{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:23:12Z","timestamp":1780582992351,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"vor","delay-in-days":173,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","journalofarrhythmia.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The CHADS<jats:sub>2<\/jats:sub> scoring system is simple and widely accepted for predicting thromboembolism in patients with nonvalvular atrial fibrillation (NVAF). Although congestive heart failure (CHF) is a component of the CHADS<jats:sub>2<\/jats:sub> score, the definition of CHF remains unclear. We previously reported that the presence of CHF was a strong predictor of left atrial appendage (LAA) thrombus. Therefore, the present study aimed to elucidate the relationship between LAA thrombus and the brain natriuretic peptide (BNP) level in patients with unanticoagulated NVAF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 524 consecutive patients with NVAF who had undergone transesophageal echocardiography to detect intracardiac thrombus before cardioversion between January 2006 and December 2008, at Hiroshima City Asa Hospital. The exclusion criteria were as follows: paroxysmal atrial fibrillation, unknown BNP levels, prothrombin time international normalized ratio \u22652.0, and hospitalization for systemic thromboembolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Receiver operating characteristic analysis yielded optimal plasma BNP cut\u2010off levels of 157.1 pg\/mL (area under the curve, 0.91; <jats:italic>p<\/jats:italic>&lt;0.01) and 251.2 pg\/mL (area under the curve, 0.70; <jats:italic>p<\/jats:italic>&lt;0.01) for identifying CHF and detecting LAA thrombus, respectively. Multivariate analyses demonstrated that a BNP level &gt;251.2 pg\/mL was an independent predictor of LAA thrombus (odds ratio, 3.51; 95% confidence interval, 1.08\u201310.7; <jats:italic>p<\/jats:italic>=0.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with unanticoagulated NVAF, a BNP level &gt;251.2 pg\/mL may be helpful for predicting the incidence of LAA thrombus and may be used as a surrogate marker of CHF. The BNP level is clinically useful for the risk stratification of systemic thromboembolism in patients with unanticoagulated NVAF.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.joa.2015.04.002","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T02:53:28Z","timestamp":1431572008000},"page":"307-312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Usefulness of brain natriuretic peptide for predicting left atrial appendage thrombus in patients with unanticoagulated nonvalvular persistent atrial fibrillation"],"prefix":"10.1002","volume":"31","author":[{"given":"Yusuke","family":"Ochiumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisuke","family":"Kagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiho","family":"Itakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Takiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntaro","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Dote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,14]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-12-200706190-00007"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021328"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.22.2864"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq278"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.177292"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2304"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00887-X"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.7.1337"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.617886"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm356"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.08.046"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.2983"},{"key":"e_1_2_12_15_2","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.290.8.1049","article-title":"A risk score for predicting stroke or death in individuals with new\u2010onset atrial fibrillation in the community: the Framingham Heart Study","volume":"2908","author":"Wang T.J.","year":"2003","journal-title":"JAMA"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.03.008"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.02.016"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0502.103010"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000127882.58426.7A"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(98)70041-9"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000025242.79963.4C"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020233"},{"key":"e_1_2_12_23_2","first-page":"1424","article-title":"Does heart failure confer a hypercoagulable state? Virchow's triad revisited","volume":"33","author":"Lip G.Y.","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2002.3259"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/14.2.205"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.1446"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.936161"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-11-199512010-00001"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.08.027"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12169"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.107128"}],"container-title":["Journal of Arrhythmia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S188042761500054X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S188042761500054X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.joa.2015.04.002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T18:30:40Z","timestamp":1696012240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.joa.2015.04.002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,14]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1016\/j.joa.2015.04.002"],"URL":"https:\/\/doi.org\/10.1016\/j.joa.2015.04.002","archive":["Portico"],"relation":{},"ISSN":["1880-4276","1883-2148"],"issn-type":[{"value":"1880-4276","type":"print"},{"value":"1883-2148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,14]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Usefulness of brain natriuretic peptide for predicting left atrial appendage thrombus in patients with unanticoagulated nonvalvular persistent atrial fibrillation","name":"articletitle","label":"Article Title"},{"value":"Journal of Arrhythmia","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.joa.2015.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Japanese Heart Rhythm Society. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}