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However, the usefulness of antiarrhythmic drugs for preventing postoperative AF recurrence in the Japanese population has not been extensively studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From a total of 118 patients who developed postoperative paroxysmal AF between April 2009 and March 2011, 72 patients (45 men, mean age 68\u00b18 years) requiring treatment for postoperative AF due to symptoms lasting \u226530 min were enrolled to prospectively investigate the efficacy of oral bepridil (100 mg\/day, <jats:italic>n<\/jats:italic>=37) or aprindine (40 mg\/day, <jats:italic>n<\/jats:italic>=35).<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The AF recurrence\u2010free survival rates at 1, 3, 7, and 14 days were 100%, 94%, 57%, and 49%, respectively, in the aprindine group, and 100%, 97%, 86%, and 76%, respectively, in the bepridil group (<jats:italic>P<\/jats:italic>=0.028, aprindine vs. bepridil).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bepridil, at a fixed dose of 100 mg\/day, was considered to be more effective than a routine dose of aprindine for the prevention of postoperative AF recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.joa.2015.04.003","type":"journal-article","created":{"date-parts":[[2015,5,16]],"date-time":"2015-05-16T20:00:20Z","timestamp":1431806420000},"page":"302-306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the effects of bepridil and aprindine for the prevention of atrial fibrillation after cardiac and aortic surgery: A prospective randomized 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