","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.molimm.2024.12.003","article-title":"Paeoniflorin ameliorates reperfusion injury in H9C2 cells through SIRT1-PINK1\/parkin-mediated mitochondrial autophagy","volume":"177","author":"Chen","year":"2025","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0018","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41401-021-00671-y","article-title":"Paeoniflorin ameliorates ischemic injury in rat brain via inhibiting cytochrome c\/caspase3\/HDAC4 pathway","volume":"43","author":"Liu","year":"2022","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0019","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1089\/ars.2010.3584","article-title":"Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin","volume":"15","author":"Knoops","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0020","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1111\/j.1742-4658.2007.06103.x","article-title":"Mitochondrial targeting of human peroxiredoxin V protein and regulation of PRDX5 gene expression by nuclear transcription factors controlling biogenesis of mitochondria","volume":"274","author":"Kropotov","year":"2007","journal-title":"FEBS J"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156426","article-title":"Chaihuang Yishen Granule ameliorates mitochondrial homeostasis by upregulating PRDX5\/TFAM axis to inhibit renal fibrosis in CKD","volume":"139","author":"Xu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0022","first-page":"9","article-title":"Ablation of Peroxiredoxin V Exacerbates Ischemia\/Reperfusion-Induced Kidney Injury in Mice","author":"Park","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0023","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202500258RR","article-title":"Salvianolic Acid B Attenuates Ferroptosis in Acute Kidney Injury by Targeting PRDX5","volume":"39","author":"Tao","year":"2025","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0024","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/hmg\/ddac218","article-title":"Prdx5 regulates DNA damage response through autophagy-dependent Sirt2-p53 axis","volume":"32","author":"Agborbesong","year":"2023","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0025","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1478-811X-9-22","article-title":"RACK1, A multifaceted scaffolding protein: Structure and function","volume":"9","author":"Adams","year":"2011","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0026","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12964-024-01603-z","article-title":"The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition","volume":"22","author":"Bao","year":"2024","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0027","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1016\/j.apsb.2025.07.019","article-title":"PARylation promotes acute kidney injury via RACK1 dimerization-mediated HIF-1alpha degradation","volume":"15","author":"Li","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0028","article-title":"Preclinical evidence of reno-protective effect of quercetin on acute kidney injury: a meta-analysis of animal studies","volume":"14","author":"Zeng","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0029","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1159\/000530485","article-title":"From Physiology to Pathology: The Role of Mitochondria in Acute Kidney Injuries and Chronic Kidney Diseases","volume":"9","author":"Zhang","year":"2023","journal-title":"Kidney Dis (Basel)"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0030","article-title":"Adaptive Antioxidant Nanomedicines Inhibit Ferroptosis in Renal Tubular Epithelial Cells to Alleviate Diabetic Kidney Disease","volume":"12","author":"Liu","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0031","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41422-025-01203-7","article-title":"Auwerx J. Mitophagy in the pathogenesis and management of disease","volume":"36","author":"Wang","year":"2026","journal-title":"Cell Res"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0032","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fphys.2020.00178","article-title":"Augmenter of Liver Regeneration Protects Renal Tubular Epithelial Cells From Ischemia-Reperfusion Injury by Promoting PINK1\/Parkin-Mediated Mitophagy","volume":"11","author":"Zhu","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0033","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1097\/IMNA-D-24-00036","article-title":"Selective Autophagy in Kidney Diseases: The Tip of the Iceberg","volume":"12","author":"Zhang","year":"2025","journal-title":"Integrative Medicine in Nephrology and Andrology"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.156284","article-title":"Therapeutic potential of natural compounds in the management of chronic diseases: Targeting PINK1-Parkin pathway","volume":"277","author":"Khedr","year":"2026","journal-title":"Pathol Res Pract"},{"issue":"1","key":"10.1016\/j.jnutbio.2026.110520_bib0035","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/2773-0387.345767","article-title":"Drug-Induced Acute Kidney Injury: Epidemiology, Mechanisms, Risk Factors, and Prevention via Traditional Chinese Medicine","volume":"9","author":"Chen","year":"2022","journal-title":"Integrative Medicine in Nephrology and Andrology"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0036","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.freeradbiomed.2015.02.032","article-title":"Antioxidant cytoprotection by peroxisomal peroxiredoxin-5","volume":"84","author":"Walbrecq","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0037","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/j.febslet.2005.03.027","article-title":"Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide","volume":"579","author":"Banmeyer","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113788","article-title":"Prx5 overexpression protect against doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and inflammation via the TLR4\/NF-kappaB pathway","volume":"146","author":"Hu","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0039","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00018-025-05963-8","article-title":"IER3 drives the transition from sepsis-associated AKI to CKD by suppressing the mitochondrial translocation of PRDX5","volume":"82","author":"Dou","year":"2025","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0040","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12906-020-03180-3","article-title":"Effect of Shenkang on renal fibrosis and activation of renal interstitial fibroblasts through the JAK2\/STAT3 pathway","volume":"21","author":"Qin","year":"2021","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2026.103408","article-title":"Acetylation of PRDX5 aggravates the oxidative stress and apoptosis of retinal neurons induced by ischemia-reperfusion","volume":"101","author":"Lu","year":"2026","journal-title":"Tissue Cell"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0042","doi-asserted-by":"crossref","first-page":"122","DOI":"10.18632\/aging.102605","article-title":"PRDX5 as a novel binding partner in Nrf2-mediated NSCLC progression under oxidative stress","volume":"12","author":"Chen","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101959","article-title":"Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities","volume":"42","author":"Bolduc","year":"2021","journal-title":"Redox Biol"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0044","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-019-03593-w","article-title":"A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification","volume":"461","author":"Bakovic","year":"2019","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2026.112519","article-title":"RACK1: A multifunctional scaffold protein involved in signal transduction, ribosomal regulation, and Cancer pathogenesis","volume":"144","author":"Yang","year":"2026","journal-title":"Cell Signal"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0046","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14836","article-title":"Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia-reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1\/Parkin axis","volume":"30","author":"Zhao","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.jnutbio.2026.110520_bib0047","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.celrep.2015.10.011","article-title":"RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK","volume":"13","author":"Zhao","year":"2015","journal-title":"Cell Rep"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326002627?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286326002627?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:51:16Z","timestamp":1792392676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286326002627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":47,"alternative-id":["S0955286326002627"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110520","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paeoniflorin Promotes Mitophagy Against Acute Kidney Injury via PRDX5-Dependent Inhibition of RACK1","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2026.110520","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110520"}}